Mechanistic investigation of the inhibition of Aβ42 assembly and neurotoxicity by Aβ42 C-terminal fragments

Biochemistry

Volumn 49, Issue 30, 2010, Pages 6358-6364

  Li, Huiyuan ^a   Monien, Bernhard H ^a,e   Lomakin, Aleksey ^c   Zemel, Reeve ^a   Fradinger, Erica A ^a,f   Tan, Miao ^a   Spring, Sean M ^a   Urbanc, Brigita ^d   Xie, Cui Wei ^a,b   Benedek, George B ^c   Bitan, Gal ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^d DREXEL UNIVERSITY   (United States)

^e GERMAN INSTITUTE OF HUMAN NUTRITION   (Germany)

^f WHITTIER COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER'S DISEASE; AMYLOID FIBRIL; C-TERMINAL FRAGMENTS; HYDRODYNAMIC RADIUS; NEUROTOXICITY; PHOTO-INDUCED; TOXIC EFFECT;

GLYCOPROTEINS; OLIGOMERS; PROTEINS; STABILIZATION;

TOXICITY;

AMYLOID; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[28-42]; AMYLOID BETA PROTEIN[29-42]; AMYLOID BETA PROTEIN[30-42]; AMYLOID BETA PROTEIN[31-42]; AMYLOID BETA PROTEIN[32-42]; AMYLOID BETA PROTEIN[33-42]; AMYLOID BETA PROTEIN[34-42]; AMYLOID BETA PROTEIN[35-42]; AMYLOID BETA PROTEIN[36-42]; AMYLOID BETA PROTEIN[37-42]; AMYLOID BETA PROTEIN[38-42]; AMYLOID BETA PROTEIN[39-42]; NEUROPEPTIDE; NEUROTOXIN; OLIGOMER; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; COMPETITIVE INHIBITION; CONTROLLED STUDY; HYDRODYNAMICS; LIGHT SCATTERING; NEUROTOXICITY; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN CROSS LINKING; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; RAT;

AMYLOID BETA-PROTEIN; DRUG DESIGN; HUMANS; NEUROTOXICITY SYNDROMES; PEPTIDE FRAGMENTS; PROTEIN MULTIMERIZATION; PROTEIN STABILITY; SOLUBILITY;

EID: 77955032523     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi100773g     Document Type: Article

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