A novel polymorphism in CDC6 is associated with the decline in lung function of ex-smokers in COPD

Biochemical and Biophysical Research Communications

Volumn 381, Issue 4, 2009, Pages 554-559

  Takabatake, Noriaki ^a,b   Toriyama, Sayumi ^c   Igarashi, Akira ^b   Tokairin, Yoshikane ^b   Takeishi, Yasuchika ^b   Konta, Tsuneo ^b   Inoue, Sumito ^b   Abe, Shuichi ^b   Shibata, Yoko ^b   Kubota, Isao ^b  

^a Tohoku Central Hospital   (Japan)

^b YAMAGATA UNIVERSITY   (Japan)

^c HuBit Genomix Research Institute   (Japan)

Author keywords

Apoptosis; CDC6 gene; Single nucleotide polymorphisms; Smoking cessation; The rapid decliners

Indexed keywords

AMINO ACID; CASPASE 3; CELL CYCLE PROTEIN 6;

APOPTOSIS; ARTICLE; CELL CYCLE PROTEIN 6 GENE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CIGARETTE SMOKING; CLINICAL EVALUATION; FORCED EXPIRATORY VOLUME; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HUMAN; LUNG FUNCTION; LUNG FUNCTION TEST; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROSPECTIVE STUDY; SINGLE NUCLEOTIDE POLYMORPHISM; SMOKING CESSATION;

CELL CYCLE PROTEINS; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HUMANS; LUNG; MALE; NUCLEAR PROTEINS; POLYMORPHISM, SINGLE NUCLEOTIDE; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; SMOKING CESSATION;

SACCHAROMYCES CEREVISIAE;

EID: 62649096255     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.02.080     Document Type: Article

References (27)

1. Murray C.J.L., and Lopez A.D. Evidence-based health policy: lessons from the global burden of disease study. Science 274 (1996) 740-743
2. Pauwels R.A., Buist A.S., Calverley P.M.A., Jenkins C.R., Hurd S.S., and on behalf of the GOLD Scientific Committee. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: NHLBI/WHO global initiative for chronic obstructive lung disease (GOLD) workshop summary. Am. J. Respir. Crit. Care. Med. 163 (2001) 1256-1276
3. 1. The Lung Health Study. JAMA 272 (1994) 1497-1505
4. Siafakas N.M., Vermeire P., Pride N.B., Paoletti P., Gibson J., Howard P., et al. On behalf of the Task Force, optimal assessment and management of chronic obstructive pulmonary disease (COPD). The European Respiratory Society Task Force. Eur. Respir. J. 8 (1995) 1398-1420
5. Pauwels R.A., and Rabe K.F. Burden and clinical features of chronic obstructive pulmonary disease (COPD). Lancet 364 (2004) 613-620
6. Fletcher C., and Peto R. The natural history of chronic airflow obstruction. BMJ 1 (1977) 1645-1648
7. Anthonisen N.R., Skeans M.A., Wise R.A., Manfreda J., Kanner R.E., and Connett J.E. Lung Health Study Research Group, the effects of a smoking cessation intervention on 14.5-year mortality: a randomized clinical trial. Ann. Intern. Med. 142 (2005) 233-239
8. Rutgers S.R., Postma D.S., ten Hacken N.H., Kauffman H.F., van Der Mark T.W., Koeter G.H., et al. Ongoing airway inflammation in patients with COPD who do not currently smoke. Thorax 55 (2000) 12-18
9. Hodge S., Hodge G., Holmes M., and Reynolds P.N. Increased airway epithelial and T-cell apoptosis in COPD remains despite smoking cessation. Eur. Respir. J. 25 (2005) 447-454
10. Ind P.W. COPD disease progression and airway inflammation: uncoupled by smoking cessation. Eur. Respir. J. 26 (2005) 764-766
11. Sandford A.J., Chagani T., Weir T.D., Connett J.E., Anthonisen N.R., and Pare P.D. Susceptibility genes for rapid decline of lung function in the lung health study. Am. J. Respir. Crit. Care. Med. 163 (2001) 469-473
12. Kelly T.J., and rown G.W.B. Regulation of chromosome replication. Annu. Rev. Biochem. 69 (2000) 829-880
13. Bell S.P., and Dutta A. DNA replication in eukaryotic cells. Annu. Rev. Biochem. 71 (2002) 333-374
14. Pelizon C., d'Adda di Fagagna F., Farrace L., and Laskey R.A. Human replication protein CDC6 is selectively cleaved by caspase 3 during apoptosis. EMBO Rep. 3 (2002) 780-784
15. Yim H., Jin Y.H., Park B.D., Choi H.J., and Lee S.K. Caspase-3-mediated cleavage of CDC6 induces nuclear localization of p49-truncated CDC6 and apoptosis. Mol. Biol. Cell. 14 (2003) 4250-4259
16. Yim H., Hwang I.S., Choi J.S., Chun K.H., Jin Y.H., Ham Y.M., et al. Cleavage of CDC6 by caspase-3 promotes ATM/ATR kinase-mediated apoptosis of HeLa cells. J. Cell. Biol. 174 (2006) 77-88
17. Imai K., Mercer B.A., Schulman L.L., Sonett J.R., and D'Armiento J.M. Correlation of lung surface area to apoptosis and proliferation in human emphysema. Eur. Respir. J. 25 (2005) 250-258
18. Yokohori N., Aoshiba K., and Nagai A. Respiratory Failure Research Group in Japan, increased levels of cell death and proliferation in alveolar wall cells in patients with pulmonary emphysema. Chest. 125 (2004) 626-632
19. Kasahara Y., Tuder R.M., Cool C.D., Lynch D.A., Flores S.C., and Voelkel N.F. Endothelial cell death and decreased expression of vascular endothelial growth factor and vascular endothelial growth factor receptor 2 in emphysema. Am. J. Respir. Crit. Care. Med. 163 (2001) 737-744
20. Japanese Society of Chest Disease, Standards of pulmonary function tests for Japanese, Jpn. J. Thorac. Dis. 31 (1993) appendix.
21. Takabatake N., Sata M., Inoue S., Shibata Y., Abe S., Wada T., et al. A novel polymorphism in secretory phospholipase A2-IID is associated with body weight loss in chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care. Med. 172 (2005) 1097-1104
22. Takabatake N., Shibata Y., Abe S., Wada T., Machiya J., Igarashi A., et al. A single nucleotide polymorphism in the CCL1 gene predicts acute exacerbations in chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care. Med. 174 (2006) 875-885
23. Haploview. Available from: (accessed March 1, 2007).
24. Schaid D.J., Rowland C.M., Tines D.E., Jacobson R.M., and Poland G.A. Score tests for association between traits and haplotypes when linkage phase is ambiguous. Am. J. Hum. Genet. 70 (2002) 425-434
25. The R Project for Statistical Computing. Available from: (accessed March 1, 2007).
26. GOLD - the Global Initiative for Chronic Obstructive Lung Disease. Available from: (accessed March 1, 2007).
27. illemse B.W.W., Postma D.S., Timens W., and Ten Hacken N.H. The impact of smoking cessation on respiratory symptoms, lung function, airway hyperresponsiveness and inflammation. Eur. Respir. J. 23 (2004) 464-476