-
2
-
-
0027423418
-
-
M. Hibi, A. Lin, T. Smeal, A. Minden, and M. Karin Genes Dev. 7 1993 2135
-
(1993)
Genes Dev.
, vol.7
, pp. 2135
-
-
Hibi, M.1
Lin, A.2
Smeal, T.3
Minden, A.4
Karin, M.5
-
4
-
-
0028329953
-
-
B. Derijard, M. Hibi, I.H. Wu, T. Barrett, B. Su, T. Deng, M. Karin, and R.J. Davis Cell 76 1994 1025
-
(1994)
Cell
, vol.76
, pp. 1025
-
-
Derijard, B.1
Hibi, M.2
Wu, I.H.3
Barrett, T.4
Su, B.5
Deng, T.6
Karin, M.7
Davis, R.J.8
-
5
-
-
0028229012
-
-
J.M. Kyriakis, P. Banerjee, E. Nikolakaki, T. Dai, E.A. Rubie, M.F. Ahmad, J. Avruch, and J.R. Woodgett Nature 369 1994 156
-
(1994)
Nature
, vol.369
, pp. 156
-
-
Kyriakis, J.M.1
Banerjee, P.2
Nikolakaki, E.3
Dai, T.4
Rubie, E.A.5
Ahmad, M.F.6
Avruch, J.7
Woodgett, J.R.8
-
6
-
-
0034644522
-
-
R.J. Davis Cell 103 2000 239
-
(2000)
Cell
, vol.103
, pp. 239
-
-
Davis, R.J.1
-
7
-
-
0030780804
-
-
D.D. Yang, C.Y. Kuan, A.J. Whitmarsh, M. Rincon, T.S. Zheng, R.J. Davis, P. Rakic, and R.A. Flavell Nature 389 1997 865
-
(1997)
Nature
, vol.389
, pp. 865
-
-
Yang, D.D.1
Kuan, C.Y.2
Whitmarsh, A.J.3
Rincon, M.4
Zheng, T.S.5
Davis, R.J.6
Rakic, P.7
Flavell, R.A.8
-
8
-
-
0029154751
-
-
D. Wilhelm, H. van Dam, I. Herr, B. Baumann, P. Herrlich, and P. Angel Immunobiology 193 1995 143
-
(1995)
Immunobiology
, vol.193
, pp. 143
-
-
Wilhelm, D.1
Van Dam, H.2
Herr, I.3
Baumann, B.4
Herrlich, P.5
Angel, P.6
-
11
-
-
0030706186
-
-
C.W. Chow, M. Rincon, J. Cavanagh, M. Dickens, and R.J. Davis Science 278 1997 1638
-
(1997)
Science
, vol.278
, pp. 1638
-
-
Chow, C.W.1
Rincon, M.2
Cavanagh, J.3
Dickens, M.4
Davis, R.J.5
-
12
-
-
0029885419
-
-
S. Gupta, T. Barrett, A.J. Whitmarsh, J. Cavanagh, H.K. Sluss, B. Derijard, and R.J. Davis EMBO J. 15 1996 2760
-
(1996)
EMBO J.
, vol.15
, pp. 2760
-
-
Gupta, S.1
Barrett, T.2
Whitmarsh, A.J.3
Cavanagh, J.4
Sluss, H.K.5
Derijard, B.6
Davis, R.J.7
-
15
-
-
0034708832
-
-
V. Aguirre, T. Uchida, L. Yenush, R. Davis, and M.F. White J. Biol. Chem. 275 2000 9047
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 9047
-
-
Aguirre, V.1
Uchida, T.2
Yenush, L.3
Davis, R.4
White, M.F.5
-
16
-
-
0037153158
-
-
J. Hirosumi, G. Tuncman, L. Chang, C.Z. Gorgun, K.T. Uysal, K. Maeda, M. Karin, and G.S. Hotamisligil Nature 420 2002 333
-
(2002)
Nature
, vol.420
, pp. 333
-
-
Hirosumi, J.1
Tuncman, G.2
Chang, L.3
Gorgun, C.Z.4
Uysal, K.T.5
Maeda, K.6
Karin, M.7
Hotamisligil, G.S.8
-
18
-
-
0036188479
-
-
Z.N. Han, L.F. Chang, Y. Yamanishi, M. Karin, and G.S. Firestein Arthritis Rheum. 46 2002 818
-
(2002)
Arthritis Rheum.
, vol.46
, pp. 818
-
-
Han, Z.N.1
Chang, L.F.2
Yamanishi, Y.3
Karin, M.4
Firestein, G.S.5
-
20
-
-
19944432162
-
-
G. Pelaia, G. Cuda, A. Vatrella, L. Gallelli, M. Caraglia, M. Marra, A. Abbruzzese, M. Caputi, R. Maselli, F.S. Costanzo, and S.A. Marsico J. Cell Physiol. 202 2005 642
-
(2005)
J. Cell Physiol.
, vol.202
, pp. 642
-
-
Pelaia, G.1
Cuda, G.2
Vatrella, A.3
Gallelli, L.4
Caraglia, M.5
Marra, M.6
Abbruzzese, A.7
Caputi, M.8
Maselli, R.9
Costanzo, F.S.10
Marsico, S.A.11
-
22
-
-
0037113913
-
-
H. Zhang, X. Shi, Q.J. Zhang, M. Hampong, H. Paddon, D. Wahyuningsih, and S. Pelech J. Biol. Chem. 277 2002 43648
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 43648
-
-
Zhang, H.1
Shi, X.2
Zhang, Q.J.3
Hampong, M.4
Paddon, H.5
Wahyuningsih, D.6
Pelech, S.7
-
24
-
-
20444403334
-
-
W.T. Kimberly, J.B. Zheng, T. Town, R.A. Flavell, and D.J. Selkoe J. Neurosci. 25 2005 5533
-
(2005)
J. Neurosci.
, vol.25
, pp. 5533
-
-
Kimberly, W.T.1
Zheng, J.B.2
Town, T.3
Flavell, R.A.4
Selkoe, D.J.5
-
25
-
-
36348979372
-
-
J. Pan, G. Wang, H.Q. Yang, Z. Hong, Q. Xiao, R.J. Ren, H.Y. Zhou, L. Bai, and S.D. Chen Mol. Pharmacol. 72 2007 1607
-
(2007)
Mol. Pharmacol.
, vol.72
, pp. 1607
-
-
Pan, J.1
Wang, G.2
Yang, H.Q.3
Hong, Z.4
Xiao, Q.5
Ren, R.J.6
Zhou, H.Y.7
Bai, L.8
Chen, S.D.9
-
26
-
-
0035923665
-
-
B.L. Bennett, D.T. Sasaki, B.W. Murray, E.C. O'Leary, S.T. Sakata, W. Xu, J.C. Leisten, A. Motiwala, S. Pierce, Y. Satoh, S.S. Bhagwat, A.M. Manning, and D.W. Anderson Proc. Natl. Acad. Sci. U.S.A. 98 2001 13681
-
(2001)
Proc. Natl. Acad. Sci. U.S.A.
, vol.98
, pp. 13681
-
-
Bennett, B.L.1
Sasaki, D.T.2
Murray, B.W.3
O'Leary, E.C.4
Sakata, S.T.5
Xu, W.6
Leisten, J.C.7
Motiwala, A.8
Pierce, S.9
Satoh, Y.10
Bhagwat, S.S.11
Manning, A.M.12
Anderson, D.W.13
-
27
-
-
19944429605
-
-
T. Ruckle, M. Biamonte, T. Grippi-Vallotton, S. Arkinstall, Y. Cambet, M. Camps, C. Chabert, D.J. Church, S. Halazy, X. Jiang, I. Martinou, A. Nichols, W. Sauer, and J.P. Gotteland J. Med. Chem. 47 2004 6921
-
(2004)
J. Med. Chem.
, vol.47
, pp. 6921
-
-
Ruckle, T.1
Biamonte, M.2
Grippi-Vallotton, T.3
Arkinstall, S.4
Cambet, Y.5
Camps, M.6
Chabert, C.7
Church, D.J.8
Halazy, S.9
Jiang, X.10
Martinou, I.11
Nichols, A.12
Sauer, W.13
Gotteland, J.P.14
-
28
-
-
25144508949
-
-
P.P. Graczyk, A. Khan, G.S. Bhatia, V. Palmer, D. Medland, H. Numata, H. Oinuma, J. Catchick, A. Dunne, M. Ellis, C. Smales, J. Whitfield, S.J. Neame, B. Shah, D. Wilton, L. Morgan, T. Patel, R. Chung, H. Desmond, J.M. Staddon, N. Sato, and A. Inoue Bioorg. Med. Chem. Lett. 15 2005 4666
-
(2005)
Bioorg. Med. Chem. Lett.
, vol.15
, pp. 4666
-
-
Graczyk, P.P.1
Khan, A.2
Bhatia, G.S.3
Palmer, V.4
Medland, D.5
Numata, H.6
Oinuma, H.7
Catchick, J.8
Dunne, A.9
Ellis, M.10
Smales, C.11
Whitfield, J.12
Neame, S.J.13
Shah, B.14
Wilton, D.15
Morgan, L.16
Patel, T.17
Chung, R.18
Desmond, H.19
Staddon, J.M.20
Sato, N.21
Inoue, A.22
more..
-
29
-
-
22244479745
-
-
P. Gaillard, I. Jeanclaude-Etter, V. Ardissone, S. Arkinstall, Y. Cambet, M. Camps, C. Chabert, D. Church, R. Cirillo, D. Gretener, S. Halazy, A. Nichols, C. Szyndralewiez, P.A. Vitte, and J.P. Gotteland J. Med. Chem. 48 2005 4596
-
(2005)
J. Med. Chem.
, vol.48
, pp. 4596
-
-
Gaillard, P.1
Jeanclaude-Etter, I.2
Ardissone, V.3
Arkinstall, S.4
Cambet, Y.5
Camps, M.6
Chabert, C.7
Church, D.8
Cirillo, R.9
Gretener, D.10
Halazy, S.11
Nichols, A.12
Szyndralewiez, C.13
Vitte, P.A.14
Gotteland, J.P.15
-
30
-
-
25844464801
-
-
B.M. Swahn, F. Huerta, E. Kallin, J. Malmstrom, T. Weigelt, J. Viklund, P. Womack, Y. Xue, and L. Ohberg Bioorg. Med. Chem. Lett. 15 2005 5095
-
(2005)
Bioorg. Med. Chem. Lett.
, vol.15
, pp. 5095
-
-
Swahn, B.M.1
Huerta, F.2
Kallin, E.3
Malmstrom, J.4
Weigelt, T.5
Viklund, J.6
Womack, P.7
Xue, Y.8
Ohberg, L.9
-
31
-
-
20644461258
-
-
M.J. Stocks, S. Barber, R. Ford, F. Leroux, S. St-Gallay, S. Teague, and Y. Xue Bioorg. Med. Chem. Lett. 15 2005 3459
-
(2005)
Bioorg. Med. Chem. Lett.
, vol.15
, pp. 3459
-
-
Stocks, M.J.1
Barber, S.2
Ford, R.3
Leroux, F.4
St-Gallay, S.5
Teague, S.6
Xue, Y.7
-
32
-
-
31344479605
-
-
B.M. Swahn, Y. Xue, E. Arzel, E. Kallin, A. Magnus, N. Plobeck, and J. Viklund Bioorg. Med. Chem. Lett. 16 2006 1397
-
(2006)
Bioorg. Med. Chem. Lett.
, vol.16
, pp. 1397
-
-
Swahn, B.M.1
Xue, Y.2
Arzel, E.3
Kallin, E.4
Magnus, A.5
Plobeck, N.6
Viklund, J.7
-
33
-
-
33847000556
-
-
R.M. Angell, F.L. Atkinson, M.J. Brown, T.T. Chuang, J.A. Christopher, M. Cichy-Knight, A.K. Dunn, K.E. Hightower, S. Malkakorpi, J.R. Musgrave, M. Neu, P. Rowland, R.L. Shea, J.L. Smith, D.O. Somers, S.A. Thomas, G. Thompson, and R. Wang Bioorg. Med. Chem. Lett. 17 2007 1296
-
(2007)
Bioorg. Med. Chem. Lett.
, vol.17
, pp. 1296
-
-
Angell, R.M.1
Atkinson, F.L.2
Brown, M.J.3
Chuang, T.T.4
Christopher, J.A.5
Cichy-Knight, M.6
Dunn, A.K.7
Hightower, K.E.8
Malkakorpi, S.9
Musgrave, J.R.10
Neu, M.11
Rowland, P.12
Shea, R.L.13
Smith, J.L.14
Somers, D.O.15
Thomas, S.A.16
Thompson, G.17
Wang, R.18
-
34
-
-
34249802615
-
-
M. Alam, R.E. Beevers, T. Ceska, R.J. Davenport, K.M. Dickson, M. Fortunato, L. Gowers, A.F. Haughan, L.A. James, M.W. Jones, N. Kinsella, C. Lowe, J.W. Meissner, A.L. Nicolas, B.G. Perry, D.J. Phillips, W.R. Pitt, A. Platt, A.J. Ratcliffe, A. Sharpe, and L.J. Tait Bioorg. Med. Chem. Lett. 17 2007 3463
-
(2007)
Bioorg. Med. Chem. Lett.
, vol.17
, pp. 3463
-
-
Alam, M.1
Beevers, R.E.2
Ceska, T.3
Davenport, R.J.4
Dickson, K.M.5
Fortunato, M.6
Gowers, L.7
Haughan, A.F.8
James, L.A.9
Jones, M.W.10
Kinsella, N.11
Lowe, C.12
Meissner, J.W.13
Nicolas, A.L.14
Perry, B.G.15
Phillips, D.J.16
Pitt, W.R.17
Platt, A.18
Ratcliffe, A.J.19
Sharpe, A.20
Tait, L.J.21
more..
-
35
-
-
63149148930
-
-
J.A. Christopher, F.L. Atkinson, B.D. Bax, M.J. Brown, A.C. Champigny, T.T. Chuang, E.J. Jones, J.E. Mosley, and J.R. Musgrave Bioorg. Med. Chem. Lett. 19 2009 2230
-
(2009)
Bioorg. Med. Chem. Lett.
, vol.19
, pp. 2230
-
-
Christopher, J.A.1
Atkinson, F.L.2
Bax, B.D.3
Brown, M.J.4
Champigny, A.C.5
Chuang, T.T.6
Jones, E.J.7
Mosley, J.E.8
Musgrave, J.R.9
-
36
-
-
65349123659
-
-
J. Cao, H. Gao, G. Bemis, F. Salituro, M. Ledeboer, E. Harrington, S. Wilke, P. Taslimi, S. Pazhanisamy, X. Xie, M. Jacobs, and J. Green Bioorg. Med. Chem. Lett. 19 2009 2891
-
(2009)
Bioorg. Med. Chem. Lett.
, vol.19
, pp. 2891
-
-
Cao, J.1
Gao, H.2
Bemis, G.3
Salituro, F.4
Ledeboer, M.5
Harrington, E.6
Wilke, S.7
Taslimi, P.8
Pazhanisamy, S.9
Xie, X.10
Jacobs, M.11
Green, J.12
-
37
-
-
35248835582
-
-
R. Jiang, D. Duckett, W. Chen, J. Habel, Y.Y. Ling, P. LoGrasso, and T.M. Kamenecka Bioorg. Med. Chem. Lett. 17 2007 6378
-
(2007)
Bioorg. Med. Chem. Lett.
, vol.17
, pp. 6378
-
-
Jiang, R.1
Duckett, D.2
Chen, W.3
Habel, J.4
Ling, Y.Y.5
Lograsso, P.6
Kamenecka, T.M.7
-
38
-
-
65949111743
-
-
Y. Shin, W. Chen, J. Habel, D. Duckett, Y.Y. Ling, M. Koenig, Y. He, T. Vojkovsky, P. LoGrasso, and T.M. Kamenecka Bioorg. Med. Chem. Lett. 19 2009 3344
-
(2009)
Bioorg. Med. Chem. Lett.
, vol.19
, pp. 3344
-
-
Shin, Y.1
Chen, W.2
Habel, J.3
Duckett, D.4
Ling, Y.Y.5
Koenig, M.6
He, Y.7
Vojkovsky, T.8
Lograsso, P.9
Kamenecka, T.M.10
-
39
-
-
67649679351
-
-
T. Kamenecka, J. Habel, D. Duckett, W. Chen, Y.Y. Ling, B. Frackowiak, R. Jiang, Y. Shin, X. Song, and P. LoGrasso J. Biol. Chem. 284 2009 12853
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 12853
-
-
Kamenecka, T.1
Habel, J.2
Duckett, D.3
Chen, W.4
Ling, Y.Y.5
Frackowiak, B.6
Jiang, R.7
Shin, Y.8
Song, X.9
Lograsso, P.10
-
40
-
-
74849136062
-
-
T. Kamenecka, R. Jiang, X. Song, D. Duckett, W. Chen, Y.Y. Ling, J. Habel, J.D. Laughlin, J. Chambers, M. Figuera-Losada, M.D. Cameron, L. Lin, C.H. Ruiz, and P.V. LoGrasso J. Med. Chem. 53 2010 419
-
(2010)
J. Med. Chem.
, vol.53
, pp. 419
-
-
Kamenecka, T.1
Jiang, R.2
Song, X.3
Duckett, D.4
Chen, W.5
Ling, Y.Y.6
Habel, J.7
Laughlin, J.D.8
Chambers, J.9
Figuera-Losada, M.10
Cameron, M.D.11
Lin, L.12
Ruiz, C.H.13
Lograsso, P.V.14
-
42
-
-
79957797711
-
-
R.J. Neitz, A.W. Konradi, H.L. Sham, W. Zmolek, K. Wong, A. Qin, C. Lorentzen, D. Nakamura, K.P. Quinn, J.M. Sauer, K. Powell, L. Ruslim, D. Chereau, Z. Ren, J. Anderson, F. Bard, T.A. Yednock, and I. Griswold-Prenner Bioorg. Med. Chem. Lett. 21 2011 3726
-
(2011)
Bioorg. Med. Chem. Lett.
, vol.21
, pp. 3726
-
-
Neitz, R.J.1
Konradi, A.W.2
Sham, H.L.3
Zmolek, W.4
Wong, K.5
Qin, A.6
Lorentzen, C.7
Nakamura, D.8
Quinn, K.P.9
Sauer, J.M.10
Powell, K.11
Ruslim, L.12
Chereau, D.13
Ren, Z.14
Anderson, J.15
Bard, F.16
Yednock, T.A.17
Griswold-Prenner, I.18
-
43
-
-
79952363889
-
-
S. Bowers, A.P. Truong, R.J. Neitz, M. Neitzel, G.D. Probst, R.K. Hom, B. Peterson, R.A. Galemmo Jr., A.W. Konradi, H.L. Sham, G. Toth, H. Pan, N. Yao, D.R. Artis, E.F. Brigham, K.P. Quinn, J.M. Sauer, K. Powell, L. Ruslim, Z. Ren, F. Bard, T.A. Yednock, and I.D. Griswold-Prenner Bioorg. Med. Chem. Lett. 21 2011 1838
-
(2011)
Bioorg. Med. Chem. Lett.
, vol.21
, pp. 1838
-
-
Bowers, S.1
Truong, A.P.2
Neitz, R.J.3
Neitzel, M.4
Probst, G.D.5
Hom, R.K.6
Peterson, B.7
Galemmo, Jr.R.A.8
Konradi, A.W.9
Sham, H.L.10
Toth, G.11
Pan, H.12
Yao, N.13
Artis, D.R.14
Brigham, E.F.15
Quinn, K.P.16
Sauer, J.M.17
Powell, K.18
Ruslim, L.19
Ren, Z.20
Bard, F.21
Yednock, T.A.22
Griswold-Prenner, I.D.23
more..
-
44
-
-
79955473645
-
-
R. Noel, Y. Shin, X. Song, Y. He, M. Koenig, W. Chen, Y.Y. Ling, L. Lin, C.H. Ruiz, P. LoGrasso, M.D. Cameron, D.R. Duckett, and T.M. Kamenecka Bioorg. Med. Chem. Lett. 21 2011 2732
-
(2011)
Bioorg. Med. Chem. Lett.
, vol.21
, pp. 2732
-
-
Noel, R.1
Shin, Y.2
Song, X.3
He, Y.4
Koenig, M.5
Chen, W.6
Ling, Y.Y.7
Lin, L.8
Ruiz, C.H.9
Lograsso, P.10
Cameron, M.D.11
Duckett, D.R.12
Kamenecka, T.M.13
-
45
-
-
79952359440
-
-
Y. He, T.M. Kamenecka, Y. Shin, X. Song, R. Jiang, R. Noel, D. Duckett, W. Chen, Y.Y. Ling, M.D. Cameron, L. Lin, S. Khan, M. Koenig, and P.V. LoGrasso Bioorg. Med. Chem. Lett. 21 2011 1719
-
(2011)
Bioorg. Med. Chem. Lett.
, vol.21
, pp. 1719
-
-
He, Y.1
Kamenecka, T.M.2
Shin, Y.3
Song, X.4
Jiang, R.5
Noel, R.6
Duckett, D.7
Chen, W.8
Ling, Y.Y.9
Cameron, M.D.10
Lin, L.11
Khan, S.12
Koenig, M.13
Lograsso, P.V.14
-
46
-
-
78650514164
-
-
G.D. Probst, S. Bowers, J.M. Sealy, A.P. Truong, R.K. Hom, R.A. Galemmo Jr., A.W. Konradi, H.L. Sham, D.A. Quincy, H. Pan, N. Yao, M. Lin, G. Toth, D.R. Artis, W. Zmolek, K. Wong, A. Qin, C. Lorentzen, D.F. Nakamura, K.P. Quinn, J.M. Sauer, K. Powell, L. Ruslim, S. Wright, D. Chereau, Z. Ren, J.P. Anderson, F. Bard, T.A. Yednock, and I. Griswold-Prenner Bioorg. Med. Chem. Lett. 21 2011 315
-
(2011)
Bioorg. Med. Chem. Lett.
, vol.21
, pp. 315
-
-
Probst, G.D.1
Bowers, S.2
Sealy, J.M.3
Truong, A.P.4
Hom, R.K.5
Galemmo, Jr.R.A.6
Konradi, A.W.7
Sham, H.L.8
Quincy, D.A.9
Pan, H.10
Yao, N.11
Lin, M.12
Toth, G.13
Artis, D.R.14
Zmolek, W.15
Wong, K.16
Qin, A.17
Lorentzen, C.18
Nakamura, D.F.19
Quinn, K.P.20
Sauer, J.M.21
Powell, K.22
Ruslim, L.23
Wright, S.24
Chereau, D.25
Ren, Z.26
Anderson, J.P.27
Bard, F.28
Yednock, T.A.29
Griswold-Prenner, I.30
more..
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47
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33846192870
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M. Liu, S. Wang, J.E. Clampit, R.J. Gum, D.L. Haasch, C.M. Rondinone, J.M. Trevillyan, C. Abad-Zapatero, E.H. Fry, H.L. Sham, and G. Liu Bioorg. Med. Chem. Lett. 17 2007 668
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(2007)
Bioorg. Med. Chem. Lett.
, vol.17
, pp. 668
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Liu, M.1
Wang, S.2
Clampit, J.E.3
Gum, R.J.4
Haasch, D.L.5
Rondinone, C.M.6
Trevillyan, J.M.7
Abad-Zapatero, C.8
Fry, E.H.9
Sham, H.L.10
Liu, G.11
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48
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80255133374
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Data to be reported elsewhere. Manuscript in progress
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Data to be reported elsewhere. Manuscript in progress.
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49
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80255140111
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For experimental protocols, see for instance: WO 2009153589 AstraZeneca
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For experimental protocols, see for instance: WO 2009153589 AstraZeneca.
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