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Volumn 64, Issue 3, 2011, Pages 199-209

Keloid fibroblasts are more sensitive to Wnt3a treatment in terms of elevated cellular growth and fibronectin expression

Author keywords

Cellular growth; Fibronectin; Keloid fibroblasts; SFRP1; Wnt

Indexed keywords

BETA CATENIN; FIBRONECTIN; MESSENGER RNA; QUERCETIN; SECRETED FRIZZLED RELATED PROTEIN 1; T CELL FACTOR PROTEIN; WNT3A PROTEIN;

EID: 80055092525     PISSN: 09231811     EISSN: 1873569X     Source Type: Journal    
DOI: 10.1016/j.jdermsci.2011.09.008     Document Type: Article
Times cited : (27)

References (50)
  • 1
    • 33645706122 scopus 로고    scopus 로고
    • Quality of life of patients with keloid and hypertrophic scarring
    • Bock O., Schmid-Ott G., Malewski P., Mrowietz U. Quality of life of patients with keloid and hypertrophic scarring. Arch Dermatol Res 2006, 297:433-438.
    • (2006) Arch Dermatol Res , vol.297 , pp. 433-438
    • Bock, O.1    Schmid-Ott, G.2    Malewski, P.3    Mrowietz, U.4
  • 3
    • 41149090611 scopus 로고    scopus 로고
    • Current progress in keloid research and treatment
    • Butler P.D., Longaker M.T., Yang G.P. Current progress in keloid research and treatment. J Am Coll Surg 2008, 206:731-741.
    • (2008) J Am Coll Surg , vol.206 , pp. 731-741
    • Butler, P.D.1    Longaker, M.T.2    Yang, G.P.3
  • 4
    • 79951511302 scopus 로고    scopus 로고
    • The role of R-Spondin2 in keratinocyte proliferation and epidermal thickening in keloid scarring
    • Chua A.W., Ma D., Gan S.U., Fu Z., Han H.C., Song C., et al. The role of R-Spondin2 in keratinocyte proliferation and epidermal thickening in keloid scarring. J Invest Dermatol 2010.
    • (2010) J Invest Dermatol
    • Chua, A.W.1    Ma, D.2    Gan, S.U.3    Fu, Z.4    Han, H.C.5    Song, C.6
  • 5
    • 33746513742 scopus 로고    scopus 로고
    • Upregulation of the Wnt/beta-catenin pathway induced by transforming growth factor-beta in hypertrophic scars and keloids
    • Sato M. Upregulation of the Wnt/beta-catenin pathway induced by transforming growth factor-beta in hypertrophic scars and keloids. Acta Derm Venereol 2006, 86:300-307.
    • (2006) Acta Derm Venereol , vol.86 , pp. 300-307
    • Sato, M.1
  • 6
    • 42149158926 scopus 로고    scopus 로고
    • Gene profiling of keloid fibroblasts shows altered expression in multiple fibrosis-associated pathways
    • Smith J.C., Boone B.E., Opalenik S.R., Williams S.M., Russell S.B. Gene profiling of keloid fibroblasts shows altered expression in multiple fibrosis-associated pathways. J Invest Dermatol 2008, 128:1298-1310.
    • (2008) J Invest Dermatol , vol.128 , pp. 1298-1310
    • Smith, J.C.1    Boone, B.E.2    Opalenik, S.R.3    Williams, S.M.4    Russell, S.B.5
  • 8
    • 34548071005 scopus 로고    scopus 로고
    • Secreted frizzled-related protein 1 loss contributes to tumor phenotype of clear cell renal cell carcinoma
    • Gumz M.L., Zou H., Kreinest P.A., Childs A.C., Belmonte L.S., LeGrand S.N., et al. Secreted frizzled-related protein 1 loss contributes to tumor phenotype of clear cell renal cell carcinoma. Clin Cancer Res 2007, 13:4740-4749.
    • (2007) Clin Cancer Res , vol.13 , pp. 4740-4749
    • Gumz, M.L.1    Zou, H.2    Kreinest, P.A.3    Childs, A.C.4    Belmonte, L.S.5    LeGrand, S.N.6
  • 9
    • 0029980524 scopus 로고    scopus 로고
    • Increased proliferation in keloid fibroblasts wounded in vitro
    • Calderon M., Lawrence W.T., Banes A.J. Increased proliferation in keloid fibroblasts wounded in vitro. J Surg Res 1996, 61:343-347.
    • (1996) J Surg Res , vol.61 , pp. 343-347
    • Calderon, M.1    Lawrence, W.T.2    Banes, A.J.3
  • 10
    • 33748312072 scopus 로고    scopus 로고
    • Stat3 contributes to keloid pathogenesis via promoting collagen production, cell proliferation and migration
    • Lim C.P., Phan T.T., Lim I.J., Cao X. Stat3 contributes to keloid pathogenesis via promoting collagen production, cell proliferation and migration. Oncogene 2006, 25:5416-5425.
    • (2006) Oncogene , vol.25 , pp. 5416-5425
    • Lim, C.P.1    Phan, T.T.2    Lim, I.J.3    Cao, X.4
  • 11
    • 24144481523 scopus 로고    scopus 로고
    • Keloid-derived fibroblasts show increased secretion of factors involved in collagen turnover and depend on matrix metalloproteinase for migration
    • Fujiwara M., Muragaki Y., Ooshima A. Keloid-derived fibroblasts show increased secretion of factors involved in collagen turnover and depend on matrix metalloproteinase for migration. Br J Dermatol 2005, 153:295-300.
    • (2005) Br J Dermatol , vol.153 , pp. 295-300
    • Fujiwara, M.1    Muragaki, Y.2    Ooshima, A.3
  • 12
    • 0031941396 scopus 로고    scopus 로고
    • The molecular basis of keloid and hypertrophic scar formation
    • Tuan T.L., Nichter L.S. The molecular basis of keloid and hypertrophic scar formation. Mol Med Today 1998, 4:19-24.
    • (1998) Mol Med Today , vol.4 , pp. 19-24
    • Tuan, T.L.1    Nichter, L.S.2
  • 13
    • 14044252936 scopus 로고    scopus 로고
    • Both ERK and Wnt/beta-catenin pathways are involved in Wnt3a-induced proliferation
    • Yun M.S., Kim S.E., Jeon S.H., Lee J.S., Choi K.Y. Both ERK and Wnt/beta-catenin pathways are involved in Wnt3a-induced proliferation. J Cell Sci 2005, 118:313-322.
    • (2005) J Cell Sci , vol.118 , pp. 313-322
    • Yun, M.S.1    Kim, S.E.2    Jeon, S.H.3    Lee, J.S.4    Choi, K.Y.5
  • 14
    • 55849119491 scopus 로고    scopus 로고
    • The gene expression profile induced by Wnt 3a in NIH 3T3 fibroblasts
    • Chen S., McLean S., Carter D.E., Leask A. The gene expression profile induced by Wnt 3a in NIH 3T3 fibroblasts. J Cell Commun Signal 2007, 1:175-183.
    • (2007) J Cell Commun Signal , vol.1 , pp. 175-183
    • Chen, S.1    McLean, S.2    Carter, D.E.3    Leask, A.4
  • 15
    • 34249301021 scopus 로고    scopus 로고
    • EGF receptor is involved in WNT3a-mediated proliferation and motility of NIH3T3 cells via ERK pathway activation
    • Kim S.E., Choi K.Y. EGF receptor is involved in WNT3a-mediated proliferation and motility of NIH3T3 cells via ERK pathway activation. Cell Signal 2007, 19:1554-1564.
    • (2007) Cell Signal , vol.19 , pp. 1554-1564
    • Kim, S.E.1    Choi, K.Y.2
  • 16
    • 33749254672 scopus 로고    scopus 로고
    • Wnt signaling regulates the invasion capacity of human mesenchymal stem cells
    • Neth P., Ciccarella M., Egea V., Hoelters J., Jochum M., Ries C. Wnt signaling regulates the invasion capacity of human mesenchymal stem cells. Stem Cells 2006, 24:1892-1903.
    • (2006) Stem Cells , vol.24 , pp. 1892-1903
    • Neth, P.1    Ciccarella, M.2    Egea, V.3    Hoelters, J.4    Jochum, M.5    Ries, C.6
  • 17
    • 79958077377 scopus 로고    scopus 로고
    • Nuclear {beta}-catenin is increased in SSc pulmonary fibrosis and promotes lung fibroblast migration and proliferation
    • Lam A.P., Flozak A.S., Russell S., Wei J., Jain M., Mutlu G.M., et al. Nuclear {beta}-catenin is increased in SSc pulmonary fibrosis and promotes lung fibroblast migration and proliferation. Am J Respir Cell Mol Biol 2011.
    • (2011) Am J Respir Cell Mol Biol
    • Lam, A.P.1    Flozak, A.S.2    Russell, S.3    Wei, J.4    Jain, M.5    Mutlu, G.M.6
  • 19
    • 0024508608 scopus 로고
    • Fibronectin is overproduced by keloid fibroblasts during abnormal wound healing
    • Babu M., Diegelmann R., Oliver N. Fibronectin is overproduced by keloid fibroblasts during abnormal wound healing. Mol Cell Biol 1989, 9:1642-1650.
    • (1989) Mol Cell Biol , vol.9 , pp. 1642-1650
    • Babu, M.1    Diegelmann, R.2    Oliver, N.3
  • 20
    • 0020624012 scopus 로고
    • Fibronectin (FN) in hypertrophic scars and keloids
    • Kischer C.W., Hendrix M.J. Fibronectin (FN) in hypertrophic scars and keloids. Cell Tissue Res 1983, 231:29-37.
    • (1983) Cell Tissue Res , vol.231 , pp. 29-37
    • Kischer, C.W.1    Hendrix, M.J.2
  • 21
    • 12844274417 scopus 로고    scopus 로고
    • Quercetin, a potent inhibitor against beta-catenin/Tcf signaling in SW480 colon cancer cells
    • Park C.H., Chang J.Y., Hahm E.R., Park S., Kim H.K., Yang C.H. Quercetin, a potent inhibitor against beta-catenin/Tcf signaling in SW480 colon cancer cells. Biochem Biophys Res Commun 2005, 328:227-234.
    • (2005) Biochem Biophys Res Commun , vol.328 , pp. 227-234
    • Park, C.H.1    Chang, J.Y.2    Hahm, E.R.3    Park, S.4    Kim, H.K.5    Yang, C.H.6
  • 23
    • 0037365757 scopus 로고    scopus 로고
    • Suppression of insulin-like growth factor signalling pathway and collagen expression in keloid-derived fibroblasts by quercetin: its therapeutic potential use in the treatment and/or prevention of keloids
    • Phan T.T., See P., Tran E., Nguyen T.T., Chan S.Y., Lee S.T., et al. Suppression of insulin-like growth factor signalling pathway and collagen expression in keloid-derived fibroblasts by quercetin: its therapeutic potential use in the treatment and/or prevention of keloids. Br J Dermatol 2003, 148:544-552.
    • (2003) Br J Dermatol , vol.148 , pp. 544-552
    • Phan, T.T.1    See, P.2    Tran, E.3    Nguyen, T.T.4    Chan, S.Y.5    Lee, S.T.6
  • 24
    • 9644263886 scopus 로고    scopus 로고
    • Suppression of transforming growth factor beta/smad signaling in keloid-derived fibroblasts by quercetin: implications for the treatment of excessive scars
    • Phan T.T., Lim I.J., Chan S.Y., Tan E.K., Lee S.T., Longaker M.T. Suppression of transforming growth factor beta/smad signaling in keloid-derived fibroblasts by quercetin: implications for the treatment of excessive scars. J Trauma 2004, 57:1032-1037.
    • (2004) J Trauma , vol.57 , pp. 1032-1037
    • Phan, T.T.1    Lim, I.J.2    Chan, S.Y.3    Tan, E.K.4    Lee, S.T.5    Longaker, M.T.6
  • 26
    • 0036106013 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling suppresses apoptosis in low serum medium and induces morphologic change in rodent fibroblasts
    • Ueda Y., Hijikata M., Takagi S., Takada R., Takada S., Chiba T., et al. Wnt/beta-catenin signaling suppresses apoptosis in low serum medium and induces morphologic change in rodent fibroblasts. Int J Cancer 2002, 99:681-688.
    • (2002) Int J Cancer , vol.99 , pp. 681-688
    • Ueda, Y.1    Hijikata, M.2    Takagi, S.3    Takada, R.4    Takada, S.5    Chiba, T.6
  • 27
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method
    • Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001, 25:402-408.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 29
    • 0011427791 scopus 로고
    • Altered steady-state ratio of type I/III procollagen mRNAs correlates with selectively increased type I procollagen biosynthesis in cultured keloid fibroblasts
    • Uitto J., Perejda A.J., Abergel R.P., Chu M.L., Ramirez F. Altered steady-state ratio of type I/III procollagen mRNAs correlates with selectively increased type I procollagen biosynthesis in cultured keloid fibroblasts. Proc Natl Acad Sci U S A 1985, 82:5935-5939.
    • (1985) Proc Natl Acad Sci U S A , vol.82 , pp. 5935-5939
    • Uitto, J.1    Perejda, A.J.2    Abergel, R.P.3    Chu, M.L.4    Ramirez, F.5
  • 30
    • 0030840611 scopus 로고    scopus 로고
    • Major suppression of pro-alpha1(I) type I collagen gene expression in the dermis after keloid excision and immediate intrawound injection of triamcinolone acetonide
    • Kauh Y.C., Rouda S., Mondragon G., Tokarek R., diLeonardo M., Tuan R.S., et al. Major suppression of pro-alpha1(I) type I collagen gene expression in the dermis after keloid excision and immediate intrawound injection of triamcinolone acetonide. J Am Acad Dermatol 1997, 37:586-589.
    • (1997) J Am Acad Dermatol , vol.37 , pp. 586-589
    • Kauh, Y.C.1    Rouda, S.2    Mondragon, G.3    Tokarek, R.4    diLeonardo, M.5    Tuan, R.S.6
  • 31
    • 35649022658 scopus 로고    scopus 로고
    • Increased CCN2 transcription in keloid fibroblasts requires cooperativity between AP-1 and SMAD binding sites
    • Xia W., Kong W., Wang Z., Phan T.T., Lim I.J., Longaker M.T., et al. Increased CCN2 transcription in keloid fibroblasts requires cooperativity between AP-1 and SMAD binding sites. Ann Surg 2007, 246:886-895.
    • (2007) Ann Surg , vol.246 , pp. 886-895
    • Xia, W.1    Kong, W.2    Wang, Z.3    Phan, T.T.4    Lim, I.J.5    Longaker, M.T.6
  • 32
    • 0029996247 scopus 로고    scopus 로고
    • Connective tissue growth factor gene expression in tissue sections from localized scleroderma, keloid, and other fibrotic skin disorders
    • Igarashi A., Nashiro K., Kikuchi K., Sato S., Ihn H., Fujimoto M., et al. Connective tissue growth factor gene expression in tissue sections from localized scleroderma, keloid, and other fibrotic skin disorders. J Invest Dermatol 1996, 106:729-733.
    • (1996) J Invest Dermatol , vol.106 , pp. 729-733
    • Igarashi, A.1    Nashiro, K.2    Kikuchi, K.3    Sato, S.4    Ihn, H.5    Fujimoto, M.6
  • 33
    • 43049178193 scopus 로고    scopus 로고
    • Anti-apoptotic action of Wnt5a in dermal fibroblasts is mediated by the PKA signaling pathways
    • Torii K., Nishizawa K., Kawasaki A., Yamashita Y., Katada M., Ito M., et al. Anti-apoptotic action of Wnt5a in dermal fibroblasts is mediated by the PKA signaling pathways. Cell Signal 2008, 20:1256-1266.
    • (2008) Cell Signal , vol.20 , pp. 1256-1266
    • Torii, K.1    Nishizawa, K.2    Kawasaki, A.3    Yamashita, Y.4    Katada, M.5    Ito, M.6
  • 34
    • 34547936369 scopus 로고    scopus 로고
    • Canonical and non-canonical Wnts differentially affect the development potential of primary isolate of human bone marrow mesenchymal stem cells
    • Baksh D., Tuan R.S. Canonical and non-canonical Wnts differentially affect the development potential of primary isolate of human bone marrow mesenchymal stem cells. J Cell Physiol 2007, 212:817-826.
    • (2007) J Cell Physiol , vol.212 , pp. 817-826
    • Baksh, D.1    Tuan, R.S.2
  • 35
    • 33846869496 scopus 로고    scopus 로고
    • Beta-catenin signaling in fibroproliferative disease
    • Bowley E., O'Gorman D.B., Gan B.S. Beta-catenin signaling in fibroproliferative disease. J Surg Res 2007, 138:141-150.
    • (2007) J Surg Res , vol.138 , pp. 141-150
    • Bowley, E.1    O'Gorman, D.B.2    Gan, B.S.3
  • 36
    • 14744305758 scopus 로고    scopus 로고
    • Prolonged beta-catenin stabilization and tcf-dependent transcriptional activation in hyperplastic cutaneous wounds
    • Cheon S., Poon R., Yu C., Khoury M., Shenker R., Fish J., et al. Prolonged beta-catenin stabilization and tcf-dependent transcriptional activation in hyperplastic cutaneous wounds. Lab Invest 2005, 85:416-425.
    • (2005) Lab Invest , vol.85 , pp. 416-425
    • Cheon, S.1    Poon, R.2    Yu, C.3    Khoury, M.4    Shenker, R.5    Fish, J.6
  • 37
    • 0038783316 scopus 로고    scopus 로고
    • Secreted antagonists of the Wnt signalling pathway
    • Kawano Y., Kypta R. Secreted antagonists of the Wnt signalling pathway. J Cell Sci 2003, 116:2627-2634.
    • (2003) J Cell Sci , vol.116 , pp. 2627-2634
    • Kawano, Y.1    Kypta, R.2
  • 38
    • 78650489190 scopus 로고    scopus 로고
    • Exogenously administered secreted frizzled related protein 2 (Sfrp2) reduces fibrosis and improves cardiac function in a rat model of myocardial infarction
    • He W., Zhang L., Ni A., Zhang Z., Mirotsou M., Mao L., et al. Exogenously administered secreted frizzled related protein 2 (Sfrp2) reduces fibrosis and improves cardiac function in a rat model of myocardial infarction. Proc Natl Acad Sci U S A 2010, 107:21110-21115.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 21110-21115
    • He, W.1    Zhang, L.2    Ni, A.3    Zhang, Z.4    Mirotsou, M.5    Mao, L.6
  • 39
    • 70649090107 scopus 로고    scopus 로고
    • The FOP metamorphogene encodes a novel type I receptor that dysregulates BMP signaling
    • Kaplan F.S., Pignolo R.J., Shore E.M. The FOP metamorphogene encodes a novel type I receptor that dysregulates BMP signaling. Cytokine Growth Factor Rev 2009, 20:399-407.
    • (2009) Cytokine Growth Factor Rev , vol.20 , pp. 399-407
    • Kaplan, F.S.1    Pignolo, R.J.2    Shore, E.M.3
  • 40
    • 77951752157 scopus 로고    scopus 로고
    • The advantages and disadvantages of sfrp1 and sfrp2 expression in pathological events
    • Esteve P., Bovolenta P. The advantages and disadvantages of sfrp1 and sfrp2 expression in pathological events. Tohoku J Exp Med 2010, 221:11-17.
    • (2010) Tohoku J Exp Med , vol.221 , pp. 11-17
    • Esteve, P.1    Bovolenta, P.2
  • 41
    • 35648981937 scopus 로고    scopus 로고
    • Wnt3a signaling promotes proliferation, myogenic differentiation, and migration of rat bone marrow mesenchymal stem cells
    • Shang Y.C., Wang S.H., Xiong F., Zhao C.P., Peng F.N., Feng S.W., et al. Wnt3a signaling promotes proliferation, myogenic differentiation, and migration of rat bone marrow mesenchymal stem cells. Acta Pharmacol Sin 2007, 28:1761-1774.
    • (2007) Acta Pharmacol Sin , vol.28 , pp. 1761-1774
    • Shang, Y.C.1    Wang, S.H.2    Xiong, F.3    Zhao, C.P.4    Peng, F.N.5    Feng, S.W.6
  • 42
    • 0344171934 scopus 로고    scopus 로고
    • The Wnt/Wg signal transducer beta-catenin controls fibronectin expression
    • Gradl D., Kuhl M., Wedlich D. The Wnt/Wg signal transducer beta-catenin controls fibronectin expression. Mol Cell Biol 1999, 19:5576-5587.
    • (1999) Mol Cell Biol , vol.19 , pp. 5576-5587
    • Gradl, D.1    Kuhl, M.2    Wedlich, D.3
  • 43
    • 2942722698 scopus 로고    scopus 로고
    • Elevated levels of beta-catenin and fibronectin in three-dimensional collagen cultures of Dupuytren's disease cells are regulated by tension in vitro
    • Howard J.C., Varallo V.M., Ross D.C., Roth J.H., Faber K.J., Alman B., et al. Elevated levels of beta-catenin and fibronectin in three-dimensional collagen cultures of Dupuytren's disease cells are regulated by tension in vitro. BMC Musculoskelet Disord 2003, 4:16.
    • (2003) BMC Musculoskelet Disord , vol.4 , pp. 16
    • Howard, J.C.1    Varallo, V.M.2    Ross, D.C.3    Roth, J.H.4    Faber, K.J.5    Alman, B.6
  • 44
    • 72949124653 scopus 로고    scopus 로고
    • Wnt signalling in mouse mesenchymal stem cells: impact on proliferation, invasion and MMP expression
    • Karow M., Popp T., Egea V., Ries C., Jochum M., Neth P. Wnt signalling in mouse mesenchymal stem cells: impact on proliferation, invasion and MMP expression. J Cell Mol Med 2009, 13:2506-2520.
    • (2009) J Cell Mol Med , vol.13 , pp. 2506-2520
    • Karow, M.1    Popp, T.2    Egea, V.3    Ries, C.4    Jochum, M.5    Neth, P.6
  • 45
    • 0037194578 scopus 로고    scopus 로고
    • Identification of membrane-type matrix metalloproteinase-1 as a target of the beta-catenin/Tcf4 complex in human colorectal cancers
    • Takahashi M., Tsunoda T., Seiki M., Nakamura Y., Furukawa Y. Identification of membrane-type matrix metalloproteinase-1 as a target of the beta-catenin/Tcf4 complex in human colorectal cancers. Oncogene 2002, 21:5861-5867.
    • (2002) Oncogene , vol.21 , pp. 5861-5867
    • Takahashi, M.1    Tsunoda, T.2    Seiki, M.3    Nakamura, Y.4    Furukawa, Y.5
  • 46
    • 0346752000 scopus 로고    scopus 로고
    • Beta-catenin activates a coordinated expression of the proinvasive factors laminin-5 gamma2 chain and MT1-MMP in colorectal carcinomas
    • Hlubek F., Spaderna S., Jung A., Kirchner T., Brabletz T. Beta-catenin activates a coordinated expression of the proinvasive factors laminin-5 gamma2 chain and MT1-MMP in colorectal carcinomas. Int J Cancer 2004, 108:321-326.
    • (2004) Int J Cancer , vol.108 , pp. 321-326
    • Hlubek, F.1    Spaderna, S.2    Jung, A.3    Kirchner, T.4    Brabletz, T.5
  • 47
    • 33847268280 scopus 로고    scopus 로고
    • Wnt signaling induces matrix metalloproteinase expression and regulates T cell transmigration
    • Wu B., Crampton S.P., Hughes C.C. Wnt signaling induces matrix metalloproteinase expression and regulates T cell transmigration. Immunity 2007, 26:227-239.
    • (2007) Immunity , vol.26 , pp. 227-239
    • Wu, B.1    Crampton, S.P.2    Hughes, C.C.3
  • 48
    • 33845355511 scopus 로고    scopus 로고
    • Diversity of LEF/TCF action in development and disease
    • Arce L., Yokoyama N.N., Waterman M.L. Diversity of LEF/TCF action in development and disease. Oncogene 2006, 25:7492-7504.
    • (2006) Oncogene , vol.25 , pp. 7492-7504
    • Arce, L.1    Yokoyama, N.N.2    Waterman, M.L.3
  • 49
    • 65349143115 scopus 로고    scopus 로고
    • Promoted activation of matrix metalloproteinase (MMP)-2 in keloid fibroblasts and increased expression of MMP-2 in collagen bundle regions: implications for mechanisms of keloid progression
    • Imaizumi R., Akasaka Y., Inomata N., Okada E., Ito K., Ishikawa Y., et al. Promoted activation of matrix metalloproteinase (MMP)-2 in keloid fibroblasts and increased expression of MMP-2 in collagen bundle regions: implications for mechanisms of keloid progression. Histopathology 2009, 54:722-730.
    • (2009) Histopathology , vol.54 , pp. 722-730
    • Imaizumi, R.1    Akasaka, Y.2    Inomata, N.3    Okada, E.4    Ito, K.5    Ishikawa, Y.6
  • 50
    • 10944224663 scopus 로고    scopus 로고
    • Signal transduction blockade and cancer: combination therapy or multi-targeted inhibitors?
    • Kerr D.J., La Thangue N.B. Signal transduction blockade and cancer: combination therapy or multi-targeted inhibitors?. Ann Oncol 2004, 15:1727-1729.
    • (2004) Ann Oncol , vol.15 , pp. 1727-1729
    • Kerr, D.J.1    La Thangue, N.B.2


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