The photoperiod, circadian regulation and chronodisruption: The requisite interplay between the suprachiasmatic nuclei and the pineal and gut melatonin

Journal of Physiology and Pharmacology

Volumn 62, Issue 3, 2011, Pages 269-274

  Reiter, Russel J ^a   Rosales Corral, S ^a   Coto Montes, A ^a   Boga, J A ^a   Tan, D X ^a   Davis, J M ^b   Konturek, P C ^b   Konturek, S J ^c   Brzozowski, T ^c  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b Department of Internal Medicine ^*  (Germany)

^c JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

Author keywords

Biological clock; Chronodisruption; Circadian rhythm; Gastrointestinal melatonin; Peptic ulcer; Pineal gland; Suprachiasmatic nucleus

Indexed keywords

MELATONIN;

BREAST CANCER; CIRCADIAN RHYTHM; CRY GENE; DIET RESTRICTION; DRUG EFFICACY; EXERCISE; GENE; GROWTH INHIBITION; HORMONE BLOOD LEVEL; HORMONE RELEASE; HORMONE SYNTHESIS; HUMAN; INTESTINE; LIGHT DARK CYCLE; LIGHT EXPOSURE; NERVE CELL; NERVE FIBER; NONALCOHOLIC FATTY LIVER; NONHUMAN; PER GENE; PHOTOPERIODICITY; PINEAL BODY; PINEALOCYTE; RETINA GANGLION CELL; REVIEW; SLEEP TIME; SUPRACHIASMATIC NUCLEUS; TUMOR GROWTH;

ANIMALS; BIOLOGICAL CLOCKS; CIRCADIAN RHYTHM; GASTROINTESTINAL TRACT; HUMANS; MELATONIN; PHOTOPERIOD; PINEAL GLAND; SUPRACHIASMATIC NUCLEUS;

EID: 80355136624     PISSN: 08675910     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (89)

1. Mazzoccoli G. The timing clockwork of life. J Biol Regul Homeost Agents 2011; 25: 137-143.
2. Karatsoreos IN, Bhagat S, Bloss EB, Morrison JH. Disruption of circadian clocks has ramifications for metabolism, brain, and behavior. Proc Natl Acad Sci USA 2011; 108: 1657-1662.
3. Schwartz WJ. Circadian rhythms: a tale of two nuclei. Curr Biol 2009; 19: R460-R462.
4. Welsh DK, Takahashi JS, Kay SA. Suprachiasmatic nucleus: cell autonomy and network properties. Annu Rev Physiol 2010; 72: 551-577.
5. Hastings MH, Reddy AB, Maywood ES. A clockwork web: circadian timing in brain and periphery in health and disease. Nat Rev Neurosci 2003; 4: 649-661.
6. Erren TC, Reiter RJ. Defining chronodisruption. J Pineal Res 2009; 46: 245-247.
7. Green CB, Takahashi J, Bass J. The meter of metabolism. Cell 2008; 134: 728-742.
8. Dibner C, Schibler U, Albrecht U. The mammalian circadian timing system. Annu Rev Physiol 2010; 72: 517-549.
9. Sack RL, Lewy AJ, Keith LD, Nakagawa H. Circadian rhythm abnormalities in totally blind people: incidence and clinical significance. J Clin Endocrinol Metab 1992; 75: 127-134.
10. Sack RL, Brandes RW, Kendall AR, Lewry AJ. Entrainment of free-running circadian rhythms by melatonin in blind people. N Eng J Med 2000; 343: 1070-1077.
11. Barnard AR, Nolan PM. When clocks go bad: neurobehavioral consequences of disrupted circadian timing. PLoS Genet 2008; 4:e1000040.
12. Rüger M, Scheer FA. Effects of circadian disruption on the cardiometabolic system. Rev Endocr Metab Disord 2009; 10: 245-260.
13. Erren TC, Pape HC, Reiter RJ, Piekarski C. Chronodisruption and cancer. Naturwissenschaften 2008; 95: 357-382.
14. Kohsaka A, Bass J. A sense of time: how molecular clocks organize metabolism. Trends Endocr Metab 2007; 18: 4-11.
15. Challet E. Entrainment of the suprachiasmatic clockwork in diurnal and nocturnal mammals. Endocrinology 2007; 148: 5648-5655.
16. Wright HR, Lack LC. Effect of light wavelength on suppression and phase delay of the melatonin rhythm. Chronobiol Int 2001; 18: 801-808.
17. Schmidt TM, Kofuji P. Structure and function of bistratified intrinsically photosensitive retinal ganglion cells in the mouse. J Comp Neurol 2011; 519: 1492-1504.
18. Do MT, Yau KW. Intrinsically photosensitive retinal ganglion cells. Physiol Rev 2010; 90: 1547-1581.
19. Ecker JL, Dumitrescu ON, Wong KY, et al. Melanopsinexpressing retinal ganglion-cell photoreceptors: cellular diversity and role in pattern vision. Neuron 2010; 67: 49-60.
20. Davies WL, Foster RG, Hankins MW. Focus on molecules: melanopsin. Exp Eye Res 2010; Aug 7: (epub ahead of print).
21. Hankins MW, Peirson SN, Foster RG. Melanopsin: an exciting photopigment. Trends Neurosci 2008; 31: 27-36.
22. Vandewalle G, Schmidt C, Albouy G, et al. Brain responses to violet, blue and green monochromatic light exposures in humans: prominent role of blue light and the brain stem. PLoS One 2007; 2: e1247.
23. Kawasaki A, Kardon RH. Intrinsically photosensitive retinal ganglion cells. J Neuroophthalmol 2007; 27: 195-204.
24. Canteros NS, Ribeiro-Barbosa ER, Goto M, Cipolla-Neto J, Swanson LW. The retinohypothalamic tract: comparison of axonal projection patterns from four major targets. Brain Res Rev 2011; 65: 150-183.
25. Morin LP, Shivers KY, Blanchard JH, Muscat L. Complex organization of mouse and rat suprachiasmatic nucleus. Neuroscience 2006; 137: 1285-1297.
26. Moore RY, Speh JC. Serotonin innervation of the primate suprachiasmatic nucleus. Brain Res 2004; 1010: 169-173.
27. Grone BP, Chang D, Bourgin P, et al. Acute light exposure suppresses circadian rhythms in clock gene expression. J Biol Rhythms 2011; 26: 78-81.
28. Maywood ES, O'Neill JS, Reddy AB, et al. Genetic and molecular analysis of the central and peripheral circadian clockwork of mice. Cold Spring Harb Symp Quant Biol 2007; 78: 85-94.
29. Asher G, Gatfield D, Stratmann M, et al. SIRT1 regulates circadian clock gene expression through PER2 deacetylation. Cell 2008; 134: 317-328.
30. O'Neill JS, Maywood ES, Chesham JE, Takahashi JS, Hastings MH. cAMP-dependent signaling as a core component of the mammalian circadian pacemaker. Science 2008; 320: 949-953.
31. Maywood ES, Chesham JE, Meng QJ, Nolan PM, Loudon AS, Hastings MH. Tuning of the period of the mammalian circadian clock: additive and independent effects of CK, 1e Tau, and Fbx13Afh mutations on mouse circadian behavior and molecular pacemaking. J Neurosci 2011; 31: 1539-1544.
32. Ptitsyn AA, Zvonic S, Conrad SA, Scott LK, Mynatt RL, Gimble JM. Circadian clocks are resounding in peripheral tissues. PLoS Comput Sci 2006; 2: e16.
33. Dibner C, Schibler U, Albrecht U. The mammalian circadian timing system: organization and coordination of central and peripheral clocks. Annu Rev Physiol 2010; 72: 517-549.
34. Gerstner JR. The aging clock: 'BMAL'icious toward learning and memory. Aging 2010; 2: 251-254.
35. Farnell YF, Shende VR, Neuendorff N, Allen GC, Earnest DJ. Immortalized cell lines for real-time analysis of circadian pacemaker and peripheral oscillator properties. Eur J Neurosci 2011; 33: 1533-1540.
36. Klerman EB, Duffy JF, Dijk DJ, Czeisler CA. Circadian phase resetting in older people by ocular bright light exposure. J Invest Med 2001; 49: 30-40.
37. Hanifin JP, Brainard GC. Photoreception for circadian, neuroendocrine and neurobehavioral regulation. J Physiol Anthropol 2007; 26: 87-94.
38. Smale L, Cassone VM, Moore RY, Morin LP. Paraventricular nucleus projects mediating pineal melatonin and gonadal responses to photoperiod in the hamster. Brain Res Bull 1989; 22: 263-269.
39. Moore RY. Neural contral of pineal function in mammals and birds. J Neural Transm 1978(Suppl): 47-58.
40. Karasek M. Ultrastructure of the mammalian pineal gland: its comparative and functional aspects. Pineal Res Rev 1983; 1: 1-48.
41. King TS, Steinlechner S. Pineal indolalkylamine synthesis and metabolism: kinetic considerations. Pineal Res Rev 1985; 3: 69-114.
42. Maronde E, Saade A, Ackermann K, et al. Dynamics in enzymatic protein complexes offer a novel principle for the regulation of melatonin synthesis in the human pineal gland. J Pineal Res 2011; 51: 145-155.
43. Vaughan GM, Pelham RW, Pang SF, et al. Nocturnal elevation of plasma melatonin and urinary 5-hydroxyindoleacetic acid in young men: attempts at modification by brief changes in environmental lighting and sleep and by autonomic drugs. J Clin Endocrinol Metab 1976; 42: 752-764.
44. Tricoire H, Locatelli A, Chemineau P, Malpaux B. Melatonin enters the cerebrospinal fluid through the pineal recess. Endocrinology 2002; 143: 84-90.
45. Tan DX, Manchester LC, Sanchez-Barcelo E, Mediavilla MD, Reiter RJ. Significance of high levels of endogenous melatonin in mammalian cerebrospinal fluid and in the central nervous system. Curr Neuropharmacol 2010; 8: 162-167.
46. Reiter RJ. Pineal melatonin: cell biology of its synthesis and of its physiological interactions. Endocr Rev 1991; 12: 151-180.
47. Lewy AJ, Wehr TA, Goodwin FK, Newsome DA, Markey SP. Light suppresses melatonin secretion in humans. Science 1980; 210: 1267-1269.
48. Stevens RG, Blask DE, Brainard GC, et al. Meeting report: the role of environmental lighting and circadian disruption in cancer and other diseases. Environ Health Perspect 2007; 115: 1357-1362.
49. Erren TC, Reiter RJ. A generalized theory of carcinogenesis due to chronodisruption. Neuroendocrinol Lett 2008; 29: 815-821.
50. Filipski E, Levi F. Circadian disruption in experimental cancer processes. Integr Cancer Ther 2009; 8: 299-302.
51. Reiter RJ, Tan DX, Sanchez-Barcelo E, Mediavilla MD, Gitto E, Korkmaz A. Circadian mechanisms in the regulation of melatonin synthesis: disruption with light at night and the pathophysiological consequences. J Exp Integr Med 2011; 1: 13-22.
52. Wehr TA. The duration of human melatonin secretion and sleep respond to changes in daylength (photoperiod). J Clin Endocrinol Metab 1991; 73: 1276-1280.
53. Gallup Organization. Sleep in America. Princeton, WJ, Gallup Organization, 1995.
54. Kripke D, Simons R, Garfinkel L, Hammond E. Short and long sleep and sleeping pills: is increased mortality associated? Arch Gen Psychiatr 1979; 36: 103-116.
55. National Center for Health Statistics. Quick stats: percentage of adults who report an average of 6 hours of sleep per 24 hour period by sex and age group-United States, 1985-2004. Biol Psychiatr 2000; 47: 921-927.
56. Van Cauter E, Spiegel K, Tasali E, Leproult R. Metabolic consequences of sleep and sleep loss. Sleep Med 2008; 9(Suppl 1): S23-S28.
57. Reiter RJ. Melatonin: that ubiquitously-acting pineal hormone. Neus Physiol Sci 1990; 6: 223-227.
58. Reiter RJ, Tan DX, Fuentes-Broto L. Melatonin: a multitasking molecule. Prog Brain Res 2010; 181: 127-151.
59. Tan DX, Chen LD, Poeggeler B, Manchester LC, Reiter RJ. Melatonin: a potent, endogenous hydroxyl radical scavenger. Endocr J 1993; 1: 57-60.
60. Paradies G, Petrosillo G, Paradies V, Reiter RJ, Ruggiero FM. Melatonin, cardiolipin and mitochondrial bioenergetics in health and disease. J Pineal Res 2010; 48: 297-310.
61. Jou MJ, Peng TI, Hsu LF, et al. Visualization of melatonin's multiple mitochondrial levels of protection against mitochondrial Ca2+ mediated permeability transition and beyond in rat brain astrocytes. J Pineal Res 2010; 48: 20-38.
62. Mukherjee D, Roy SC, Bandyopadhyay A, et al. Melatonin protects against isoproterenol-induced myocardial injury in the rat: antioxidative mechanisms. J Pineal Res 2010; 48: 251-262.
63. Reiter RJ, Paredes SD, Manchester LC, Tan DX. Reducing oxidative/nitrosative stress: a newly-discovered genre for melatonin. Crit Rev Biochem Mol Biol 2009; 44: 175-200.
64. Acuna-Castroviejo D, Lopez LC, Escames G, Lopez A, Garcia JA, Reiter RJ. Melatonin-mitochondria interplay in health and disease. Curr Top Med Chem 2011; 11: 221-240.
65. Reiter RJ, Richardson BA, Johnson LY, Ferguson BN, Dinh DT. Pineal melatonin rhythm: reduction in aging Syrian hamsters. Science 1980; 210: 1372-1373.
66. Reiter RJ, Craft CM, Johnson LY, et al. Age-associated reduction in nocturnal pineal melatonin levels in female rats. Endocrinology 1981; 109: 1295-1297.
67. Sack RL, Lewy AJ, Erb DL, Vollmer WM, Singer CM. Human melatonin production decreases with age. J Pineal Res 1986; 3: 379-388.
68. Harman D. Aging: overview. Ann NY Acad Sci 2001; 928: 1-21.
69. Chahbouni M, Escames G, Venegas C, et al. Melatonin treatment normalized plasma pro-inflammatory cytokines and nitrosative/oxidative stress in patients suffering from Duchenne muscular dystrophy. J Pineal Res 2010; 48: 282-290.
70. Akbulut KG, Gonul B, Akbulut H. Exogenous melatonin decreases age-induced lipid peroxidation in the brain. Brain Res 2008; 1238: 31-35.
71. Molpeceres V, Mauriz JL, Garcia-Mediavilla MV, Gonzalez P, Barrio JP, Gonzalez-Gallego J. Melatonin is able to reduce the apoptotic liver changes induced by aging via inhibition of the intrinsic pathway of apoptosis. J Gerontol A Biol Sci Med Sci 2007; 62: 687-695.
72. Cardinali DP, Furio AM, Brusco JI. Clinical aspects of melatonin intervention in Alzheimer's disease progression. Curr Neuropharmacol 2010; 8: 218-227.
73. Turek FW, Joshu C, Kohsaka A, et al. Obesity and metabolic syndrome in circadian Clock mutant mice. Science 2005; 308: 1043-1045.
74. Garaulet M, Madrid JA. Chronobiology, genetic and metabolic syndrome. Curr Opin Lipidol 2009; 20: 127-134.
75. Reiter RJ, Tan DX, Korkmaz A. The circadian melatonin rhythm and its modulation: possible impact in hypertension. J Hypertens (Suppl) 2009; 27: S17-S20.
76. Reiter RJ, Tan DX, Korkmaz A, Ma S. Obesity and metabolic syndrome: association with chronodisruption, sleep deprivation and melatonin suppression. Ann Med 2011; Jun 13: (epub ahead of print).
77. Dominguez-Rodriguez A, Abreu-Gonzalez P, Sanchez-Sanchez JJ, Kaski JC, Reiter RJ. Melatonin and circadian biology in human cardiovascular disease. J Pineal Res 2010; 49: 14-22.
78. Jung-Hynes B, Reiter RJ, Ahmad N. Sirtuins, melatonin and circadian rhythms: building a bridge between aging and cancer. J Pineal Res 2010; 48: 9-19.
79. Bubenik GA, Konturek SJ. Melatonin and aging: prospects for human treatment. J Physiol Pharmacol 2011; 62: 13-19.
80. Bron R, Furness JB. The rhythm of digestion: keeping time in the gastrointestinal tract. Clin Exp Pharmacol Physiol 2009; 36: 1041-1048.
81. Reiter RJ, Tan DX, Korkmaz A, et al. Light at night, chronodisruption, melatonin suppression, and cancer risk: a review. Crit Rev Oncogen 2007; 13: 303-328.
82. Blask DE. Melatonin, sleep disturbances and cancer risk. Sleep Med Rev 2009; 13: 357-364.
83. Hill SM, Frasch T, Xiang S, Yuan L, Duplessis T, Mao L. Molecular mechanisms of melatonin anticancer effects. Integr Cancer Ther 2009; 8: 337-346.
84. Wood PA, Yang X, Hrushesky WJ. Clock genes and cancer. Integr Cancer Ther 2009; 8: 301-308.
85. Reiter RJ, Tan DX, Erren TC, Fuentes-Broto L, Paredes SD. Light-mediated perturbations of circadian timing and cancer risk: a mechanistic analysis. Integr Cancer Ther 2009; 8: 354-360.
86. Brzozowski I, Ptak-Belowska A, Pawlik M, et al. Mucosal strengthening activity of central and peripheral melatonin in the mechanism of gastric defense. J Physiol Pharmacol 2009; 60: 47-56.
87. Konturek PC, Celinski K, Slomka M, et al. Melatonin and its precursor L-tryptophan prevent acute gastric mucosal damage induced by aspirin in humans. J Physiol Pharmacol 2008; 59(Suppl 2): 67-75.
88. Gonciarz M, Gonciarz Z, Bielanski W, et al. The pilot study of a 3-month course of melatonin treatment of patients with nonalcoholic steatohepatitis: Effect on plasma levels of liver enzymes, lipids and melatonin. J Physiol Pharmacol 2010; 61: 705-710.
89. Konturek SJ, Konturek PC, Brzozowski T, Bubenik GA. Role of melatonin in the upper gastrpomtestinal tract. J Physiol Pharmacol 2008; 58(Suppl 6): 23-52.