Promoted activation of matrix metalloproteinase (MMP)-2 in keloid fibroblasts and increased expression of MMP-2 in collagen bundle regions: Implications for mechanisms of keloid progression

Histopathology

Volumn 54, Issue 6, 2009, Pages 722-730

  Imaizumi, Risa ^b   Akasaka, Yoshikiyo ^a   Inomata, Naomi ^b   Okada, Emi ^b   Ito, Kinji ^a   Ishikawa, Yukio ^a   Maruyama, Yu ^b  

^a TOHO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TOHO UNIVERSITY   (Japan)

Author keywords

Fibroblast; Invasion; Keloid; MMP 2; MT1 MMP; Remodelling; TIMP 2

Indexed keywords

COLLAGEN FIBER; GELATINASE A; MATRIX METALLOPROTEINASE 14; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TISSUE INHIBITOR OF METALLOPROTEINASE 3;

ADULT; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; FIBROBLAST; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE; KELOID; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCAR; WESTERN BLOTTING; ZYMOGRAPHY;

ADULT; COLLAGEN; ENZYME ACTIVATION; EXTRACELLULAR MATRIX; FIBROBLASTS; HUMANS; IMMUNOHISTOCHEMISTRY; KELOID; MATRIX METALLOPROTEINASE 2; TISSUE INHIBITOR OF METALLOPROTEINASE-2; TISSUE INHIBITOR OF METALLOPROTEINASE-3; WOUND HEALING;

EID: 65349143115     PISSN: 03090167     EISSN: 13652559     Source Type: Journal    
DOI: 10.1111/j.1365-2559.2009.03287.x     Document Type: Article

References (44)

1. Robles DT, Berg D. Abnormal wound healing: keloids. Clin. Dermatol. 2007 25 26 32. (Pubitemid 46177462)
2. Colwell AS, Phan TT, Kong W, Longaker MT, Lorenz PH. Hypertrophic scar fibroblasts have increased connective tissue growth factor expression after transforming growth factor-beta stimulation. Plast. Reconstr. Surg. 2005 116 1387 1390. (Pubitemid 41456511)
3. Marneros AG, Krieg T. Keloids - clinical diagnosis, pathogenesis, and treatment options. J. Dtsch Dermatol. Ges. 2004 2 905 913. (Pubitemid 39472352)
4. Al-Attar A, Mess S, Thomassen JM, Kauffman CL, Davison SP. Keloid pathogenesis and treatment. Plast. Reconstr. Surg. 2006 117 286 300. (Pubitemid 44391579)
5. Atiyeh BS, Costagliola M, Hayek SN. Keloid or hypertrophic scar: the controversy: review of the literature. Ann. Plast. Surg. 2005 54 676 680. (Pubitemid 40726841)
6. Lee JY, Yang CC, Chao SC, Wong TW. Histopathological differential diagnosis of keloid and hypertrophic scar. Am. J. Dermatopathol. 2004 26 379 384. (Pubitemid 39287358)
7. Tredget EE, Nedelec B, Scott PG, Ghahary A. Hypertrophic scars, keloids, and contractures. The cellular and molecular basis for therapy. Surg. Clin. North Am. 1997 77 701 730. (Pubitemid 27256042)
8. Varelias A, Cowin AJ, Adams D et al. Mitogenic bovine whey extract modulates matrix metalloproteinase-2, -9, and tissue inhibitor of matrix metalloproteinase-2 levels in chronic leg ulcers. Wound Repair Regen. 2006 14 28 37.
9. Ravanti L, Kähäri VM. Matrix metalloproteinases in wound repair (review). Int. J. Mol. Med. 2000 6 391 407.
10. Vaalamo M, Leivo T, Saarialho-Kere U. Differential expression of tissue inhibitors of metalloproteinases (TIMP-1, -2, -3, and -4) in normal and aberrant wound healing. Hum. Pathol. 1999 30 795 802. (Pubitemid 29325786)
11. Birkedal-Hansen H. Proteolytic remodeling of extracellular matrix. Curr. Opin. Cell Biol. 1995 7 728 735.
12. Gill SE, Parks WC. Metalloproteinases and their inhibitors: regulators of wound healing. Int. J. Biochem. Cell Biol. 2008 40 1334 1347.
13. Baker AH, Edwards DR, Murphy G. Metalloproteinase inhibitors: biological actions and therapeutic opportunities. J. Cell Sci. 2002 115 3719 3727. (Pubitemid 35203598)
14. Stricklin GP, Li L, Nanney LB. Localization of mRNAs representing interstitial collagenase, 72-kda gelatinase, and TIMP in healing porcine burn wounds. J. Invest. Dermatol. 1994 103 352 358. (Pubitemid 24329756)
15. Okada A, Tomasetto C, Lutz Y, Bellocq JP, Rio MC, Basset P. Expression of matrix metalloproteinases during rat skin wound healing: evidence that membrane type-1 matrix metalloproteinase is a stromal activator of pro-gelatinase A. J. Cell Biol. 1997 137 67 77. (Pubitemid 27167296)
16. Parks WC. Matrix metalloproteinases in repair. Wound Repair Regen. 1999 7 423 432. (Pubitemid 30027564)
17. Gillard JA, Reed MW, Buttle D, Cross SS, Brown NJ. Matrix metalloproteinase activity and immunohistochemical profile of matrix metalloproteinase-2 and -9 and tissue inhibitor of metalloproteinase-1 during human dermal wound healing. Wound Repair Regen. 2004 12 295 304. (Pubitemid 38880438)
18. Pardo A, Selman M. MMP-1: the elder of the family. Int. J. Biochem. Cell Biol. 2005 37 283 288. (Pubitemid 39330190)
19. Fujiwara M, Muragaki Y, Ooshima A. Keloid-derived fibroblasts show increased secretion of factors involved in collagen turnover and depend on matrix metalloproteinase for migration. Br. J. Dermatol. 2005 153 295 300. (Pubitemid 41228425)
20. Neely AN, Clendening CE, Gardner J, Greenhalgh DG, Warden GD. Gelatinase activity in keloids and hypertrophic scars. Wound Repair Regen. 1999 7 166 171. (Pubitemid 29331920)
21. Akasaka Y, Ono I, Tominaga A et al. Basic fibroblast growth factor in an artificial dermis promotes apoptosis and inhibits expression of alpha-smooth muscle actin, leading to reduction of wound contraction. Wound Repair Regen. 2007 15 378 389. (Pubitemid 46817414)
22. Strup-Perrot C, Vozenin-Brotons MC, Vandamme M, Benderitter M, Mathe D. Expression and activation of MMP -2, -3, -9, -14 are induced in rat colon after abdominal X-irradiation. Scand. J. Gastroenterol. 2006 41 60 70. (Pubitemid 43030893)
23. Togashi M, Tamura K, Nitta T, Ishizaki M, Sugisaki Y, Fukuda Y. Role of matrix metalloproteinases and their tissue inhibitor of metalloproteinases in myxomatous change of cardiac floppy valves. Pathol. Int. 2007 57 251 259. (Pubitemid 46595029)
24. Maeta H, Ohgi S, Terada T. Protein expression of matrix metalloproteinases 2 and 9 and tissue inhibitors of metalloproteinase 1 and 2 in papillary thyroid carcinomas. Virchows Arch. 2001 438 121 128. (Pubitemid 32186579)
25. Bérubé M, Deschambeault A, Boucher M, Germain L, Petitclerc E, Guérin SL. MMP-2 expression in uveal melanoma: differential activation status dictated by the cellular environment. Mol. Vis. 2005 11 1101 1111. (Pubitemid 41819513)
26. La Rocca G, Anzalone R, Magno F, Farina F, Cappello F, Zummo G. Cigarette smoke exposure inhibits extracellular MMP-2 (gelatinase A) activity in human lung fibroblasts. Respir. Res. 2007 8 23.
27. Määttä M, Tervahartiala T, Vesti E, Airaksinen J, Sorsa T. Levels and activation of matrix metalloproteinases in aqueous humor are elevated in uveitis-related secondary glaucoma. J. Glaucoma 2006 15 229 237. (Pubitemid 43916816)
28. Zucker S, Lysik RM, Gurfinkel M et al. Immunoassay of type IV collagenase/gelatinase (MMP-2) in human plasma. J. Immunol. Methods 1992 148 189 198.
29. Westerlund A, Hujanen E, Puistola U, Turpeenniemi-Hujanen T. Fibroblasts stimulate human ovarian cancer cell invasion and expression of 72-kDa gelatinase A (MMP-2). Gynecol. Oncol. 1997 67 76 82. (Pubitemid 27433332)
30. Zucker S, Drews M, Conner C et al. Tissue inhibitor of metalloproteinase-2 (TIMP-2) binds to the catalytic domain of the cell surface receptor, membrane type 1-matrix metalloproteinase 1 (MT1-MMP). J. Biol. Chem. 1998 273 1216 1222. (Pubitemid 28049224)
31. Butler GS, Butler MJ, Atkinson SJ et al. The TIMP2 membrane type 1 metalloproteinase "receptor" regulates the concentration and efficient activation of progelatinase A. A kinetic study. J. Biol. Chem. 1998 273 871 880. (Pubitemid 28049179)
32. Itoh Y, Takamura A, Ito N et al. Homophilic complex formation of MT1-MMP facilitates proMMP-2 activation on the cell surface and promotes tumor cell invasion. EMBO J. 2001 20 4782 4793. (Pubitemid 32848631)
33. Ruangpanit N, Price JT, Holmbeck K et al. MT1-MMP-dependent and -independent regulation of gelatinase A activation in long-term, ascorbate-treated fibroblast cultures: regulation by fibrillar collagen. Exp. Cell Res. 2002 272 109 118.
34. Ra HJ, Parks WC. Control of matrix metalloproteinase catalytic activity. Matrix Biol. 2007 26 587 596. (Pubitemid 350180394)
35. Sounni NE, Janssen M, Foidart JM, Noel A. Membrane type-1 matrix metalloproteinase and TIMP-2 in tumor angiogenesis. Matrix Biol. 2003 22 55 61. (Pubitemid 36444507)
36. Hofmann UB, Westphal JR, Van Kraats AA, Ruiter DJ, Van Muijen GN. Expression of integrin alpha(v)beta(3) correlates with activation of membrane-type matrix metalloproteinase-1 (MT1-MMP) and matrix metalloproteinase-2 (MMP-2) in human melanoma cells in vitro and in vivo. Int. J. Cancer 2000 87 12 19. (Pubitemid 30368410)
37. Zucker S, Pei D, Cao J, Lopez-Otin C. Membrane type-matrix metalloproteinases (MT-MMP). Curr. Top. Dev. Biol. 2003 54 1 74. (Pubitemid 137639464)
38. Nomura H, Sato H, Seiki M, Mai M, Okada Y. Expression of membrane-type matrix metalloproteinase in human gastric carcinomas. Cancer Res. 1995 55 3263 3266.
39. Hofmann UB, Westphal JR, Zendman AJ, Becker JC, Ruiter DJ, van Muijen GN. Expression and activation of matrix metalloproteinase-2 (MMP-2) and its co-localization with membrane-type 1 matrix metalloproteinase (MT1-MMP) correlate with melanoma progression. J. Pathol. 2000 191 245 256. (Pubitemid 30441247)
40. Nakahara H, Howard L, Thompson EW et al. Transmembrane/cytoplasmic domain-mediated membrane type 1-matrix metalloprotease docking to invadopodia is required for cell invasion. Proc. Natl Acad. Sci. USA 1997 94 7959 7964. (Pubitemid 27343757)
41. Polette M, Nawrocki B, Gilles C et al. MT-MMP expression and localisation in human lung and breast cancers. Virchows Arch. 1996 428 29 35. (Pubitemid 26151339)
42. Bisson C, Blacher S, Polette M et al. Restricted expression of membrane type 1-matrix metalloproteinase by myofibroblasts adjacent to human breast cancer cells. Int. J. Cancer 2003 105 7 13. (Pubitemid 36418478)
43. Okada A, Bellocq JP, Rouyer N et al. Membrane-type matrix metalloproteinase (MT-MMP) gene is expressed in stromal cells of human colon, breast, and head and neck carcinomas. Proc. Natl Acad. Sci. USA 1995 92 2730 2734.
44. Murray JC. Keloids and hypertrophic scars. Clin. Dermatol. 1994 12 27 37. (Pubitemid 24050735)