Inhibition of phosphatidylinositol-3-kinase causes cell death through a protein kinase B (PKB)-dependent mechanism and growth arrest through a PKB-independent mechanism

International Journal of Radiation Oncology Biology Physics

Volumn 61, Issue 4, 2005, Pages 1183-1188

  Gottschalk, Alexander R ^a,b   Doan, Albert ^a   Nakamura, Jean L ^a   Haas Kogan, Daphne A ^a,b   Stokoe, David ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

AKT; Apoptosis; p27kip1; Prostate; PTEN

Indexed keywords

CELLS; ENZYME INHIBITION; HORMONES; RADIOTHERAPY; TUMORS;

APOPTOSIS; CANCER THERAPY; PROSTRATE CANCER; PROTEIN KINASE B (PKB);

ENZYMES;

2 MORPHOLINO 8 PHENYLCHROMONE; CYCLIN DEPENDENT KINASE INHIBITOR 1B; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER CELL DESTRUCTION; CELL CYCLE G1 PHASE; CELL DEATH; CELL PROLIFERATION; CELL PROTECTION; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME DEGRADATION; ENZYME INACTIVATION; ENZYME INHIBITION; FLOW CYTOMETRY; GROWTH INHIBITION; HORMONE INHIBITION; HUMAN; HUMAN CELL; MITOSIS INHIBITION; PRIORITY JOURNAL; PROSTATE CARCINOMA; PROTEIN EXPRESSION; WESTERN BLOTTING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; APOPTOSIS; CELL CYCLE PROTEINS; CELL LINE; CHROMONES; CYCLIN-DEPENDENT KINASE INHIBITOR P27; ENZYME ACTIVATION; ENZYME INHIBITORS; G1 PHASE; MORPHOLINES; POLY(ADP-RIBOSE) POLYMERASES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; TUMOR SUPPRESSOR PROTEINS;

EID: 14844329891     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2004.12.024     Document Type: Article

References (28)

1. J. Downward Mechanisms and consequences of activation of protein kinase B/Akt Curr Opin Cell Biol 10 1998 262 267
2. Li J, Yen C, Liaw D, et al [see comments], Science PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer 275 1997 1943 1947
3. D. Haas-Kogan, N. Shalev, M. Wong Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC Curr Biol 8 1998 1195 1198
4. R.C. Stein, M.D. Waterfield PI3-kinase inhibition: A target for drug development? Mol Med Today 6 2000 347 357
5. L.E. Rameh, L.C. Cantley The role of phosphoinositide 3-kinase lipid products in cell function J Biol Chem 274 1999 8347 8350
6. C.L. Carpenter, L.C. Cantley Phosphoinositide 3-kinase and the regulation of cell growth Biochim Biophys Acta 1288 1996 M11 M16
7. T. Maehama, J.E. Dixon The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate J Biol Chem 273 1998 13375 13378
8. M.P. Myers, J.P. Stolarov, C. Eng P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase Proc Nat Acad Sci U S A 94 1997 9052 9057
9. F.B. Furnari, H.J. Huang, W.K. Cavenee The phosphoinositol phosphatase activity of PTEN mediates a serum-sensitive G1 growth arrest in glioma cells Cancer Res 58 1998 5002 5008
10. D.M. Li, H. Sun PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells Proc Nat Acad Sci U S A 95 1998 15406 15411
11. S. Ramaswamy, N. Nakamura, F. Vazquez Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway Proc Nat Acad Sci U S A 96 1999 2110 2115
12. A.R. Gottschalk, D. Basila, M. Wong p27Kip1 is required for PTEN-induced G1 growth arrest Cancer Res 61 2001 2105 2111
13. J.R. Graff, B.W. Konicek, A.M. McNulty Increased AKT activity contributes to prostate cancer progression by dramatically accelerating prostate tumor growth and diminishing p27Kip1 expression J Biol Chem 275 2000 24500 24505
14. P.F. Dijkers, R.H. Medema, C. Pals Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27(KIP1) Mol Cell Biol 20 2000 9138 9148
15. N. Nakamura, S. Ramaswamy, F. Vazquez Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN Mol Cell Biol 20 2000 8969 8982
16. S.R. Datta, H. Dudek, X. Tao Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery Cell 91 1997 231 241
17. J. Zha, H. Harada, E. Yang Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L) Cell 87 1996 619 628
18. M.A. Davies, D. Koul, H. Dhesi A Regulation of Akt/PKB activity, cellular growth, and apoptosis in prostate carcinoma cells by MMAC/PTEN Cancer Res 59 1999 2551 2556
19. G.J. van Steenbrugge, M. Groen, J.W. van Dongen The human prostatic carcinoma cell line LNCaP and its derivatives An overview Urol Res 17 1989 71 77
20. R.C. Stein Prospects for phosphoinositide 3-kinase inhibition as a cancer treatment Endocr Relat Cancer 8 2001 237 248
21. G.J. Brunn, J. Williams, C. Sabers Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002 EMBO J 15 1996 5256 5267
22. B. Vanhaesebroeck, D.R. Alessi The PI3K-PDK1 connection: More than just a road to PKB Biochem J 346 2000 561 576
23. A.D. Kohn, A. Barthel, K.S. Kovacina A Construction and characterization of a conditionally active version of the serine/threonine kinase Akt J Biol Chem 273 1998 11937 11943
24. H. Murillo, H. Huang, L.J. Schmidt Role of PI3K signaling in survival and progression of LNCaP prostate cancer cells to the androgen refractory state Endocrinology 142 2001 4795 4805
25. J. Lin, R.M. Adam, E. Santiestevan The phosphatidylinositol 3′-kinase pathway is a dominant growth factor-activated cell survival pathway in LNCaP human prostate carcinoma cells Cancer Res 59 1999 2891 2897
26. H.C. Welch, W.J. Coadwell, C.D. Ellson P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac Cell 108 2002 809 821
27. S. Krugmann, K.E. Anderson, S.H. Ridley Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices Mol Cell 9 2002 95 108
28. M. Shinohara, Y. Terada, A. Iwamatsu SWAP-70 is a guanine-nucleotide- exchange factor that mediates signaling of membrane ruffling Nature 416 2002 759 763