Structure-activity relationships and X-ray structures describing the selectivity of aminopyrazole inhibitors for c-Jun N-terminal kinase 3 (JNK3) over p38

Journal of Biological Chemistry

Volumn 284, Issue 19, 2009, Pages 12853-12861

  Kamenecka, Ted ^a   Habel, Jeff ^a   Duckett, Derek ^a   Chen, Weimin ^a   Ling, Yuan Yuan ^a   Frackowiak, Bozena ^a   Jiang, Rong ^a   Shin, Youseung ^a   Song, Xinyi ^a   LoGrasso, Philip ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR; ACTIVE SITE; C-JUN N-TERMINAL KINASE; CELL-BASED; INDAZOLE; MEDICINAL CHEMISTRY; MITOGEN ACTIVATED PROTEIN KINASE; N-LINKED; POTENT INHIBITOR; PYRAZOLE; ROOT MEAN SQUARE DEVIATIONS; SELECTIVE INHIBITORS; STRUCTURAL FEATURE; STRUCTURE ACTIVITY RELATIONSHIPS; STRUCTURE-BASED DRUG DESIGN; X-RAY STRUCTURE;

CHEMICAL ACTIVATION; TRANSCRIPTION; TRANSCRIPTION FACTORS;

ENZYME ACTIVITY;

AMINOPYRAZOLE INHIBITOR; SR 3576; SR 3737; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; SYNAPTOPHYSIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CRYSTALLOGRAPHY; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; IC 50; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; STRUCTURE ACTIVITY RELATION;

ACTIVATING TRANSCRIPTION FACTOR 2; ANIMALS; CELLS, CULTURED; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HUMANS; INSULIN-SECRETING CELLS; MITOGEN-ACTIVATED PROTEIN KINASE 10; MODELS, MOLECULAR; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN CONFORMATION; PYRAZOLES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 67649679351     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M809430200     Document Type: Article

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