Cell biology of the hippocampal formation in schizophrenia

Biological Psychiatry

Volumn 45, Issue 4, 1999, Pages 395-402

  Weinberger, Daniel R ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

Gene expression; Hippocampus; Proteins; Schizophrenia

Indexed keywords

6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; ALPHA BUNGAROTOXIN; CHOLECYSTOKININ; FLUNITRAZEPAM; FORSKOLIN; GLUTAMATE RECEPTOR; KAINIC ACID; MESSENGER RNA; MUSCIMOL; NEUROMODULIN; NEUROTENSIN RECEPTOR; NICOTINIC RECEPTOR; NIPECOTIC ACID; PAROXETINE; PROTIRELIN RECEPTOR; SYNAPTOPHYSIN; TRITIUM;

GENE EXPRESSION; HIPPOCAMPUS; HUMAN; LIGAND BINDING; MENTAL DISEASE; NEUROPATHOLOGY; PHENOTYPE; PRIORITY JOURNAL; PSYCHOSIS; REVIEW; SCHIZOPHRENIA;

EID: 0033557735     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3223(98)00331-X     Document Type: Review

References (49)

1. Adams C.E., DeMasters B.K., Freedman R. Regional zinc staining in postmortem hippocampus from schizophrenic patients. Schizophr Res. 18:1995;71-77.
2. Adler L.E., Olincy A., Waldo M., Harris J.G., Griffith J., Stevens K., Flach K., Nagamoto H., Bickford P., Leonard S., Freedman R. Schizophrenia, sensory gating, and nicotinic receptors. Schizophr Bull. 24:1998;189-202.
3. Akil M., Lewis D.A. Cytoarchitecture of the entorhinal cortex in schizophrenia. Am J Psychiatry. 154:1997;1010-1012.
4. Arnold S.E., Franz B.R., Gur R.C., Gur R.E., Shapiro R.M., Moberg P.J., Trojanowski J.Q. Smaller neuron size in schizophrenia in hippocampal subfields that mediate cortical-hippocampal interactions. Am J Psychiatry. 152:1995;738-748.
5. Arnold S.E., Hyman B.T., Van Hoesen G.W., Damasio A.R. Some cytoarchitectural abnormalities of the entorhinal cortex in schizophrenia. Arch Gen Psychiatry. 48:1991;625-632.
6. Arnold S.E., Ruscheinsky D.D., Han L.-Y. Further evidence of abnormal cytoarchitecture of the entorhinal cortex in schizophrenia using spatial point pattern analyses. Biol Psychiatry. 42:1997;639-647.
7. Bartanusz V., Aubry J.M., Pagluisi S., Jezova D., Baffi J., Kiss J.Z. Stress-induced changes in messenger RNA levels of N-methyl-D-aspartate and AMPA receptor subunits in selected regions of the rat hippocampus and hypothalamus. Neuroscience. 66:1995;247-252.
8. Benes F.M., Sorensen I., Bird E.D. Reduced neuronal size in posterior hippocampus of schizophrenic patients. Schizophr Bull. 17:1991;597-608.
9. Bertolino A., Kumra S., Callicott J.H., Mattay V.S., Lestz R.M., Jacobsen L., Barnett A.S., Duyn J.H., Frank J.A., Rapoport J.L., Weinberger D.R. A common pattern of cortical pathology in childhood onset and adult onset schizophrenia as identified by proton magnetic resonance spectroscopic imaging. Am J Psychiatry. 1998;1376-1383.
10. Bogerts B., Hantsch J., Herzer M. A morphometric study of the dopamine-containing cell groups in the mesencephalon on normals, Parkinson patients, and schizophrenics. Biol Psychiatry. 18:1983;951-969.
11. Breese C.R., Freedman R., Leonard S.S. Glutamate receptor subtype expression in human postmortem brain tissue from schizophrenics and alcohol abusers. Brain Res. 674:1995;82-90.
12. Bruton C.J., Crow T.J., Frith C.D., Johnstone E.C., Owens D.G., Roberts G.W. Schizophrenia and the brain A prospective clinico-pathological study . Psychol Med. 28:1990;127-143.
13. Callicott J.H., Egan M.F., Bertolino A., Mattay V.S., Langheim F.J.P., Duyn J.H., Frank J.A., Weinberger D.R. Hippocampal n-acetyl aspartate in unaffected siblings of patients with schizophrenia A possible intermediate neurobiological phenotype . Biol Psychiatry. 1998;941-950.
14. DeLisi L.E., Sakuma M., Tew W., Kushner M., Hoff A.L., Grimson R. Schizophrenia as a chronic active brain process A study of progressive brain structural change subsequent to the onset of schizophrenia . Psychiatry Res Neuroimaging. 74:1997;129-140.
15. Dwork A.J. Postmortem studies of the hippocampal formation in schizophrenia. Schizophr Bull. 23:1997;385-402.
16. Frotscher M., Soriano E., Misgeld U. Divergence of hippocampal mossy fibers. Synapse. 16:1994;148-160.
17. Goldsmith S.K., Joyce J.N. Alterations in hippocampal mossy fiber pathway in schizophrenia and Alzheimer's disease. Biol Psychiatry. 37:1995;122-126.
18. Heinsen H., Gössmann E., Rüb U., Eisenmenger W., Bauer M., Ulmar G., Berthke B., Schüler M., Schmitt H.-P., Götz M., Lockermann U., Püschel K. Variability in the human entorhinal region may confound neuropsychiatric diagnoses. Acta Anatomica. 157:1996;226-237.
19. Ikonomovic M.D., Sheffield R., Armstrong D.M. AMPA-selective glutamate receptor subtype immunoreactivity in the hippocampal formation of patients with Alzheimer's disease. Hippocampus. 5:1995;469-486.
20. Jakob H., Beckmann H. Prenatal developmental disturbances in the limbic allocortex in schizophrenics. J Neural Transm. 65:1986;303-326.
21. Kleinman J.E., Hyde T.M., Herman M.M. Methodological issues in the neuropathology of mental Illness. Bloom F.E., Kupfer D.J. Psychopharmacology The Fourth Generation of Progress . 1995;859-864 Raven Press, New York.
22. Kovelman J.A., Scheibel A.B. A neurohistological correlate of schizophrenia. Biol Psychiatry. 19:1984;1601-1621.
23. Krimer L.S., Herman M.M., Saunders R.C., Boyd J.C., Hyde T.M., Carter J.M., Kleinman J.E., Weinberger D.R. A qualitative and quantitative analysis of the entorhinal cortex in schizophrenia. Cerebr Cortex. 7:1997;732-739.
24. Lewis D.A. Development of the prefrontal cortex during adolescence Insights into vulnerable neural circuits in schizophrenia . Neuropsychopharmacology. 16:1997;385-398.
25. Lipska B.K., Al-Amin H.A., Weinberger D.R. Excitotoxic lesions of the rat medial prefrontal cortex Effects on abnormal behaviors associated with neonatal hippocampal damage . Neuropsychopharmacology. 1998;451-464.
26. MacLean P.D. The Triune Brain in Evolution Role in Paleocerebral Functions . 1990;Plenum Press, New York.
27. Magarinos A.M., McEwen B.S. Stress induced atrophy of apical dendrites of hippocampal CA3c neurons Involvement of glucocorticoid secretion and excitatory amino acid receptors . Neuroscience. 69:1995;89-98.
28. Marin-Padilla M. Developmental neuropathology and impact of perinatal brain damage. II White matter lesions of the neocortex . J Neuropathol Exp Neurol. 56:1997;219-235.
29. Mathern G.W., Pretorius J.K., Kornblum H.I., Mendoza D., Lozada A., Leite J.P., Chimelli L.M., Fried I., Sakamoto A.C., Assirati J.A., Levesque M.F., Adelson P.D., Peacock W.J. Human hippocampal AMPA and NMDA mRNA levels in temporal lobe epilepsy patients. Brain. 120:1997;1937-1959.
30. McCoy L., Cox C., Richfield E.K. Antipsychotic drug regulation of AMPA receptor affinity states and GluR1, GluR2 splice variant expression. Synapse. 28:1998;195-207.
31. McEwen B.S., Magarinos A.M. Stress effects on morphology and function of the hippocampus. Ann NY Acad Sci. 821:1997;271-284.
32. Michaelis E.K. Molecular biology of glutamate receptors in the central nervous system and their role in excitotoxicity, oxidative stress, and aging. Prog Neurobiol. 54:1998;369-415.
33. Morrison J.H., Hoff P.R. Life and death of neurons in the aging brain. Science. 278:1997;412-418.
34. Nelson M.D., Saykin A.J., Flashman L.A., Riordan J.H. Hippocampal volume reduction in schizophrenia as assessed by magnetic resonance imaging A meta-analytic study . Arch Gen Psychiatry. 55:1998;433-440.
35. Selemon L.D., Rajkowska G., Goldman-Rakic P.S. Elevated neuronal density in prefrontal area 46 in brains from schizophrenic patients Application of a three-dimensional, stereologic counting method . J Comp Neurol. 392:1998;402-412.
36. Rolls E.T. A theory of hippocampal function in memory. Hippocampus. 6:1996;601-620.
37. Schwarzer C., Sperk G., Samanin R., Rizzi M., Gariboldi M., Vezzani A. Neuropeptides-immunoreactivity and their mRNA expression in kindling Functional implications for limbic epileptogenesis . Brain Res Rev. 22:1996;27-50.
38. Saunders R.C., Kolachana B.S., Bachevalier J., Weinberger D.R. Neonatal lesions of the medial temporal lobe disrupt prefrontal cortical regulation of striatal dopamine. Nature. 393:1998;169-171.
39. Suddath R.L., Christison G.W., Torrey E.F., Casanova M.F., Weinberger D.R. Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia. NEJM. 322:1990;789-794.
40. Sutula T., Cascino G., Cavazos J., Parada I., Ramirez L. Mossy fiber synaptic reorganization in the epileptic human temporal lobe. Ann Neurol. 26:1989;321-330.
41. Torrey E.F., Peterson M.R. Schizophrenia and the limbic system. Lancet. 19:1974;942-945.
42. Uno H., Lohmiller L., Thieme C., Kemnitz J.W., Engle M.J., Roecker E.B., Farrell P.M. Brain damage induced by prenatal exposure to dexamethasone in fetal rhesus macaques. I. Hippocampus. Dev Biol. 53:1990;157-167.
43. Watanabe Y., Weiland N.G., McEwen B.S. Effects of adrenal steroid manipulations and repeated restraint stress on dynorphin mRNA levels and excitatory amino acid receptor binding in hippocampus. Brain Res. 680:1995;217-225.
44. Shannon-Weickert C.S., Weinberger D.R. A candidate molecule approach to defining developmental neuropathology in schizophrenia. Schizophr Bull. 24:(2):1998;303-316.
45. Weinberger D.R. Anteromedial temporal-prefrontal connectivity A functional neuroanatomical system implicated in schizophrenia . Carroll B.J., Barrett J.E. Psychopathology and the Brain. 1991;25-39 Raven Press, New York.
46. Weinberger D.R., Berman K.F., Suddath R., Torrey E.F. Evidence for dysfunction of a prefrontal-limbic network in schizophrenia An MRI and rCBF study of discordant monozygotic twins . Am J Psychiatry. 149:1992;890-897.
47. Wolf S.S., Hyde T.M., Saunders R.C., Herman M.M., Weinberger D.R., Kleinman J.E. Autoradiographic characterization of neurotensin receptors in the entorhinal cortex of schizophrenic patients and control subjects. J Neural Transm. 102:1995;55-65.
48. Woolley C.S., Gould E., McEwen B.S. Exposure to excess glucocorticoids alters dendritic morphology of adult hippocampal pyramidal neurons. Brain Res. 531:1990;225-231.
49. Zaidel D.W., Esiri M.M., Harrison P.J. Size, shape, and orientation of neurons in the left and right hippocampus Investigation of normal asymmetries and alterations in schizophrenia . Am J Psychiatry. 154:1997;812-818.