The role of R-spondin2 in keratinocyte proliferation and epidermal thickening in keloid scarring

Journal of Investigative Dermatology

Volumn 131, Issue 3, 2011, Pages 644-654

  Chua, Alvin W C ^a,b   Ma, Dongrui ^a   Gan, Shu U ^b   Fu, Zhenying ^b   Han, Hwan C ^b   Song, Colin ^a   Sabapathy, Kanaga ^c   Phan, Toan T ^b,d  

^a SINGAPORE GENERAL HOSPITAL   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c DIVISION OF MEDICAL ONCOLOGY   (Singapore)

^d NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; CELL PROTEIN; R SPONDIN1; R SPONDIN2; UNCLASSIFIED DRUG; WNT PROTEIN; WNT3A PROTEIN;

ARTICLE; CELL CULTURE; CELL PROLIFERATION; CONTROLLED STUDY; EPIDERMIS; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; KELOID; KERATINOCYTE; MOLECULAR INTERACTION; PARACRINE SIGNALING; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; SCAR; SKIN FIBROBLAST;

EID: 79951511302     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2010.371     Document Type: Article

References (43)

1. Andriessen MP, Niessen FB, Van De Kerkhof PC et al. (1998) Hypertrophic scarring is associated with epidermal abnormalities: an immunohisto-chemical study. J Pathol 186:192-200 (Pubitemid 28467830)
2. Baksh D, Tuan RS (2007) Canonical and non-canonical Wnts differentially affect the development potential of primary isolate of human bone marrow mesenchymal stem cells. J Cell Physiol 212:817-26 (Pubitemid 47267551)
3. Bowley E, O'Gorman DB, Gan BS (2007) Beta-catenin signaling in fibroproliferative disease. J Surg Res 138:141-50
4. Boyce ST, Ham RG (1983) Calcium-regulated differentiation of normal human epidermal keratinocytes in chemically defined clonal culture and serum-free serial culture. J Invest Dermatol 81:33s-40s (Pubitemid 13030411)
5. Butler PD, Longaker MT, Yang GP (2008a) Current progress in keloid research and treatment. J Am Coll Surg 206:731-41
6. Butler PD, Ly DP, Longaker MT et al. (2008b) Use of organotypic coculture to study keloid biology. Am J Surg 195:144-8
7. Cheon S, Poon R, Yu C et al. (2005) Prolonged beta-catenin stabilization and tcf-dependent transcriptional activation in hyperplastic cutaneous wounds. Lab Invest 85:416-25 (Pubitemid 40333158)
8. Dietrich C, Scherwat J, Faust D et al. (2002) Subcellular localization of beta-catenin is regulated by cell density. Biochem Biophys Res Commun 292:195-9 (Pubitemid 34687348)
9. Fusenig NE (1994) Epithelial-mesenchymal interactions regulate keratinocyte growth and differentiation in vitro. In: The Keratinocyte Handbook (Leigh I, Lane B, Watt F eds). Cambridge University Press: Cambridge, 71-94
10. Harrison CA, MacNeil S (2008) The mechanism of skin graft contraction: an update on current research and potential future therapies. Burns 34:153-63
11. Jia L, Zhou J, Peng S et al. (2008) Effects of Wnt3a on proliferation and differentiation of human epidermal stem cells. Biochem Biophys Res Commun 368:483-8
12. Kamata T, Katsube K, Michikawa M et al. (2004) R-spondin, a novel gene with thrombospondin type 1 domain, was expressed in the dorsal neural tube and affected in Wnts mutants. Biochim Biophys Acta 1676:51-62 (Pubitemid 38367730)
13. Kazanskaya O, Glinka A, del Barco Barrantes I et al. (2004) R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis. Dev Cell 7:525-34 (Pubitemid 39341838)
14. Kazanskaya O, Ohkawara B, Heroult M et al. (2008) The Wnt signaling regulator R-spondin 3 promotes angioblast and vascular development. Development 135:3655-64
15. Kim KA, Kakitani M, Zhao J et al. (2005) Mitogenic influence of human R-spondin1 on the intestinal epithelium. Science 309:1256-9 (Pubitemid 41170922)
16. Kim KA, Wagle M, Tran K et al. (2008) R-Spondin family members regulate the Wnt pathway by a common mechanism. Mol Biol Cell 19:2588-96
17. Kim KA, Zhao J, Andarmani S et al. (2006) R-Spondin proteins: a novel link to beta-catenin activation. Cell Cycle 5:23-6
18. Kischer CW, Shetlar MR, Chvapil M (1982) Hypertrophic scars and keloids: a review and new concept concerning their origin. Scan Electron Microsc, 4:1699-713 (Pubitemid 14486984)
19. Kitagawa T, Matsuda K, Inui S et al. (2009) Keratinocyte growth inhibition through the modification of Wnt signaling by androgen in balding dermal papilla cells. J Clin Endocrinol Metab 94:1288-94
20. Lim IJ, Phan TT, Bay BH et al. (2002) Fibroblasts cocultured with keloid keratinocytes: normal fibroblasts secrete collagen in a keloidlike manner. Am J Physiol Cell Physiol 283:C212-22 (Pubitemid 34670565)
21. Lim IJ, Phan TT, Song C et al. (2001) Investigation of the influence of keloid-derived keratinocytes on fibroblast growth and proliferation in vitro. Plast Reconstr Surg 107:797-808 (Pubitemid 32180128)
22. Linares HA, Larson DL, Willis-Galstaun BA (1993) Historical notes on the use of pressure in the treatment of hypertrophic scars or keloids. Burns 19:17-21 (Pubitemid 23059384)
23. Lu W, Kim KA, Liu J et al. (2008) R-spondin1 synergizes with Wnt3A in inducing osteoblast differentiation and osteoprotegerin expression. FEBS Lett 582:643-50
24. Maas-Szabowski N, Shimotoyodome A, Fusenig NE (1999) Keratinocyte growth regulation in fibroblast cocultures via a double paracrine mechanism. J Cell Sci 112(Part 12):1843-53 (Pubitemid 29338810)
25. Machesney M, Tidman N, Waseem A et al. (1998) Activated keratinocytes in the epidermis of hypertrophic scars. Am J Pathol 152:1133-41 (Pubitemid 28221864)
26. Memezawa A, Takada I, Takeyama K et al. (2007) Id2 gene-targeted crosstalk between Wnt and retinoid signaling regulates proliferation in human keratinocytes. Oncogene 26:5038-45 (Pubitemid 47206951)
27. Mustoe TA, Cooter RD, Gold MH et al. (2002) International clinical recommendations on scar management. Plast Reconstr Surg 110:560-71 (Pubitemid 34815962)
28. Ong CT, Khoo YT, Mukhopadhyay A et al. (2010) Comparative proteomic analysis between normal skin and keloid scar. Br J Dermatol 162:1302-15
29. Ong CT, Khoo YT, Tan EK et al. (2007) Epithelial-mesenchymal interactions in keloid pathogenesis modulate vascular endothelial growth factor expression and secretion. J Pathol 211:95-108 (Pubitemid 46092034)
30. Ooi B, Mukhopadhyay A, Masilamani J et al. (2010) Hepatoma-derived growth factor and its role in keloid pathogenesis. J Cell Mol Med 14:1328-37
31. Parma P, Radi O, Vidal V et al. (2006) R-spondin1 is essential in sex determination, skin differentiation and malignancy. Nat Genet 38:1304-9 (Pubitemid 44646293)
32. Russell SB, Russell JD, Trupin KM et al. (2010) Epigenetically altered wound healing in keloid fibroblasts. J Invest Dermatol 130:2489-96
33. Sato M (2006) Upregulation of the Wnt/beta-catenin pathway induced by transforming growth factor-beta in hypertrophic scars and keloids. Acta Derm Venereol 86:300-7 (Pubitemid 44133374)
34. Smiley AK, Klingenberg JM, Boyce ST et al. (2006) Keratin expression in cultured skin substitutes suggests that the hyperproliferative phenotype observed in vitro is normalized after grafting. Burns 32:135-8 (Pubitemid 43197646)
35. Smith JC, Boone BE, Opalenik SR et al. (2008) Gene profiling of keloid fibroblasts shows altered expression in multiple fibrosis-associated pathways. J Invest Dermatol 128:1298-310 (Pubitemid 351543197)
36. Smola H, Stark HJ, Thiekotter G et al. (1998) Dynamics of basement membrane formation by keratinocyte-fibroblast interactions in organo-typic skin culture. Exp Cell Res 239:399-410 (Pubitemid 28366640)
37. Torii K, Nishizawa K, Kawasaki A et al. (2008) Anti-apoptotic action of Wnt5a in dermal fibroblasts is mediated by the PKA signaling pathways. Cell Signal 20:1256-66
38. Vaccariello MA, Javaherian A, Parenteau N et al. (1998) Use of skin equivalent technology in a wound healing model. In: Tissue Engineering Methods and Protocols (Morgan JR, Yarmush ML, eds) vol. 18. Humana Press: Totowa, NJ, 391-405
39. Veeman MT, Slusarski DC, Kaykas A et al. (2003) Zebrafish prickle, a modulator of noncanonical Wnt/Fz signaling, regulates gastrulation movements. Curr Biol 13:680-5 (Pubitemid 36453318)
40. Wei Q, Yokota C, Semenov MV et al. (2007) R-spondin1 is a high affinity ligand for LRP6 and induces LRP6 phosphorylation and beta-catenin signaling. J Biol Chem 282:15903-11 (Pubitemid 47093310)
41. Wu Y, Zhang Q, Ann DK et al. (2004) Increased vascular endothelial growth factor may account for elevated level of plasminogen activator inhibitor-1 via activating ERK1/2 in keloid fibroblasts. Am J Physiol Cell Physiol 286:C905-12 (Pubitemid 38543819)
42. Zhao J, Kim KA, De Vera J et al. (2009) R-Spondin1 protects mice from chemotherapy or radiation-induced oral mucositis through the canonical Wnt/beta-catenin pathway. Proc Natl Acad Sci USA 106:2331-6
43. Zhu AJ, Watt FM (1999) beta-catenin signalling modulates proliferative potential of human epidermal keratinocytes independently of intercellular adhesion. Development 126:2285-98 (Pubitemid 29271712)