Increased proliferation in keloid fibroblasts wounded in vitro

Journal of Surgical Research

Volumn 61, Issue 2, 1996, Pages 343-347

  Calderon, Marlene ^a   Lawrence, W Thomas ^a   Banes, Albert J ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; THYMIDINE; TRITIUM;

ARTICLE; CELL CYCLE S PHASE; CELL DAMAGE; CELL PROLIFERATION; CONTROLLED STUDY; DNA SYNTHESIS; FIBROBLAST; HUMAN; HUMAN CELL; KELOID; LABELING INDEX; PRIORITY JOURNAL; SKIN FIBROBLAST; WOUND;

EID: 0029980524     PISSN: 00224804     EISSN: None     Source Type: Journal    
DOI: 10.1006/jsre.1996.0127     Document Type: Article

References (28)

1. Peacock, E. E., Jr., Madden, J. W., and Trier, W. C. Biological basis for the treatment of keloids and hypertrophic scars. South Med. J. 63: 755-760, 1970.
2. Rudolph, R. Wide spread scars, hypertrophic scars, and keloids. Clin. Plast. Surg. 14: 253-260, 1987.
3. Lawrence, W. T. The optimal treatment of keloids. Ann. Plast. Surg. 27: 164-178, 1991.
4. Rockwell, W. B., Cohen, I. K., and Ehrlich, H. P. Keloids and hypertrophic scars: A comprehensive review. Plast. Reconstr. Surg. 84: 827-837, 1989.
5. Databo-Brown, D. D. Keloids: A review of the literature. Br. J. Plast. Surg. 43: 70-77, 1990.
6. Mancini, R. E., and Quaife, J. V. Histogenesis of experimentally produced keloids. J. Invest. Dermatol. 38: 143-181, 1962.
7. Matsuoka, L. Y., Uitto, J., Wortsman, J., Abergel, R. P., and Dietrich, J. Ultrastructural characteristics of keloid fibroblasts. Am. J. Dermatopathol. 10: 505-508, 1988.
8. Kischer, C. W., and Brody, G. S. Structure of the collagen nodule from hypertrophic scars and keloids. Scanning Electron Microsc. III: 371-376, 1981.
9. Kischer, C. W. Comparative ultrastructure of hypertrophic scars and keloids. Scanning Electron Microsc. 1:423-431, 1984.
10. Kischer, C. W: The microvessels in hypertrophic scars, keloids and related lesions: a review. J. Submicrosc. Cytol. Pathol. 24: 281-296, 1992.
11. Blackburn, W. R., and Cosman, B. Histologic basis of keloid and hypertrophic scar differentiation. Arch. Pathol. 82: 65-71, 1966.
12. Russell, J. D., and Witt, W. S. Cell size and growth characteristics of cultured fibroblasts isolated from normal and keloid tissue. Plast. Reconstr. Surg. 57: 207-212, 1976.
13. Diegelmann, R. F., Cohen, I. K., and McCoy, B. J. Growth kinetics and collagen synthesis of normal skin, normal scar, and keloid fibroblasts in vitro. J. Cell. Physiol. 98: 341-346, 1979.
14. McCoy, B. J., Galdun, J., and Cohen, I. K. Effects of density and cellular aging on collagen synthesis and growth kinetics in keloid and normal skin fibroblasts. In Vitro 18: 79-86, 1982.
15. Oko, T., Takigawa, M., and Yamada, M. Cell proliferation kinetics of cultured human keratinocytes and fibroblasts measured using a monoclonal antibody. Br. J. Dermatol. 116: 673-679, 1987.
16. Banes, A. J., Link, G. W., Gilbert, J. W., and Monbureau, O. Culturing cells in a mechanically active environment. Am. Biotech. Labs. 8: 13-20, 1990.
17. Cohen, I. K., Keiser, H. R., and Sjoerdsma, A. Collagen synthesis in human keloid and hypertrophic scar. Surg. Forum 22: 488-489, 1971.
18. Craig, R. D. P., Schofield, J. D., and Jackson, S. S. Collagen biosynthesis in normal human skin, normal and hypertrophic scar and keloid. Eur. J. Clin. Invest. 5: 69-74, 1975.
19. Cohen, I. K., Diegelmann, R. F., and Keiser, H. R. Collagen metabolism in keloid and hypertrophic scar. In J. J. Longacre (Ed.), The Ultrastructure of Collagen. Springfield: Charles C. Thomas, 1976. Pp. 199-212.
20. McCoy, B. J., and Cohen, I. K. Effects of various sera on growth kinetics and collagen synthesis by keloid and normal dermal fibroblasts. Plast. Reconstr. Surg. 67: 505-509, 1981.
21. Abergel, R. P., Pizzurro, D., Meeker, C. A., Lask, G., Matsuoko, L. Y., Minor, R. R., Chu, M. L., and Uitto, J. Biochemical composition of the connective tissue in keloids and analysis of collagen metabolism in keloid fibroblast cultures. J. Invest. Dermatol. 84: 384-390, 1985.
22. Uitto, J., Perejda, A. J., Abergel, R. P., Chu, M. L., and Ramirez, F. Altered steady-state ratio of type I/III procollagen mRNAs correlates with selectively increased type I procollagen biosynthesis in cultured keloid fibroblasts. Proc. Natl. Acad. Sci. USA 82: 5935-5939, 1985.
23. Kischer, C. W., Wagner, H. N., Jr., Pindur, J., Holubec, H., Jones, M., Ulreich, J. B., and Schuderi, P. Increased fibronectin production by cell lines from hypertrophic scar and keloid. Connect Tissue Res. 23: 279-288, 1989.
24. Babu, M., Diegelmann, R., and Oliver, N. Fibronectin is over-produced by keloid fibroblasts during abnormal wound healing. Mol. Cell. Biol. 9: 1642-1650, 1989.
25. Russell, S. B., Trupin, K. M., Rodriguez-Eaton, S., Russell, J. D., and Trupin, J. S. Reduced growth-factor requirement of keloid-derived fibroblasts may account for tumor growth. Proc. Natl. Acad. Sci. USA 85: 587-591, 1988.
26. Harper, R. A. Keloid fibroblasts in culture: Abnormal growth behavior and altered response to the epidermal growth factor. Cell. Biol. Int. Rep. 13: 325-335, 1989.
27. Kikuchi, K., Kadono, T., and Takehara, K. Effects of various growth factors and histamine on cultured keloid fibroblasts. Dermatology 190: 4-8, 1995.
28. Haisa, M., Okochi, H., and Grotendorst, G. R. Elevated levels of PDGF alpha receptors in keloid fibroblasts contribute to an enhanced response to PDGF. J. Invest. Dermatol. 103: 560-563, 1994.