Engineering of α-conotoxin MII-derived peptides with increased selectivity for native α6β2* nicotinic acetylcholine receptors

FASEB Journal

Volumn 25, Issue 11, 2011, Pages 3775-3789

  Pucci, Luca ^a   Grazioso, Giovanni ^a   Dallanoce, Clelia ^a   Rizzi, Luca ^a   De Micheli, Carlo ^a   Clementi, Francesco ^a   Bertrand, Sonia ^b   Bertrand, Daniel ^b   Longhi, Renato ^c   De Amici, Marco ^c   Gotti, Cecilia ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b HiQScreen Sarl   (Switzerland)

^c CNR   (Italy)

Author keywords

Binding assays; Molecular modeling; Neurotransmitter release; Striatum

Indexed keywords

ALPHA CONOTOXIN MII; ARGININE; ASPARTIC ACID; DOPAMINE; HYBRID PROTEIN; NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA3BETA2; NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA6BETA2; NICOTINIC RECEPTOR; PEPTIDE DERIVATIVE; PROLINE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CENTRAL NERVOUS SYSTEM; CORPUS STRIATUM; DOPAMINE RELEASE; DRUG POTENCY; DRUG RECEPTOR BINDING; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VIVO STUDY; MALE; MOLECULAR DOCKING; MOLECULAR MODEL; NONHUMAN; OOCYTE; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN ENGINEERING; PROTEIN MOTIF; RAT; RECEPTOR AFFINITY;

ANIMALS; CONOTOXINS; MALE; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; NICOTINIC ANTAGONISTS; PROTEIN BINDING; PROTEIN ENGINEERING; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, NICOTINIC;

RATTUS;

EID: 80355129761     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.10-179853     Document Type: Article

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