Opposite Effects of Catechol-O-Methyltransferase Val158Met on Cortical Function in Healthy Subjects and Patients with Schizophrenia

Biological Psychiatry

Volumn 65, Issue 6, 2009, Pages 473-480

  Prata, Diana P ^a   Mechelli, Andrea ^a   Fu, Cynthia H Y ^a   Picchioni, Marco ^a   Kane, Fergus ^a   Kalidindi, Sridevi ^a   McDonald, Colm ^b   Howes, Oliver ^a   Kravariti, Eugenia ^a   Demjaha, Arsime ^a   Toulopoulou, Timothea ^a   Diforti, Marta ^a   Murray, Robin M ^a   Collier, David A ^a   McGuire, Philip K ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b NATIONAL UNIVERSITY OF IRELAND   (Ireland)

Author keywords

Catechol O methyltransferase; cerebral cortex; cognitive symptoms; dopamine; imaging; schizophrenia

Indexed keywords

CATECHOL METHYLTRANSFERASE; DOPAMINE; METHIONINE; VALINE;

ADULT; ALLELE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; FRONTAL CORTEX; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; IMAGE ANALYSIS; INSULA; MALE; MOTOR PERFORMANCE; OPERCULUM; PRIORITY JOURNAL; SCHIZOPHRENIA; SYLVIAN CORTEX; TASK PERFORMANCE; TEMPORAL CORTEX;

ADULT; CASE-CONTROL STUDIES; CATECHOL O-METHYLTRANSFERASE; CEREBRAL CORTEX; COGNITION; FEMALE; GENOTYPE; HUMANS; LANGUAGE TESTS; MALE; NEURAL PATHWAYS; POLYMORPHISM, SINGLE NUCLEOTIDE; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY;

EID: 60349127839     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2008.09.027     Document Type: Article

References (68)

1. Saito S., Iida A., Sekine A., Miura Y., Sakamoto T., Ogawa C., et al. Identification of 197 genetic variations in six human methyltransferase genes in the Japanese population. J Hum Genet 46 (2001) 529-537
2. Matsumoto M., Weickert C.S., Akil M., Lipska B.K., Hyde T.M., Herman M.M., et al. Catechol O-methyltransferase mRNA expression in human and rat brain: Evidence for a role in cortical neuronal function. Neuroscience 116 (2003) 127-137
3. Hong J., Shu-Leong H., Tao X., and Lap-Ping Y. Distribution of catechol-O-methyltransferase expression in human central nervous system. Neuroreport 9 (1998) 2861-2864
4. Gogos J.A., Morgan M., Luine V., Santha M., Ogawa S., Pfaff D., et al. Catechol-O-methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior. Proc Natl Acad Sci U S A 95 (1998) 9991-9996
5. Sesack S.R., Hawrylak V.A., Guido M.A., and Levey A.I. Cellular and subcellular localization of the dopamine transporter in rat cortex. Adv Pharmacol 42 (1998) 171-174
6. Tunbridge E., Burnet P.W., Sodhi M.S., and Harrison P.J. Catechol-o-methyltransferase (COMT) and proline dehydrogenase (PRODH) mRNAs in the dorsolateral prefrontal cortex in schizophrenia, bipolar disorder, and major depression. Synapse 51 (2004) 112-118
7. Chen J., Lipska B.K., Halim N., Ma Q.D., Matsumoto M., Melhem S., et al. Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain. Am J Hum Genet 75 (2004) 807-821
8. Diamond A., Briand L., Fossella J., and Gehlbach L. Genetic and neurochemical modulation of prefrontal cognitive functions in children. Am J Psychiatry 161 (2004) 125-132
9. Egan M.F., Goldberg T.E., Kolachana B.S., Callicott J.H., Mazzanti C.M., Straub R.E., et al. Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proc Natl Acad Sci U S A 98 (2001) 6917-6922
10. Goldberg T.E., Egan M.F., Gscheidle T., Coppola R., Weickert T., Kolachana B.S., et al. Executive subprocesses in working memory: Relationship to catechol-O-methyltransferase Val158Met genotype and schizophrenia. Arch Gen Psychiatry 60 (2003) 889-896
11. Malhotra A.K., Kestler L.J., Mazzanti C., Bates J.A., Goldberg T., and Goldman D. A functional polymorphism in the COMT gene and performance on a test of prefrontal cognition. Am J Psychiatry 159 (2002) 652-654
12. Bertolino A., Caforio G., Blasi G., De C.M., Latorre V., Petruzzella V., et al. Interaction of COMT (Val(108/158)Met) genotype and olanzapine treatment on prefrontal cortical function in patients with schizophrenia. Am J Psychiatry 161 (2004) 1798-1805
13. Bertolino A., Rubino V., Sambataro F., Blasi G., Latorre V., Fazio L., et al. Prefrontal-hippocampal coupling during memory processing is modulated by COMTVal158Met genotype. Biol Psychiatry 60 (2006) 1250-1258
14. Bertolino A., Caforio G., Petruzzella V., Latorre V., Rubino V., Dimalta S., et al. Prefrontal dysfunction in schizophrenia controlling for COMTVal158Met genotype and working memory performance. Psychiatry Res 147 (2006) 221-226
15. Blasi G., Mattay V.S., Bertolino A., Elvevag B., Callicott J.H., Das S., et al. Effect of catechol-O-methyltransferase val158met genotype on attentional control. J Neurosci 25 (2005) 5038-5045
16. Winterer G., Musso F., Vucurevic G., Stoeter P., Konrad A., Seker B., et al. COMT genotype predicts BOLD signal and noise characteristics in prefrontal circuits. Neuroimage 32 (2006) 1722-1732
17. Tunbridge E.M., Bannerman D.M., Sharp T., and Harrison P.J. Catechol-o-methyltransferase inhibition improves set-shifting performance and elevates stimulated dopamine release in the rat prefrontal cortex. J Neurosci 24 (2004) 5331-5335
18. Gogos J.A., Morgan M., Luine V., Santha M., Ogawa S., Pfaff D., et al. Catechol-O-methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior. Proc Natl Acad Sci U S A 95 (1998) 9991-9996
19. Huotari M., Gogos J.A., Karayiorgou M., Koponen O., Forsberg M., Raasmaja A., et al. Brain catecholamine metabolism in catechol-O-methyltransferase (COMT)-deficient mice. Eur J Neurosci 15 (2002) 246-256
20. Mattay V.S., Goldberg T.E., Fera F., Hariri A.R., Tessitore A., Egan M.F., et al. Catechol O-methyltransferase val158-met genotype and individual variation in the brain response to amphetamine. Proc Natl Acad Sci U S A 100 (2003) 6186-6191
21. Meyer-Lindenberg A., and Weinberger D.R. Intermediate phenotypes and genetic mechanisms of psychiatric disorders. Nat Rev Neurosci 7 (2006) 818-827
22. Akil M., Kolachana B.S., Rothmond D.A., Hyde T.M., Weinberger D.R., and Kleinman J.E. Catechol-O-methyltransferase genotype and dopamine regulation in the human brain. J Neurosci 23 (2003) 2008-2013
23. Weinberger D.R., Egan M.F., Bertolino A., Callicott J.H., Mattay V.S., Lipska B.K., et al. Prefrontal neurons and the genetics of schizophrenia. Biol Psychiatry 50 (2001) 825-844
24. Abi-Dargham A., Mawlawi O., Lombardo I., Gil R., Martinez D., Huang Y., et al. Prefrontal dopamine D1 receptors and working memory in schizophrenia. J Neurosci 22 (2002) 3708-3719
25. Akil M., Pierri J.N., Whitehead R.E., Edgar C.L., Mohila C., Sampson A.R., et al. Lamina-specific alterations in the dopamine innervation of the prefrontal cortex in schizophrenic subjects. Am J Psychiatry 156 (1999) 1580-1589
26. Meyer-Lindenberg A., Miletich R.S., Kohn P.D., Esposito G., Carson R.E., Quarantelli M., et al. Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophrenia. Nat Neurosci 5 (2002) 267-271
27. Bertolino A., Breier A., Callicott J.H., Adler C., Mattay V.S., Shapiro M., et al. The relationship between dorsolateral prefrontal neuronal N-acetylaspartate and evoked release of striatal dopamine in schizophrenia. Neuropsychopharmacology 22 (2000) 125-132
28. Grace A.A. Gating of information flow within the limbic system and the pathophysiology of schizophrenia. Brain Res Brain Res Rev 31 (2000) 330-341
29. Fletcher P.C., Frith C.D., Grasby P.M., Friston K.J., and Dolan R.J. Local and distributed effects of apomorphine on fronto-temporal function in acute unmedicated schizophrenia. J Neurosci 16 (1996) 7055-7062
30. Curtis V.A., Bullmore E.T., Brammer M.J., Wright I.C., Williams S.C., Morris R.G., et al. Attenuated frontal activation during a VF task in patients with schizophrenia. Am J Psychiatry 155 (1998) 1056-1063
31. Yurgelun-Todd D.A., Waternaux C.M., Cohen B.M., Gruber S.A., English C.D., and Renshaw P.F. Functional magnetic resonance imaging of schizophrenic patients and comparison subjects during word production. Am J Psychiatry 153 (1996) 200-205
32. Fu C.H., Morgan K., Suckling J., Williams S.C., Andrew C., Vythelingum G.N., et al. A functional magnetic resonance imaging study of overt letter VF using a clustered acquisition sequence: greater anterior cingulate activation with increased task demand. Neuroimage 17 (2002) 871-879
33. Fu C.H., Suckling J., Williams S.C., Andrew C.M., Vythelingum G.N., and McGuire P.K. Effects of psychotic state and task demand on prefrontal function in schizophrenia: An fMRI study of overt VF. Am J Psychiatry 162 (2005) 485-494
34. Artiges E., Martinot J.L., Verdys M., Attar-Levy D., Mazoyer B., Tzourio N., et al. Altered hemispheric functional dominance during word generation in negative schizophrenia. Schizophr Bull 26 (2000) 709-721
35. Friston K.J. Introduction: Experimental design and statistical parametric mapping. In: Frackowiak R.S. (Ed). Human Brain Function (2003), Academic Press, San Diego, CA xii
36. Penny W.D., Holmes A.P., and Friston K.J. Random-effects analysis. In: Frackowiak R.S. (Ed). Human Brain Function (2003), Academic Press, San Diego, CA 843-850
37. Lewis D.A., Hayes T.L., Lund J.S., and Oeth K.M. Dopamine and the neural circuitry of primate prefrontal cortex: Implications for schizophrenia research. Neuropsychopharmacology 6 (1992) 127-134
38. Spence S.A., Liddle P.F., Stefan M.D., Hellewell J.S., Sharma T., Friston K.J., et al. Functional anatomy of VF in people with schizophrenia and those at genetic risk. Focal dysfunction and distributed disconnectivity reappraised. Br J Psychiatry 176 (2000) 52-60
39. Manoach D.S., Gollub R.L., Benson E.S., Searl M.M., Goff D.C., Halpern E., et al. Schizophrenic subjects show aberrant fMRI activation of dorsolateral prefrontal cortex and basal ganglia during working memory performance. Biol Psychiatry 48 (2000) 99-109
40. Callicott J.H., Bertolino A., Mattay V.S., Langheim F.J., Duyn J., Coppola R., et al. Physiological dysfunction of the dorsolateral prefrontal cortex in schizophrenia revisited. Cereb Cortex 10 (2000) 1078-1092
41. Perlstein W.M., Carter C.S., Noll D.C., and Cohen J.D. Relation of prefrontal cortex dysfunction to working memory and symptoms in schizophrenia. Am J Psychiatry 158 (2001) 1105-1113
42. Winterer G., and Weinberger D.R. Genes, dopamine and cortical signal-to-noise ratio in schizophrenia. Trends Neurosci 27 (2004) 683-690
43. Friston K.J., and Frith C.D. Schizophrenia: A disconnection syndrome?. Clin Neurosci 3 (1995) 89-97
44. Nolan K.A., Bilder R.M., Lachman H.M., and Volavka J. Catechol O-methyltransferase Val158Met polymorphism in schizophrenia: Differential effects of Val and Met alleles on cognitive stability and flexibility. Am J Psychiatry 161 (2004) 359-361
45. Bilder R.M., Volavka J., Czobor P., Malhotra A.K., Kennedy J.L., Ni X., et al. Neurocognitive correlates of the COMT Val(158)Met polymorphism in chronic schizophrenia. Biol Psychiatry 52 (2002) 701-707
46. Barnett J.H., Jones P.B., Robbins T.W., and Muller U. Effects of the catechol-O-methyltransferase Val158Met polymorphism on executive function: A meta-analysis of the Wisconsin Card Sort Test in schizophrenia and healthy controls. Mol Psychiatry 12 (2007) 502-509
47. Rosa A., Peralta V., Cuesta M.J., Zarzuela A., Serrano F., Martinez-Larrea A., et al. New evidence of association between COMT gene and prefrontal neurocognitive function in healthy individuals from sibling pairs discordant for psychosis. Am J Psychiatry 161 (2004) 1110-1112
48. Barnett J.H., Scoriels L., and Munafo M.R. Meta-analysis of the cognitive effects of the Catechol-O-methyltransferase gene Val158/108Met polymorphism. Biol Psychiatry 64 (2008) 137-144
49. Drabant E.M., Hariri A.R., Meyer-Lindenberg A., Munoz K.E., Mattay V.S., Kolachana B.S., et al. Catechol O-methyltransferase val158met genotype and neural mechanisms related to affective arousal and regulation. Arch Gen Psychiatry 63 (2006) 1396-1406
50. Smolka M.N., Schumann G., Wrase J., Grusser S.M., Flor H., Mann K., et al. Catechol-O-methyltransferase val158met genotype affects processing of emotional stimuli in the amygdala and prefrontal cortex. J Neurosci 25 (2005) 836-842
51. Blasi G., Mattay V.S., Bertolino A., Elvevag B., Callicott J.H., Das S., et al. Effect of catechol-O-methyltransferase val158met genotype on attentional control. J Neurosci 25 (2005) 5038-5045
52. Frodl T., Meisenzahl E.M., Zill P., Baghai T., Rujescu D., Leinsinger G., et al. Reduced hippocampal volumes associated with the long variant of the serotonin transporter polymorphism in major depression. Arch Gen Psychiatry 61 (2004) 177-183
53. Addington A.M., Gornick M.C., Shaw P., Seal J., Gogtay N., Greenstein D., et al. Neuregulin 1 (8p12) and childhood-onset schizophrenia: Susceptibility haplotypes for diagnosis and brain developmental trajectories. Mol Psychiatry 12 (2007) 195-205
54. Sommer I.E., Ramsey N.F., and Kahn R.S. Language lateralization in schizophrenia, an fMRI study. Schizophr Res 52 (2001) 57-67
55. McGuire P.K., Bates J.F., and Goldman-Rakic P.S. Interhemispheric integration: I. Symmetry and convergence of the corticocortical connections of the left and the right principal sulcus (PS) and the left and the right supplementary motor area (SMA) in the rhesus monkey. Cereb Cortex 1 (1991) 390-407
56. McGuire P.K., Bates J.F., and Goldman-Rakic P.S. Interhemispheric integration: II. Symmetry and convergence of the corticostriatal projections of the left and the right principal sulcus (PS) and the left and the right supplementary motor area (SMA) of the rhesus monkey. Cereb Cortex 1 (1991) 408-417
57. Lotta T., Vidgren J., Tilgmann C., Ulmanen I., Melen K., Julkunen I., et al. Kinetics of human soluble and membrane-bound catechol O-methyltransferase: A revised mechanism and description of the thermolabile variant of the enzyme. Biochemistry 34 (1995) 4202-4210
58. Nackley A.G., Shabalina S.A., Tchivileva I.E., Satterfield K., Korchynskyi O., Makarov S.S., et al. Human catechol-O-methyltransferase haplotypes modulate protein expression by altering mRNA secondary structure. Science 314 (2006) 1930-1933
59. Abi-Dargham A. Do we still believe in the dopamine hypothesis?. New data bring new evidence. Int J Neuropsychopharmacol 7 suppl 1 (2004) S1-S5
60. Howes O.D., Montgomery A.J., Asselin M.C., Murray R.M., Grasby P.M., and McGuire P.K. Molecular imaging studies of the striatal dopaminergic system in psychosis and predictions for the prodromal phase of psychosis. Br J Psychiatry Suppl 51 (2007) s13-s18
61. McGowan S., Lawrence A.D., Sales T., Quested D., and Grasby P. Presynaptic dopaminergic dysfunction in schizophrenia: A positron emission tomographic [18F]fluorodopa study. Arch Gen Psychiatry 61 (2004) 134-142
62. Meyer-Lindenberg A., Kohn P.D., Kolachana B., Kippenhan S., Inerney-Leo A., Nussbaum R., et al. Midbrain dopamine and prefrontal function in humans: Interaction and modulation by COMT genotype. Nat Neurosci 8 (2005) 594-596
63. Slifstein M., Kolachana B., Simpson E.H., Tabares P., Cheng B., Duvall M., et al. COMT genotype predicts cortical-limbic D1 receptor availability measured with [(11)C]NNC112 and PET. Mol Psychiatry 13 (2008) 821-827
64. Goldman-Rakic P.S., Muly III E.C., and Williams G.V. D(1) receptors in prefrontal cells and circuits. Brain Res Brain Res Rev 31 (2000) 295-301
65. Seeman P., Chau-Wong M., Tedesco J., and Wong K. Brain receptors for antipsychotic drugs and dopamine: Direct binding assays. Proc Natl Acad Sci U S A 72 (1975) 4376-4380
66. Creese I., Burt D.R., and Snyder S.H. Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs. Science 192 (1976) 481-483
67. Gogos J.A., Morgan M., Luine V., Santha M., Ogawa S., Pfaff D., et al. Catechol-O-methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior. Proc Natl Acad Sci U S A 95 (1998) 9991-9996
68. Shifman S., Bronstein M., Sternfeld M., Pisante-Shalom A., Lev-Lehman E., Weizman A., et al. A highly significant association between a COMT haplotype and schizophrenia. Am J Hum Genet 71 (2002) 1296-1302