Converting the highly amyloidogenic human calcitonin into a powerful fibril inhibitor by three-dimensional structure homology with a non-amyloidogenic analogue

Journal of Biological Chemistry

Volumn 286, Issue 4, 2011, Pages 2707-2718

  Andreotti, Giuseppina ^a   Vitale, Rosa Maria ^a   Avidan Shpalter, Carmit ^b   Amodeo, Pietro ^a   Gazit, Ehud ^b   Motta, Andrea ^a  

^a CNR Consiglio Nazionale delle Ricerche   (Italy)

^b TEL AVIV UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOIDOGENESIS; AMYLOIDOGENIC PEPTIDES; FIBRIL FORMATION; HUMAN CALCITONIN; HUMAN DISEASE; INTRACELLULAR CAMP; IRREVERSIBLE AGGREGATION; NEW FORMS; NEW STRATEGY; RESISTANT MUTANTS; SALMON CALCITONIN; SOLUTION STRUCTURES; STRUCTURAL HOMOLOGY; THERAPEUTIC ACTIVITY; THREE-DIMENSIONAL STRUCTURE;

BIOCHEMISTRY; FETAL MONITORING;

MIXTURES;

ASPARAGINE; ASPARTIC ACID; CALCITONIN; GLUTAMINE; LEUCINE; LYSINE; PHENYLALANINE; PROTEIN INHIBITOR;

ALPHA HELIX; AMINO ACID SEQUENCE; AMYLOIDOSIS; ARTICLE; BIOTRANSFORMATION; CELLULAR DISTRIBUTION; CIRCULAR DICHROISM; CONTROLLED STUDY; HUMAN; HUMAN CELL; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ENGINEERING; PROTEIN LOCALIZATION; RESIDUE ANALYSIS; STRUCTURAL HOMOLOGY; STRUCTURE ANALYSIS;

AMINO ACID SUBSTITUTION; AMYLOID; ANIMALS; CALCITONIN; CELL LINE, TUMOR; CIRCULAR DICHROISM; HUMANS; MUTATION, MISSENSE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN STRUCTURE, TERTIARY; SALMON; STRUCTURAL HOMOLOGY, PROTEIN;

EID: 78951482692     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.182014     Document Type: Article

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