Major suppression of pro-α1(I) type I collagen gene expression in the dermis after keloid excision and immediate intrawound injection of triamcinolone acetonide

Journal of the American Academy of Dermatology

Volumn 37, Issue 4, 1997, Pages 586-589

  Kauh, Y C ^a   Rouda, S ^a   Mondragon, G ^a   Tokarek, R ^a   DiLeonardo, M ^a   Tuan, R S ^a   Tan, E M L ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 1; TRIAMCINOLONE ACETONIDE;

ADOLESCENT; ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; COLLAGEN SYNTHESIS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DERMIS; DOSE RESPONSE; DRUG EFFICACY; GENE EXPRESSION; HUMAN; HUMAN TISSUE; INTRALESIONAL DRUG ADMINISTRATION; KELOID; PRIORITY JOURNAL; WOUND HEALING;

EID: 0030840611     PISSN: 01909622     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0190-9622(97)70176-2     Document Type: Article

References (20)

1. J Uitto AJ Perejda RP Abergel Altered steady-state ratio of type I/type III procollagen mRNAs correlates with selectively increased type I procollagen biosynthesis in cultured keloid fibroblasts Proc Natl Acad Sci U S A 82 1985 5935 5939
2. RP Abergel D Pizzurro CA Meeker Biochemical composition of the connective tissue in keloids and analysis of collagen metabolism in keloid fibroblast culture J Invest Dermatol 84 1985 384 390
3. J Uitto AJ Perejda RP Abergel Altered type I/III procollagen mRNA ratio in cultured keloid fibroblasts: evidence for regulation on the transcriptional level Ann NY Acad Sci 460 1985 514 516
4. CC Zouboulis U Blume P Buttner Outcomes of cryosurgery in keloids and hypertrophic scars: a prospective consecutive trial of case series Arch Dermatol 129 1993 1146 1151
5. L Rusciani G Rossi R Bono Use of cryotherapy in the treatment of keloids J Dermatol Surg Oncol 19 1993 529 534
6. JE Norris Superficial x-ray therapy in keloid management: a retrospective study of 24 cases and literature review Plast Reconstr Surg 95 1995 1051 1055
7. MR Chaudhry S Akhtar F Duvalsaint Ear lobe keloids, surgical excision followed by radiation therapy: a 10-year experience Ear Nose Throat J 73 1994 779 781
8. DI Klumpar JC Murray M Anscher Keloids treated with excision followed by radiation therapy J Am Acad Dermatol 31 1994 225 231
9. TS Alster CM Williams Treatment of keloid sternotomy scars with 585 nm flashlamp-pumped pulsed-dye laser Lancet 345 1995 1198 1200
10. JC Murray Keloids and hypertrophic scars Clin Dermatol 12 1994 27 37
11. LA Brown HE Pierce Keloids: scar revision J Dermatol Surg Oncol 12 1986 51 56
12. WB Rockwell IK Cohen HP Ehrlich Keloids and hypertrophic scars: a comprehensive review Plast Reconstr Surg 84 1989 827 837
13. RAF Clark Cutaneous tissue repair: basic biological considerations J Am Acad Dermatol 13 1985 701 725
14. K Scharffetter W Stolz B Lankat-Buttgereit Localization of collagen α1(I) gene expression during wound healing by in situ hybridization J Invest Dermatol 93 1989 405 412
15. MP Welch GF Odland RAF Clark Temporal relationships of F-actin bundle formation, collagen and fibronectin matrix assembly, and fibronectin receptor expression to wound contraction J Cell Biol 110 1990 133 145
16. M-L Chu JC Myers MP Bernard Cloning and characterization of five overlapping cDNAs specific for the human pro α1(I) collagen gene Nucleic Acids Res 10 1982 5925 5934
17. A Balmain R Krumlauf JK Vass Cloning and characterization of the abundant cytoplasmic 7s RNA from mouse cells Nucleic Acids Res 10 1982 4259 4277
18. SA McDonald RS Tuan Expression of collagen type transcripts in chick embryonic bone detected by in situ cDNA-mRNA hybridization Dev Biol 133 1989 221 234
19. RS Tuan BT Lamb CB Jesinkey Mouse placental 57-kDa calcium-binding protein: II. Localization of mRNA in mouse and human placentae by in situ cDNA hybridization Differentiation 37 1988 198 204
20. RS Tuan Analysis of gene expression in skeletal tissues by in situ hybridization Bone 14 1993 309 314