Effect of cetuximab and fractionated irradiation on tumour micro-environment

Radiotherapy and Oncology

Volumn 97, Issue 2, 2010, Pages 322-329

  Santiago, Alina ^a   Eicheler, Wolfgang ^a   Bussink, Jan ^b   Rijken, Paul ^b   Yaromina, Ala ^a   Beuthien Baumann, Bettina ^a   Van Der Kogel, Albert J ^b   Baumann, Michael ^a   Krause, Mechthild ^a  

^a UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Biomarkers; C225; Cetuximab; EGFR inhibition; Hypoxia; Monoclonal antibodies; Pimonidazole; Radiotherapy; Signal transduction; Tumour micro environment

Indexed keywords

CETUXIMAB; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; MITOGEN ACTIVATED PROTEIN KINASE; PIMONIDAZOLE; PROTEIN KINASE B;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER RADIOTHERAPY; CONTROLLED STUDY; FEMALE; HEAD AND NECK CARCINOMA; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RADIATION DOSE; THERAPY EFFECT; TUMOR MICROENVIRONMENT; TUMOR XENOGRAFT;

ANIMALS; ANOXIA; ANTIBODIES, MONOCLONAL; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; COMBINED MODALITY THERAPY; DOSE FRACTIONATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MICE; NEOPLASMS; NITROIMIDAZOLES; RADIATION-SENSITIZING AGENTS; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; TRANSPLANTATION, HETEROLOGOUS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 78149360444     PISSN: 01678140     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.radonc.2010.07.007     Document Type: Article

References (42)

1. M. Zimmermann, A. Zouhair, D. Azria, and M. Ozsahin The epidermal growth factor receptor (EGFR) in head and neck cancer: its role and treatment implications Radiat Oncol 1 2006 11
2. M. Baumann, and M. Krause Targeting the epidermal growth factor receptor in radiotherapy: radiobiological mechanisms, preclinical and clinical results Radiother Oncol 72 2004 257 266
3. M. Baumann, M. Krause, and E. Dikomey EGFR-targeted anti-cancer drugs in radiotherapy: preclinical evaluation of mechanisms Radiother Oncol 83 2007 238 248
4. K. Dittmann, C. Mayer, R. Kehlbach, M.C. Rothmund, and H. Peter Rodemann Radiation-induced lipid peroxidation activates src kinase and triggers nuclear EGFR transport Radiother Oncol 92 2009 379 382
5. H.P. Rodemann, K. Dittmann, and M. Toulany Radiation-induced EGFR-signaling and control of DNA-damage repair Int J Radiat Biol 83 2007 781 791
6. K. Dittmann, C. Mayer, and B. Fehrenbacher Radiation-induced epidermal growth factor receptor nuclear import is linked to activation of DNA-dependent protein kinase J Biol Chem 280 2005 31182 31189
7. D. Bandyopadhyay, M. Mandal, L. Adam, J. Mendelsohn, and R. Kumar Physical interaction between epidermal growth factor receptor and DNA-dependent protein kinase in mammalian cells J Biol Chem 273 1998 1568 1573
8. H.W. Lo, and M.C. Hung Nuclear EGFR signalling network in cancers: linking EGFR pathway to cell cycle progression, nitric oxide pathway and patient survival Br J Cancer 94 2006 184 188
9. G. Wanner, C. Mayer, R. Kehlbach, H.P. Rodemann, and K. Dittmann Activation of protein kinase Cepsilon stimulates DNA-repair via epidermal growth factor receptor nuclear accumulation Radiother Oncol 86 2008 383 390
10. R.E. Meyn, A. Munshi, J.V. Haymach, L. Milas, and K.K. Ang Receptor signaling as a regulatory mechanism of DNA repair Radiother Oncol 92 2009 316 322
11. S.Y. Lin, K. Makino, and W. Xia Nuclear localization of EGF receptor and its potential new role as a transcription factor Nat Cell Biol 3 2001 802 808
12. M.G. Waugh, and J.J. Hsuan EGF receptors as transcription factors: ridiculous or sublime? Nat Cell Biol 3 2001 E209 211
13. R.K. Schmidt-Ullrich, K. Valerie, P.B. Fogleman, and J. Walters Radiation-induced autophosphorylation of epidermal growth factor receptor in human malignant mammary and squamous epithelial cells Radiat Res 145 1996 81 85
14. P. Dent, D.B. Reardon, and J.S. Park Radiation-induced release of transforming growth factor alpha activates the epidermal growth factor receptor and mitogen-activated protein kinase pathway in carcinoma cells, leading to increased proliferation and protection from radiation-induced cell death Mol Biol Cell 10 1999 2493 2506
15. C. Petersen, W. Eicheler, and A. Frommel Proliferation and micromilieu during fractionated irradiation of human FaDu squamous cell carcinoma in nude mice Int J Radiat Biol 79 2003 469 477
16. C. Petersen, D. Zips, and M. Krause Repopulation of FaDu human squamous cell carcinoma during fractionated radiotherapy correlates with reoxygenation Int J Radiat Oncol Biol Phys 51 2001 483 493
17. S.M. Thomas, and J.R. Grandis Pharmacokinetic and pharmacodynamic properties of EGFR inhibitors under clinical investigation Cancer Treat Rev 30 2004 255 268
18. K. Dittmann, C. Mayer, and H.P. Rodemann Inhibition of radiation-induced EGFR nuclear import by C225 (Cetuximab) suppresses DNA-PK activity Radiother Oncol 76 2005 157 161
19. S.M. Huang, and P.M. Harari Modulation of radiation response after epidermal growth factor receptor blockade in squamous cell carcinomas: inhibition of damage repair, cell cycle kinetics, and tumor angiogenesis Clin Cancer Res 6 2000 2166 2174
20. S. Nasu, K.K. Ang, Z. Fan, and L. Milas C225 antiepidermal growth factor receptor antibody enhances tumor radiocurability Int J Radiat Oncol Biol Phys 51 2001 474 477
21. L. Milas, F.M. Fang, and K.A. Mason Importance of maintenance therapy in C225-induced enhancement of tumor control by fractionated radiation Int J Radiat Oncol Biol Phys 67 2007 568 572
22. M. Krause, C. Schutze, and C. Petersen Different classes of EGFR inhibitors may have different potential to improve local tumour control after fractionated irradiation: a study on C225 in FaDu hSCC Radiother Oncol 74 2005 109 115
23. M. Krause, G. Ostermann, and C. Petersen Decreased repopulation as well as increased reoxygenation contribute to the improvement in local control after targeting of the EGFR by C225 during fractionated irradiation Radiother Oncol 76 2005 162 167
24. M. Krause, and M. Baumann Clinical biomarkers of kinase activity: examples from EGFR inhibition trials Cancer Metastasis Rev 27 2008 387 402
25. M. Krause, K. Gurtner, Y. Deuse, and M. Baumann Heterogeneity of tumour response to combined radiotherapy and EGFR inhibitors: Differences between antibodies and TK inhibitors Int J Radiat Biol 85 2010 943 954
26. O. Riesterer, K.A. Mason, and U. Raju Enhanced response to C225 of A431 tumor xenografts growing in irradiated tumor bed Radiother Oncol 92 2009 383 387
27. W. Eicheler, D. Zips, A. Dorfler, R. Grenman, and M. Baumann Splicing mutations in TP53 in human squamous cell carcinoma lines influence immunohistochemical detection J Histochem Cytochem 50 2002 197 204
28. A.L. Zietman, H.D. Suit, J.R. Ramsay, V. Silobrcic, and R.S. Sedlacek Quantitative studies on the transplantability of murine and human tumors into the brain and subcutaneous tissues of NCr/Sed nude mice Cancer Res 48 1988 6510 6516
29. S.M. Bentzen, B.M. Atasoy, and F.M. Daley Epidermal growth factor receptor expression in pretreatment biopsies from head and neck squamous cell carcinoma as a predictive factor for a benefit from accelerated radiation therapy in a randomized controlled trial J Clin Oncol 23 2005 5560 5567
30. S. Sebastian, J. Settleman, S.J. Reshkin, A. Azzariti, A. Bellizzi, and A. Paradiso The complexity of targeting EGFR signalling in cancer: From expression to turnover Biochim Biophys Acta 1766 2006 120 139
31. H. Sunada, B.E. Magun, J. Mendelsohn, and C.L. MacLeod Monoclonal antibody against epidermal growth factor receptor is internalized without stimulating receptor phosphorylation Proc Natl Acad Sci USA 83 1986 3825 3829
32. Z. Fan, J. Mendelsohn, H. Masui, and R. Kumar Regulation of epidermal growth factor receptor in NIH3T3/HER14 cells by antireceptor monoclonal antibodies J Biol Chem 268 1993 21073 21079
33. T. Yoshida, I. Okamoto, and T. Okabe Matuzumab and cetuximab activate the epidermal growth factor receptor but fail to trigger downstream signaling by Akt or Erk Int J Cancer 122 2008 1530 1538
34. T. Goldkorn, N. Balaban, M. Shannon, and K. Matsukuma EGF receptor phosphorylation is affected by ionizing radiation Biochim Biophys Acta 1358 1997 289 299
35. L.M. Sturla, G. Amorino, M.S. Alexander, R.B. Mikkelsen, K. Valerie, and R.K. Schmidt-Ullrichr Requirement of Tyr-992 and Tyr-1173 in phosphorylation of the epidermal growth factor receptor by ionizing radiation and modulation by SHP2 J Biol Chem 280 2005 14597 14604
36. M. Baumann, M. Krause, and D. Zips Selective inhibition of the epidermal growth factor receptor tyrosine kinase by BIBX1382BS and the improvement of growth delay, but not local control, after fractionated irradiation in human FaDu squamous cell carcinoma in the nude mouse Int J Radiat Biol 79 2003 547 559
37. T. Mukohara, J.A. Engelman, and N.H. Hanna Differential effects of gefitinib and cetuximab on non-small-cell lung cancers bearing epidermal growth factor receptor mutations J Natl Cancer Inst 97 2005 1185 1194
38. F.Y. Feng, C.A. Lopez, and D.P. Normolle Effect of epidermal growth factor receptor inhibitor class in the treatment of head and neck cancer with concurrent radiochemotherapy in vivo Clin Cancer Res 13 2007 2512 2518
39. M. Toulany, R. Kehlbach, and U. Florczak Targeting of AKT1 enhances radiation toxicity of human tumor cells by inhibiting DNA-PKcs-dependent DNA double-strand break repair Mol Cancer Ther 7 2008 1772 1781
40. M. Toulany, M. Baumann, and H.P. Rodemann Stimulated PI3K-AKT signaling mediated through ligand or radiation-induced EGFR depends indirectly, but not directly, on constitutive K-Ras activity Mol Cancer Res 5 2007 863 872
41. H. Masui, T. Kawamoto, J.D. Sato, B. Wolf, G. Sato, and J. Mendelsohn Growth inhibition of human tumor cells in athymic mice by anti-epidermal growth factor receptor monoclonal antibodies Cancer Res 44 1984 1002 1007
42. H. Bier, K.A. Reiffen, I. Haas, and P. Stasiecki Dose-dependent access of murine anti-epidermal growth factor receptor monoclonal antibody to tumor cells in patients with advanced laryngeal and hypopharyngeal carcinoma Eur Arch Otorhinolaryngol 252 1995 433 439