Ionic strength and transition metals control PrPSc protease resistance and conversion-inducing activity

Journal of Biological Chemistry

Volumn 279, Issue 39, 2004, Pages 40788-40794

  Nishina, Koren ^a   Jenks, Samantha ^a   Supattapone, Surachai ^a  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COPPER; IONIC STRENGTH; POSITIVE IONS; TRANSITION METALS; ZINC;

DIVALENT CATIONS; IONIC STRENGTH BUFFERS;

ENZYMES;

COPPER; PRION PROTEIN; PRION PROTEIN PROTEASE; PROTEINASE; PROTEINASE K; UNCLASSIFIED DRUG; ZINC;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BRAIN CELL; CONCENTRATION RESPONSE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME MECHANISM; HAMSTER; IN VITRO STUDY; IONIC STRENGTH; METAL BINDING; MOUSE; NONHUMAN; PRION DISEASE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN FOLDING; SCRAPIE; SENSITIVITY ANALYSIS; STRUCTURE ANALYSIS;

ANIMALS; BRAIN; CATIONS; CELL MEMBRANE; COPPER; CRICETINAE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOPEPTIDASE K; ENDOPEPTIDASES; IMMUNOBLOTTING; IONS; MESOCRICETUS; METALS; MICE; PROTEIN CONFORMATION; PRPSC PROTEINS; SCRAPIE; SUBCELLULAR FRACTIONS; TIME FACTORS; ZINC;

ANIMALIA; CRICETINAE;

EID: 4644331407     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M406548200     Document Type: Article

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