Focus on molecules: Maspin

Experimental Eye Research

Volumn 90, Issue 1, 2010, Pages 2-3

  Narayan, Malathi ^a   Twining, Sally ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

adhesion; angiogenesis; cancer; cornea; maspin; serpin; wound healing

Indexed keywords

MASPIN;

ALPHA HELIX; ANTIANGIOGENIC ACTIVITY; BETA SHEET; CELLULAR DISTRIBUTION; CORNEA STROMA; GENE EXPRESSION; HUMAN; MOLECULAR MECHANICS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REGULATORY MECHANISM; SHORT SURVEY; STRUCTURE ANALYSIS; TUMOR CELL; TUMOR SUPPRESSOR GENE; WOUND HEALING;

ANIMALS; ANTINEOPLASTIC AGENTS; CORNEA; CORNEAL NEOVASCULARIZATION; EYE NEOPLASMS; HUMANS; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; SERINE PROTEINASE INHIBITORS; SERPINS;

EID: 70749148972     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exer.2009.07.003     Document Type: Short Survey

References (4)

1. Horswill M.A., Narayan M., Warejcka D.J., Cirillo L.A., and Twining S.S. Epigenetic silencing of maspin expression occurs early in the conversion of keratocytes to fibroblasts. Exp. Eye Res. 86 (2008) 586-600
2. Law R.H., Irving J.A., Buckle A.M., Ruzyla K., Buzza M., Bashtannyk-Puhalovich T.A., Beddoe T.C., Nguyen K., Worrall D.M., Bottomley S.P., Bird P.I., Rossjohn J., and Whisstock J.C. The high resolution crystal structure of the human tumor suppressor maspin reveals a novel conformational switch in the G-helix. J. Biol. Chem. 280 (2005) 22356-22364
3. Ngamkitidechakul C., Warejcka D.J., Burke J.M., O'Brien W.J., and Twining S.S. Sufficiency of the reactive site loop of maspin for induction of cell-matrix adhesion and inhibition of cell invasion. Conversion of ovalbumin to a maspin-like molecule. J. Biol. Chem. 278 (2003) 31796-31806
4. Zou Z., Anisowicz A., Hendrix M.J., Thor A., Neveu M., Sheng S., Rafidi K., Seftor E., and Sager R. Maspin, a serpin with tumor-suppressing activity in human mammary epithelial cells. Science 263 (1994) 526-529