-
1
-
-
43549098268
-
Calcium cycling and signaling in cardiac myocytes
-
DOI 10.1146/annurev.physiol.70.113006.100455
-
Bers DM. Calcium cycling and signaling in cardiac myocytes. Annu Rev Physiol. 2008;70:23-49. (Pubitemid 351738170)
-
(2008)
Annual Review of Physiology
, vol.70
, pp. 23-49
-
-
Bers, D.M.1
-
2
-
-
25144446880
-
Alterations in cAMP-Mediated Signaling and Their Role in the Pathophysiology of Dilated Cardiomyopathy
-
DOI 10.1016/S0070-2153(05)68002-7, PII S0070215305680027
-
Movsesian MA, Bristow MR. Alterations in cAMP-mediated signaling and their role in the pathophysiology of dilated cardiomyopathy. Curr Top Dev Biol. 2005;68:25-48. (Pubitemid 43588862)
-
(2005)
Current Topics in Developmental Biology
, vol.68
, pp. 25-48
-
-
Movsesian, M.A.1
Bristow, M.R.2
-
3
-
-
0242637601
-
What Is the Role of β-Adrenergic Signaling in Heart Failure?
-
DOI 10.1161/01.RES.0000102042.83024.CA
-
Lohse MJ, Engelhardt S, Eschenhagen T. What is the role of beta-adrenergic signaling in heart failure? Circ Res. 2003;93:896-906. (Pubitemid 37433227)
-
(2003)
Circulation Research
, vol.93
, Issue.10
, pp. 896-906
-
-
Lohse, M.J.1
Engelhardt, S.2
Eschenhagen, T.3
-
4
-
-
33749665081
-
Compartmentation of cyclic nucleotide signaling in the heart: The role of cyclic nucleotide phosphodiesterases
-
DOI 10.1161/01.RES.0000246118.98832.04, PII 0000301220061013000007
-
Fischmeister R, Castro LR, Abi-Gerges A, et al. Compartmentalization of cyclic nucleotide signaling in the heart: the role of cyclic nucleotide phosphodiesterases. Circ Res. 2006;99:816-828. (Pubitemid 44556380)
-
(2006)
Circulation Research
, vol.99
, Issue.8
, pp. 816-828
-
-
Fischmeister, R.1
Castro, L.R.V.2
Abi-Gerges, A.3
Rochais, F.4
Jurevicius, J.5
Leroy, J.6
Vandecasteele, G.7
-
5
-
-
75749117558
-
Underpinning compartmentalised cAMP signaling through targeted cAMP breakdown
-
Houslay MD. Underpinning compartmentalised cAMP signaling through targeted cAMP breakdown. Trends Biochem Sci. 2010;35:91-100.
-
(2010)
Trends Biochem Sci.
, vol.35
, pp. 91-100
-
-
Houslay, M.D.1
-
6
-
-
77950473713
-
A-kinase anchoring proteins: Getting to the heart of the matter
-
Scott JD, Santana LF. A-kinase anchoring proteins: getting to the heart of the matter. Circulation. 2010;121:1264-1271.
-
(2010)
Circulation.
, vol.121
, pp. 1264-1271
-
-
Scott, J.D.1
Santana, L.F.2
-
7
-
-
77949538387
-
Epac: Defining a new mechanism for cAMP action
-
Gloerich M, Bos JL. Epac: defining a new mechanism for cAMP action. Annu Rev Pharmacol Toxicol. 2010;50:355-375.
-
(2010)
Annu Rev Pharmacol Toxicol.
, vol.50
, pp. 355-375
-
-
Gloerich, M.1
Bos, J.L.2
-
8
-
-
77149123965
-
Ca2+ cycling and new therapeutic approaches for heart failure
-
Lompre AM, Hajjar RJ, Harding SE, et al. Ca2+ cycling and new therapeutic approaches for heart failure. Circulation. 2010;121:822-830.
-
(2010)
Circulation
, vol.121
, pp. 822-830
-
-
Lompre, A.M.1
Hajjar, R.J.2
Harding, S.E.3
-
9
-
-
0032189129
-
3-adrenoceptor stimulation is mediated by activation of a nitric oxide synthase pathway in human ventricle
-
Gauthier C, Leblais V, Kobzik L, et al. The negative inotropic effect of beta3-adrenoceptor stimulation is mediated by activation of a nitric oxide synthase pathway in human ventricle. J Clin Invest. 1998;102:1377-1384. (Pubitemid 28467566)
-
(1998)
Journal of Clinical Investigation
, vol.102
, Issue.7
, pp. 1377-1384
-
-
Gauthier, C.1
Leblais, V.2
Kobzik, L.3
Trochu, J.-N.4
Khandoudi, N.5
Bril, A.6
Balligand, J.-L.7
Le Marec, H.8
-
10
-
-
51349085441
-
Beta3-adrenergic receptor activation increases human atrial tissue contractility and stimulates the L-type Ca2+ current
-
Skeberdis VA, Gendviliene V, Zablockaite D, et al. beta3-adrenergic receptor activation increases human atrial tissue contractility and stimulates the L-type Ca2+ current. J Clin Invest. 2008;118:3219-3227.
-
(2008)
J Clin Invest.
, vol.118
, pp. 3219-3227
-
-
Skeberdis, V.A.1
Gendviliene, V.2
Zablockaite, D.3
-
11
-
-
0033545724
-
β2-adrenergic cAMP signaling is uncoupled from phosphorylation of cytoplasmic proteins in canine heart
-
Kuschel M, Zhou YY, Spurgeon HA, et al. beta2-adrenergic cAMP signaling is uncoupled from phosphorylation of cytoplasmic proteins in canine heart. Circulation. 1999;99:2458-2465. (Pubitemid 29218244)
-
(1999)
Circulation
, vol.99
, Issue.18
, pp. 2458-2465
-
-
Kuschel, M.1
Zhou, Y.-Y.2
Spurgeon, H.A.3
Bartel, S.4
Karczewski, P.5
Zhang, S.-J.6
Krause, E.-G.7
Lakatta, E.G.8
Xiao, R.-P.9
-
12
-
-
0037332597
-
2+/calmodulin kinase II
-
DOI 10.1172/JCI200316326
-
Zhu WZ, Wang SQ, Chakir K, et al. Linkage of beta1-adrenergic stimulation to apoptotic heart cell death through protein kinase Aindependent activation of Ca2+/calmodulin kinase II. J Clin Invest. 2003;111:617-625. (Pubitemid 36278580)
-
(2003)
Journal of Clinical Investigation
, vol.111
, Issue.5
, pp. 617-625
-
-
Zhu, W.-Z.1
Wang, S.-Q.2
Chakir, K.3
Yang, D.4
Zhang, T.5
Brown, J.H.6
Devic, E.7
Kobilka, B.K.8
Cheng, H.9
Xiao, R.-P.10
-
13
-
-
0033535942
-
1- adrenergic receptor transgenic mice
-
DOI 10.1073/pnas.96.12.7059
-
Engelhardt S, Hein L, Wiesmann F, Lohse MJ. Progressive hypertrophy and heart failure in beta1-adrenergic receptor transgenic mice. Proc Natl Acad Sci USA. 1999;96:7059-7064. (Pubitemid 29275009)
-
(1999)
Proceedings of the National Academy of Sciences of the United States of America
, vol.96
, Issue.12
, pp. 7059-7064
-
-
Engelhardt, S.1
Hein, L.2
Wiesmann, F.3
Lohse, M.J.4
-
14
-
-
0034636061
-
2-adrenergic receptor overexpression in mouse hearts: Critical role for expression level
-
Liggett SB, Tepe NM, Lorenz JN, et al. Early and delayed consequences of beta(2)-adrenergic receptor overexpression in mouse hearts: critical role for expression level. Circulation. 2000;101:1707-1714. (Pubitemid 30196632)
-
(2000)
Circulation
, vol.101
, Issue.14
, pp. 1707-1714
-
-
Liggett, S.B.1
Tepe, N.M.2
Lorenz, J.N.3
Canning, A.M.4
Jantz, T.D.5
Mitarai, S.6
Yatani, A.7
Dorn II, G.W.8
-
15
-
-
0141618295
-
1-AR-mediated positive inotropic effect in myocytes from failing rat hearts
-
DOI 10.1161/01.CIR.0000087595.17277.73
-
Xiao RP, Zhang SJ, Chakir K, et al. Enhanced G(I) signaling selectively negates beta2-adrenergic receptor (AR)-but not beta1- AR-mediated positive inotropic effect in myocytes from failing rat hearts. Circulation. 2003;108:1633-1639. (Pubitemid 37187792)
-
(2003)
Circulation
, vol.108
, Issue.13
, pp. 1633-1639
-
-
Xiao, R.-P.1
Zhang, S.-J.2
Chakir, K.3
Avdonin, P.4
Zhu, W.5
Bond, R.A.6
Balke, C.W.7
Lakatta, E.G.8
Cheng, H.9
-
16
-
-
80052792976
-
Beta(2) AR agonists in treatment of chronic heart failure: Long path to translation
-
In press
-
Talan MI, Ahmet I, Xiao RP, Lakatta EG. beta(2) AR agonists in treatment of chronic heart failure: long path to translation. J Mol Cell Cardiol. 2010, In press
-
(2010)
J Mol Cell Cardiol.
-
-
Talan, M.I.1
Ahmet, I.2
Xiao, R.P.3
Lakatta, E.G.4
-
17
-
-
0034731376
-
Differential targeting of β-adrenergic receptor subtypes and adenylyl cyclase to cardiomyocyte caveolae: A mechanism to functionally regulate the cAMP signaling pathway
-
DOI 10.1074/jbc.M006951200
-
Rybin VO, Xu X, Lisanti MP, Steinberg SF. Differential targeting of beta -adrenergic receptor subtypes and adenylyl cyclase to cardiomyocyte caveolae. A mechanism to functionally regulate the cAMP signaling pathway. J Biol Chem. 2000;275:41447-41457. (Pubitemid 32054981)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.52
, pp. 41447-41457
-
-
Rybin, V.O.1
Xu, X.2
Lisanti, M.P.3
Steinberg, S.F.4
-
18
-
-
0030025596
-
CAMP compartmentalization is responsible for a local activation of cardiac Ca2+ channels by betaadrenergic agonists
-
Jurevicius J, Fischmeister R. cAMP compartmentalization is responsible for a local activation of cardiac Ca2+ channels by betaadrenergic agonists. Proc Natl Acad Sci USA. 1996;93:295-299.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 295-299
-
-
Jurevicius, J.1
Fischmeister, R.2
-
19
-
-
75149159588
-
Fluorescent protein-based biosensors: Resolving spatiotemporal dynamics of signaling
-
DiPilato LM, Zhang J. Fluorescent protein-based biosensors: resolving spatiotemporal dynamics of signaling. Curr Opin Chem Biol. 2010;14:37-42.
-
(2010)
Curr Opin Chem Biol.
, vol.14
, pp. 37-42
-
-
DiPilato, L.M.1
Zhang, J.2
-
20
-
-
33750910207
-
Cyclic AMP imaging in adult cardiac myocytes reveals far-reaching β1-adrenergic but locally confined β2-adrenergic receptor-mediated signaling
-
DOI 10.1161/01.RES.0000250046.69918.d5, PII 0000301220061110000010
-
Nikolaev VO, Bunemann M, Schmitteckert E, et al. Cyclic AMP imaging in adult cardiac myocytes reveals far-reaching beta1- adrenergic but locally confined beta2-adrenergic receptormediated signaling. Circ Res. 2006;99:1084-1091. (Pubitemid 44729932)
-
(2006)
Circulation Research
, vol.99
, Issue.10
, pp. 1084-1091
-
-
Nikolaev, V.O.1
Bunemann, M.2
Schmitteckert, E.3
Lohse, M.J.4
Engelhardt, S.5
-
21
-
-
77950286813
-
Beta2-adrenergic receptor redistribution in heart failure changes cAMP compartmentalization
-
Nikolaev VO, Moshkov A, Lyon AR, et al. Beta2-adrenergic receptor redistribution in heart failure changes cAMP compartmentalization. Science. 2010; 327:1653-1657.
-
(2010)
Science
, Issue.327
, pp. 1653-1657
-
-
Nikolaev, V.O.1
Moshkov, A.2
Lyon, A.R.3
-
22
-
-
69249211018
-
CAMP signal transduction in the heart: Understanding spatial control for the development of novel therapeutic strategies
-
Zaccolo M. cAMP signal transduction in the heart: understanding spatial control for the development of novel therapeutic strategies. Br J Pharmacol. 2009;158:50-60.
-
(2009)
Br J Pharmacol.
, vol.158
, pp. 50-60
-
-
Zaccolo, M.1
-
23
-
-
0036500494
-
Discrete microdomains with high concentration of cAMP in stimulated rat neonatal cardiac myocytes
-
DOI 10.1126/science.1069982
-
Zaccolo M, Pozzan T. Discrete microdomains with high concentration of cAMP in stimulated rat neonatal cardiac myocytes. Science. 2002;295:1711-1715. (Pubitemid 34202906)
-
(2002)
Science
, vol.295
, Issue.5560
, pp. 1711-1715
-
-
Zaccolo, M.1
Pozzan, T.2
-
24
-
-
3142723295
-
Fluorescence resonance energy transfer-based analysis of cAMP dynamics in live neonatal rat cardiac myocytes reveals distinct functions of compartmentalized phosphodiesterases
-
DOI 10.1161/01.RES.0000134629.84732.11
-
Mongillo M, McSorley T, Evellin S, et al. Fluorescence resonance energy transfer-based analysis of cAMP dynamics in live neonatal rat cardiac myocytes reveals distinct functions of compartmentalized phosphodiesterases. Circ Res. 2004;95:67-75. (Pubitemid 38931837)
-
(2004)
Circulation Research
, vol.95
, Issue.1
, pp. 67-75
-
-
Mongillo, M.1
McSorley, T.2
Evellin, S.3
Sood, A.4
Lissandron, V.5
Terrin, A.6
Huston, E.7
Hannawacker, A.8
Lohse, M.J.9
Pozzan, T.10
Houslay, M.D.11
Zaccolo, M.12
-
25
-
-
33646776455
-
A specific pattern of phosphodiesterases controls the cAMP signals generated by different Gs-coupled receptors in adult rat ventricular myocytes
-
Rochais F, Abi-Gerges A, Horner K, et al. A specific pattern of phosphodiesterases controls the cAMP signals generated by different Gs-coupled receptors in adult rat ventricular myocytes. Circ Res. 2006;98:1081-1088.
-
(2006)
Circ Res.
, vol.98
, pp. 1081-1088
-
-
Rochais, F.1
Abi-Gerges, A.2
Horner, K.3
-
26
-
-
38549107922
-
2-adrenergic receptors is defined by differential interactions with PDE4
-
DOI 10.1038/sj.emboj.7601968, PII 7601968
-
Richter W, Day P, Agrawal R, et al. Signaling from beta1- to beta2-adrenergic receptors is defined by differential interactions with PDE4. EMBO J. 2008;27:384-393. (Pubitemid 351161657)
-
(2008)
EMBO Journal
, vol.27
, Issue.2
, pp. 384-393
-
-
Richter, W.1
Day, P.2
Agrawal, R.3
Bruss, M.D.4
Granier, S.5
Wang, Y.L.6
Rasmussen, S.G.F.7
Horner, K.8
Wang, P.9
Lei, T.10
Patterson, A.J.11
Kobilka, B.12
Conti, M.13
-
27
-
-
0037174646
-
2-adrenergic receptors by β-arrestins
-
DOI 10.1126/science.1074683
-
Perry SJ, Baillie GS, Kohout TA, et al. Targeting of cyclic AMP degradation to beta 2-adrenergic receptors by beta-arrestins. Science. 2002;298:834-836. (Pubitemid 35231537)
-
(2002)
Science
, vol.298
, Issue.5594
, pp. 834-836
-
-
Perry, S.J.1
Baillie, G.S.2
Kohout, T.A.3
McPhee, I.4
Magiera, M.M.5
Ang, K.L.6
Miller, W.E.7
McLean, A.J.8
Conti, M.9
Houslay, M.D.10
Lefkowitz, R.J.11
-
28
-
-
0037417890
-
i
-
DOI 10.1073/pnas.262787199
-
Baillie GS, Sood A, McPhee I, et al. beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to Gi. Proc Natl Acad Sci USA. 2003;100:940-945. (Pubitemid 36183934)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.3
, pp. 940-945
-
-
Baillie, G.S.1
Sood, A.2
McPhee, I.3
Gall, I.4
Perry, S.J.5
Lefkowitz, R.J.6
Houslay, M.D.7
-
29
-
-
43449095725
-
2+ channel regulation in adult rat ventricular myocytes: Role of phosphodiesterases
-
DOI 10.1161/CIRCRESAHA.107.167817, PII 0000301220080509000014
-
Leroy J, Abi-Gerges A, Nikolaev VO, et al. Spatiotemporal dynamics of beta-adrenergic cAMP signals and L-type Ca2+ channel regulation in adult rat ventricular myocytes: role of phosphodiesterases. Circ Res. 2008; 102:1091-1100. (Pubitemid 351667863)
-
(2008)
Circulation Research
, vol.102
, Issue.9
, pp. 1091-1100
-
-
Leroy, J.1
Abi-Gerges, A.2
Nikolaev, V.O.3
Richter, W.4
Lechene, P.5
Mazet, J.-L.6
Conti, M.7
Fischmeister, R.8
Vandecasteele, G.9
-
30
-
-
70350133628
-
Decreased expression and activity of cAMP phosphodiesterases in cardiac hypertrophy and its impact on beta-adrenergic cAMP signals
-
Abi-Gerges A, Richter W, Lefebvre F, et al. Decreased expression and activity of cAMP phosphodiesterases in cardiac hypertrophy and its impact on beta-adrenergic cAMP signals. Circ Res. 2009;105:784-792.
-
(2009)
Circ Res.
, vol.105
, pp. 784-792
-
-
Abi-Gerges, A.1
Richter, W.2
Lefebvre, F.3
-
31
-
-
21044453725
-
Functional role of phosphodiesterase 3 in cardiomyocyte apoptosis: Implication in heart failure
-
DOI 10.1161/01.CIR.0000165128.39715.87
-
Ding B, Abe J, Wei H, et al. Functional role of phosphodiesterase 3 in cardiomyocyte apoptosis: implication in heart failure. Circulation. 2005;111:2469-2476. (Pubitemid 40696135)
-
(2005)
Circulation
, vol.111
, Issue.19
, pp. 2469-2476
-
-
Ding, B.1
Abe, J.-I.2
Wei, H.3
Huang, Q.4
Walsh, R.A.5
Molina, C.A.6
Zhao, A.7
Sadoshima, J.8
Blaxall, B.C.9
Berk, B.C.10
Yan, C.11
-
32
-
-
26244467287
-
Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias
-
DOI 10.1016/j.cell.2005.07.030, PII S0092867405007610
-
Lehnart SE, Wehrens XH, Reiken S, et al. Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias. Cell. 2005;123:25-35. (Pubitemid 41414526)
-
(2005)
Cell
, vol.123
, Issue.1
, pp. 25-35
-
-
Lehnart, S.E.1
Wehrens, X.H.T.2
Reiken, S.3
Warrier, S.4
Belevych, A.E.5
Harvey, R.D.6
Richter, W.7
Jin, S.-L.C.8
Conti, M.9
Marks, A.R.10
-
33
-
-
79953696776
-
Disruption of the cyclic AMP phosphodiesterase-4 (PDE4)-HSP20 complex attenuates the betaagonist induced hypertrophic response in cardiac myocytes
-
In press
-
Sin YY, Edwards HV, Li X, et al. Disruption of the cyclic AMP phosphodiesterase-4 (PDE4)-HSP20 complex attenuates the betaagonist induced hypertrophic response in cardiac myocytes. J Mol Cell Cardiol. 2011, In press
-
(2011)
J Mol Cell Cardiol.
-
-
Sin, Y.Y.1
Edwards, H.V.2
Li, X.3
-
34
-
-
0035901502
-
MAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module
-
DOI 10.1093/emboj/20.8.1921
-
Dodge KL, Khouangsathiene S, Kapiloff MS, et al. mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module. EMBO J. 2001;20:1921-1930. (Pubitemid 32397394)
-
(2001)
EMBO Journal
, vol.20
, Issue.8
, pp. 1921-1930
-
-
Dodge, K.L.1
Khouangsathiene, S.2
Kapiloff, M.S.3
Mouton, R.4
Hill, E.V.5
Houslay, M.D.6
Langeberg, L.K.7
Scott, J.D.8
-
35
-
-
33646777831
-
Compartmentalization of cyclic nucleotide signaling in the heart: The role of A-kinase anchoring proteins
-
Dodge-Kafka KL, Langeberg L, Scott JD. Compartmentalization of cyclic nucleotide signaling in the heart: the role of A-kinase anchoring proteins. Circ Res. 2006;98:993-1001.
-
(2006)
Circ Res.
, vol.98
, pp. 993-1001
-
-
Dodge-Kafka, K.L.1
Langeberg, L.2
Scott, J.D.3
-
36
-
-
35748952503
-
2+ re-uptake into heart sarcoplasmic reticulum
-
DOI 10.1038/sj.embor.7401081, PII 7401081
-
Lygren B, Carlson CR, Santamaria K, et al. AKAP complex regulates Ca2+ re-uptake into heart sarcoplasmic reticulum. EMBO Rep. 2007;8:1061-1067. (Pubitemid 350042342)
-
(2007)
EMBO Reports
, vol.8
, Issue.11
, pp. 1061-1067
-
-
Lygren, B.1
Carlson, C.R.2
Santamaria, K.3
Lissandron, V.4
McSorley, T.5
Litzenberg, J.6
Lorenz, D.7
Wiesner, B.8
Rosenthal, W.9
Zaccolo, M.10
Tasken, K.11
Klussmann, E.12
-
37
-
-
59449102704
-
Disruption of protein kinase A interaction with A-kinase-anchoring proteins in the heart in vivo: Effects on cardiac contractility, protein kinaseAphosphorylation, and troponin I proteolysis
-
McConnell BK, Popovic Z, Mal N, et al. Disruption of protein kinase A interaction with A-kinase-anchoring proteins in the heart in vivo: effects on cardiac contractility, protein kinaseAphosphorylation, and troponin I proteolysis. J Biol Chem. 2009;284:1583-1592.
-
(2009)
J Biol Chem.
, vol.284
, pp. 1583-1592
-
-
McConnell, B.K.1
Popovic, Z.2
Mal, N.3
-
38
-
-
0034789448
-
MAKAP and the ryanodine receptor are part of a multi-component signaling complex on the cardiomyocyte nuclear envelope
-
Kapiloff MS, Jackson N, Airhart N. mAKAP and the ryanodine receptor are part of a multi-component signaling complex on the cardiomyocyte nuclear envelope. J Cell Sci. 2001;114:3167-3176. (Pubitemid 32910471)
-
(2001)
Journal of Cell Science
, vol.114
, Issue.17
, pp. 3167-3176
-
-
Kapiloff, M.S.1
Jackson, N.2
Airhart, N.3
-
39
-
-
53949090573
-
AKAP-Lbc mobilizes a cardiac hypertrophy signaling pathway
-
Carnegie GK, Soughayer J, Smith FD, et al. AKAP-Lbc mobilizes a cardiac hypertrophy signaling pathway. Mol Cell. 2008; 32:169-179.
-
(2008)
Mol Cell.
, vol.32
, pp. 169-179
-
-
Carnegie, G.K.1
Soughayer, J.2
Smith, F.D.3
-
40
-
-
79953189372
-
Small molecule AKAP/ PKA interaction disruptors that activate PKA interfere with compartmentalized cAMP signaling in cardiac myocytes
-
In press
-
Christian F, Szaszak M, Friedl S, et al. Small molecule AKAP/ PKA interaction disruptors that activate PKA interfere with compartmentalized cAMP signaling in cardiac myocytes. J Biol Chem. 2011, In press
-
(2011)
J Biol Chem.
-
-
Christian, F.1
Szaszak, M.2
Friedl, S.3
-
41
-
-
85006314494
-
A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK
-
DOI 10.1038/ncb874
-
Enserink JM, Christensen AE, de Rooij J, et al. A novel Epacspecific cAMP analogue demonstrates independent regulation of Rap1 and ERK. Nat Cell Biol. 2002;4:901-906. (Pubitemid 35331366)
-
(2002)
Nature Cell Biology
, vol.4
, Issue.11
, pp. 901-906
-
-
Enserink, J.M.1
Christensen, A.E.2
De Rooij, J.3
Van Triest, M.4
Schwede, F.5
Genieser, H.G.6
Dokeland, S.O.7
Blank, J.L.8
Bos, J.L.9
-
42
-
-
79955789030
-
Rap-linked cAMP signaling Epac proteins: Compartmentalization, functioning and disease implications
-
In press
-
Breckler M, Berthouze M, Laurent AC, et al. Rap-linked cAMP signaling Epac proteins: compartmentalization, functioning and disease implications. Cell Signal. 2011, In press
-
(2011)
Cell Signal.
-
-
Breckler, M.1
Berthouze, M.2
Laurent, A.C.3
-
43
-
-
42549128214
-
Epac mediates β-adrenergic receptor-induced cardiomyocyte hypertrophy
-
DOI 10.1161/CIRCRESAHA.107.164947
-
Metrich M, Lucas A, Gastineau M, et al. Epac mediates betaadrenergic receptor-induced cardiomyocyte hypertrophy. Circ Res. 2008;102:959-965. (Pubitemid 351591548)
-
(2008)
Circulation Research
, vol.102
, Issue.8
, pp. 959-965
-
-
Metrich, M.1
Lucas, A.2
Gastineau, M.3
Samuel, J.-L.4
Heymes, C.5
Morel, E.6
Lezoualc'h, F.7
-
44
-
-
33845800991
-
Capturing cyclic nucleotides in action: Snapshots from crystallographic studies
-
DOI 10.1038/nrm2082, PII NRM2082
-
Rehmann H, Wittinghofer A, Bos JL. Capturing cyclic nucleotides in action: snapshots from crystallographic studies. Nat Rev Mol Cell Biol. 2007;8:63-73. (Pubitemid 46012015)
-
(2007)
Nature Reviews Molecular Cell Biology
, vol.8
, Issue.1
, pp. 63-73
-
-
Rehmann, H.1
Wittinghofer, A.2
Bos, J.L.3
-
45
-
-
77950930736
-
Role of the cAMPbinding protein Epac in cardiovascular physiology and pathophysiology
-
Metrich M, Berthouze M, Morel E, et al. Role of the cAMPbinding protein Epac in cardiovascular physiology and pathophysiology. Pflugers Arch. 2010;459:535-546.
-
(2010)
Pflugers Arch.
, vol.459
, pp. 535-546
-
-
Metrich, M.1
Berthouze, M.2
Morel, E.3
-
46
-
-
33644667603
-
CAMP-binding protein Epac induces cardiomyocyte hypertrophy
-
Morel E, Marcantoni A, Gastineau M, et al. cAMP-binding protein Epac induces cardiomyocyte hypertrophy. Circ Res. 2005;97:1296-1304.
-
(2005)
Circ Res.
, vol.97
, pp. 1296-1304
-
-
Morel, E.1
Marcantoni, A.2
Gastineau, M.3
-
47
-
-
34548385746
-
Developmental changes in gene expression of Epac and its upregulation in myocardial hypertrophy
-
DOI 10.1152/ajpheart.00159.2007
-
Ulucan C, Wang X, Baljinnyam E, et al. Developmental changes in gene expression of Epac and its upregulation in myocardial hypertrophy. Am J Physiol Heart Circ Physiol. 2007;293:H1662-H1672. (Pubitemid 47367213)
-
(2007)
American Journal of Physiology - Heart and Circulatory Physiology
, vol.293
, Issue.3
-
-
Ulucan, C.1
Wang, X.2
Baljinnyam, E.3
Bai, Y.4
Okumura, S.5
Sato, M.6
Minamisawa, S.7
Hirotani, S.8
Ishikawa, Y.9
-
48
-
-
77954532839
-
Epac activation induces histone deacetylase nuclear export via a Ras-dependent signaling pathway
-
Metrich M, Laurent AC, Breckler M, et al. Epac activation induces histone deacetylase nuclear export via a Ras-dependent signaling pathway. Cell Signal. 2010; 22:1459-1468.
-
(2010)
Cell Signal.
, vol.22
, pp. 1459-1468
-
-
Metrich, M.1
Laurent, A.C.2
Breckler, M.3
-
49
-
-
34548322692
-
2+/calmodulin kinase signalling pathway in rat cardiac myocytes
-
DOI 10.1113/jphysiol.2007.133066
-
Pereira L, Metrich M, Fernandez-Velasco M, et al. The cAMP binding protein Epac modulates Ca2+ sparks by a Ca2+/ calmodulin kinase signaling pathway in rat cardiac myocytes. J Physiol. 2007;583:685-694. (Pubitemid 47343498)
-
(2007)
Journal of Physiology
, vol.583
, Issue.2
, pp. 685-694
-
-
Pereira, L.1
Metrich, M.2
Fernandez-velasco, M.3
Lucas, A.4
Leroy, J.5
Perrier, R.6
Morel, E.7
Fischmeister, R.8
Richard, S.9
Benitah, J.-P.10
Lezoualc'h, F.11
Gomez, A.M.12
-
50
-
-
39849104590
-
PDE4 inhibitor, roflumilast protects cardiomyocytes against NO-induced apoptosis via activation of PKA and Epac dual pathways
-
Kwak HJ, Park KM, Choi HE, et al. PDE4 inhibitor, roflumilast protects cardiomyocytes against NO-induced apoptosis via activation of PKA and Epac dual pathways. Cell Signal. 2008;20:803-814.
-
(2008)
Cell Signal.
, vol.20
, pp. 803-814
-
-
Kwak, H.J.1
Park, K.M.2
Choi, H.E.3
-
51
-
-
44049098742
-
The cyclic AMP effector Epac integrates pro- and anti-fibrotic signals
-
DOI 10.1073/pnas.0801490105
-
Yokoyama U, Patel HH, Lai NC, et al. The cyclic AMP effector Epac integrates pro- and anti-fibrotic signals. Proc Natl Acad Sci USA. 2008;105:6386-6391. (Pubitemid 351758355)
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, Issue.17
, pp. 6386-6391
-
-
Yokoyama, U.1
Patel, H.H.2
Lai, N.C.3
Aroonsakool, N.4
Roth, D.M.5
Insel, P.A.6
-
52
-
-
26244462666
-
Enhanced functional gap junction neoformation by protein kinase A-dependent and Epac-dependent signals downstream of cAMP in cardiac myocytes
-
DOI 10.1161/01.RES.0000183880.49270.f9
-
Somekawa S, Fukuhara S, Nakaoka Y, et al. Enhanced functional gap junction neoformation by protein kinase A-dependent and Epac-dependent signals downstream of cAMP in cardiac myocytes. Circ Res. 2005;97:655-662. (Pubitemid 41416334)
-
(2005)
Circulation Research
, vol.97
, Issue.7
, pp. 655-662
-
-
Somekawa, S.1
Fukuhara, S.2
Nakaoka, Y.3
Fujita, H.4
Saito, Y.5
Mochizuki, N.6
-
53
-
-
69549133920
-
The cAMP binding protein Epac regulates cardiac myofilament function
-
Cazorla O, Lucas A, Poirier F, et al. The cAMP binding protein Epac regulates cardiac myofilament function. Proc Natl Acad Sci USA. 2009;106:14144-14149.
-
(2009)
Proc Natl Acad Sci USA.
, vol.106
, pp. 14144-14149
-
-
Cazorla, O.1
Lucas, A.2
Poirier, F.3
-
54
-
-
25644452031
-
The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways
-
DOI 10.1038/nature03966, PII N03966
-
Dodge-Kafka KL, Soughayer J, Pare GC, et al. The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways. Nature. 2005;437:574-578. (Pubitemid 41613557)
-
(2005)
Nature
, vol.437
, Issue.7058
, pp. 574-578
-
-
Dodge-Kafka, K.L.1
Soughayer, J.2
Pare, G.C.3
Carlisle Michel, J.J.4
Langeberg, L.K.5
Kapiloff, M.S.6
Scott, J.D.7
-
55
-
-
78751480860
-
AKAP9 regulation of microtubule dynamics promotes Epac1-induced endothelial barrier properties
-
Sehrawat S, Ernandez T, Cullere X, et al. AKAP9 regulation of microtubule dynamics promotes Epac1-induced endothelial barrier properties. Blood. 2011;117:708-718.
-
(2011)
Blood
, vol.117
, pp. 708-718
-
-
Sehrawat, S.1
Ernandez, T.2
Cullere, X.3
-
56
-
-
78649543303
-
Spatial regulation of cyclic AMP-Epac1 signaling in cell adhesion by ERM proteins
-
Gloerich M, Ponsioen B, Vliem MJ, et al. Spatial regulation of cyclic AMP-Epac1 signaling in cell adhesion by ERM proteins. Mol Cell Biol. 2010;30:5421-5431.
-
(2010)
Mol Cell Biol.
, vol.30
, pp. 5421-5431
-
-
Gloerich, M.1
Ponsioen, B.2
Vliem, M.J.3
|