Dynamics in enzymatic protein complexes offer a novel principle for the regulation of melatonin synthesis in the human pineal gland

Journal of Pineal Research

Volumn 51, Issue 1, 2011, Pages 145-155

  Maronde, Erik ^a   Saade, Anastasia ^a   Ackermann, Katrin ^a,d   Goubran Botros, Hany ^b   Pagan, Cecile ^b   Bux, Roman ^a   Bourgeron, Thomas ^b   Dehghani, Faramarz ^c   Stehle, Jörg H ^a  

^a GOETHE UNIVERSITY   (Germany)

^b INSTITUT PASTEUR   (France)

^c UNIVERSITY OF LEIPZIG   (Germany)

^d ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

14 3 3; acetyl serotonin methyltransferase; arylalkylamine N acetyltransferase; human; pineal gland; protein interaction

Indexed keywords

ACETYL SEROTONIN METHYLTRANSFERASE; ACYLTRANSFERASE; MELATONIN; METHYLTRANSFERASE; RETINA S ANTIGEN; THREONINE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ANTIBODY DETECTION; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DEPHOSPHORYLATION; ENZYME ACTIVITY; HORMONE SYNTHESIS; HUMAN; HUMAN TISSUE; NONHUMAN; PHOSPHORYLATION; PINEAL BODY; PINEALOCYTE; PROTEIN ANALYSIS; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; RAT; REGULATORY MECHANISM; TIME OF DEATH;

ACETYLSEROTONIN O-METHYLTRANSFERASE; ADULT; AGED; ANALYSIS OF VARIANCE; ANIMALS; ANTIBODIES, MONOCLONAL; ARYLALKYLAMINE N-ACETYLTRANSFERASE; BLOTTING, WESTERN; FEMALE; HUMANS; LINEAR MODELS; MALE; MELATONIN; MICROSCOPY, FLUORESCENCE; MIDDLE AGED; PINEAL GLAND; RATS; RNA, MESSENGER; SHEEP;

EID: 79960365673     PISSN: 07423098     EISSN: 1600079X     Source Type: Journal    
DOI: 10.1111/j.1600-079X.2011.00880.x     Document Type: Article

References (42)

1. Maronde E, Stehle J,. The mammalian pineal gland: known facts, unknown facets. Trends Endocrinol Metab 2007; 18: 142-149. (Pubitemid 46617271)
2. Klein DC,. Arylalkylamine N-acetyltransferase: "the timezyme". J Biol Chem 2007; 282: 4233-4237.
3. Ackermann K, Stehle JH,. Melatonin synthesis in the human pineal gland: advantages, implications, and difficulties. Chronobiol Int 2006; 23: 369-379. (Pubitemid 43739048)
4. Stehle J, Saade A, Rawashdeh O, et al., A survey of molecular details in the human pineal gland in the light of phylogeny, structure, function and chronobiological diseases. J Pineal Res, doi:.
5. Simonneaux V, Ribelayga C,. Generation of the melatonin endocrine message in mammals: a review of the complex regulation of melatonin synthesis by norepinephrine, peptides, and other pineal transmitters. Pharmacol Rev 2003; 55: 325-395. (Pubitemid 36666050)
6. Reppert SM, Weaver DR,. Coordination of circadian timing in mammals. Nature 2002; 418: 935-941. (Pubitemid 34976023)
7. Klein DC, Moore RY, Reppert SM,. Suprachiasmatic Nucleus: The Mind's Clock. Oxford University Press, Oxford, UK, 1991.
8. Klein DC, Coon SL, Roseboom PH, et al., The melatonin rhythm-generating enzyme: molecular regulation of serotonin N-acetyltransferase in the pineal gland. Recent Prog Horm Res 1997; 52: 307-358.
9. Sinitskaya N, Salingre A, Klosen P, et al., Differential expression of activator protein-1 proteins in the pineal gland of Syrian hamster and rat may explain species diversity in arylalkylamine N-acetyltransferase gene expression. Endocrinology 2006; 147: 5052-5060. (Pubitemid 44790556)
10. Ishida I, Obinata M, Deguchi T,. Molecular cloning and nucleotide sequence of cDNA encoding hydroxyindole O-methyltransferase of bovine pineal glands. J Biol Chem 1987; 262: 2895-2899.
11. Stehle JH, Von Gall C, Schomerus C, et al., Of rodents and ungulates and melatonin: creating a uniform code for darkness by different signaling mechanisms. J Biol Rhythms 2001; 16: 312-325. (Pubitemid 32706865)
12. Borjigin J, Wang MM, Snyder SH,. Diurnal variation in mRNA encoding serotonin N-acetyltransferase in pineal gland. Nature 1995; 378: 783-785. (Pubitemid 26004410)
13. Roseboom PH, Coon SL, Baler R, et al., Melatonin synthesis: analysis of the more than 150-fold nocturnal increase in serotonin N-acetyltransferase messenger ribonucleic acid in the rat pineal gland. Endocrinology 1996; 137: 3033-3045.
14. Coon SL, Del Olmo E, Young WS, et al., Melatonin synthesis enzymes in Macaca mulatta: focus on arylalkylamine N-acetyltransferase (ec 2.3.1.87). J Clin Endocrinol Metab 2002; 87: 4699-4706. (Pubitemid 35247064)
15. Ackermann K, Bux R, Rüb U, et al., Characterization of human melatonin synthesis using autoptic pineal tissue. Endocrinology 2006; 147: 3235-3242. (Pubitemid 43901115)
16. Johnston JD, Bashforth R, Diack A, et al., Rhythmic melatonin secretion does not correlate with the expression of arylalkylamine N-acetyltransferase, inducible cyclic AMP early repressor, period1 or cryptochrome1 mRNA in the sheep pineal. Neuroscience 2004; 124: 789-795. (Pubitemid 38328768)
17. Schomerus C, Korf HW, Laedtke E, et al., Selective adrenergic/cyclic AMP-dependent switch-off of proteasomal proteolysis alone switches on neural signal transduction: an example from the pineal gland. J Neurochem 2000; 75: 2123-2132.
18. Gastel JA, Roseboom PH, Rinaldi PA, et al., Melatonin production: proteasomal proteolysis in serotonin N-acetyltransferase regulation. Science 1998; 279: 1358-1360. (Pubitemid 28119578)
19. Ganguly S, Gastel JA, Weller JL, et al., Role of a pineal cAMP-operated arylalkylamine N-acetyltransferase/14-3-3-binding switch in melatonin synthesis. Proc Natl Acad Sci USA 2001; 98: 8083-8088. (Pubitemid 32642690)
20. Coon SL, Roseboom PH, Baler R, et al., Pineal serotonin N-acetyltransferase: expression cloning and molecular analysis. Science 1995; 270: 1681-1683. (Pubitemid 26002447)
21. Ganguly S, Weller JL, Ho A, et al., Melatonin synthesis: 14-3-3-dependent activation and inhibition of arylalkylamine N-acetyltransferase mediated by phosphoserine-205. Proc Natl Acad Sci USA 2005; 102: 1222-1227. (Pubitemid 40170753)
22. De Leersnyder H,. Inverted rhythm of melatonin secretion in Smith-Magenis syndrome: from symptoms to treatment. Trends Endocrinol Metab 2006; 17: 291-298. (Pubitemid 44287474)
23. Melke J, Goubran Botros H, Chaste P, et al., Abnormal melatonin synthesis in autism spectrum disorders. Mol Psychiatry 2008; 13: 90-98. (Pubitemid 350275181)
24. Klerman EB,. Clinical aspects of human circadian rhythms. J Biol Rhythms 2005; 20: 375-386. (Pubitemid 41022980)
25. Wu Y, Feenstra MGP, Zhou J, et al., Molecular changes underlying reduced pineal melatonin levels in Alzheimer disease: alterations in preclinical and clinical stages. J Clin Endocrinol Metab 2003; 88: 5898-5906. (Pubitemid 38033070)
26. Arendt J, Van Someren EJW, Appleton R, et al., Clinical update: melatonin and sleep disorders. Clin Med 2008; 8: 381-383.
27. Arendt J,. Melatonin and human rhythms. Chronobiol Int 2006; 23: 21-37. (Pubitemid 43739016)
28. Pagani L, Semenova EA, Moriggi E, et al., The physiological period length of the human circadian clock in vivo is directly proportional to period in human fibroblasts. PLoS ONE 2010; 5: e13376.
29. Ackermann K, Dehghani F, Bux R, et al., Day-night expression patterns of clock genes in the human pineal gland. J Pineal Res 2007; 43: 185-194. (Pubitemid 47077222)
30. Koch M, Dehghani F, Habazettl I, et al., Cannabinoids attenuate norepinephrine-induced melatonin biosynthesis in the rat pineal gland by reducing arylalkylamine N-acetyltransferase activity without involvement of cannabinoid receptors. J Neurochem 2006; 98: 267-278. (Pubitemid 43882951)
31. Maronde E, Pfeffer M, Glass Y, et al., Transcription factor dynamics in pineal gland and liver of the Syrian hamster (Mesocricetus auratus) adapts to prevailing photoperiod. J Pineal Res 2007; 43: 16-24. (Pubitemid 47035217)
32. Ben-Abdallah M, Bondet V, Fauchereau F, et al., Production of soluble, active acetyl serotonin methyl transferase in Leishmania tarentolae. Protein Expr Purif 2011; 75: 114-118.
33. Dehghani F, Hischebeth GTR, Wirjatijasa F, et al., The immunosuppressant mycophenolate mofetil attenuates neuronal damage after excitotoxic injury in hippocampal slice cultures. Eur J Neurosci 2003; 18: 1061-1072. (Pubitemid 37115028)
34. Nikonov SS, Brown BM, Davis JA, et al., Mouse cones require an arrestin for normal inactivation of phototransduction. Neuron 2008; 59: 462-474.
35. Lu W, Meng Q, Tyler NJC, et al., A circadian clock is not required in an arctic mammal. Curr Biol 2010; 20: 533-537.
36. Lee SJ, Liu T, Chattoraj A, et al., Posttranscriptional regulation of pineal melatonin synthesis in Octodon degus. J Pineal Res 2009; 47: 75-81.
37. Obsil T, Ghirlando R, Klein DC, et al., Crystal structure of the 14-3-3zeta:serotonin N-acetyltransferase complex. A role for scaffolding in enzyme regulation. Cell 2001; 105: 257-267. (Pubitemid 32429515)
38. Hickman AB, Klein DC, Dyda F,. Melatonin biosynthesis: the structure of serotonin N-acetyltransferase at 2.5 a resolution suggests a catalytic mechanism. Mol Cell 1999; 3: 23-32. (Pubitemid 29292474)
39. Huang SK, Klein DC, Korf HW,. Immunocytochemical demonstration of rod-opsin, S-antigen, and neuron-specific proteins in the human pineal gland. Cell Tissue Res 1992; 267: 493-498.
40. Korf HW, Oksche A, Ekström P, et al., Pinealocyte projections into the mammalian brain revealed with S-antigen antiserum. Science 1986; 231: 735-737. (Pubitemid 16104047)
41. Coon SL, Weller JL, Korf HW, et al., cAMP regulation of arylalkylamine N-acetyltransferase (Aanat, ec 2.3.1.87): a new cell line (1e7) provides evidence of intracellular Aanat activation. J Biol Chem 2001; 276: 24097-24107.
42. Fukuda T, Akiyama N, Ikegami M, et al., Expression of hydroxyindole-O-methyltransferase enzyme in the human central nervous system and in pineal parenchymal cell tumors. J Neuropathol Exp Neurol 2010; 69: 498-510.