Long-term nicotine treatment decreases striatal α6* nicotinic acetylcholine receptor sites and function in mice

Molecular Pharmacology

Volumn 67, Issue 5, 2005, Pages 1639-1647

  Lai, Albert ^a   Parameswaran, Neeraja ^a   Khwaja, Mirium ^a   Whiteaker, Paul ^b   Lindstrom, Jon M ^c   Fan, Hong ^d   McIntosh, J Michael ^e   Grady, Sharon R ^b   Quik, Maryka ^a  

^a PARKINSON S INSTITUTE   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 (2 AZETIDINYLMEHTOXY)PYRIDINE I 125; 3 (2 AZETIDINYLMETHOXY)PYRIDINE; ALPHA BUNGAROTOXIN I 125; ALPHA CONOTOXIN MII; ALPHA CONOTOXIN MII I 125; COTININE; DRINKING WATER; EPIBATIDINE I 125; NICOTINE; NICOTINIC RECEPTOR; RECEPTOR SUBTYPE; TRACER; UNCLASSIFIED DRUG;

ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINE RELEASE; DRUG RECEPTOR BINDING; IMMUNOPRECIPITATION; IMMUNOREACTIVITY; LONG TERM CARE; MALE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION;

ANIMALS; CORPUS STRIATUM; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; MICE; MICE, INBRED C57BL; NICOTINE; PROTEIN BINDING; RECEPTORS, NICOTINIC; TIME FACTORS;

EID: 17844406112     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.104.006429     Document Type: Article

References (40)

1. Buisson B and Bertrand D (2002) Nicotine addiction: the possible role of functional upregulation. Trends Pharmacol Sci 23:130-136.
2. Champtiaux N, Gotti C, Cordero-Erausquin M, David DJ, Przybylski C, Lena C, Clementi F, Moretti M, Rossi FM, Le Novere N, et al. (2003) Subunit composition of functional nicotinic receptors in dopaminergic neurons investigated with knock-out mice. J Neurosci 23:7820-7829.
3. Champtiaux N, Han ZY, Bessis A, Rossi FM, Zoli M, Marubio L, McIntosh JM, and Changeux JP (2002) Distribution and pharmacology of α6-containing nicotinic acetylcholine receptors analyzed with mutant mice. J Neurosci 22:1208-1217.
4. Collins AC, Luo Y, Selvaag S, and Marks MJ (1994) Sensitivity to nicotine and brain nicotinic receptors are altered by chronic nicotine and mecamylamine infusion. J Pharmacol Exp Ther 271:125-133.
5. Creese I and Sibley DR (1981) Receptor adaptations to centrally acting drugs. Annu Rev Pharmacol Toxicol 21:357-391.
6. Cui C, Booker TK, Allen RS, Grady SR, Whiteaker P, Marks MJ, Salminen O, Tritto T, Butt CM, Allen WR, et al. (2003) The β3 nicotinic receptor subunit: a component of α-conotoxin MII-binding nicotinic acetylcholine receptors that modulate dopamine release and related behaviors. J Neurosci 23:11045-11053.
7. Dani JA (2001) Overview of nicotinic receptors and their roles in the central nervous system. Biol Psychiatry 49:166-174.
8. 125I]epibatidine in adrenal gland, superior cervical ganglia, pineal or retina. J Neurochem 85:1237-1246.
9. Flores CM, Davila-Garcia MI, Ulrich YM, and Kellar KJ (1997) Differential regulation of neuronal nicotinic receptor binding sites following chronic nicotine administration. J Neurochem 69:2216-2219.
10. Flores CM, Rogers SW, Pabreza LA, Wolfe BB, and Kellar KJ (1992) A subtype of nicotinic cholinergic receptor in rat brain is composed of α4 and β2 subunits and is up-regulated by chronic nicotine treatment. Mol Pharmacol 41:31-37.
11. Franklin KBJ and Paxinos G (1997) The Mouse Brain in Srereotaxic Coordinates. Academic Press, San Diego.
12. Gentry CL and Lukas RJ (2002) Regulation of nicotinic acetylcholine receptor numbers and function by chronic nicotine exposure. Curr Drug Targets CNS Neurol Disord 1:359-385.
13. Grady SR, Meinerz NM, Cao J, Reynolds AM, Picciotto MR, Changeux JP, McIntosh JM, Marks MJ, and Collins AG (2001) Nicotinic agonists stimulate acetylcholine release from mouse interpeduncular nucleus: a function mediated by a different nAChR than dopamine release from striatum. J Neurochem 76:258-268.
14. Lowry OH, Rosebrough NJ, Fair AL, and Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 183:265-275.
15. Marks MJ, Grady SR, and Collins AC (1993) Downregulation of nicotinic receptor function after chronic nicotine infusion. J Pharmacol Exp Ther 266:1268-1276.
16. Marks MJ, Pauly JR, Gross SD, Deneris ES, Hermans-Borgmeyer I, Heinemann SF, and Collins AC (1992) Nicotine binding and nicotinic receptor subunit RNA after chronic nicotine treatment. J Neurosci 12:2765-2784.
17. 125I]- epibatidine binding sites in C57BL/6 mouse brain are differentially affected by chronic nicotine treatment. Neuropharmacology 46:1141-1157.
18. McIntosh JM, Azam L, Staheli S, Dowell C, Lindstrom JM, Kuryatov A, Garrett JE, Marks MJ, and Whiteaker P (2004) Analogs of α-conotoxin MII are selective for α6-containing nicotinic acetylcholine receptors. Mol Pharmacol 65:944-952.
19. McIntosh JM, Santos AD, and Olivera BM (1999) Conus peptides targeted to specific nicotinic acetylcholine receptor subtypes. Annu Rev Biochem 68:59-88.
20. Mukhin AG, Gundisch D, Horti AG, Koren AO, Tamagnan G, Kimes AS, Chambers J, Vaupel DB, King SL, Picciotto MR, et al. (2000) 5-Iodo-A-85380, an α4β2 subtype-selective ligand for nicotinic acetylcholine receptors. Mol Pharmacol 57:642-649.
21. Nguyen HN, Rasmussen BA, and Perry DC (2003) Subtype-selective up-regulation by chronic nicotine of high-affinity nicotinic receptors in rat brain demonstrated by receptor autoradiography. J Pharmacol Exp Ther 307:1090-1097.
22. Nguyen HN, Rasmussen BA, and Perry DC (2004) Binding and functional activity of nicotinic cholinergic receptors in selected rat brain regions are increased following long-term but not short-term nicotine treatment. J Neurochem 90:40-49.
23. Overstreet DH and Yamamura HI (1979) Receptor alterations and drug tolerance. Life Sci 25:1865-1877.
24. Parker SL, Fu Y, McAllen K, Luo J, McIntosh JM, Lindstrom JM, and Sharp BM (2004) Up-regulation of brain nicotinic acetylcholine receptors in the rat during long-term self-administration of nicotine: disproportionate increase of the α6 subunit. Mol Pharmacol 65:611-622.
25. Paterson D and Nordberg A (2000) Neuronal nicotinic receptors in the human brain. Prog Neurobiol 61:75-111.
26. Pauly JR, Marks MJ, Gross SD, and Collins AC (1991) An autoradiographic analysis of cholinergic receptors in mouse brain after chronic nicotine treatment. J Pharmacol Exp Ther 258:1127-1136.
27. Pauly JR, Marks MJ, Robinson SF, van de Kamp JL, and Collins AC (1996) Chronic nicotine and mecamylamine treatment increase brain nicotinic receptor binding without changing α4 or β2 mRNA levels. J Pharmacol Exp Ther 278:361-369.
28. Quik M (2004) Smoking, nicotine, and Parkinson's disease. Trends Neurosci 27:561-568.
29. Quit M, Polonskaya Y, Kulak JM, and McIntosh JM (2001) Vulnerability of 1251-α-conotoxin MII binding sites to nigrostriatal damage in monkey. J Neurosci 21:5494-5500.
30. Quik M, Sum JD, Whiteaker P, McCallum SE, Marks MJ, Musachio J, McIntosh JM, Collins AC, and Grady SR (2003) Differential declines in striatal nicotinic receptor subtype function after nigrostriatal damage in mice. Mol Pharmacol 63:1169-1179.
31. Rogers SW, Gahring LC, Collins AC, and Marks M (1998) Age-related changes in neuronal nicotinic acetylcholine receptor subunit α4 expression are modified by long-term nicotine administration. J Neurosci 18:4825-4832.
32. Ryan RE, Ross SA, Drago J, and Loiacono RE (2001) Dose-related neuroprotective effects of chronic nicotine in 6-hydroxydopamine treated rats and loss of neuroprotection in α4 nicotinic receptor subunit knockout mice. Br J Pharmacol 132:1650-1656.
33. Salminen O, Grady SR, Collins AC, McIntosh JM, and Marks MJ (2004a) Chronic nicotine infusion downregulates α-conotoxin MII sensitive nicotinic acetylcholine receptors in C57bl/6 mice. Soc Neurosci Abstr 30:48.21.
34. Salminen O, Murphy KL, McIntosh JM, Drago J, Marks MJ, Collins AC, and Grady SR (2004b) Subunit composition and pharmacology of two classes of striatal presynaptic nicotinic acetylcholine receptors mediating dopamine release in mice. Mol Pharmacol 65:1526-1535.
35. Sparks JA and Pauly JR (1999) Effects of continuous oral nicotine administration on brain nicotinic receptors and responsiveness to nicotine in C57B1/6 mice. Psychopharmacology 141:145-153.
36. 125I-α-Conotoxin MII identifies a novel nicotinic acetylcholine receptor population in mouse brain. Mol Pharmacol 57:913-925.
37. Whiteaker P, Peterson CG, Xu W, McIntosh JM, Paylor R, Beaudet AL, Collins AC, and Marks MJ (2002) Involvement of the α3 subunit in central nicotinic binding populations. J Neurosci 22:2522-2529.
38. Wonnacott S (1990) The paradox of nicotinic acetylcholine receptor upregulation by nicotine. Trends Pharmacol Sci 11:216-219.
39. Wonnacott S (1997) Presynaptic nicotinic ACh receptors. Trends Neurosci 20:92-98.
40. Zoli M, Moretti M, Zanardi A, McIntosh JM, Clementi F, and Gotti C (2002) Identification of the nicotinic receptor subtypes expressed on dopaminergic terminals in the rat striatum. J Neurosci 22:8785-8789.