메뉴 건너뛰기




Volumn 101, Issue 1, 2011, Pages 140-146

Function of erbB receptors and DNA-PKcs on phosphorylation of cytoplasmic and nuclear Akt at S473 induced by erbB1 ligand and ionizing radiation

Author keywords

DNA PKcs; erbB1 ligands; Ionizing radiation; P Akt (S473)

Indexed keywords

DNA; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; PROTEIN KINASE B; PROTEIN KINASE C; SMALL INTERFERING RNA;

EID: 80655124677     PISSN: 01678140     EISSN: 18790887     Source Type: Journal    
DOI: 10.1016/j.radonc.2011.06.004     Document Type: Article
Times cited : (28)

References (47)
  • 1
    • 54949109808 scopus 로고    scopus 로고
    • PI3K/Akt: Getting it right matters
    • T.F. Franke PI3K/Akt: getting it right matters Oncogene 27 2008 6473 6488
    • (2008) Oncogene , vol.27 , pp. 6473-6488
    • Franke, T.F.1
  • 2
    • 0036185848 scopus 로고    scopus 로고
    • The protein kinase B/Akt signalling pathway in human malignancy
    • DOI 10.1016/S0898-6568(01)00271-6, PII S0898656801002716
    • K.M. Nicholson, and N.G. Anderson The protein kinase B/Akt signalling pathway in human malignancy Cell Signal 14 2002 381 395 (Pubitemid 34214843)
    • (2002) Cellular Signalling , vol.14 , Issue.5 , pp. 381-395
    • Nicholson, K.M.1    Anderson, N.G.2
  • 5
    • 0034708482 scopus 로고    scopus 로고
    • Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site
    • DOI 10.1074/jbc.275.12.8271
    • A. Toker, and A.C. Newton Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site J Biol Chem 275 2000 8271 8274 (Pubitemid 30180163)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.12 , pp. 8271-8274
    • Toker, A.1    Newton, A.C.2
  • 7
    • 0035920145 scopus 로고    scopus 로고
    • Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: Critical roles for kinase activity and amino acids arginine 211 and serine 343
    • S. Persad, S. Attwell, and V. Gray Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343 J Biol Chem 276 2001 27462 27469
    • (2001) J Biol Chem , vol.276 , pp. 27462-27469
    • Persad, S.1    Attwell, S.2    Gray, V.3
  • 8
    • 34848886113 scopus 로고    scopus 로고
    • Parathyroid hormone-related protein induces cell survival in human renal cell carcinoma through the PI3K-Akt pathway: Evidence for a critical role for integrin-linked kinase and nuclear factor kappa B
    • DOI 10.1093/carcin/bgm106
    • A. Agouni, C. Sourbier, and S. Danilin Parathyroid hormone-related protein induces cell survival in human renal cell carcinoma through the PI3K Akt pathway: evidence for a critical role for integrin-linked kinase and nuclear factor kappa B Carcinogenesis 28 2007 1893 1901 (Pubitemid 47500600)
    • (2007) Carcinogenesis , vol.28 , Issue.9 , pp. 1893-1901
    • Agouni, A.1    Sourbier, C.2    Danilin, S.3    Rothhut, S.4    Lindner, V.5    Jacqmin, D.6    Helwig, J.-J.7    Lang, H.8    Massfelder, T.9
  • 9
    • 13844312400 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    • DOI 10.1126/science.1106148
    • D.D. Sarbassov, D.A. Guertin, S.M. Ali, and D.M. Sabatini Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex Science 307 2005 1098 1101 (Pubitemid 40262113)
    • (2005) Science , vol.307 , Issue.5712 , pp. 1098-1101
    • Sarbassov, D.D.1    Guertin, D.A.2    Ali, S.M.3    Sabatini, D.M.4
  • 10
    • 28844434558 scopus 로고    scopus 로고
    • 473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes
    • DOI 10.1074/jbc.M508361200
    • R.C. Hresko, and M. Mueckler mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes J Biol Chem 280 2005 40406 40416 (Pubitemid 41780527)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.49 , pp. 40406-40416
    • Hresko, R.C.1    Mueckler, M.2
  • 13
    • 4644359805 scopus 로고    scopus 로고
    • Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase
    • DOI 10.1074/jbc.M406731200
    • J. Feng, J. Park, P. Cron, D. Hess, and B.A. Hemmings Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase J Biol Chem 279 2004 41189 41196 (Pubitemid 39287721)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.39 , pp. 41189-41196
    • Feng, J.1    Park, J.2    Cron, P.3    Hess, D.4    Hemmings, B.A.5
  • 14
    • 42949165854 scopus 로고    scopus 로고
    • PKBα/Akt1 Acts Downstream of DNA-PK in the DNA Double-Strand Break Response and Promotes Survival
    • DOI 10.1016/j.molcel.2008.02.024, PII S1097276508001718
    • L. Bozulic, B. Surucu, D. Hynx, and B.A. Hemmings PKBalpha/Akt1 acts downstream of DNA-PK in the DNA double-strand break response and promotes survival Mol Cell 30 2008 203 213 (Pubitemid 351626686)
    • (2008) Molecular Cell , vol.30 , Issue.2 , pp. 203-213
    • Bozulic, L.1    Surucu, B.2    Hynx, D.3    Hemmings, B.A.4
  • 15
    • 51049105757 scopus 로고    scopus 로고
    • Targeting of AKT1 enhances radiation toxicity of human tumor cells by inhibiting DNA-PKcs-dependent DNA double-strand break repair
    • M. Toulany, R. Kehlbach, and U. Florczak Targeting of AKT1 enhances radiation toxicity of human tumor cells by inhibiting DNA-PKcs-dependent DNA double-strand break repair Mol Cancer Ther 7 2008 1772 1781
    • (2008) Mol Cancer Ther , vol.7 , pp. 1772-1781
    • Toulany, M.1    Kehlbach, R.2    Florczak, U.3
  • 16
    • 33746088022 scopus 로고    scopus 로고
    • Blockage of epidermal growth factor receptor-phosphatidylinositol 3-kinase-AKT signaling increases radiosensitivity of K-RAS mutated human tumor cells in vitro by affecting DNA repair
    • DOI 10.1158/1078-0432.CCR-05-2454
    • M. Toulany, U. Kasten-Pisula, and I. Brammer Blockage of epidermal growth factor receptor-phosphatidylinositol 3-kinase-AKT signaling increases radiosensitivity of K-RAS mutated human tumor cells in vitro by affecting DNA repair Clin Cancer Res 12 2006 4119 4126 (Pubitemid 44078101)
    • (2006) Clinical Cancer Research , vol.12 , Issue.13 , pp. 4119-4126
    • Toulany, M.1    Kasten-Pisula, U.2    Brammer, I.3    Wang, S.4    Chen, J.5    Dittmann, K.6    Baumann, M.7    Dikomey, E.8    Rodemann, H.P.9
  • 17
    • 74549173597 scopus 로고    scopus 로고
    • Radiocontrast media affect radiation-induced DNA damage repair in vitro and in vivo by affecting Akt signalling
    • M. Toulany, R. Kehlbach, H.P. Rodemann, and H. Mozdarani Radiocontrast media affect radiation-induced DNA damage repair in vitro and in vivo by affecting Akt signalling Radiother Oncol 94 2010 110 116
    • (2010) Radiother Oncol , vol.94 , pp. 110-116
    • Toulany, M.1    Kehlbach, R.2    Rodemann, H.P.3    Mozdarani, H.4
  • 18
    • 69949148071 scopus 로고    scopus 로고
    • 2-Methoxyestradiol-induced radiosensitization is independent of SOD but depends on inhibition of Akt and DNA-PKcs activities
    • U. Florczak, M. Toulany, R. Kehlbach, and H.P. Rodemann 2-Methoxyestradiol-induced radiosensitization is independent of SOD but depends on inhibition of Akt and DNA-PKcs activities Radiother Oncol 92 2009 334 338
    • (2009) Radiother Oncol , vol.92 , pp. 334-338
    • Florczak, U.1    Toulany, M.2    Kehlbach, R.3    Rodemann, H.P.4
  • 19
    • 77956492379 scopus 로고    scopus 로고
    • Targeting nonhomologous end-joining through epidermal growth factor receptor inhibition: Rationale and strategies for radiosensitization
    • B. Mukherjee, H. Choy, C. Nirodi, and S. Burma Targeting nonhomologous end-joining through epidermal growth factor receptor inhibition: rationale and strategies for radiosensitization Semin Radiat Oncol 20 2010 250 257
    • (2010) Semin Radiat Oncol , vol.20 , pp. 250-257
    • Mukherjee, B.1    Choy, H.2    Nirodi, C.3    Burma, S.4
  • 20
    • 78149358861 scopus 로고    scopus 로고
    • ErbB2 expression through heterodimerization with erbB1 is necessary for ionizing radiation- but not EGF-induced activation of Akt survival pathway
    • M. Toulany, M. Minjgee, R. Kehlbach, J. Chen, M. Baumann, and H.P. Rodemann ErbB2 expression through heterodimerization with erbB1 is necessary for ionizing radiation- but not EGF-induced activation of Akt survival pathway Radiother Oncol 97 2010 338 345
    • (2010) Radiother Oncol , vol.97 , pp. 338-345
    • Toulany, M.1    Minjgee, M.2    Kehlbach, R.3    Chen, J.4    Baumann, M.5    Rodemann, H.P.6
  • 21
    • 14744298238 scopus 로고    scopus 로고
    • Radiosensitization of Ras-mutated human tumor cells in vitro by the specific EGF receptor antagonist BIBX1382BS
    • DOI 10.1016/j.radonc.2004.11.008
    • M. Toulany, K. Dittmann, M. Baumann, and H.P. Rodemann Radiosensitization of Ras-mutated human tumor cells in vitro by the specific EGF receptor antagonist BIBX1382BS Radiother Oncol 74 2005 117 129 (Pubitemid 40331868)
    • (2005) Radiotherapy and Oncology , vol.74 , Issue.2 , pp. 117-129
    • Toulany, M.1    Dittmann, K.2    Baumann, M.3    Rodemann, H.P.4
  • 22
    • 28444475478 scopus 로고    scopus 로고
    • Radioresistance of K-Ras mutated human tumor cells is mediated through EGFR-dependent activation of PI3K-AKT pathway
    • DOI 10.1016/j.radonc.2005.06.024, PII S0167814005002665
    • M. Toulany, K. Dittmann, M. Kruger, M. Baumann, and H.P. Rodemann Radioresistance of K-Ras mutated human tumor cells is mediated through EGFR-dependent activation of PI3K-AKT pathway Radiother Oncol 76 2005 143 150 (Pubitemid 41725440)
    • (2005) Radiotherapy and Oncology , vol.76 , Issue.2 , pp. 143-150
    • Toulany, M.1    Dittmann, K.2    Kruger, M.3    Baumann, M.4    Rodemann, H.P.5
  • 24
    • 53549118024 scopus 로고    scopus 로고
    • The catalytic subunit of DNA-dependent protein kinase regulates proliferation, telomere length, and genomic stability in human somatic cells
    • B.L. Ruis, K.R. Fattah, and E.A. Hendrickson The catalytic subunit of DNA-dependent protein kinase regulates proliferation, telomere length, and genomic stability in human somatic cells Mol Cell Biol 28 2008 6182 6195
    • (2008) Mol Cell Biol , vol.28 , pp. 6182-6195
    • Ruis, B.L.1    Fattah, K.R.2    Hendrickson, E.A.3
  • 25
    • 52049105154 scopus 로고    scopus 로고
    • PI3K-Akt signaling regulates basal, but MAP-kinase signaling regulates radiation-induced XRCC1 expression in human tumor cells in vitro
    • M. Toulany, K. Dittmann, B. Fehrenbacher, M. Schaller, M. Baumann, and H.P. Rodemann PI3K-Akt signaling regulates basal, but MAP-kinase signaling regulates radiation-induced XRCC1 expression in human tumor cells in vitro DNA Repair (Amst) 7 2008 1746 1756
    • (2008) DNA Repair (Amst) , vol.7 , pp. 1746-1756
    • Toulany, M.1    Dittmann, K.2    Fehrenbacher, B.3    Schaller, M.4    Baumann, M.5    Rodemann, H.P.6
  • 26
    • 78149360444 scopus 로고    scopus 로고
    • Effect of cetuximab and fractionated irradiation on tumour micro-environment
    • A. Santiago, W. Eicheler, and J. Bussink Effect of cetuximab and fractionated irradiation on tumour micro-environment Radiother Oncol 97 2010 322 329
    • (2010) Radiother Oncol , vol.97 , pp. 322-329
    • Santiago, A.1    Eicheler, W.2    Bussink, J.3
  • 27
    • 66149094649 scopus 로고    scopus 로고
    • Pro-survival AKT and ERK signaling from EGFR and mutant EGFRvIII enhances DNA double-strand break repair in human glioma cells
    • S.E. Golding, R.N. Morgan, B.R. Adams, A.J. Hawkins, L.F. Povirk, and K. Valerie Pro-survival AKT and ERK signaling from EGFR and mutant EGFRvIII enhances DNA double-strand break repair in human glioma cells Cancer Biol Ther 8 2009 730 738
    • (2009) Cancer Biol Ther , vol.8 , pp. 730-738
    • Golding, S.E.1    Morgan, R.N.2    Adams, B.R.3    Hawkins, A.J.4    Povirk, L.F.5    Valerie, K.6
  • 28
    • 14844329891 scopus 로고    scopus 로고
    • Inhibition of phosphatidylinositol-3-kinase causes cell death through a protein kinase B (PKB)-dependent mechanism and growth arrest through a PKB-independent mechanism
    • DOI 10.1016/j.ijrobp.2004.12.024, PII S0360301604031426
    • A.R. Gottschalk, A. Doan, J.L. Nakamura, D.A. Haas-Kogan, and D. Stokoe Inhibition of phosphatidylinositol-3-kinase causes cell death through a protein kinase B (PKB)-dependent mechanism and growth arrest through a PKB-independent mechanism Int J Radiat Oncol Biol Phys 61 2005 1183 1188 (Pubitemid 40340914)
    • (2005) International Journal of Radiation Oncology Biology Physics , vol.61 , Issue.4 , pp. 1183-1188
    • Gottschalk, A.R.1    Doan, A.2    Nakamura, J.L.3    Haas-Kogan, D.A.4    Stokoe, D.5
  • 29
    • 68449105085 scopus 로고    scopus 로고
    • Linking PTEN with genomic instability and DNA repair
    • R.E. Meyn Linking PTEN with genomic instability and DNA repair Cell Cycle 8 2009 2322 2323
    • (2009) Cell Cycle , vol.8 , pp. 2322-2323
    • Meyn, R.E.1
  • 30
    • 66249149058 scopus 로고    scopus 로고
    • EGFRvIII and DNA double-strand break repair: A molecular mechanism for radioresistance in glioblastoma
    • B. Mukherjee, B. McEllin, and C.V. Camacho EGFRvIII and DNA double-strand break repair: a molecular mechanism for radioresistance in glioblastoma Cancer Res 69 2009 4252 4259
    • (2009) Cancer Res , vol.69 , pp. 4252-4259
    • Mukherjee, B.1    McEllin, B.2    Camacho, C.V.3
  • 34
    • 70349974841 scopus 로고    scopus 로고
    • The pyridinylfuranopyrimidine inhibitor, PI-103, chemosensitizes glioblastoma cells for apoptosis by inhibiting DNA repair
    • M.A. Westhoff, J.A. Kandenwein, and S. Karl The pyridinylfuranopyrimidine inhibitor, PI-103, chemosensitizes glioblastoma cells for apoptosis by inhibiting DNA repair Oncogene 28 2009 3586 3596
    • (2009) Oncogene , vol.28 , pp. 3586-3596
    • Westhoff, M.A.1    Kandenwein, J.A.2    Karl, S.3
  • 35
    • 79953132806 scopus 로고    scopus 로고
    • Membrane receptor signaling and control of DNA repair after exposure to ionizing radiation
    • M. Toulany, and H.P. Rodemann Membrane receptor signaling and control of DNA repair after exposure to ionizing radiation Nuklearmedizin 49 2010 S26 S30
    • (2010) Nuklearmedizin , vol.49
    • Toulany, M.1    Rodemann, H.P.2
  • 36
    • 36849032852 scopus 로고    scopus 로고
    • Radiation-induced EGFR-signaling and control of DNA-damage repair
    • DOI 10.1080/09553000701769970, PII 787783391
    • H.P. Rodemann, K. Dittmann, and M. Toulany Radiation-induced EGFR-signaling and control of DNA-damage repair Int J Radiat Biol 83 2007 781 791 (Pubitemid 350219102)
    • (2007) International Journal of Radiation Biology , vol.83 , Issue.11-12 , pp. 781-791
    • Rodemann, H.P.1    Dittmann, K.2    Toulany, M.3
  • 37
    • 5144220297 scopus 로고    scopus 로고
    • Modulation of DNA repair in vitro after treatment with chemotherapeutic agents by the epidermal growth factor receptor inhibitor Gefitinib (ZD1839)
    • DOI 10.1158/1078-0432.CCR-04-0586
    • B. Friedmann, M. Caplin, J.A. Hartley, and D. Hochhauser Modulation of DNA repair in vitro after treatment with chemotherapeutic agents by the epidermal growth factor receptor inhibitor gefitinib (ZD1839) Clin Cancer Res 10 2004 6476 6486 (Pubitemid 39346543)
    • (2004) Clinical Cancer Research , vol.10 , Issue.19 , pp. 6476-6486
    • Friedmann, B.1    Caplin, M.2    Hartley, J.A.3    Hochhauser, D.4
  • 38
    • 33644987412 scopus 로고    scopus 로고
    • Interaction of the epidermal growth factor receptor and the DNA-dependent protein kinase pathway following gefitinib treatment
    • B.J. Friedmann, M. Caplin, and B. Savic Interaction of the epidermal growth factor receptor and the DNA-dependent protein kinase pathway following gefitinib treatment Mol Cancer Ther 5 2006 209 218
    • (2006) Mol Cancer Ther , vol.5 , pp. 209-218
    • Friedmann, B.J.1    Caplin, M.2    Savic, B.3
  • 40
    • 52049105154 scopus 로고    scopus 로고
    • PI3K-Akt signaling regulates basal, but MAP-kinase signaling regulates radiation-induced XRCC1 expression in human tumor cells in vitro
    • M. Toulany, K. Dittmann, B. Fehrenbacher, M. Schaller, M. Baumann, and H.P. Rodemann PI3K-Akt signaling regulates basal, but MAP-kinase signaling regulates radiation-induced XRCC1 expression in human tumor cells in vitro DNA Repair (Amst) 7 2008 1746 1756
    • (2008) DNA Repair (Amst) , vol.7 , pp. 1746-1756
    • Toulany, M.1    Dittmann, K.2    Fehrenbacher, B.3    Schaller, M.4    Baumann, M.5    Rodemann, H.P.6
  • 42
    • 57649219414 scopus 로고    scopus 로고
    • In vivo analysis of protein kinase B (PKB)/Akt regulation in DNA-PKcs-null mice reveals a role for PKB/Akt in DNA damage response and tumorigenesis
    • B. Surucu, L. Bozulic, D. Hynx, A. Parcellier, and B.A. Hemmings In vivo analysis of protein kinase B (PKB)/Akt regulation in DNA-PKcs-null mice reveals a role for PKB/Akt in DNA damage response and tumorigenesis J Biol Chem 283 2008 30025 30033
    • (2008) J Biol Chem , vol.283 , pp. 30025-30033
    • Surucu, B.1    Bozulic, L.2    Hynx, D.3    Parcellier, A.4    Hemmings, B.A.5
  • 43
    • 79551510855 scopus 로고    scopus 로고
    • EGFR nuclear translocation modulates DNA repair following cisplatin and ionizing radiation treatment
    • G. Liccardi, J.A. Hartley, and D. Hochhauser EGFR nuclear translocation modulates DNA repair following cisplatin and ionizing radiation treatment Cancer Res 71 2011 1103 1114
    • (2011) Cancer Res , vol.71 , pp. 1103-1114
    • Liccardi, G.1    Hartley, J.A.2    Hochhauser, D.3
  • 44
    • 78149357809 scopus 로고    scopus 로고
    • Dasatinib blocks cetuximab- and radiation-induced nuclear translocation of the epidermal growth factor receptor in head and neck squamous cell carcinoma
    • C. Li, M. Iida, E.F. Dunn, and D.L. Wheeler Dasatinib blocks cetuximab- and radiation-induced nuclear translocation of the epidermal growth factor receptor in head and neck squamous cell carcinoma Radiother Oncol 97 2010 330 337
    • (2010) Radiother Oncol , vol.97 , pp. 330-337
    • Li, C.1    Iida, M.2    Dunn, E.F.3    Wheeler, D.L.4
  • 45
    • 69949126092 scopus 로고    scopus 로고
    • Radiation-induced lipid peroxidation activates src kinase and triggers nuclear EGFR transport
    • K. Dittmann, C. Mayer, R. Kehlbach, M.C. Rothmund, and H.P. Rodemann Radiation-induced lipid peroxidation activates src kinase and triggers nuclear EGFR transport Radiother Oncol 92 2009 379 382
    • (2009) Radiother Oncol , vol.92 , pp. 379-382
    • Dittmann, K.1    Mayer, C.2    Kehlbach, R.3    Rothmund, M.C.4    Rodemann, H.P.5
  • 47
    • 8144228424 scopus 로고    scopus 로고
    • PIKE/nuclear PI 3-kinase signaling mediates the antiapoptotic actions of NGF in the nucleus
    • DOI 10.1038/sj.emboj.7600392
    • J.Y. Ahn, R. Rong, X. Liu, and K. Ye PIKE/nuclear PI3-kinase signaling mediates the antiapoptotic actions of NGF in the nucleus EMBO J 23 2004 3995 4006 (Pubitemid 39472421)
    • (2004) EMBO Journal , vol.23 , Issue.20 , pp. 3995-4006
    • Ahn, J.-Y.1    Rong, R.2    Liu, X.3    Ye, K.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.