Integrin cytoplasmic interactions and bidirectional transmembrane signalling

Current Opinion in Cell Biology

Volumn 8, Issue 5, 1996, Pages 657-669

  Dedhar, Shoukat ^a   Hannigan, Gregory E ^b,c  

^a SUNNYBROOK RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; ANKYRIN; CELL RECEPTOR; CYTOPLASM PROTEIN; CYTOSKELETON PROTEIN; ENDONEXIN; GROWTH FACTOR; INTEGRIN; MEMBRANE PROTEIN; PROTEIN SERINE THREONINE KINASE;

AMINO ACID SEQUENCE; CELL ADHESION; CELL MEMBRANE; CELL MIGRATION; CYTOPLASM; CYTOSKELETON; MEMBRANE TRANSPORT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION;

EID: 0030272735     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0955-0674(96)80107-4     Document Type: Article

References (86)

1. Schwartz MA, Schaller MD, Ginsberg MH: Integrins: emerging paradigms of signal transduction. Annu Rev Cell Biol Dev Biol 1995, 11:549-600. An up to date, extremely detailed review on integrin-mediated signal transduction. An excellent reference that describes integrin-induced protein tyrosine phosphorylation in great detail, and discusses current paradigms in this fast moving area of research.
2. Hynes RO: Integrins: versatility, modulation, and signalling in cell adhesion. Cell 1992, 69:11-25.
3. Clark EA, Brugge JS: Integrins and signal transduction pathways: the road taken. Science 1995, 268:233-239. A current general review of integrin-mediated signal transduction. Excellent reference material.
4. Roskelley CD, Srebrow A, Bissel MJ: A hierarchy of ECM-mediated signalling regulates tissue-specific gene expression. Curr Opin Cell Biol 1995, 7:736-747. A critical and thought-provoking review about ECM-mediated signal transduction, with emphasis on the regulation of gene expression and coordination of signals in vivo.
5. Yamada KM, Miyamoto S: Integrin transmembrane signalling and cytoskeletal control. Curr Opin Cell Biol 1995, 7:681-689. A very well written current review of integrin signalling and the cytoskeleton. The review focuses on, and uses as a paradigm, the spatial organization of cytoskeletal and signalling molecules upon integrin engagement and clustering.
6. Resales C, O'Brien V, Kornberg L, Juliano R: Signal transduction by cell adhesion receptors. Biochim Biophys Acta 1995, 1242:77-98. A detailed general review of signal transduction by a variety of cell adhesion molecules.
7. Damsky CH, Werb Z: Signal transduction by integrin receptors for extracellular matrix: cooperative processing of extracellular information. Curr Opin Cell Biol 1992, 4:772-781.
8. Juliano R, Haskill S: Signal transduction from the extracellular matrix. J Cell Biol 1993, 120:577-585.
9. Richardson A, Parsons JT: Signal transduction through integrins: a central role for focal adhesion kinase? Bioessays 1995, 17:229-236. A careful, detailed review about how integrins initiate signals via protein kinases. Focuses on FAK.
10. LaFlamme SE, Akiyama SK, Yamada KW: Regulation of fibronectin receptor distribution. J Cell Biol 1992, 117:437-447.
11. Akiyama SK, Yamada SS, Yamada KM, LaFlamme SE: Transmembrane signal transduction by integrin cytoplasmic domains expressed in single-subunit chimeras. J Biol Chem 1994, 269:15961-15964.
12. Lukashev ME, Sheppard D, Pytela R: Disruption of integrin function and induction of tyrosine phosphorylation by the autonomously expressed β1 integrin cytoplasmic domain. J Biol Chem 1994, 269:18311-18314.
13. Ylanne J, Chen Y, O'Toole TE, Loftus JC, Takada Y, Ginsberg MH: Distinct functions of integrin α and β subunit cytoplasmic domains in cell spreading and formation of focal adhesions. J Cell Biol 1993, 122:223-233.
14. Rojiani M, Finlay BB, Gray V, Dedhar S: In vitro interaction of a polypeptide homologous to human Ro/SSA antigen (calreticulin) with a highly conserved amino acid sequence in the cytoplasmic domain of integrin α subunits. Biochemistry 1991, 30:9859-9866.
15. Dedhar S: Novel functions for calreticulin: interaction with integrins and modulation of gene expression? Trends Biochem Sci 1994, 19:269-271.
16. Leung-Hagesteijn C, Milankov K, Michalak M, Wilkins J, Dedhar S: Cell attachment to extracellular matrix substrates is inhibited upon downregulation of expression of calreticulin, an intracellular integrin α-subunit-binding protein. J Cell Sei 1994, 107:589-600.
17. 1 activation either by 'activating'-type monoclonal antibodies or by phorbol esters.
18. Kieffer JD, Plopper G, Ingber DE, Hartwig JH, Kupper TS: Direct binding of F actin to the cytoplasmic domain of the α2 integrin chain in vitro. Biochem Biophys Res Commun 1995, 217:466-474.
19. Vouri K, Ruoshalti E: Association of insulin receptor substrate-1 with integrins. Science 1994, 266:1576-1578.
20. vβ integrin associates with a 190-kDa protein that is phosphorylated on tyrosine in response to platelet-derived growth factor. J Biol Chem 1993, 268:17270-17276.
21. Berditchevski F, Zutter MM, Hemler ME: Characterization of novel complexes on the cell surface between integrins and proteins with 4 transmembrane domains (TM4 proteins). Mol Biol Cell 1996, 7:193-207.
22. Otey CA, Pavalko FM, Burridge K: An interaction between α-actinin and the β1 integrin subunit in vitro. J Cell Biol 1990, 111:721-729.
23. Horwitz A, Duggan K, Buck C, Beckerle MC, Burridge K: Interactions of plasma membrane fibronectin receptor with talin - a transmembrane linkage. Nature 1985, 320:531-533.
24. Tapley P, Horwitz A, Buck C, Burridge K, Duggan K, Rohrschneider L: Analysis of the avian fibronectin receptor (integrin) as a direct substrate for pp60v-src. Oncogene 1989, 4:325-333.
25. Belkin AM, Koteliansky VE: Interaction of iodinated vinculin, metavinculin and a actinin with cytoskeletal proteins. FEBS Lett 1987, 220:291-294.
26. Otey CA, Vasquez GB, Burridge K, Erickson BW: Mapping of the α-actinin binding site within the β1 integrin cytoplasmic domain. J Biol Chem 1993, 268:21193-21197.
27. 1A integrin required for association with these proteins in vivo. The data obtained raise some critical issues because although some findings are similar to those found in vitro by peptide binding, others are clearly different.
28. 1. J Immunol 1995, 154:3461-3470.
29. 1A integrin cytoplasmic domain. The kinase (ILK) is found in integrin immunoprecipitates and its activity is modulated by cell attachment to the ECM. Interestingly, overexpression of ILK in intestinal epithelial cells induces both an alteration in cell morphology and anchorageindependent growth.
30. 3 subunit.
31. Schaller MD, Otey CA, Hildebrand JD, Parson JT: Focal adhesion kinase and paxillin bind to peptides mimicking β integrin cytoplasmic domains. J Cell Biol 1995, 130:1181-1187.
32. 4 mediated cell adhesion to laminins. J Cell Biol 1995, 129:473-467.
33. 4 integrin is also shown to be required for localization of the integrin to hemidesmosomes.
34. Miyamoto S, Akiyama SK, Yamada KM: Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function. Science 1995, 267:883-885. Describes the first demonstration of spatial localization of cytoskeletal and signalling molecules with integrins. The paper dissects the roles of receptor occupancy and integrin aggregation in these localizations. These findings are expanded in [35] and reviewed in [5**].
35. Miyamoto S, Teramoto H, Coso OA, Gutkind JS, Burbelo PD, Akiyama SK, Yamada KM: Integrin function: molecular hierarchies of cytoskeletal and signalling molecules. J Cell Biol 1995,131:791-805.
36. Nobes CO, Hall A: Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell 1995, 81:53-62. An elegant evaluation of the roles of the small GTP-binding proteins Rho, Rac and Cdc42 in the assembly of actin cytoskeletal associated focal complexes, lamellipodia and filopodia.
37. Hotchin NA, Hall A: The assembly of integrin adhesion complexes requires both extracellular matrix and intracellular rho/rac GTPases. J Cell Biol 1995, 131:1857-1865. A very important paper demonstrating, for the first time, that both the assembly of integrin adhesion complexes and the resulting downstream signalling events require Rho/Rac GTPases.
38. Chong LK, Traynor-Kaplan A, Bokoch G, Schwartz MA: The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells. Cell 1994, 79:507-513.
39. Ishizaki T, Maekawa M, Fujisawa K, Okawa K, Iwamatsu A, Fuita A, Watanabe N, Saito Y, Kakizuka A, Morii N, Narumiya S: The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase. EMBO J 1996,15:1885-1893.
40. Watanabe G, Saito Y, Madaule P, Ishizaki T, Fujisawa K, Morii N, Mukai H, Ono Y, Kakizuka A, Narumiya S: Protein kinase N (PKN) and PKN-related protein rhophilin as targets of small GTPase Rho. Science 1996, 271:645-648.
41. Amano M, Kukai H, Ono Y, Chihara K, Matsui T, Hamajima Y, Okawa K, Iwamatsu A, Kaibuchi K: Identification of a putative target for Rho as the serine-threonine kinase protein kinase N. Science 1996, 271:648-650.
42. Burbelo PD, Miyamoto S, Utani A, Brills S, Yamada KM, Halls A, Yamada Y: p190-B, a new member of the Rho GAP family, and Rho are induced to cluster after integrin cross-linking. J Biol Chem 1995, 270:30919-30926.
43. McGlade J, Brunkhorst B, Anderson D, Mbamalu G, Settleman J, Dedhar S, Rozakis-Adcock M, Chen LB, Pawson T: The amino terminal region of GAP regulates cytoskeletal structure and cell adhesion. EMBO J 1993, 12:3073-3081.
44. Williams MJ, Hughes PE, O'Toole TE, Ginsberg MH: The inner world of cell adhesion: integrin cytoplasmic domains. Trends Cell Biol 1994, 4:109-112.
45. 3 (GP11b-IIIa) by the cytoplasmic domain of allb. Science 1991, 254:845-847.
46. O'Toole TE, Katagiri Y, Faull RJ, Peter K, Tamura R, Quaranta V, Loftus JC, Shattil SJ, Ginsberg MH: Integrin cytoplasmic domains mediate inside-out signal transduction. J Cell Biol 1994, 124:1047-1059.
47. Zhang Z, Vuori K, Wang M, Reed JC, Ruoslahti E: Integrin activation by R-ras. Cell 1996, 85:61-69. An exciting paper demonstrating that ectopic expression of R-Ras induces cell attachment and spreading in nonadherent cells. Dominant-negative forms of R-Ras inhibit cell attachment, indicating a role of R-Ras in regulating integrin-affinity states. This paper opens up a potential new area of investigation and implicates small GTPases in the regulation of integrin-affinity states.
48. OToole TE, Ylanne J, Culley BM: Regulation of integrin affinity states through an NPXY motif in the β subunit cytoplasmic domain. J Biol Chem 1995, 270:8553-8558.
49. Hughes PE, Diaz-Gonzalez F, Leong L, Wu C, McDonald JA, Shattil SJ, Ginsberg MH: Breaking the integrin hinge. J Biol Chem 1996, 271:6571-6574. A convincing demonstration of the power of mutational analysis. The data demonstrate the requirements of both the β and α integrin subunit membrane-proximal domains in the regulation of integrin-affinity states. The work invokes the role of a salt bridge between these domains in this regulation.
50. Gimond C, De Melker A, Aumailley M, Sonnenberg A: The cytoplasmic domain of α6A Integrin subunit is an in vitro substrate for protein kinase C. Exp Cell Res 1995, 216:232-235.
51. Valmu L, Gahmberg CG: Treatment with okadaic acid reveals strong threonine phosphorylation of CD18 after activation of CD11/CD18 leukocyte integrins with phorbol esters or CD3 antibodies. J Immunol 1995, 155:1175-1183.
52. Wu C, Keivens VM, O'Toole TE, McDonald JA, Ginsberg MH: Integrin activation and cytoskeletal interaction are essential for the assembly of a fibronectin matrix. Cell 1995, 83:715-724. This paper provides the first clear evidence for the requirement of integrin activation in the assembly of a fibronectin matrix, and provides a functional measure for integrin inside-out signalling.
53. Meredith J, Bazeli B, Schwartz M: The extracellular matrix as a survival factor. Mol Biol Cell 1993, 4:953-961.
54. Frisch SM, Francis H: Disruption of epithelial cell-matrix interactions induces apoptosis. J Cell Biol 1994, 124:619-626.
55. Guadagno TM, Ohtsubo M, Roberts JM, Assoian RK: A link between cyclin A expression and adhesion-dependent cell cycle progression. Science 1993, 262:1572-1575.
56. 1 integrins and ICE-dependent pathways.
57. Kip. See also [58*].
58. Zhu X, Ohtsubo M, Bohmer RM, Roberts JM, Assoian RK: Adhesion-dependent cell cycle progression linked to the expression of cyclin D1, activation of cyclin E-cdk2, and phosphorylation of the retinoblastoma protein. J Cell Biol 1996, 133:391-403. A similar, but more in-depth, study to that described in [57*], also showing the induction of expression of cyclin D1 and hyperphosphorylation of the retinoblastoma protein, Rb, upon cell adhesion. Neither of these papers implicates integrin engagement directly, but rather achieve this indirectly via plating cells on ECM proteins.
59. Zhang Z, Vuori K, Reed JC, Ruoslahti E: The α5β1 integrin supports survival of cells on fibronectin and up-regulates Bcl-2 expression. Proc Natl Acad Sei USA 1995, 92:6161-6165.
60. 1 integrin can have distinct effects on cell growth. The mechanisms of this inhibition are not understood.
61. 4 is required for this effect.
62. Zhu X, Assoian RK: Integrin-dependent activation of MAP kinase: a link to shape-dependent cell proliferation. Mol Biol Cell 1995, 6:273-282.
63. Streuli CH, Bissell MJ: Expression of extracellular matrix components is regulated by substratum. J Cell Biol 1990, 110:1405-1415.
64. Streuli CH, Schmidhauser C, Bailey N, Yurchenco P, Skubitz APN, Roskelley C, Bissell MJ: Laminin mediates tissue-specific gene expression in mammary epithelia. J Cell Biol 1995, 129:591-603.
65. Roskelley CD, Desprez PY, Bissell MJ: Extracellular matrix-dependent tissue-specific gene expression in mammary epithelial cells requires both physical and biochemical signal transduction. Proc Natl Acad Sci USA 1994, 91:12378-12382.
66. Tremble P, Damsky CH, Werb Z: Components of the nuclear signalling cascade that regulate collagenase gene expression in response to integrin-derived signals. J Cell Biol 1995, 129:1707-1720.
67. Vuori K, Ruoslahti E: Activation of protein kinase C precedes α5β1 integrin-mediated cell spreading on fibronectin. J Biol Chem 1993, 268:21459-21462.
68. + antiporter by clustering and immobilizing integrin α5β1, independent of cell shape. Proc Natl Acad Sei USA 1991, 88:7849-7853.
69. McNamee HP, Ingber DE, Schwartz MA: Adhesion to fibronectin stimulates inositol lipid synthesis and enhances PDGF-induced inositol lipid breakdown. J Cell Biol 1993, 121:673-678.
70. Schwartz MA: Spreading of human endothelial cells on fibronectin or vitronectin triggers elevation of intracellular free calcium. J Cell Biol 1993, 120:1003-1010.
71. ras upon antibody-mediated α2β1 integrin activation in T-lymphoblastic cells. J Biol Chem 1993, 268:20701-20704.
72. FAK, a structurally distinctive protein-tyrosine kinase associated with focal adhesions. Proc Natl Acad Sei USA 1992,89:5192-5196.
73. Jewell K, Kapron-Bras C, Jeevaratnam P, Dedhar S: Stimulation of tyrosine phosphorylation of distinct proteins in response to antibody-mediated ligation and clustering of α3 and α6 integrins. J Cell Sei 1995, 108:1165-1174.
74. Lin TH, Yurochko A, Komberg L, Morris J, Walker JJ, Haskill S, Juliano R: The role of protein tyrosine phosphorylation in integrin mediated gene induction in monocytes. J Cell Biol 1994, 126:1585-1593.
75. FAK. Nature 1996, 380:538-540.
76. Guan JL, Shalloway D: Regulation of focal adhesion associated protein tyrosine kinase by both cellular adhesion and oncogenic transformation. Nature 1992, 358:390-392.
77. Zachary I, Sinnet-Smith J, Rozengurt E: Bombesin, vassopresin, and endothelin stimulation of tyrosine phosphorylation in Swiss 3T3 cells. Identification of a novel tyrosine kinase as a major substrate. J Biol Chem 1992, 267:19031-19034.
78. src. Mol Cell Biol 1994, 14:1680-1688.
79. Schlaepfer DD, Hanks SK, Hunter T, Van der Geer P: Integrin-mediated signal transduction linked to ras pathway by GRB-2 binding to focal adhesion kinase. Nature 1994, 372:786-791.
80. Lin TH, Rosales C, Mondal K, Bolen JB, Haskill S, Juliano RL: Integrin-mediated tyrosine phosphorylation and cytokine message induction in monocytic cells. J Biol Chem 1995, 270:16189-16197.
81. Chen Q, Kinch MS, Lin TH, Burridge K, Juliano R: Integrin-mediated cell adhesion activates mitogen-activated protein kinases. J Biol Chem 1994, 269:26602-26605.
82. 1 integrins on fibroblasts induces PDGF independent tyrosine phosphorylation of PDGF β receptors. J Cell Biol 1996, 132:741-752.
83. Ridley AJ, Hall A: The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell 1992, 70:389-399.
84. 6 cytoplasmic subunit inhibits cell proliferation and induces cell differentiation. Describes an elegant use of chimeric integrin subunits combined with an excellent model system of cell differentiation.
85. 3 antagonists on angiogenesis.
86. Chan BMC, Krassner PD, Schiro JA, Byers HR, Kuppa TS, Hemler ME: Distinct cellular functions mediated by different VLA integrins a subunit cytoplasmic domains. Cell 1992, 68:1051-1060.