Molecular mimicry as the key to the dominance of the house dust mite allergen der p 2

Expert Review of Clinical Immunology

Volumn 5, Issue 3, 2009, Pages 233-237

  Thomas, Wayne R ^a,b  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

Allergen; Der p 2; House dust mite; Immunodominance; Lipopolysaccharide; MD 2; Molecular mimicry; TLR4

Indexed keywords

HOUSE DUST ALLERGEN; IMMUNOGLOBULIN E ANTIBODY; TOLL LIKE RECEPTOR 4;

ALLERGENICITY; DERMATOPHAGOIDES PTERONYSSINUS; GENE ACTIVATION; MOLECULAR MIMICRY; MOUSE; NONHUMAN; NOTE; PROTEIN DOMAIN; SENSITIZATION;

EID: 77649111195     PISSN: 1744666X     EISSN: None     Source Type: Journal    
DOI: 10.1586/eci.09.5     Document Type: Note

References (41)

1. Hales BJ, Martin AC, Pearce LJ et al. IgE and IgG anti-house dust mite specificities in allergic disease. J. Allergy Clin. Immunol. 118(2), 361-367 (2006).
2. Holt PG, Thomas WR. Sensitization to airborne environmental allergens: unresolved issues. Nat. Immunol. 6(10), 957-960 (2005).
3. Eisenbarth SC, Zhadkevich A, Ranney P, Herrick CA, Bottomly K. IL-4-dependent Th2 collateral priming to inhaled antigens independent of Toll-like receptor 4 and myeloid differentiation factor 88. J. Immunol. 172(7), 4527-4534 (2004).
4. Blumchen K, Gerhold K, Schwede M et al. Effects of established allergen sensitization on immune and airway responses after secondary allergen sensitization. J. Allergy Clin. Immunol. 118(3), 615-621 (2006).
5. Pifferi M, Baldini G, Marrazzini G et al. Benefits of immunotherapy with a standardized Dermatophagoides pteronyssinus extract in asthmatic children: a three-year prospective study. Allergy 57(9), 785-790 (2002).
6. Inal A, Altintas DU, Yilmaz M, Karakoc GB, Kendirli SG, Sertdemir Y. Prevention of new sensitizations by specific immunotherapy in children with rhinitis and/or asthma monosensitized to house dust mite. Allergol. Clin. Immunol. 17(2), 85-91 (2007).
7. Asero R. Injection immunotherapy with different airborne allergens did not prevent de novo sensitization to ragweed and birch pollen north of Milan. Int. Arch. Allergy Immunol. 133(1), 49-54 (2004).
8. Batard T, Hrabina A, Bi XZ et al. Production and proteomic characterization of pharmaceutical-grade Dermatophagoides pteronyssinus and Dermatophagoides farinae extracts for allergy vaccines. Int. Arch. Allergy Immunol. 140(4), 295-305 (2006).
9. Chapman MD, Wunschmann S, Pomes A. Proteases as Th2 adjuvants. Curr. Allergy Asthma Rep. 7(5), 363-367 (2007).
10. Soto-Mera MT, Lopez-Rico MR, Filgueira JF, Villamil E, Cidras R. Occupational allergy to papain. Allergy 55(10), 983-984 (2000).
11. Gough L, Campbell E, Bayley D, Van Heeke G, Shakib F. Proteolytic activity of the house dust mite allergen Der p 1 enhances allergenicity in a mouse inhalation model. Clin. Exp. Allergy. 33(8), 1159-1163 (2003).
12. Gough L. Sewell HF, Shakib F. The proteolytic activity of the major dust mite allergen Der p 1 enhances the IgE antibody response to a bystander antigen. Clin. Exp. Allergy 31(10), 1594-1598 (2001).
13. McGlade JP, Gorman S, Lenzo JC et al. Effect of both ultraviolet B irradiation and histamine receptor function on allergic responses to an inhaled antigen. J. Immunol. 178(5), 2794-2802 (2007).
14. Sokol CL, Barton GM, Farr AG, Medzhitov R. A mechanism for the initiation of allergen-induced T helper type 2 responses. Nat. Immunol. 9(3), 310-318 (2008).
15. Trompette A, Divanovic S, Visintin A et al. Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein. Nature 457(7229), 585-588 (2009).
16. Akashi-Takamura S, Miyake K. TLR accessory molecules. Curr. Opin Immunol. 20(4), 420-425 (2008).
17. Heaton T, Rowe J, Turner S et al. An immunoepidemiological approach to asthma: identification of in-vitro T-cell response patterns associated with different wheezing phenotypes in children Lancet 365(9454), 142-149 (2005).
18. Piggott DA, Eienbarth SC, Xu L et al. MyD88-dependent induction of allergic Th2 responses to intranasal antigen. J. Clin. Invest. 115(2), 459-467 (2005).
19. Holt PG, Batty JE, Turner KJ. Inhibition of specific IgE responses in mice by pre-exposure to inhaled antigen. Immunology 42(3), 409-417 (1981).
20. Derewenda U, Li J, Derewenda Z et al. The crystal structure of a major dust mite allergen Der p 2, and its biological implications. J. Mol. Biol. 318(1), 189-197 (2002).
21. Ohto U, Fukase K, Miyake K, Satow Y. Crystal structures of human MD-2 and its complex with antiendotoxic lipid IVa. Science 316(5831), 1632-1634 (2007).
22. Re F, Strominger JL. Separate functional domains of human MD-2 mediate Toll-like receptor 4-binding and lipopolysaccharide responsiveness. J. Immunol. 171(10), 5272-5276 (2003).
23. Chua KY, Cheong N, Kuo IC et al. The Blomia tropicalis allergens. Prot. Peptide Letters. 14(4), 325-333 (2007).
24. Aalberse RC. Structural biology of allergens. J. Allergy Clin. Immunol. 106(2), 228-238 (2000).
25. Radauer C, Bublin M, Wagner S, Mari A, Breiteneder H. Allergens are distributed into few protein families and possess a restricted number of biochemical functions. J. Allergy Clin. Immunol. 121(4), 847-8452 (2008).
26. Thomas WR, Heinrich TK, Smith WA, Hales BJ. Pyroglyphid house dust mite allergens. Prot. Peptide Letters 14(10), 943-953 (2007).
27. Weghofer M, Grote M, Dall'Antonia Y et al. Characterization of folded recombinant Der p 5, a potential diagnostic marker allergen for house dust mite allergy. Int. Arch. Allergy Immunol. 147(2), 101-109 (2008).
28. Weghofer M, Dall'Antonia Y, Grote M et al. Characterization of Der p 21, a new important allergen derived from the gut of house dust mites. Allergy 63(6), 758-767 (2008).
29. Thomas WR, Hales BJ. T and B cell responses to HDM allergens and antigens. Immunologic Res. 37(3), 187-199 (2007).
30. Thomas WR, Hales BJ, Smith WA. Structural biology of allergens. Curr. Allergy Asthma Rep. 5(5), 388-393 (2005).
31. Satinover SM, Reefer AJ, Pomes A, Chapman MD, Platts-Mills TA, Woodfolk JA. Specific IgE and IgG antibody-binding patterns to recombinant cockroach allergens. J. Allergy Clin. Immunol. 115(4), 803-809 (2005).
32. Kaiser L, Velickovic TC, Badia-Martinez D et al. Structural characterization of the tetrameric form of the major cat allergen Feld 1. J. Mol. Biol. 370(4), 714-727 (2007).
33. Smith W, Butler AJ, Hazell LA et al. Feld 4, a cat lipocalin allergen. Clin. Exp. Allergy 34(11), 1732-1738 (2004).
34. Konieczny A, Morgenstern JP, Bizinkauskas CB et al. The major dog allergens, Can f 1 and Can f 2, are salivary lipocalin proteins: cloning and immunological characterization of the recombinant forms. Immunology 92(4), 577-586 (1997).
35. Krop EJ, Matsui EC, Sharrow SD et al. Recombinant major urinary proteins of the mouse in specific IgE and IgG testing. Int. Arch. Allergy Immunol. 144(4), 296-304 (2007).
36. Gajhede M, Osmark P, Poulsen FM et al. X-ray and NMR structure of Bet v 1, the origin of birch pollen allergy. Nat. Struct. Biol. 3(12), 1040-1045 (1996).
37. Schrantz N, Sagiv Y, Liu Y, Savage PB, Bendelac A, Teyton L. The Niemann-Pick type C2 protein loads isoglobotrihexosylceramide onto CD1d molecules and contributes to the thymic selection of NKT cells. J. Exp. Med. 204(4), 841-852 (2007).
38. Brewer JM, Pollock KG, Tetley L, Russell DG. Vesicle size influences the trafficking, processing, and presentation of antigens in lipid vesicles. J. Immunol. 173(10), 6143-6150 (2004).
39. Lau YF, Deliyannis G, Zeng W, Mansell A, Jackson DC, Brown LE. Lipid-containing mimetics of natural triggers of innate immunity as CTL-inducing influenza vaccines. Int. Immunol. 18(12), 1801-1813 (2006).
40. Keber MM, Gradisar H, Jerala R. MD-2 and Der p 2 - a tale of two cousins or distant relatives? J. Endotoxin Res. 11(3), 186-192 (2005).
41. Gafvelin G, Parmley S, Neimert-Andersson T et al. Hypoallergens for allergen-specific immunotherapy by directed molecular evolution of mite group 2 allergens, J. Biol. Chem. 282(6), 3778-13378 (2007).