Parathyroid hormone-related protein induces cell survival in human renal cell carcinoma through the PI3K-Akt pathway: Evidence for a critical role for integrin-linked kinase and nuclear factor kappa B

Carcinogenesis

Volumn 28, Issue 9, 2007, Pages 1893-1901

  Agouni, Abdelali ^a   Sourbier, Carole ^a   Danilin, Sabrina ^a   Rothhut, Sylvie ^a   Lindner, Véronique ^a,b   Jacqmin, Didier ^b   Helwig, Jean Jacques ^a   Lang, Hervé ^a,b   Massfelder, Thierry ^a  

^a INSERM   (France)

^b UNIVERSITY HOSPITAL OF STRASBOURG   (France)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTEGRIN LINKED KINASE; PARATHYROID HORMONE RELATED PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE B; VON HIPPEL LINDAU PROTEIN;

ARTICLE; CANCER GROWTH; CARCINOGENESIS; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; KIDNEY CARCINOMA; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; RNA INTERFERENCE; TUMOR SUPPRESSOR GENE; WESTERN BLOTTING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; APOPTOSIS; CARCINOMA, RENAL CELL; CARRIER PROTEINS; CELL DIVISION; CELL LINE, TUMOR; CELL SURVIVAL; HUMANS; KIDNEY NEOPLASMS; NF-KAPPA B; PARATHYROID HORMONE-RELATED PROTEIN; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RNA INTERFERENCE; TRANSFECTION;

EID: 34848886113     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgm106     Document Type: Article

References (45)

1. Curti,B.D. (2004) Renal cell carcinoma. JAMA, 292, 97-100.
2. Cohen,H.T. (2005) Renal cell carcinom. N. Engl. J. Med., 353 2477-2490.
3. Sourbier,C. et al. (2006) Parathyroid hormone-related protein in human renal cell carcinoma. Cancer Lett., 240, 170-182.
4. Latif,F. et al. (1993) Identification of the von Hippel-Lindau disease tumor suppressor gene. Science, 260, 1317-1320.
5. Gnarra,J.R. et al. (1994) Mutations of the VHL tumour suppressor gene in renal carcinoma. Nat. Genet., 7, 85-90.
6. Friedrich,C.A. (1999) Von Hippel-Lindau syndrome. A pleomorphic condition. Cancer, 86, 2478-2482.
7. Wiesener,M.S. et al. (2001) Constitutive activation of hypoxia-inducible genes related to overexpression of hypoxia-inducible factor-1 in clear cell renal carcinomas. Cancer Res., 61, 5215-5222.
8. Kim,W. et al. (2003) The von Hippel-Lindau tumor suppressor protein: New insights into oxygen sensing and cancer. Curr. Opin. Genet. Dev., 13, 55-60.
9. Esbrit,P. et al. (2000) The emerging role of parathyroid hormone-related protein as a renal regulating factor. Nephrol. Dial. Transplant., 15, 1109-1111.
10. Massfelder,T. et al. (2004) Parathyroid hormone-related protein is an essential growth factor for human clear cell renal carcinoma and a target for the von Hippel-Lindau tumor suppressor gene. Cancer Res. 64, 180-188.
11. Talon,I. et al. (2006) Anti-tumor effect of parathyroid hormone-related protein neutralizing antibody in human renal cell carcinoma in vitro and in vivo. Carcinogenesis, 27, 73-83.
12. Nicholson,K.M. et al. (2002) The protein kinase B/AKt signalling pathway in human malignancy. Cell. Signal., 14, 381-395.
13. Hanada,M. et al. (2004) Structure, regulation and function of PKB/ AKT - a major therapeutic target. Biochem. Biophys. Acta, 1697 3-16.
14. Dong,L.Q. et al. (2005) PDK2: The missing piece in the receptor tyrosine kinase signaling pathway puzzle. Am. J. Physiol. Endocrinol. Metab., 289, E187-E1196.
15. Sourbier,C. et al. (2006) The phosphoinositide 3-kinase/Akt pathway: A new target in human renal cell carcinoma therapy. Cancer Res., 66, 5130-5142.
16. Iliopoulos,O. et al. (1995) Tumour suppression by the human von Hippel-Lindau gene product. Nat. Med., 1, 822-826.
17. Lowry,O.H. et al. (1951) Protein measurement with the Folin phenol reagent. J. Biol. Chem., 193, 265-275.
18. Fresno Vara,J.A. et al. (2004) PI3K/Akt signalling pathway and cancer. Cancer. Treat. Rev., 30, 193-204.
19. Skinner,H.D. et al. (2004) Vascular endothelial growth factor transcriptional activation is mediated by hypoxia-inducible factor 1alpha, HDM2, and p70S6K1 in response to phosphatidylinositol 3-kinase/ AKT signaling. J. Biol. Chem., 279, 45643-45651.
20. Chen,H.L. et al. (2002) Parathyroid hormone and parathyroid hormone-related protein exert both pro- and anti-apoptotic effects in mesenchymal cells. J. Biol. Chem., 277, 19374-19381.
21. Grzesiak,J.J. et al. (2005) GSK3 and PKB/Akt are associated with integrin-mediated regulation of PTHrP, IL-6 and IL-8 expression in FG pancreatic cancer cells. Int. J. Cancer., 114, 522-530.
22. Ortega,A. et al. (2006) Role of parathyroid hormone-related protein in tubulointerstitial apoptosis and fibrosis after folic acid-induced nephrotoxicity. J. Am. Soc. Nephrol., 17, 1594-1603.
23. O'toole,A. et al. (2001) Tumour necrosis factor-alpha activation of prtein kinase B in WEHI-164 cells is accompanied by increased phosphorylation of Ser473, but not Thr308. Biochem J., 359, 119-127.
24. Weigert,C. et al. (2005) Interleukin-6 acts as insulin sensitizer on glycogen synthesis in human skeletal muscle cells by phosphorylation of Ser473 of Akt. Am. J. Physiol. Endocrinol. Metab., 289, E251-E257.
25. Hannigan,G. et al. (2005) Integrin-linked kinase: A cancer therapeutic target unique among its ILK. Nat. Rev. Cancer, 5 51-63.
26. Persad,S. et al. (2001) Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: Critical roles for kinase activity and amino acids arginine 211 and serine 343. J. Biol. Chem. 276, 27462-27469.
27. Lynch,D.K. et al. (1999) Integrin-linked kinase regulates phosphorylation of serine 473 of protein kinase B by an indirect mechanism. Oncogene, 18, 8024-8032.
28. Chan,T.O. et al. (2001) PDK2: A complex tail in one Akt. Sci. STKE, 66, PE1.
29. Hill,M.M. et al. (2002) Identification of a plasma membrane Raft-associated PKB Ser473 kinase activity that is distinct from ELK and PDK1. Curr. Biol., 12, 1251-1255.
30. Grashoff,C. et al. (2003) Integrin-linked kinase regulates chondrocyte shape and proliferation. EMBO Rep., 4, 432-443.
31. Sakai,T. et al. (2003) Integrin-linked kinase (ILK) is required for polarizing the epiblast, cell adhesion, and controlling actin accumulation. Genes Dev., 17, 926-940.
32. Zervas,C.G. et al. (2001) Drosophila integrin-linked. kinase is required at sites of integrin adhesion to link the cytoskeleton to the plasma membrane. J. Cell Biol., 152, 1007-1018.
33. Mackinnon,A.C. et al. (2002) C. elegans PAT-4/ILK functions as an adaptor protein within integrin adhesion complexes. Curr. Biol., 12, 787-797.
34. Jacinto,E. et al. (2006) SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell, 127, 125-137.
35. Hayden,M.S. et al. (2004) Signaling to NF-kappaB. Genes Dev. 18, 2195-2224.
36. Oya,M. et al. (2001) Constitutive activation of nuclear factor-kappaB prevents TRAIL-induced apoptosis in-renal cancer cells. Oncogene, 20, 3888-3896.
37. Oya,M. et al. (2003) Increased nuclear factor-kappa B activation is related to the tumor development of renal cell carcinoma. Carcinogenesis, 24, 377-384.
38. An,J. et al. (2005) VHL expression in renal cell carcinoma sensitizes to bortezomib (PS-341) through an NF-kappaB-dependent mechanism. Oncogene, 24, 1563-1570.
39. An,J. et al. (2005) Mechanism of von Hippel-Lindau protein-mediated suppression of nuclear factor kappa B activity, Mol. Cell. Biol. 25, 7546-7556.
40. Pawlowski,J.E. et al. (2000) NF-kappa B does not modulate sensitivity of renal carcinoma cells to TNF alpha-related apoptosis-inducing ligand (TRAIL). Anticancer Res., 20, 4243-4255.
41. An,J. et al. (2004) Maximal apoptosis of renal cell carcinoma by the proteasome inhibitor bortezomib is nuclear factor-kappaB dependent. Mol. Cancer Ther., 3, 727-736.
42. Guillen,C. et al, (2002) Both N- and C-terminal domains of parathyroid hormone-related protein increase interleukin-6 by nuclear factor-kappa B activation in osteoblastic cells. J. Biol. Chem., 277, 28109-28117.
43. Zuscik,M.J. et al. (2002) Lead alters parathyroid hormone-related peptide and transforming growth factor-beta1 effects and AP-1 and NF-kappaB signaling in chondrocytes. J. Orthop. Res., 20, 811-818.
44. Martin-Ventura,J.L. et al. (2003) Possible role of parathyroid hormone-related protein as a proinflammatory cytokine in atherosclerosis. Stroke, 34, 1783-1789.
45. Ueno,S. et al. (2006) Plasma membrane-associated sialidase is upregulated in renal cell carcinoma and promotes interleukin-6-induced apoptosis suppression and cell motility. J. Biol. Chem., 281 7756-7764.