Conformational selection in the recognition of phosphorylated substrates by the catalytic domain of human pin1

Biochemistry

Volumn 50, Issue 44, 2011, Pages 9605-9615

  Velazquez, Hector A ^a   Hamelberg, Donald ^a  

^a GEORGIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYTIC DOMAINS; CATALYTIC TURNOVER; CELL SIGNALING; CIS-TRANS ISOMERIZATION; CONFORMATIONAL CHANGE; CONFORMATIONAL SELECTION; CORRELATED MOTIONS; DRUG DESIGN; DRUG TARGETS; ENZYME-SUBSTRATE COMPLEXES; MOLECULAR DYNAMICS SIMULATIONS; PEPTIDE SUBSTRATES; PHOSPHORYLATED SUBSTRATES; SIGNALING PROTEINS; SUB-CELLULAR; TRANSITION STATE;

AMINO ACIDS; ENZYMES; ISOMERIZATION; ISOMERS; MOLECULAR DYNAMICS; PEPTIDES; PHOSPHORYLATION; SIGNALING;

SUBSTRATES;

HUMAN PIN1 PROTEIN; MEMBRANE PROTEIN; PROTEIN SERINE THREONINE KINASE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CELL COMMUNICATION; DRUG TARGETING; ENZYME SUBSTRATE; ISOMERIZATION; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN STRUCTURE; X RAY CRYSTALLOGRAPHY;

CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; DRUG SYNERGISM; HUMANS; MOLECULAR DYNAMICS SIMULATION; PEPTIDYLPROLYL ISOMERASE; PHOSPHORYLATION; PROTEIN CONFORMATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; STEREOISOMERISM; SUBSTRATE SPECIFICITY;

EID: 80155203126     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi2009954     Document Type: Article

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