IL-13 receptor α1 differentially regulates aeroallergen-induced lung responses

Journal of Immunology

Volumn 187, Issue 9, 2011, Pages 4873-4880

  Rothenberg, Marc E ^a   Wen, Ting ^a   Shik, Dana ^b   Cole, Eric T ^a   Mingler, Melissa M ^a   Munitz, Ariel ^a,b  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b TEL AVIV UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; EOTAXIN; EOTAXIN 2; IMMUNOGLOBULIN E; INTERLEUKIN 13; INTERLEUKIN 13 RECEPTOR ALPHA1; INTERLEUKIN 4; THYMUS AND ACTIVATION REGULATED CHEMOKINE; TRANSFORMING GROWTH FACTOR BETA;

ADOPTIVE TRANSFER; AIRWAY RESISTANCE; ALLERGENICITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPERGILLUS; ASTHMA; BIOACCUMULATION; CELL SUBPOPULATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; DERMATOPHAGOIDES; EOSINOPHIL; EOSINOPHILIA; IMMUNOGLOBULIN PRODUCTION; IMMUNOREGULATION; LEUKOCYTOSIS; LOEFFLER PNEUMONIA; LUNG LAVAGE; LYMPH NODE BIOPSY; MOUSE; MUCUS SECRETION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TH2 CELL;

AIR POLLUTANTS; ALLERGENS; ANIMALS; BRONCHIAL HYPERREACTIVITY; INTERLEUKIN-13 RECEPTOR ALPHA1 SUBUNIT; LUNG; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; MUCUS; RESPIRATORY HYPERSENSITIVITY; TRANSFORMING GROWTH FACTOR BETA;

EID: 80555133276     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1004159     Document Type: Article

References (47)

1. Wynn, T. A. 2003. IL-13 effector functions. Annu. Rev. Immunol. 21: 425-456. (Pubitemid 37174537)
2. Elias, J. A., C. G. Lee, T. Zheng, Y. Shim, and Z. Zhu. 2003. Interleukin-13 and leukotrienes: an intersection of pathogenetic schema. Am. J. Respir. Cell Mol. Biol. 28: 401-404. (Pubitemid 36399360)
3. Munitz, A., E. B. Brandt, M. Mingler, F. D. Finkelman, and M. E. Rothenberg. 2008. Distinct roles for IL-13 and IL-4 via IL-13 receptor alpha1 and the type II IL-4 receptor in asthma pathogenesis. Proc. Natl. Acad. Sci. USA 105: 7240-7245. (Pubitemid 351754462)
4. Wills-Karp, M. 2004. Interleukin-13 in asthma pathogenesis. Immunol. Rev. 202: 175-190. (Pubitemid 39576912)
5. Lewis, C. C., B. Aronow, J. Hutton, J. Santeliz, K. Dienger, N. Herman, F. D. Finkelman, and M. Wills-Karp. 2009. Unique and overlapping gene expression patterns driven by IL-4 and IL-13 in the mouse lung. J. Allergy Clin. Immunol. 123: 795-804.
6. Mitchell, J., V. Dimov, and R. G. Townley. 2010. IL-13 and the IL-13 receptor as therapeutic targets for asthma and allergic disease. Curr. Opin. Investig. Drugs 11: 527-534.
7. Ramalingam, T. R., J. T. Pesce, F. Sheikh, A. W. Cheever, M. M. Mentink-Kane, M. S. Wilson, S. Stevens, D. M. Valenzuela, A. J. Murphy, G. D. Yancopoulos, et al. 2008. Unique functions of the type II interleukin 4 receptor identified in mice lacking the interleukin 13 receptor alpha1 chain. Nat. Immunol. 9: 25-33. (Pubitemid 350286200)
8. Kuperman, D. A., and R. P. Schleimer. 2008. Interleukin-4, interleukin-13, signal transducer and activator of transcription factor 6, and allergic asthma. Curr. Mol. Med. 8: 384-392.
9. Wills-Karp, M., J. Luyimbazi, X. Xu, B. Schofield, T. Y. Neben, C. L. Karp, and D. D. Donaldson. 1998. Interleukin-13: central mediator of allergic asthma. Science 282: 2258-2261. (Pubitemid 29004074)
10. Zimmermann, N., N. E. King, J. Laporte, M. Yang, A. Mishra, S. M. Pope, E. E. Muntel, D. P. Witte, A. A. Pegg, P. S. Foster, et al. 2003. Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis. J. Clin. Invest. 111: 1863-1874. (Pubitemid 38057731)
11. Munitz, A., I. Bachelet, F. D. Finkelman, M. E. Rothenberg, and F. Levi-Schaffer. 2007. CD48 is critically involved in allergic eosinophilic airway inflammation. Am. J. Respir. Crit. Care Med. 175: 911-918. (Pubitemid 46684701)
12. Caldwell, J.M., C. Blanchard, M. H. Collins, P. E. Putnam, A. Kaul, S. S. Aceves, C. A. Bouska, and M.E. Rothenberg. 2010. Glucocorticoid-regulated genes in eosinophilic esophagitis: a role for FKBP51. J. Allergy Clin. Immunol. 125: 879-888.
13. Blanchard, C., E. M. Stucke, K. Burwinkel, J. M. Caldwell, M. H. Collins, A. Ahrens, B. K. Buckmeier, S. C. Jameson, A. Greenberg, A. Kaul, et al. 2010. Coordinate interaction between IL-13 and epithelial differentiation cluster genes in eosinophilic esophagitis. J. Immunol. 184: 4033-4041.
14. Fulkerson, P. C., C. A. Fischetti, L. M. Hassman, N. M. Nikolaidis, and M. E. Rothenberg. 2006. Persistent effects induced by IL-13 in the lung. Am. J. Respir. Cell Mol. Biol. 35: 337-346. (Pubitemid 44353402)
15. Fulkerson, P. C., C. A. Fischetti, M. L. McBride, L. M. Hassman, S. P. Hogan, and M. E. Rothenberg. 2006. A central regulatory role for eosinophils and the eotaxin/CCR3 axis in chronic experimental allergic airway inflammation. Proc. Natl. Acad. Sci. USA 103: 16418-16423. (Pubitemid 44715211)
16. Dyer, K. D., J. M. Moser, M. Czapiga, S. J. Siegel, C. M. Percopo, and H. F. Rosenberg. 2008. Functionally competent eosinophils differentiated ex vivo in high purity from normal mouse bone marrow. J. Immunol. 181: 4004-4009.
17. Smit, J. J., and N.W. Lukacs. 2006. A closer look at chemokines and their role in asthmatic responses. Eur. J. Pharmacol. 533: 277-288. (Pubitemid 43340019)
18. Greenberger, P. A. 2002. Allergic bronchopulmonary aspergillosis. J. Allergy Clin. Immunol. 110: 685-692. (Pubitemid 35423169)
19. Buckland, K. F., E. C. O'connor, E. M. Coleman, S. A. Lira, N. W. Lukacs, and C. M. Hogaboam. 2007. Remission of chronic fungal asthma in the absence of CCR8. J. Allergy Clin. Immunol. 119: 997-1004.
20. Mishra, A., S. P. Hogan, E. B. Brandt, and M. E. Rothenberg. 2001. An etiological role for aeroallergens and eosinophils in experimental esophagitis. J. Clin. Invest. 107: 83-90. (Pubitemid 32047417)
21. Busse, W.W., and R. F. Lemanske, Jr. 2001. Asthma.N. Engl. J. Med. 344: 350-362. (Pubitemid 32107645)
22. Busse, W. W., and L. J. Rosenwasser. 2003. Mechanisms of asthma. J. Allergy Clin. Immunol. 111(3, Suppl.): S799-S804. (Pubitemid 36324228)
23. Irañeta, S. G., V. G. Duschak, S. M. Rodríguez, and A. Alonso. 2002. Serine proteinases with gelatinolytic activity in an Aspergillus fumigatus allergenic extract. J. Investig. Allergol. Clin. Immunol. 12: 257-262. (Pubitemid 36713148)
24. Trompette, A., S. Divanovic, A. Visintin, C. Blanchard, R. S. Hegde, R. Madan, P. S. Thorne, M. Wills-Karp, T. L. Gioannini, J. P. Weiss, and C. L. Karp. 2009. Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein. Nature 457: 585-588.
25. Nathan, A. T., E. A. Peterson, J. Chakir, and M. Wills-Karp. 2009. Innate immune responses of airway epithelium to house dust mite are mediated through beta-glucan-dependent pathways. J. Allergy Clin. Immunol. 123: 612-618.
26. Grünig, G., M. Warnock, A. E. Wakil, R. Venkayya, F. Brombacher, D. M. Rennick, D. Sheppard, M. Mohrs, D. D. Donaldson, R. M. Locksley, and D. B. Corry. 1998. Requirement for IL-13 independently of IL-4 in experimental asthma. Science 282: 2261-2263. (Pubitemid 29004075)
27. Ramalingam, T. R., J. T. Pesce, F. Sheikh, A. W. Cheever, M. M. Mentink-Kane, M. S. Wilson, S. Stevens, D. M. Valenzuela, A. J. Murphy, G. D. Yancopoulos, et al. 2008. Unique functions of the type II interleukin 4 receptor identified in mice lacking the interleukin 13 receptor alpha1 chain. Nat. Immunol. 9: 25-33. (Pubitemid 350286200)
28. Mishra, A., and M. E. Rothenberg. 2003. Intratracheal IL-13 induces eosinophilic esophagitis by an IL-5, eotaxin-1, and STAT6-dependent mechanism. Gastroenterology 125: 1419-1427. (Pubitemid 37409762)
29. Blanchard, C., M. K. Mingler, M. Vicario, J. P. Abonia, Y. Y. Wu, T. X. Lu, M. H. Collins, P. E. Putnam, S. I. Wells, and M. E. Rothenberg. 2007. IL-13 involvement in eosinophilic esophagitis: transcriptome analysis and reversibility with glucocorticoids. J. Allergy Clin. Immunol. 120: 1292-1300. (Pubitemid 350225686)
30. Sherrill, J. D., and M. E. Rothenberg. 2011. Genetic dissection of eosinophilic esophagitis provides insight into disease pathogenesis and treatment strategies. J. Allergy Clin. Immunol. 128: 23-32, quiz 33-34.
31. Zuo, L., P. C. Fulkerson, F. D. Finkelman, M. Mingler, C. A. Fischetti, C. Blanchard, and M. E. Rothenberg. 2010. IL-13 induces esophageal remodeling and gene expression by an eosinophil-independent, IL-13R alpha 2-inhibited pathway. J. Immunol. 185: 660-669.
32. Hammad, H., M. Chieppa, F. Perros, M. A. Willart, R. N. Germain, and B. N. Lambrecht. 2009. House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells. Nat. Med. 15: 410-416.
33. Thomas, W. R. 2009. Molecular mimicry as the key to the dominance of the house dust mite allergen Der p 2. Expert Rev. Clin. Immunol. 5: 233-237.
34. Shen, H. D., M. F. Tam, R. B. Tang, and H. Chou. 2007. Aspergillus and Penicillium allergens: focus on proteases. Curr. Allergy Asthma Rep. 7: 351-356. (Pubitemid 47377323)
35. Tai, H. Y., M. F. Tam, H. Chou, H. J. Peng, S. N. Su, D. W. Perng, and H. D. Shen. 2006. Pen ch 13 allergen induces secretion of mediators and degradation of occludin protein of human lung epithelial cells. Allergy 61: 382-388. (Pubitemid 43381817)
36. Kaur, D., R. Saunders, P. Berger, S. Siddiqui, L. Woodman, A. Wardlaw, P. Bradding, and C. E. Brightling. 2006. Airway smooth muscle and mast cell-derived CC chemokine ligand 19 mediate airway smooth muscle migration in asthma. Am. J. Respir. Crit. Care Med. 174: 1179-1188. (Pubitemid 44924818)
37. Yamashita, N., H. Tashimo, Y. Matsuo, H. Ishida, K. Yoshiura, K. Sato, N. Yamashita, T. Kakiuchi, and K. Ohta. 2006. Role of CCL21 and CCL19 in allergic inflammation in the ovalbumin-specific murine asthmatic model. J. Allergy Clin. Immunol. 117: 1040-1046.
38. Hartigan, A. J., J. Westwick, G. Jarai, and C. M. Hogaboam. 2009. CCR7 deficiency on dendritic cells enhances fungal clearance in a murine model of pulmonary invasive aspergillosis. J. Immunol. 183: 5171-5179.
39. Lambrecht, B. N., and H. Hammad. 2009. Biology of lung dendritic cells at the origin of asthma. Immunity 31: 412-424.
40. Fulkerson, P. C., N. Zimmermann, L. M. Hassman, F. D. Finkelman, and M. E. Rothenberg. 2004. Pulmonary chemokine expression is coordinately regulated by STAT1, STAT6, and IFN-gamma. J. Immunol. 173: 7565-7574. (Pubitemid 39628198)
41. Pope, S. M., N. Zimmermann, K. F. Stringer, M. L. Karow, and M. E. Rothenberg. 2005. The eotaxin chemokines and CCR3 are fundamental regulators of allergen-induced pulmonary eosinophilia. J. Immunol. 175: 5341-5350. (Pubitemid 41456420)
42. Rothenberg, M. E., and S. P. Hogan. 2006. The eosinophil. Annu. Rev. Immunol. 24: 147-174.
43. Fichtner-Feigl, S.,W. Strober, K. Kawakami, R. K. Puri, and A. Kitani. 2006. IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGFbeta1 production and fibrosis. Nat. Med. 12: 99-106. (Pubitemid 43050083)
44. Fichtner-Feigl, S., I. J. Fuss, C. A. Young, T. Watanabe, E. K. Geissler, H. J. Schlitt, A. Kitani, and W. Strober. 2007. Induction of IL-13 triggers TGF-beta1-dependent tissue fibrosis in chronic 2,4,6-trinitrobenzene sulfonic acid colitis. J. Immunol. 178: 5859-5870. (Pubitemid 46674383)
45. Cho, J. Y., M. Miller, K. J. Baek, J. W. Han, J. Nayar, S. Y. Lee, K. McElwain, S. McElwain, S. Friedman, and D. H. Broide. 2004. Inhibition of airway remodeling in IL-5-deficient mice. J. Clin. Invest. 113: 551-560. (Pubitemid 38542504)
46. Levi-Schaffer, F., E. Garbuzenko, A. Rubin, R. Reich, D. Pickholz, P. Gillery, H. Emonard, A. Nagler, and F. A. Maquart. 1999. Human eosinophils regulate human lung- and skin-derived fibroblast properties in vitro: a role for transforming growth factor beta (TGF-beta). Proc. Natl. Acad. Sci. USA 96: 9660-9665. (Pubitemid 29398788)
47. Herrick, C. A., L. Xu, A. N. McKenzie, R. E. Tigelaar, and K. Bottomly. 2003. IL-13 is necessary, not simply sufficient, for epicutaneously induced Th2 responses to soluble protein antigen. J. Immunol. 170: 2488-2495. (Pubitemid 36245638)