β2-adrenergic cAMP signaling is uncoupled from phosphorylation of cytoplasmic proteins in canine heart

Circulation

Volumn 99, Issue 18, 1999, Pages 2458-2465

  Kuschel, Meike ^a   Zhou, Ying Ying ^a   Spurgeon, Harold A ^a   Bartel, Sabine ^b   Karczewski, Peter ^b   Zhang, Sheng Jun ^a   Krause, Ernst Georg ^b   Lakatta, Edward G ^a   Xiao, Rui Ping ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

Adrenergic; Beta; Contractility; Phospholamban; Receptors; Relaxation; Troponin I

Indexed keywords

CELL MEMBRANE PROTEIN; PHOSPHOLAMBAN; TROPONIN I; 5 [2 [[2 HYDROXY 3 [4 (1 METHYL 4 TRIFLUOROMETHYL 2 IMIDAZOLYL)PHENOXY]PROPYL]AMINO]ETHOXY]SALICYLAMIDE; ADENOSINE 3',5' PHOSPHOROTHIOATE; ADENOSINE-3',5'-CYCLIC PHOSPHOROTHIOATE; ADRENERGIC RECEPTOR STIMULATING AGENT; BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; CALCIUM BINDING PROTEIN; CARDIOTONIC AGENT; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; DRUG DERIVATIVE; GLYCOGEN PHOSPHORYLASE; GLYCOGEN PHOSPHORYLASE B; IMIDAZOLE DERIVATIVE; ISOQUINOLINE DERIVATIVE; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; NORADRENALIN; NUCLEOTIDE; PHOSPHORYLASE KINASE; RESERPINE; SULFONAMIDE; TROPONIN C;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BETA ADRENERGIC STIMULATION; CHRONOTROPISM; CONTROLLED STUDY; DOG; ENZYME ACTIVATION; EXCITATION CONTRACTION COUPLING; HEART MUSCLE CELL; HEART PERFORMANCE; INOTROPISM; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SARCOLEMMA; ANIMAL; COMPARATIVE STUDY; DRUG EFFECT; HEART; HEART CONTRACTION; HEART MUSCLE; METABOLISM; MICROFILAMENT; MUSCLE RELAXATION; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN PROCESSING; SECOND MESSENGER;

ADRENERGIC AGENTS; ANIMALS; CALCIUM-BINDING PROTEINS; CARDIOTONIC AGENTS; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DOGS; HEART; IMIDAZOLES; ISOQUINOLINES; MICROFILAMENTS; MUSCLE RELAXATION; MYOCARDIAL CONTRACTION; MYOCARDIUM; NOREPINEPHRINE; PHOSPHORYLASE A; PHOSPHORYLASE B; PHOSPHORYLASE KINASE; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECEPTORS, ADRENERGIC, BETA-1; RECEPTORS, ADRENERGIC, BETA-2; RESERPINE; SARCOLEMMA; SECOND MESSENGER SYSTEMS; SULFONAMIDES; THIONUCLEOTIDES; TROPONIN C;

EID: 0033545724     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.99.18.2458     Document Type: Article

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