Iκbε-deficient mice: Reduction of one T cell precursor subspecies and enhanced Ig isotype switching and cytokine synthesis

Journal of Immunology

Volumn 163, Issue 11, 1999, Pages 5994-6005

  Mémet, Sylvie ^a   Laouini, Dhafer ^b   Epinat, Jean Charles ^a,c   Whiteside, Simon T ^a,d   Goudeau, Bertrand ^a   Philpott, Dana ^b   Kayal, Samer ^b   Sansonetti, Philippe J ^b   Berche, Patrick ^b   Kanellopoulos, Jean ^b   Israël, Alain ^a  

^a INSTITUT PASTEUR   (France)

^b INSERM   (France)

^c Boston University ^*  (United States)

^d Hybrigenics SA   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; CYTOKINE; HERMES ANTIGEN; IMMUNOGLOBULIN CLASS; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN M; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 6; MESSENGER RNA; RIBONUCLEASE; THIOGLYCOLIC ACID; TRANSCRIPTION FACTOR; I KAPPA B; MITOGENIC AGENT; NFKBIE PROTEIN, MOUSE; ONCOPROTEIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; BONE MARROW; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENE SWITCHING; KNOCKOUT MOUSE; LYMPH NODE; MACROPHAGE; NONHUMAN; PRIORITY JOURNAL; PROLYMPHOCYTE; SPLEEN; T LYMPHOCYTE SUBPOPULATION; THYMUS; ANIMAL; ANTIBODY SPECIFICITY; BIOSYNTHESIS; CYTOLOGY; GENE REARRANGEMENT; GENETICS; HEMATOPOIETIC STEM CELL; IMMUNOLOGY; LISTERIOSIS; LYMPHOCYTE COUNT; MOUSE; MOUSE MUTANT; SHIGELLA FLEXNERI; SHIGELLOSIS; UPREGULATION;

ANIMALS; ANTIBODY SPECIFICITY; CYTOKINES; DYSENTERY, BACILLARY; HEMATOPOIETIC STEM CELLS; I-KAPPA B PROTEINS; IMMUNOGLOBULIN CLASS SWITCHING; LISTERIA INFECTIONS; LYMPH NODES; LYMPHOCYTE COUNT; MICE; MICE, KNOCKOUT; MITOGENS; PROTO-ONCOGENE PROTEINS; SHIGELLA FLEXNERI; SPLEEN; T-LYMPHOCYTE SUBSETS; THYMUS GLAND; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 0033248129     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (68)

1. Grilli, M., J. I. S. Chiu, and M. Lenardo. 1993. NF-κ-B and rel: participants in a multiform transcriptional regulatory system. Int. Rev. Cytol. 143:1.
2. May, M. J., and S. Ghosh. 1998. Signal transduction through NF-κB. Immunol. Today 19:80.
3. Baldwin, A. S. 1996. The NF-κB and IκB proteins: new discoveries and insights. Annu. Rev. Immunol. 14:649.
4. Attar, R. M., J. Caamano, D. Carrasco, V. Iotsova, H. Ishikawa, R. P. Ryseck, F. Weih, and R. Bravo. 1997. Genetic approaches to study rel/NF-κB/IκB function in mice. Semin. Cancer Biol. 8:93.
5. Gerondakis, S., R. Grumont, I. Rourke, and M. Grossmann. 1998. The regulation and roles of rel/NF-κB transcription factors during lymphocyte activation. Curr. Opin. Immunol. 10:353.
6. Ghosh, S., M. J. May, and E. B. Kopp. 1998. NF-κB and rel proteins: evolutionary conserved mediators of immune responses. Annu. Rev. Immunol. 16:225.
7. Sha, W. C. 1998. Regulation of immune responses by NF-κB/rel transcription factors. J. Exp. Med. 187:143.
8. Baeuerle, P. A., and T. Henkel. 1994. Function and activation of NF-κκB in the immune system. Annu. Rev. Immunol. 12:141.
9. Schmidt-Ullrich, R., S. Mémet, A. Lilienbaum, J. Feuillard, M. Raphael, and A. Israel. 1996. NF-κB activity in transgenic mice: developmental regulation and tissue specificity. Development 122:2117.
10. Whileside, S. T., and A. Israel. 1997. IκB proteins: structure, function and regulation. Semin. Cancer Biol. 8:75.
11. Ghosh, S., and D. Baltimore. 1990. Activation in vitro of NF-κB by phosphorylation of its inhibitor IκB. Nature 344:678.
12. Zabel, U., and P. A. Baeuerle. 1990, Purified human IκB can rapidly dissociate the complex of the NF-κB transcription factor with its cognate DNA. Cell 61: 255.
13. Haskill, S., A. A. Beg, S. M. Tompkins, J. S. Morris, A. D. Yurochko, A. Sampson-Johannes, K. Mondal, P. Ralph, and A. S. Baldwin. 1991. Characterization of an immediate-early gene induced in adherent monocytes that encodes IκB-like activity. Cell 65:1281.
14. Thompson, J. E., R. J. Phillips, H. Erdjument-Bromage, P. Tempst, and S. Ghosh. 1995. IκBβ regulates the persistent response in a biphasic activation of NF-κB. Cell 80:573.
15. Whiteside, S. T., J. C. Epinat, N. R. Rice, and A. Israel. 1997. IκBε, a novel member of the IκB family, controls relA and c-rel NF-κB activity. EMBO J. 16:1413.
16. Li, Z., and G. J. Nabel. 1997. A new member of the IκB protein family, IκBε, inhibits relA (p65)-mediated NF-κB transcription. Mol. Cell. Biol. 17:6184.
17. Simeonidis, S., S. Liang, G. Y. Chen, and D. Thanos. 1997. Cloning and functional characterization of mouse IκBε. Proc. Natl. Acad. Sci. USA 94:14372.
18. Whiteside, S. T., M. K. Ernst, O. LeBail, C. Laurent-Winter, N. R. Rice, and A. Israel. 1995. N- and C-terminal sequences control degradation of MAD3/IκBα in response to inducers of NF-κB activity. Mol. Cell. Biol. 15:5339.
19. Arenzana Seisdedos, F., J. Thompson, M. S. Rodriguez, F. Bachelerie, D. Thomas, and R. T. Hay. 1995. Inducible nuclear expression of newly synthesized IκBα negatively regulates DNA-binding and transcriptional activities of NF-κB. Mol. Cell. Biol. 15:2689.
20. Arenzana Seisdedos, F., P. Turpin, M. Rodriguez, D. Thomas, R. T. Hay, J. L. Virelizier, and C. Dargemont. 1997. Nuclear localization of IκBα promotes active transport of NF-κB from the nucleus to the cytoplasm. J. Cell Sci. 110:369.
21. Suyang, H., R. Phillips, I. Douglas, and S. Ghosh. 1996. Role of unphosphorylated, newly synthesized IκBβ in persistent activation of NF-κB. Mol. Cell. Biol. 16:5444.
22. Beg, A. A., W. C. Sha, R. T. Bronson, S. Ghosh, and D. Baltimore. 1995. Embryonic lethality and liver degeneration in mice lacking the ReIA component of NF-κB. Nature 376:167.
23. Klement, J. F., N. R. Rice, B. D. Car, S. J. Abbondanzo, G. D. Powers, H. Bhatt, C. H. Chen, C. A. Rosen, and C. L. Stewart. 1996. IκBα deficiency results in a sustained NF-κB response and severe widespread dermatitis in mice. Mol. Cell. Biol. 16:2341.
24. Cheng, J. D., R. P. Ryseck, R. M. Attar, D. Dambach, and R. Bravo. 1998. Functional redundancy of the nuclear factor KB inhibitors IκBα and IκBβ. J. Exp. Med. 188:1055.
25. Attar, R. M., H. Macdonald-Bravo, C. Raventos-Suarez, S. K. Durham, and R. Bravo. 1998. Expression of constitutively active IκBβ in T cells of transgenic mice: persistent NF-κB activity is required for T-cell immune responses. Mol. Cell. Biol. 18:477.
26. Boothby, M. R., A. L. Mora, D C. Scherer, J. A. Brockman, and D. W. Ballard. 1997. Perturbation of the T lymphocyte lineage in transgenic mice expressing a constitutive repressor of nuclear factor NF-κB. J. Exp. Med. 185:1897.
27. Tybulewicz, V. L., C. E. Crawford, P. K. Jackson, R. T. Bronson, and R. C. Mulligan. 1991. Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene. Cell 65:1153.
28. Laird, P. W., A. Zidjerveld, K. Linders, M. A. Rudnicki, R. Jaenisch, and A. Berns. 1991. Simplified mammalian DNA isolation procedure. Nucleic Acids Res. 19:4293.
29. Church, G. M., and W. Gilbert. 1984. Genomic sequencing. Proc. Natl. Acad. Sci. USA 81:1991.
30. Fiering, S., J. P. Northrop, G. P. Nolan, P. S. Mattila, G. R. Crabtree, and L. A. Herzenberg. 1990. Single cell assay of a transcription factor reveals a threshold in transcription activated by signals emanating from the T-cell antigen receptor. Genes Dev. 4:1823.
31. Phalipon, A., M. Kaufmann, P. Michetti, J.-M. Cavaillon, M. Huerre, P. Sansonetti, and J.-P. Kraehenbuhl. 1995. Monoclonal immunoglobulin A antibody directed against serotype-specific epitope of Shigella flexneri lipopolysaccharide protects against murine experimental shigellosis. J. Exp. Med. 182:769.
32. Gaillard, J. L., P. Berche, C. Fréhel, E. Gouin, and P. Cossart. 1991. Entry of L. monocytogenes into cells is mediated by internalin, a repeat protein reminiscent of surface antigen from Gram-positive cocci. Cell 65:1127.
33. Le Mouellic, H., Y. Lallemand, and P. Brulet. 1990. Targeted replacement of the homeobox gene Hox-3.1 by the Escherichia coli lacZ in mouse. Proc. Natl. Acad. Sci. USA 87:4712.
34. Jeannotte, L., J. C. Ruiz, and E. J. Robertson. 1991. Low level of Hox1.3 gene expression does not preclude the use of promoterless vectors to generate a targeted gene disruption. Mol. Cell. Biol. 11:5578.
35. Kim, D. G., H. M. Kang, S. K. Jang, and H.-S. Shin. 1992. Construction of a bifunctional mRNA in the mouse by using the internal ribosomal entry site of the encephalomyocarditis virus. Mol. Cell. Biol. 12:3636.
36. Mansour, S. L., K. R. Thomas, and M. R. Capecchi. 1988. Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes. Nature 336:348.
37. Yagi, T., Y. Ikawa, K. Yoshida, Y. Shigetani, N. Takeda, I. Mabuchi, T. Yamamoto, and S. Aizawa. 1990. Homologous recombination at c-fyn locus of mouse embryonic stem cells with use of diphtheria toxin A-fragment gene in negative selection. Proc. Natl. Acad. Sci. USA 87:9918.
38. Nolan, G. P., S. Fiering, J. F. Nicolas, and L. A. Herzenberg. 1988. Fluorescence-activated cell analysis and sorting of viable mammalian cells based on β-D-galactosidase activity after transaction of Escherichia coli lacZ. Proc. Natl. Acad. Sci. USA 85:2603.
39. Hardy, R. R., C. E. Carmack, S. A. Shinton, J. D. Kemp, and K. Hayakawa. 1991. Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow. J. Exp. Med. 173:1213.
40. Ziegler-Heitbrock, H. W. L. 1989. The biology of the monocyte system. Eur. J. Cell Biol. 49:1.
41. Eckmann, L., M. F. Kagnoff, and J. Fierer. 1993. Epithelial cells secrete the chemokine interleukin-8 in response to bacterial entry. Infect. Immun. 61:4569.
42. Jung, H. C., L. Eckmann, S.-K. Yang, A. Panja, I. Fierer, E. Morzycka-Wroblewska, and M. F. Kagnoff. 1995. A distinct array of proinflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasion. J. Clin. Invest. 95:55.
43. Kayal, S., A. Lilienbaum, C. Poyart, S. Mémet, A. Israël, and P. Berche. 1999. Listeriolysin O-dependent activation of endothelial cells during infection with Listeria monocytogenes: activation of NF-κB and up-regulalion of adhesion molecules and chemokines. Mol. Microbiol. 31:1709.
44. Beg, A. A., W. C. Sha, R. T. Bronson, and D. Baltimore. 1995. Constitutive NF-κB activation, enhanced granulopoiesis, and neonatal lethality in IκBα-deficient mice. Genes Dev. 9:2736.
45. Fiering, S. N., M. Roederer, G. P. Nolan, D. R. Micklem, D. R. Parks, and L. A. Herzenberg. 1991. Improved FACS-Ga1: flow cytometric analysis and sorting of viable eukaryotic cells expressing reporter gene constructs. Cytometry 12:291.
46. Brown, K., S. Park, T. Kanno, G. Franzoso, and U. Siebenlist. 1993. Mutual regulation of the transcriptional activator NF-κB and its inhibitor, IκBα. Proc. Natl. Acad. Sci. USA 90:2532.
47. LeBail, O., R. Schmidt Ullrich, and A. Israel. 1993. Promoter analysis of the gene encoding the IκBα/MAD3 inhibitor of NF-κB: positive regulation by members of the rel/NF-κB family. EMBO J. 12:5043.
48. Rice, N. R., and M. K. Ernst. 1993. In vivo control of NF-κB activation by IκBα. EMBO J. 12:4685.
49. Scott, M. L., T. Fujita, H. C. Liou, G. P. Nolan, and D. Baltimore. 1993. The p65-subunit of NF-κB regulates IκB by 2 distinct mechanisms. Genes Dev. 7:1266.
50. Sun, S. C., P. A. Ganchi, D. W. Ballard, and W. C. Greene. 1993. NF-κB controls expression of inhibitor IκBα: evidence for an inducible autoregulatory pathway. Science 259:1912.
51. Godfrey, D. I., and A. Zlotnik. 1993. Control points in early T-cell development. Immunol. Today 14:547.
52. Willerford, D. M., J. Chen, J. A. Ferry, L. Davidson, A. Ma, and F. W. Alt. 1995. Interleukin-2 receptor or chain regulates the size and content of the peripheral lymphoid compartment. Immunity 3:521.
53. Kontgen, F., R. J. Grumont, A. Strasser, D. Metcalf, R. L. Li, D. Tarlinton, and S. Gerondakis. 1995. Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression. Genes Dev. 9:1965.
54. Weih, F., D. Carrasco, S. K. Durham, D. S. Barton, C. A. Rizzo, R. P. Ryseck, S. A. Lira, and R. Bravo. 1995. Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-κB/Rel family. Cell 80:331.
55. Sha, W. C., H. C. Liou, E. I. Tuomanen, and D. Baltimore. 1995. Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses. Cell 80:321.
56. Doi, T. S., T. Takahashi, O. Taguchi, T. Azuma, and Y. Obata. 1997. NF-κB relA-deficient lymphocytes: normal development of T cells and B cells, impaired production of IgA and IgG1 and reduced proliferative responses. J. Exp. Med. 185:953.
57. Franzoso, G., L. Carlson, L. P. Xing, L. Poljak, E. W. Shores, K. D. Brown, A. Leonardi, T. Tran, B. F. Boyce, and U. Siebenlist. 1997. Requirement for NF-κB in osteoclast and B-cell development. Genes Dev. 11:3482.
58. Caamano, J. H., C. A. Rizzo, S. K. Durham, D. S. Barton, C. Raventos-Suarez, C. M. Snapper, and R. Bravo. 1998. Nuclear factor (NF)-κB2 (p100/p52) is required for normal splenic microarchitecture and B cell-mediated immune responses. J. Exp. Med 187:185.
59. Franzoso, G., L. Carlson, L. Poljak, E. W. Shores, S. Epstein, A. Leonardi, A. Grinberg, T. Tran, T. Schartonkersten, M. Anver, P. Love, K. Brown, and U. Siebenlist. 1998. Mice deficient in nuclear factor (NF)-κB/p52 present with defects in humoral responses, germinal center reactions, and splenic microarchitecture. J. Exp. Med. 187:147.
60. Cogné, M., R. Lansdorf, A. Bottaro, J. Zhang, J. Gorman, F. Young, H.-L. Cheng, and F. W. Alt. 1994. A class switch control region at the 3′ end of the immunoglobulin heavy chain locus. Cell 77:737.
61. Michaelson, J. S., M. Singh, C. M. Snapper, W. C. Sha, D. Baltimore, and B. K. Birshtein. 1996. Regulation of 3′ IgH enhancers by a common set of factors including κB-binding proteins. J. Immunol. 156:2828.
62. Lin, S. C., and J. Stavnezer. 1996. Activation of NF-κB/Rel by CD40 engagement induces the mouse germ line immunoglobulin Cγ1 promoter. Mol. Cell. Biol. 16:4591.
63. Iciek, L. A., S. A. Delphin, and J. Stavnezer. 1997. CD40 cross-linking induces Ig-ε germline transcripts in B cells via activation of NF-κB: synergy with IL-4 induction. J. Immunol. 158:4769.
64. Weih, F., G. Warr, H. Yang, and R. Bravo. 1997. Multifocal defects in immune responses in relB-deficient mice. J. Immunol. 158:5211.
65. Hiscott, J., J. Marois, J. Garoufalis, M. D'Addario, A. Roulston, I. Kwan, N. Pepin, J. Lacoste, H. Nguyen, G. Bensi, and M. Fenton. 1993. Characterization of a functional NF-κB site in the human interleukin 1β promoter: evidence for a positive autoregulalory loop. Mol. Cell. Biol. 13:6231.
66. Cogswell, J. P., M. M. Godlevski, G. B. Wisely, W. C. Clay, L. M. Leesnitzer, J. P. Ways, and J. G. Gray. 1994. NF-κB regulates IL-1β transcription through a consensus NF-κB binding site and a nonconsensus CRE-like site. J. Immunol. 153:712.
67. Parry, G. C. N., and N. Mackman. 1994. A set of inducible genes expressed by activated human monocytic and endothelial cells contain κB-like sites that specifically bind c-Rel-p65 heterodimers. J. Biol. Chem. 269:20823.
68. Vincent, S., L. Marty, and P. Fort. 1993. S26 ribosomal protein RNA: an invariant control for gene regulation experiments in eucaryotic cells and tissues. Nucleic Acids Res. 21:1498.