Catechol-O-methyltransferase Val158Met association with parahippocampal physiology during memory encoding in schizophrenia

Psychological Medicine

Volumn 41, Issue 8, 2011, Pages 1721-1731

  Di Giorgio, A ^a,b,c   Caforio, G ^a   Blasi, G ^a   Taurisano, P ^a,b   Fazio, L ^a   Romano, R ^a   Ursini, G ^a,b   Gelao, B ^a   Bianco, L Lo ^a   Papazacharias, A ^a   Sinibaldi, L ^b   Popolizio, T ^b   Bellomo, A ^d   Bertolino, A ^a,b  

^a UNIVERSITY OF BARI   (Italy)

^b CASA SOLLIEVO DELLA SOFFERENZA HOSPITAL   (Italy)

^c UNIVERSITY OF CATANIA   (Italy)

^d UNIVERSITY OF FOGGIA   (Italy)

Author keywords

COMT; fMRI; memory encoding; schizophrenia

Indexed keywords

CATECHOL METHYLTRANSFERASE;

ADULT; ANALYSIS OF VARIANCE; ARTICLE; CASE CONTROL STUDY; CHI SQUARE DISTRIBUTION; ENZYMOLOGY; FEMALE; GENETICS; GENOTYPE; HIPPOCAMPUS; HUMAN; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PARAHIPPOCAMPAL GYRUS; PATHOPHYSIOLOGY; PHYSIOLOGY; RECALL; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM; SOCIOECONOMICS;

ADULT; ANALYSIS OF VARIANCE; CASE-CONTROL STUDIES; CATECHOL O-METHYLTRANSFERASE; CHI-SQUARE DISTRIBUTION; FEMALE; GENOTYPE; HIPPOCAMPUS; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MENTAL RECALL; PARAHIPPOCAMPAL GYRUS; POLYMORPHISM, SINGLE NUCLEOTIDE; SCHIZOPHRENIA; SOCIOECONOMIC FACTORS;

EID: 80055004433     PISSN: 00332917     EISSN: 14698978     Source Type: Journal    
DOI: 10.1017/S0033291710002278     Document Type: Article

References (80)

1. Achim AM, Lepage M (2005). Episodic memory-related activation in schizophrenia: meta-analysis. British Journal of Psychiatry 187, 500-509. (Pubitemid 41752738)
2. Aleman A, Hijman R, de Haan EH, Kahn RS (1999). Memory impairment in schizophrenia: a meta-analysis. American Journal of Psychiatry 156, 1358-1366. (Pubitemid 29416531)
3. Altshuler LL, Casanova MF, Goldberg TE, Kleinman JE (1990). The hippocampus and parahippocampus in schizophrenia, suicide, and control brains. Archives of General Psychiatry 47, 1029-1034. (Pubitemid 20377513)
4. Arnsten AF, Goldman-Rakic PS (1998). Noise stress impairs prefrontal cortical cognitive function in monkeys: evidence for a hyperdopaminergic mechanism. Archives of General Psychiatry 55, 362-368. (Pubitemid 28173626)
5. Bertolino A, Blasi G (2009). The genetics of schizophrenia. Neuroscience 164, 288-299.
6. Bertolino A, Caforio G, Blasi G, De Candia M, Latorre V, Petruzzella V, Altamura M, Nappi G, Papa S, Callicott JH, Mattay VS, Bellomo A, Scarabino T, Weinberger DR, Nardini M (2004). Interaction of COMT Val108/158 Met genotype and olanzapine treatment on prefrontal cortical function in patients with schizophrenia. American Journal of Psychiatry 161, 1798-1805. (Pubitemid 39314673)
7. Bertolino A, Caforio G, Petruzzella V, Latorre V, Rubino V, Dimalta S, Torraco A, Blasi G, Quartesan R, Mattay VS, Callicott JH, Weinberger DR, Scarabino T (2006a). Prefrontal dysfunction in schizophrenia controlling for COMT Val(158)Met genotype and working memory performance. Psychiatry Research 147, 221-226. (Pubitemid 44397473)
8. Bertolino A, Callicott JH, Elman I, Mattay VS, Tedeschi G, Frank JA, Breier A, Weinberger DR (1998). Regionally specific neuronal pathology in untreated patients with schizophrenia: a proton magnetic resonance spectroscopic imaging study. Biological Psychiatry 43, 641-648. (Pubitemid 28222384)
9. Bertolino A, Di Giorgio A, Blasi G, Sambataro F, Caforio G, Sinibaldi L, Latorre V, Rampino A, Taurisano P, Fazio L, Romano R, Douzgou S, Popolizio T, Kolachana B, Nardini M, Weinberger DR, Dallapiccola B (2008). Epistasis between dopamine regulating genes identifies a nonlinear response of the human hippocampus during memory tasks. Biological Psychiatry 64, 226-234.
10. Bertolino A, Fazio L, Di Giorgio A, Blasi G, Romano R, Taurisano P, Caforio G, Sinibaldi L, Ursini G, Popolizio T, Tirotta E, Papp A, Dallapiccola B, Borrelli E, Sadee W (2009). Genetically determined interaction between the dopamine transporter and the D2 receptor on prefronto-striatal activity and volume in humans. Journal of Neuroscience 29, 1224-1234.
11. Bertolino A, Nawroz S, Mattay VS, Barnett AS, Duyn JH, Moonen CT, Frank JA, Tedeschi G, Weinberger DR (1996). Regionally specific pattern of neurochemical pathology in schizophrenia as assessed by multislice proton magnetic resonance spectroscopic imaging. American Journal of Psychiatry 153, 1554-1563. (Pubitemid 26406165)
12. Bertolino A, Rubino V, Sambataro F, Blasi G, Latorre V, Fazio L, Caforio G, Petruzzella V, Kolachana B, Hariri A, Meyer-Lindenberg A, Nardini M, Weinberger DR, Scarabino T (2006b). Prefrontal-hippocampal coupling during memory processing is modulated by COMT Val158Met genotype. Biological Psychiatry 60, 1250-1258. (Pubitemid 44693539)
13. Boyer P, Phillips JL, Rousseau FL, Ilivitsky S (2007). Hippocampal abnormalities and memory deficits: new evidence of a strong pathophysiological link in schizophrenia. Brain Research Reviews 54, 92-112. (Pubitemid 46509660)
14. Callicott JH, Straub RE, Pezawas L, Egan MF, Mattay VS, Hariri AR, Verchinski BA, Meyer-Lindenberg A, Balkissoon R, Kolachana B, Goldberg TE, Weinberger DR (2005). Variation in DISC1 affects hippocampal structure and function and increases risk for schizophrenia. Proceedings of the National Academy of Sciences USA 102, 8627-8632. (Pubitemid 40862786)
15. Cannon TD, Zorrilla LE, Shtasel D, Gur RE, Gur RC, Marco EJ, Moberg P, Price RA (1994). Neuropsychological functioning in siblings discordant for schizophrenia and healthy volunteers. Archives of General Psychiatry 51, 651-661. (Pubitemid 24249107)
16. Carlsson A (1988). The current status of the dopamine hypothesis of schizophrenia. Neuropsychopharmacology 1, 179-186. (Pubitemid 19126130)
17. Carlsson A (2006). The neurochemical circuitry of schizophrenia. Pharmacopsychiatry 39 (Suppl. 1), S10-S14. (Pubitemid 43357100)
18. Chen J, Lipska BK, Halim N, Ma QD, Matsumoto M, Melhem S, Kolachana BS, Hyde TM, Herman MM, Apud J, Egan MF, Kleinman JE, Weinberger DR (2004). Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain. American Journal of Human Genetics 75, 807-821. (Pubitemid 39390488)
19. Danion JM, Huron C, Vidailhet P, Berna F (2007). Functional mechanisms of episodic memory impairment in schizophrenia. Canadian Journal of Psychiatry 52, 693-701. (Pubitemid 350085582)
20. Deicken RF, Pegues M, Amend D (1999). Reduced hippocampal N-acetylaspartate without volume loss in schizophrenia. Schizophrenia Research 37, 217-223. (Pubitemid 29298091)
21. Di Giorgio A, Blasi G, Sambataro F, Rampino A, Papazacharias A, Gambi F, Romano R, Caforio G, Rizzo M, Latorre V, Popolizio T, Kolachana B, Callicott JH, Nardini M, Weinberger DR, Bertolino A (2008). Association of the SerCys DISC1 polymorphism with human hippocampal formation gray matter and function during memory encoding. European Journal of Neuroscience 28, 2129-2136.
22. Di Giorgio A, Sambataro F, Bertolino A (2009). Functional imaging as a tool to investigate the relationship between genetic variation and response to treatment with antipsychotics. Current Pharmaceutical Design 15, 2560-2572.
23. Drabant EM, Hariri AR, Meyer-Lindenberg A, Munoz KE, Mattay VS, Kolachana BS, Egan MF, Weinberger DR (2006). Catechol O-methyltransferase val158met genotype and neural mechanisms related to affective arousal and regulation. Archives of General Psychiatry 63, 1396-1406. (Pubitemid 44878523)
24. Egan MF, Goldberg TE, Kolachana BS, Callicott JH, Mazzanti CM, Straub RE, Goldman D, Weinberger DR (2001). Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proceedings of the National Academy of Sciences USA 98, 6917-6922. (Pubitemid 32538317)
25. Eisenberg DP, Sarpal D, Kohn PD, Meyer-Lindenberg A, Wint D, Kolachana B, Apud J, Weinberger DR, Berman KF (2009). Catechol-O-methyltransferase valine(158)methionine genotype and resting regional cerebral blood flow in medication-free patients with schizophrenia. Biological Psychiatry 67, 287-290.
26. Fan JB, Zhang CS, Gu NF, Li XW, Sun WW, Wang HY, Feng GY, St Clair D, He L (2005). Catechol-O-methyltransferase gene Val/Met functional polymorphism and risk of schizophrenia: a large-scale association study plus meta-analysis. Biological Psychiatry 57, 139-144. (Pubitemid 40103578)
27. Friston K (2003). Experimental design and statistical parametric mapping. In Human Brain Function (ed. R. Frackowiak, K. Friston, C. Frith, R. Dolan, K. Friston, C. Price, S. Zeki, J. Ashburner and W. Penny), chapter 1, pp. 1-67. Academic Press: London.
28. Glahn DC, Almasy L, Blangero J, Burk GM, Estrada J, Peralta JM, Meyenberg N, Castro MP, Barrett J, Nicolini H, Raventos H, Escamilla MA (2007). Adjudicating neurocognitive endophenotypes for schizophrenia. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics 144B, 242-249. (Pubitemid 46606651)
29. Glatt SJ, Faraone SV, Tsuang MT (2003). Association between a functional catechol O-methyltransferase gene polymorphism and schizophrenia: meta-analysis of case-control and family-based studies. American Journal of Psychiatry 160, 469-476. (Pubitemid 41094254)
30. Gold JM (2004). Cognitive deficits as treatment targets in schizophrenia. Schizophrenia Research 72, 21-28. (Pubitemid 39452902)
31. Goldberg TE, Egan MF, Gscheidle T, Coppola R, Weickert T, Kolachana BS, Goldman D, Weinberger DR (2003). Executive subprocesses in working memory : relationship to catechol-O-methyltransferase Val158Met genotype and schizophrenia. Archives of General Psychiatry 60, 889-896. (Pubitemid 37122307)
32. Goldberg TE, Goldman RS, Burdick KE, Malhotra AK, Lencz T, Patel RC, Woerner MG, Schooler NR, Kane JM, Robinson DG (2007). Cognitive improvement after treatment with second-generation antipsychotic medications in first-episode schizophrenia: is it a practice effect? Archives of General Psychiatry 64, 1115-1122. (Pubitemid 47529336)
33. Hariri AR, Goldberg TE, Mattay VS, Kolachana BS, Callicott JH, Egan MF, Weinberger DR (2003). Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance. Journal of Neuroscience 23, 6690-6694. (Pubitemid 36951196)
34. Harrison P, Lewis D (2003). Neuropathology of schizophrenia. In Schizophrenia (ed. S. Hirsch and D. Weinberger), pp. 310-325. Blackwell Science Ltd: Oxford.
35. Honea R, Crow TJ, Passingham D, Mackay CE (2005). Regional deficits in brain volume in schizophrenia : a meta-analysis of voxel-based morphometry studies. American Journal of Psychiatry 162, 2233-2245. (Pubitemid 41740200)
36. Karoum F, Chrapusta SJ, Egan MF (1994). 3-Methoxytyramine is the major metabolite of released dopamine in the rat frontal cortex: reassessment of the effects of antipsychotics on the dynamics of dopamine release and metabolism in the frontal cortex, nucleus accumbens, and striatum by a simple two pool model. Journal of Neurochemistry 63, 972-979.
37. Kay SR, Fiszbein A, Opler LA (1987). The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophrenia Bulletin 13, 261-276. (Pubitemid 18039085)
38. Krach S, Jansen A, Krug A, Markov V, Thimm M, Sheldrick AJ, Eggermann T, Zerres K, Stocker T, Shah NJ, Kircher T (2010). COMT genotype and its role on hippocampal-prefrontal regions in declarative memory. NeuroImage 53, 978-984.
39. Lachman HM, Morrow B, Shprintzen R, Veit S, Parsia SS, Faedda G, Goldberg R, Kucherlapati R, Papolos DF (1996). Association of codon 108/158 catechol-O-methyltransferase gene polymorphism with the psychiatric manifestations of velo-cardio-facial syndrome. American Journal of Medical Genetics 67, 468-472.
40. Lang PJ, Bradley MM, Cuthbert BN (1997). International Affective Picture System (IAPS): technical manual and affective ratings. NIMH Center for the Study of Emotion and Attention, University of Florida: Gainesville, FL.
41. Leavitt VM, Goldberg TE (2009). Episodic memory in schizophrenia. Neuropsychology Review 19, 312-323.
42. Lefebvre AA, Cellard C, Tremblay S, Achim A, Rouleau N, Maziade M, Roy MA (2009). Familiarity and recollection processes in patients with recent-onset schizophrenia and their unaffected parents. Psychiatry Research 175, 15-21.
43. Lepage M, Sergerie K, Pelletier M, Harvey PO (2007). Episodic memory bias and the symptoms of schizophrenia. Canadian Journal of Psychiatry 52, 702-709. (Pubitemid 350085583)
44. Lidow MS, Koh PO, Arnsten AF (2003). D1 dopamine receptors in the mouse prefrontal cortex: immunocytochemical and cognitive neuropharmacological analyses. Synapse 47, 101-108. (Pubitemid 36020281)
45. Lipska BK, Weinberger DR (2000). To model a psychiatric disorder in animals: schizophrenia as a reality test. Neuropsychopharmacology 23, 223-229.
46. Lisman JE, Grace AA (2005). The hippocampal-VTA loop: controlling the entry of information into long-term memory. Neuron 46, 703-713. (Pubitemid 40733126)
47. Livak K (1999). Allelic discrimination using fluorogenic probes and the 5knuclease assay. Genetic Analysis 14, 143-149. (Pubitemid 29095371)
48. Maier M, Ron MA, Barker GJ, Tofts PS (1995). Proton magnetic resonance spectroscopy: an in vivo method of estimating hippocampal neuronal depletion in schizophrenia. Psychological Medicine 25, 1201-1209.
49. Matsumoto M, Weickert CS, Akil M, Lipska BK, Hyde TM, Herman MM, Kleinman JE, Weinberger DR (2003). Catechol O-methyltransferase mRNA expression in human and rat brain: evidence for a role in cortical neuronal function. Neuroscience 116, 127-137. (Pubitemid 36110440)
50. Maxwell M (1992). Family Interview for Genetic Studies (FIGS): Manual for FIGS. Clinical Neurogenetics Branch, Intramural Research Program, National Institute of Mental Health: Bethesda, MD.
51. Meyer-Lindenberg A, Nichols T, Callicott JH, Ding J, Kolachana B, Buckholtz J, Mattay VS, Egan M, Weinberger DR (2006). Impact of complex genetic variation in COMT on human brain function. Molecular Psychiatry 11, 867-877. (Pubitemid 44299108)
52. Meyer-Lindenberg A, Poline JB, Kohn PD, Holt JL, Egan MF, Weinberger DR, Berman KF (2001). Evidence for abnormal cortical functional connectivity during working memory in schizophrenia. American Journal of Psychiatry 158, 1809-1817. (Pubitemid 33054773)
53. Meyer-Lindenberg AS, Olsen RK, Kohn PD, Brown T, Egan MF, Weinberger DR, Berman KF (2005). Regionally specific disturbance of dorsolateral prefrontal-hippocampal functional connectivity in schizophrenia. Archives of General Psychiatry 62, 379-386. (Pubitemid 40471687)
54. Mier D, Kirsch P, Meyer-Lindenberg A (2009). Neural substrates of pleiotropic action of genetic variation in COMT: a meta-analysis. Molecular Psychiatry 15, 918-927.
55. Nelson MD, Saykin AJ, Flashman LA, Riordan HJ (1998). Hippocampal volume reduction in schizophrenia as assessed by magnetic resonance imaging: a meta-analytic study. Archives of General Psychiatry 55, 433-440. (Pubitemid 28237277)
56. Nicodemus KK, Kolachana BS, Vakkalanka R, Straub RE, Giegling I, Egan MF, Rujescu D, Weinberger DR (2007). Evidence for statistical epistasis between catechol-O-methyltransferase (COMT) and polymorphisms in RGS4, G72 (DAOA), GRM3, and DISC1: influence on risk of schizophrenia. Human Genetics 120, 889-906. (Pubitemid 46128844)
57. Owen MJ, Williams NM, O'Donovan MC (2004). The molecular genetics of schizophrenia: new findings promise new insights. Molecular Psychiatry 9, 14-27. (Pubitemid 38175078)
58. Papaleo F, Crawley JN, Song J, Lipska BK, Pickel J, Weinberger DR, Chen J (2008). Genetic dissection of the role of catechol-O-methyltransferase in cognition and stress reactivity in mice. Journal of Neuroscience 28, 8709-8723.
59. Penny W, Holmes A, Friston K (2003). Random effects analysis. In Human Brain Function (ed. R. Frackowiak, K. Friston, C. Frith, R. Dolan, K. Friston, C. Price, S. Zeki, J. Ashburner and W. Penny), chapter 12, pp. 843-850. Academic Press: London.
60. Prata DP, Mechelli A, Fu CH, Picchioni M, Kane F, Kalidindi S, McDonald C, Howes O, Kravariti E, Demjaha A, Toulopoulou T, Diforti M, Murray RM, Collier DA, McGuire PK (2009a). Opposite effects of catechol-O-methyltransferase Val158Met on cortical function in healthy subjects and patients with schizophrenia. Biological Psychiatry 65, 473-480.
61. Prata DP, Mechelli A, Fu CH, Picchioni M, Toulopoulou T, Bramon E, Walshe M, Murray RM, Collier DA, McGuire P (2009b). Epistasis between the DAT 3k UTR VNTR and the COMT Val158Met SNP on cortical function in healthy subjects and patients with schizophrenia. Proceedings of the National Academy of Sciences USA 106, 13600-13605.
62. Ragland JD, Gur RC, Valdez J, Turetsky BI, Elliott M, Kohler C, Siegel S, Kanes S, Gur RE (2004). Event-related fMRI of frontotemporal activity during word encoding and recognition in schizophrenia. American Journal of Psychiatry 161, 1004-1015. (Pubitemid 38735986)
63. Ranganath C, Minzenberg MJ, Ragland JD (2008). The cognitive neuroscience of memory function and dysfunction in schizophrenia. Biological Psychiatry 64, 18-25.
64. Schacter DL, Wagner AD (1999). Medial temporal lobe activations in fMRI and PET studies of episodic encoding and retrieval. Hippocampus 9, 7-24. (Pubitemid 29129356)
65. Schott BH, Seidenbecher CI, Fenker DB, Lauer CJ, Bunzeck N, Bernstein HG, Tischmeyer W, Gundelfinger ED, Heinze HJ, Duzel E (2006). The dopaminergic midbrain participates in human episodic memory formation: evidence from genetic imaging. Journal of Neuroscience 26, 1407-1417. (Pubitemid 43237011)
66. Shifman S, Bronstein M, Sternfeld M, Pisante-Shalom A, Lev-Lehman E, Weizman A, Reznik I, Spivak B, Grisaru N, Karp L, Schiffer R, Kotler M, Strous RD, Swartz-Vanetik M, Knobler HY, Shinar E, Beckmann JS, Yakir B, Risch N, Zak NB, Darvasi A (2002). A highly significant association between a COMT haplotype and schizophrenia. American Journal of Human Genetics 71, 1296-1302. (Pubitemid 36015884)
67. Smolka MN, Schumann G, Wrase J, Grusser SM, Flor H, Mann K, Braus DF, Goldman D, Buchel C, Heinz A (2005). Catechol-O-methyltransferase val158met genotype affects processing of emotional stimuli in the amygdala and prefrontal cortex. Journal of Neuroscience 25, 836-842. (Pubitemid 40170998)
68. Squire LR, Stark CE, Clark RE (2004). The medial temporal lobe. Annual Review of Neuroscience 27, 279-306. (Pubitemid 39050405)
69. Squire LR, Wixted JT, Clark RE (2007). Recognition memory and the medial temporal lobe: a new perspective. Nature Reviews Neuroscience 8, 872-883. (Pubitemid 350006215)
70. Thermenos HW, Seidman LJ, Poldrack RA, Peace NK, Koch JK, Faraone SV, Tsuang MT (2007). Elaborative verbal encoding and altered anterior parahippocampal activation in adolescents and young adults at genetic risk for schizophrenia using FMRI. Biological Psychiatry 61, 564-574. (Pubitemid 46185344)
71. Tulving E (1983). Elements of Episodic Memory. Oxford University Press: New York.
72. Van Strien NM, Cappaert NL, Witter MP (2009). The anatomy of memory: an interactive overview of the parahippocampal-hippocampal network. Nature Reviews Neuroscience 10, 272-282.
73. Velakoulis D, Pantelis C, McGorry PD, Dudgeon P, Brewer W, Cook M, Desmond P, Bridle N, Tierney P, Murrie V, Singh B, Copolov D (1999). Hippocampal volume in first-episode psychoses and chronic schizophrenia: a high-resolution magnetic resonance imaging study. Archives of General Psychiatry 56, 133-141.
74. Vijayraghavan S, Wang M, Birnbaum SG, Williams GV, Arnsten AF (2007). Inverted-U dopamine D1 receptor actions on prefrontal neurons engaged in working memory. Nature Neuroscience 10, 376-384.
75. Weinberger DR (1987). Implications of normal brain development for the pathogenesis of schizophrenia. Archives of General Psychiatry 44, 660-669. (Pubitemid 17099795)
76. Weinberger DR (1999). Cell biology of the hippocampal formation in schizophrenia. Biological Psychiatry 45, 395-402. (Pubitemid 29130435)
77. Witthaus H, Kaufmann C, Bohner G, Ozgurdal S, Gudlowski Y, Gallinat J, Ruhrmann S, Brune M, Heinz A, Klingebiel R, Juckel G (2009). Gray matter abnormalities in subjects at ultra-high risk for schizophrenia and first-episode schizophrenic patients compared to healthy controls. Psychiatry Research 173, 163-169.
78. Wright IC, Rabe-Hesketh S, Woodruff PW, David AS, Murray RM, Bullmore ET (2000). Meta-analysis of regional brain volumes in schizophrenia. American Journal of Psychiatry 157, 16-25. (Pubitemid 30027416)
79. Yacubian J, Sommer T, Schroeder K, Glascher J, Kalisch R, Leuenberger B, Braus DF, Buchel C (2007). Gene-gene interaction associated with neural reward sensitivity. Proceedings of the National Academy of Sciences USA 104, 8125-8130. (Pubitemid 47185886)
80. Zahrt J, Taylor JR, Mathew RG, Arnsten AF (1997). Supranormal stimulation of D1 dopamine receptors in the rodent prefrontal cortex impairs spatial working memory performance. Journal of Neuroscience 17, 8528-8535. (Pubitemid 27461074)