Structure-based design and parallel synthesis of N-benzyl isatin oximes as JNK3 MAP kinase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 10, 2009, Pages 2891-2895

  Cao, Jingrong ^a   Gao, Huai ^a   Bemis, Guy ^a   Salituro, Francesco ^a   Ledeboer, Mark ^a   Harrington, Edmund ^a   Wilke, Susanne ^a   Taslimi, Paul ^a   Pazhanisamy, S ^a   Xie, Xiaoling ^a   Jacobs, Marc ^a   Green, Jeremy ^a  

^a VERTEX PHARMACEUTICALS   (United States)

Author keywords

Isatin; JNK3; JNK3 inhibitors; MAP kinase

Indexed keywords

C JUN N TERMINAL KINASE 3 INHIBITOR; ISATIN DERIVATIVE; METHIONINE; MITOGEN ACTIVATED PROTEIN KINASE 10; N BENZYLISATIN OXIME DERIVATIVE; OXIME DERIVATIVE; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; REACTION ANALYSIS; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ISATIN; MITOGEN-ACTIVATED PROTEIN KINASE 10; OXIMES; PROTEIN KINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

PYRONIA TITHONUS;

EID: 65349123659     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.03.043     Document Type: Article

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