Copper induces conformational changes in the N-terminal part of cell-surface PrPC

Archives of Virology

Volumn 151, Issue 11, 2006, Pages 2103-2109

  Leclerc, E ^a   Serban, H ^b   Prusiner, S B ^b,c   Burton, D R ^a   Williamson, R A ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COPPER; EPITOPE; IMMUNOGLOBULIN F(AB) FRAGMENT; MONOCLONAL ANTIBODY; PRION PROTEIN;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; CHEMISTRY; CHO CELL; DRUG EFFECT; EPITOPE MAPPING; HAMSTER; IMMUNOLOGY; METABOLISM; MOLECULAR GENETICS; PROTEIN CONFORMATION;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; CHO CELLS; COPPER; CRICETINAE; EPITOPE MAPPING; EPITOPES; IMMUNOGLOBULIN FAB FRAGMENTS; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; PRPC PROTEINS;

EID: 33750344296     PISSN: 03048608     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00705-006-0804-1     Document Type: Article

References (37)

1. 2+ binding sites in the N-terminal domain of the prion protein by EPR and CD spectroscopy Biochemistry 39 13760 13771
2. TC Blochberger C Cooper D Peretz J Tatzelt OH Griffith MA Baldwin SB Prusiner 1997 Prion protein expression in Chinese hamster ovary cells using a glutamine synthetase selection and amplification system Protein Eng 10 1465 1473
3. DR Brown 2002 Copper and prions diseases Biochem Soc Trans 30 742 745
4. DR Brown K Qin JW Herms A Madlung J Manson R Strome PE Fraser T Kruck A von Bohlen W Schulz-Schaeffer A Giese D Westaway H Kretzschmar 1997 The cellular prion protein binds copper in vivo Nature 390 684 687
5. DR Brown B Wong F Hafiz C Clive SJ Haswell IM Jones 1999 Normal prion protein has an activity that of superoxide dismutase Biochem J 344 1 5
6. CS Burns 2003 Copper coordination in the full-length, recombinant prion protein Biochemistry 42 6794 6803
7. CS Burns E Aronoff-Spencer CM Dunham P Lario NI Avdievich WE Antholine MM Olmstead GJ Vrielink J Peisach WG Scott GL Milhauser 2002 Molecular features of the copper binding sites in the octarepeat domain of the prion protein Biochemistry 41 3991 4001
8. 2+ to the C-terminal domain of the murine prion protein Biophysical J 81 516 525
9. RMC Dawson DC Elliott WH Elliott KM Jones 1986 Data for biochemical research Oxford University Press Oxford 399 415
10. DG Donne JH Viles D Groth I Mehlhorn TL James FE Cohen SB Prusiner PE Wright HJ Dyson 1997 Structure of the recombinant full-length hamster prion protein PrP(29-231): the N terminus is highly flexible Proc Natl Acad Sci USA 94 13452 13457
11. M Fischer T Rulicke A Raeber A Sailer M Moser B Oesch S Brandner A Aguzzi C Weissmann 1996 Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie EMBO J 15 1255 1264
12. AP Garnett JH Viles 2003 Copper binding to the octarepeats of the prion protein J Biol Chem 278 6795 6802
13. 91-231 and its low-resolution structure in solution J Mol Biol 311 467 473
14. FL Heppner C Musahl I Arrighi MA Klein T Rulicke B Oesch RM Zinkernagel U Kalinke A Aguzzi 2001 Prevention of Scrapie pathogenesis by transgenic expression of anti-prion protein antibodies Science 294 178 182
15. MP Hornshaw JR [tmp] McDermott JM Candy 1995 Copper binding to the N-terminal tandem repeat regions of mammalian and avian prion protein Biochem Biophys Res Commun 207 621 629
16. MP Hornshaw JR [tmp] McDermott JM Candy JH Lakey 1995 Copper binding to the N-terminal tandem repeat region of mammalian and avian prion protein: structural studies using synthetic peptides Biochem Biophys Res Commun 214 993 999
17. GS Jackson I Murray LLP Hosszu N Gibbs JP Waltho AR Clarke J Collinge 2001 Location and properties of metal-binding sites on the human prion protein Proc Natl Acad Sci USA 98 8531 8535
18. ML Kramer HD Kratzin B Schmidt A Romer O Windl S Liemann S Hornemann H Kretzschmar 2001 Prion protein binds copper within the physiological concentration range J Biol Chem 276 16711 16719
19. C on the cell surface as probed by antibody J Mol Biol 326 475 483
20. S Lehmann 2002 Metal ions and prion diseases Curr Opin Chem Biol 6 187 192
21. F Lopez Garcia R Zahn R Riek K Wuthrich 2000 NMR structure of the bovine prion protein Proc Natl Acad USA 97 8334 8339
22. E [tmp] McKintosh SJ Tabrizi J Collinge 2003 Prion diseases J Neurovirol 9 183 193
23. T Miura A Hori-i H Mototani H Takeuchi 1999 Raman spectroscopic study on the copper(II) binding mode of prion octapeptide and its pH dependence Biochemistry 38 11560 11569
24. F Owen M Poulter R Lofthouse J Collinge TJ Crow D Risby HF Baker RM Ridley K Hsiao SB Prusiner 1989 Insertion in prion protein gene in familial Creutzfeldt-Jakob disease Lancet I 51 52
25. PC Pauly DA Harris 1998 Copper stimulates endocytosis of the prion protein J Biol Chem 273 33107 33110
26. K Qin Y Yang P Mastrangelo D Westaway 2002 Mapping Cu(II) binding sites in prion proteins by diethyl pyrocarbonate modification and Matrix-Assisted Laser Desorption Ionization-Time of Flight (MALDI-TOF) mass spectrometric footprinting J Biol Chem 277 1981 1990
27. W Rachidi A Mange A Senator P Guiraud J Riondel M Benboubetra A Favier S Lehmann 2003 Prion infection impairs copper binding of cultured cells J Biol Chem 278 14595 14598
28. W Rachidi D Vilette P Guiraud M Arlotto J Riondel H Laude S Lehmann A Favier 2003 Expression of prion protein increases cellular copper binding and antioxydant enzyme activities but not copper delivery J Biol Chem 278 9064 9072
29. R Riek S Hornemann G Wider R Glockshuber K Wüthrich 1997 NMR characterization of the full-length recombinant murine prion protein, mPrP(23-231) FEBS Lett 413 282 288
30. EM Sigurdsson DR Brown MA Alim H Scholtzova R Carp HC Meeker F Prelli B Frangione T Wisniewski 2003 Copper chelation delays the onset of prion disease J Biol Chem 278 46199 46202
31. J Stockel J Safar AC Wallace FE Cohen SB Prusiner 1998 Prion protein selectively binds copper (II) ions Biochemistry 37 7185 7193
32. JH Viles EF Cohen SB Prusiner DB Goodin PE Wright HJ Dyson 1999 Copper binding to the prion protein: structural implications of four identical cooperative binding sites Proc Natl Acad Sci USA 96 2042 2047
33. C Weissmann M Enari PC Klohn D Rossi E Flechsig 2002 Transmission of prions J Infect Dis 186 [Suppl 2] S157 S165
34. RM Whittal HL Ball FE Cohen AL Burlingame SB Prusiner MA Baldwin 2000 Copper binding to octarepeat peptides of the prion protein monitored by mass spectrometry Protein Sci 9 332 343
35. RA Williamson D Peretz N Smorodinsky R Bastidas H Serban I Mehlhorn SJ DeArmond SB Prusiner DR Burton 1996 Circumventing tolerance to generate autologous monoclonal antibodies to the prion protein Proc Natl Acad Sci USA 93 7279 7282
36. R Zahn A Liu T Luhrs R Riek C von Schroetter F Lopez Garcia M Billeter L Calzolai G Wider K Wuthrich 2000 NMR solution structure of the human prion protein Proc Natl Acad Sci USA 94 13452 13457
37. A Zgirski E Frieden 1990 Binding of Cu(II) to non-prosthetic sites in ceruloplasmin and bovine serum albumin J Inorg Biochem 39 137 148