Copper alters aggregation behavior of prion protein and induces novel interactions between its N- and C-terminal regions

Journal of Biological Chemistry

Volumn 286, Issue 44, 2011, Pages 38533-38545

  Thakur, Abhay Kumar ^a   Srivastava, Atul Kumar ^b   Srinivas, Volety ^a   Chary, Kandala Venkata Ramana ^b   Rao, Chintalagiri Mohan ^a  

^a CENTRE FOR CELLULAR AND MOLECULAR BIOLOGY   (India)

^b TATA INSTITUTE OF FUNDAMENTAL RESEARCH   (India)

Author keywords

[No Author keywords available]

Indexed keywords

AGGREGATION BEHAVIOR; AMYLOID FIBRIL FORMATION; BINDING STUDIES; C-TERMINAL REGIONS; INTER-DOMAIN; ISOTHERMAL CALORIMETRY; LONG RANGE; LOOP REGIONS; N-TERMINALS; PHYSIOLOGICAL TEMPERATURE; PRION PROTEIN; SMALL ANGLE X-RAY SCATTERING; TEMPERATURE DEPENDENT;

PHYSIOLOGY; SCATTERING; X RAY SCATTERING;

PROTEINS;

AMYLOID; COPPER; HISTIDINE; PRION PROTEIN;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; LOW TEMPERATURE; MOUSE; NONHUMAN; OCTAPEPTIDE REPEAT; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN STRUCTURE;

ANIMALS; BINDING SITES; CALORIMETRY; COPPER; HISTIDINE; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MOLECULAR CONFORMATION; PRION DISEASES; PRIONS; PROTEIN STRUCTURE, TERTIARY; SCATTERING, RADIATION; SPECTROPHOTOMETRY; TEMPERATURE; X-RAYS;

EID: 80055066890     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.265645     Document Type: Article

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