메뉴 건너뛰기




Volumn 152, Issue 11, 2011, Pages 4138-4147

Cellular leptin resistance impairs the leptin-mediated suppression of neuropeptide Y secretion in hypothalamic neurons

Author keywords

[No Author keywords available]

Indexed keywords

2 (4 MORPHOLINYL) 8 PHENYL 1(4H) 1 BENZOPYRAN 4 ONE; 5 AMINO 4 IMIDAZOLECARBOXAMIDE; ACETYL COENZYME A CARBOXYLASE; GREEN FLUORESCENT PROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; LEPTIN; NEUROPEPTIDE Y; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN C FOS; RIBONUCLEOTIDE; UNCLASSIFIED DRUG;

EID: 80054908167     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2011-0178     Document Type: Article
Times cited : (39)

References (54)
  • 2
    • 0029048408 scopus 로고
    • Recombinant mouse OB protein: Evidence for a peripheral signal linking adiposity and central neural networks
    • Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P 1995 Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 269:546-549
    • (1995) Science , vol.269 , pp. 546-549
    • Campfield, L.A.1    Smith, F.J.2    Guisez, Y.3    Devos, R.4    Burn, P.5
  • 3
    • 0036866913 scopus 로고    scopus 로고
    • Leptin: A review of its peripheral actions and interactions
    • DOI 10.1038/sj.ijo.0802142
    • Margetic S, Gazzola C, Pegg GG, Hill RA 2002 Leptin: a review of its peripheral actions and interactions. Int J Obes Relat Metab Disord 26:1407-1433 (Pubitemid 36007818)
    • (2002) International Journal of Obesity , vol.26 , Issue.11 , pp. 1407-1433
    • Margetic, S.1    Gazzola, C.2    Pegg, G.G.3    Hill, R.A.4
  • 4
    • 0033180532 scopus 로고    scopus 로고
    • Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area
    • DOI 10.1016/S0896-6273(01)80035-0
    • Elias CF, Aschkenasi C, Lee C, Kelly J, Ahima RS, Bjorbaek C, Flier JS, Saper CB, Elmquist JK 1999 Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area. Neuron 23:775-786 (Pubitemid 29411566)
    • (1999) Neuron , vol.23 , Issue.4 , pp. 775-786
    • Elias, C.F.1    Aschkenasi, C.2    Lee, C.3    Kelly, J.4    Ahima, R.S.5    Bjorbaek, C.6    Flier, J.S.7    Saper, C.B.8    Elmquist, J.K.9
  • 5
    • 0033038418 scopus 로고    scopus 로고
    • Interacting appetite-regulating pathways in the hypothalamic regulation of body weight
    • DOI 10.1210/er.20.1.68
    • Kalra SP, Dube MG, Pu S, Xu B, Horvath TL, Kalra PS 1999 Interacting appetite-regulating pathways in the hypothalamic regulation of body weight. Endocr Rev 20:68-100 (Pubitemid 29092036)
    • (1999) Endocrine Reviews , vol.20 , Issue.1 , pp. 68-100
    • Kalra, S.P.1    Dube, M.G.2    Pu, S.3    Xu, B.4    Horvath, T.L.5    Kalra, P.S.6
  • 8
    • 0022873040 scopus 로고
    • Neuropeptide Y chronically injected into the hypothalamus: A powerful neurochemical inducer of hyperphagia and obesity
    • DOI 10.1016/0196-9781(86)90149-X
    • Stanley BG, Kyrkouli SE, Lampert S, Leibowitz SF 1986 Neuropeptide Y chronically injected into the hypothalamus: a powerful neurochemical inducer of hyperphagia and obesity. Peptides 7:1189-1192 (Pubitemid 17226746)
    • (1986) Peptides , vol.7 , Issue.6 , pp. 1189-1192
    • Stanley, B.G.1    Kyrkouli, S.E.2    Lampert, S.3    Leibowitz, S.F.4
  • 9
    • 33745204479 scopus 로고    scopus 로고
    • AMPK integrates nutrient and hormonal signals to regulate food intake and energy balance through effects in the hypothalamus and peripheral tissues
    • DOI 10.1113/jphysiol.2006.113217
    • Xue B, Kahn BB 2006 AMPK integrates nutrient and hormonal signals to regulate food intake and energy balance through effects in the hypothalamus and peripheral tissues. J Physiol 574:73-83 (Pubitemid 43905798)
    • (2006) Journal of Physiology , vol.574 , Issue.1 , pp. 73-83
    • Xue, B.1    Kahn, B.B.2
  • 10
    • 0037122766 scopus 로고    scopus 로고
    • Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase
    • DOI 10.1038/415339a
    • Minokoshi Y, Kim YB, Peroni OD, Fryer LG, Müller C, Carling D, Kahn BB 2002 Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase. Nature 415:339-343 (Pubitemid 34087557)
    • (2002) Nature , vol.415 , Issue.6869 , pp. 339-343
    • Minokoshi, Y.1    Kim, Y.-B.2    Peroni, O.D.3    Fryer, L.G.D.4    Muller, C.5    Carling, D.6    Kahn, B.B.7
  • 12
    • 0347320633 scopus 로고    scopus 로고
    • Leptin signaling in the hypothalamus: Emphasis on energy homeostasis and leptin resistance
    • DOI 10.1016/j.yfrne.2003.10.001
    • Sahu A 2003 Leptin signaling in the hypothalamus: emphasis on energy homeostasis and leptin resistance. Front Neuroendocrinol 24:225-253 (Pubitemid 38064317)
    • (2003) Frontiers in Neuroendocrinology , vol.24 , Issue.4 , pp. 225-253
    • Sahu, A.1
  • 14
    • 27644513401 scopus 로고    scopus 로고
    • Hypothalamic phosphatidylinositol 3-kinase-phosphodiesterase 3B-cyclic AMP pathway of leptin signalling is impaired following chronic central leptin infusion
    • DOI 10.1111/j.1365-2826.2005.01362.x
    • Sahu A, Metlakunta AS 2005 Hypothalamic phosphatidylinositol 3-kinase-phosphodiesterase 3B-cyclic AMP pathway of leptin signalling is impaired following chronic central leptin infusion. J Neuroendocrinol 17:720-726 (Pubitemid 41568098)
    • (2005) Journal of Neuroendocrinology , vol.17 , Issue.11 , pp. 720-726
    • Sahu, A.1    Metlakunta, A.S.2
  • 15
    • 12944261926 scopus 로고    scopus 로고
    • Leptin and insulin stimulation of signalling pathways in arcuate nucleus neurones: PI3K dependent actin reorganization and KATP channel activation
    • Mirshamsi S, Laidlaw HA, Ning K, Anderson E, Burgess LA, Gray A, Sutherland C, Ashford ML 2004 Leptin and insulin stimulation of signalling pathways in arcuate nucleus neurones: PI3K dependent actin reorganization and KATP channel activation. BMC Neurosci 5:54
    • (2004) BMC Neurosci , vol.5 , pp. 54
    • Mirshamsi, S.1    Laidlaw, H.A.2    Ning, K.3    Anderson, E.4    Burgess, L.A.5    Gray, A.6    Sutherland, C.7    Ashford, M.L.8
  • 17
    • 9244219587 scopus 로고    scopus 로고
    • Region-specific leptin resistance within the hypothalamus of diet-induced obese mice
    • DOI 10.1210/en.2004-0726
    • Münzberg H, Flier JS, Bjørbaek C 2004 Region-specific leptin resistance within the hypothalamus of diet-induced obese mice. Endocrinology 145:4880-4889 (Pubitemid 39551104)
    • (2004) Endocrinology , vol.145 , Issue.11 , pp. 4880-4889
    • Munzberg, H.1    Flier, J.S.2    Bjorbaek, C.3
  • 18
    • 17844401180 scopus 로고    scopus 로고
    • Molecular and anatomical determinants of central leptin resistance
    • DOI 10.1038/nn1454
    • Münzberg H, Myers Jr MG 2005 Molecular and anatomical determinants of central leptin resistance. Nat Neurosci 8:566-570 (Pubitemid 40594195)
    • (2005) Nature Neuroscience , vol.8 , Issue.5 , pp. 566-570
    • Munzberg, H.1    Myers Jr., M.G.2
  • 19
    • 2342439732 scopus 로고    scopus 로고
    • Leptin signaling in the central nervous system and the periphery
    • Bjørbaek C, Kahn BB 2004 Leptin signaling in the central nervous system and the periphery. Recent Prog Horm Res 59:305-331
    • (2004) Recent Prog Horm Res , vol.59 , pp. 305-331
    • Bjørbaek, C.1    Kahn, B.B.2
  • 20
    • 34548387367 scopus 로고    scopus 로고
    • Leptin receptor signaling and action in the central nervous system
    • Leshan RL, Bjornholm M, Munzberg H, Myers Jr MG 2006 Leptin receptor signaling and action in the central nervous system. Obesity 14(Suppl 5):208S-212S
    • (2006) Obesity , vol.14 , Issue.SUPPL. 5
    • Leshan, R.L.1    Bjornholm, M.2    Munzberg, H.3    Myers Jr., M.G.4
  • 21
    • 0347717868 scopus 로고    scopus 로고
    • Generation of a Phenotypic Array of Hypothalamic Neuronal Cell Models to Study Complex Neuroendocrine Disorders
    • DOI 10.1210/en.2003-0946
    • Belsham DD, Cai F, Cui H, Smukler SR, Salapatek AM, Shkreta L 2004 Generation of a phenotypic array of hypothalamic neuronal cell models to study complex neuroendocrine disorders. Endocrinology 145:393-400 (Pubitemid 38094535)
    • (2004) Endocrinology , vol.145 , Issue.1 , pp. 393-400
    • Belsham, D.D.1    Cai, F.2    Cui, H.3    Smukler, S.R.4    Salapatek, A.M.F.5    Shkreta, L.6
  • 22
    • 72749091486 scopus 로고    scopus 로고
    • Ciliary neurotrophic factor recruitment of glucagon-like peptide-1 mediates neurogenesis, allowing immortalization of adult murine hypothalamic neurons
    • Belsham DD, Fick LJ, Dalvi PS, Centeno ML, Chalmers JA, Lee PK, Wangv Y, Drucker DJ, Koletar MM 2009 Ciliary neurotrophic factor recruitment of glucagon-like peptide-1 mediates neurogenesis, allowing immortalization of adult murine hypothalamic neurons. FASEB J 23:4256-4265
    • (2009) FASEB J , vol.23 , pp. 4256-4265
    • Belsham, D.D.1    Fick, L.J.2    Dalvi, P.S.3    Centeno, M.L.4    Chalmers, J.A.5    Lee, P.K.6    Wangv, Y.7    Drucker, D.J.8    Koletar, M.M.9
  • 23
    • 33845672095 scopus 로고    scopus 로고
    • Leptin signaling in neurotensin neurons involves STAT, MAP kinases ERK1/2, and p38 through c-Fos and ATF1
    • Cui H, Cai F, Belsham DD 2006 Leptin signaling in neurotensin neurons involves STAT, MAP kinases ERK1/2, and p38 through c-Fos and ATF1. FASEB J 20:2654-2656
    • (2006) FASEB J , vol.20 , pp. 2654-2656
    • Cui, H.1    Cai, F.2    Belsham, D.D.3
  • 25
    • 46749087424 scopus 로고    scopus 로고
    • Estrogen facilitates both phosphatidylinositol 3-kinase/Akt and ERK1/2 mitogen- Activated protein kinase membrane signaling required for long-term neuropeptide Y transcriptional regulation in clonal, immortalized neurons
    • Titolo D, Mayer CM, Dhillon SS, Cai F, Belsham DD 2008 Estrogen facilitates both phosphatidylinositol 3-kinase/Akt and ERK1/2 mitogen- activated protein kinase membrane signaling required for long-term neuropeptide Y transcriptional regulation in clonal, immortalized neurons. J Neurosci 28:6473-6482
    • (2008) J Neurosci , vol.28 , pp. 6473-6482
    • Titolo, D.1    Mayer, C.M.2    Dhillon, S.S.3    Cai, F.4    Belsham, D.D.5
  • 26
    • 33747813597 scopus 로고    scopus 로고
    • Coordinate regulation of neuropeptide Y and agouti-related peptide gene expression by estrogen depends on the ratio of estrogen receptor (ER) α to ERβ in clonal hypothalamic neurons
    • DOI 10.1210/me.2006-0027
    • Titolo D, Cai F, Belsham DD 2006 Coordinate regulation of neuropeptide Y and agouti-related peptide gene expression by estrogen depends on the ratio of estrogen receptor (ER)α to ERβ in clonal hypothalamic neurons. Mol Endocrinol 20:2080-2092 (Pubitemid 44286706)
    • (2006) Molecular Endocrinology , vol.20 , Issue.9 , pp. 2080-2092
    • Titolo, D.1    Cai, F.2    Belsham, D.D.3
  • 27
    • 74949110443 scopus 로고    scopus 로고
    • Palmitate attenuates insulin signaling and induces endoplasmic reticulum stress and apoptosis in hypothalamic neurons: Rescue of resistance and apoptosis through adenosine 5′ monophosphate-activated protein kinase activation
    • Mayer CM, Belsham DD 2010 Palmitate attenuates insulin signaling and induces endoplasmic reticulum stress and apoptosis in hypothalamic neurons: rescue of resistance and apoptosis through adenosine 5′ monophosphate-activated protein kinase activation. Endocrinology 151:576-585
    • (2010) Endocrinology , vol.151 , pp. 576-585
    • Mayer, C.M.1    Belsham, D.D.2
  • 29
    • 0031789878 scopus 로고    scopus 로고
    • Leptin decreases food intake induced by melanin-concentrating hormone (MCH), galanin (GAL) and neuropeptide Y (NPY) in the rat
    • DOI 10.1210/en.139.11.4739
    • Sahu A 1998 Leptin decreases food intake induced by melanin-concentrating hormone (MCH), galanin (GAL) and neuropeptide Y (NPY) in the rat. Endocrinology 139:4739-4742 (Pubitemid 28487794)
    • (1998) Endocrinology , vol.139 , Issue.11 , pp. 4739-4742
    • Sahu, A.1
  • 31
    • 50049091255 scopus 로고    scopus 로고
    • AMPK: A key regulator of energy balance in the single cell and the whole organism
    • Hardie DG 2008 AMPK: a key regulator of energy balance in the single cell and the whole organism. Int J Obes 32(Suppl 4):S7-S12
    • (2008) Int J Obes , vol.32 , Issue.4
    • Hardie, D.G.1
  • 33
    • 33947357840 scopus 로고    scopus 로고
    • Glucose regulates AMP-activated protein kinase activity and gene expression in clonal, hypothalamic neurons expressing proopiomelanocortin: Additive effects of leptin or insulin
    • DOI 10.1677/JOE-06-0080
    • Cai F, Gyulkhandanyan AV, Wheeler MB, Belsham DD 2007 Glucose regulates AMP-activated protein kinase activity and gene expression in clonal, hypothalamic neurons expressing proopiomelanocortin: additive effects of leptin or insulin. J Endocrinol 192:605-614 (Pubitemid 46455963)
    • (2007) Journal of Endocrinology , vol.192 , Issue.3 , pp. 605-614
    • Cai, F.1    Gyulkhandanyan, A.V.2    Wheeler, M.B.3    Belsham, D.D.4
  • 34
    • 26844475055 scopus 로고    scopus 로고
    • Anorexigenic hormones leptin, insulin, and α-melanocyte-stimulating hormone directly induce neurotensin (NT) gene expression in novel NT-expressing cell models
    • DOI 10.1523/JNEUROSCI.2269-05.2005
    • Cui H, Cai F, Belsham DD 2005 Anorexigenic hormones leptin, insulin, and α-melanocyte-stimulating hormone directly induce neurotensin (NT) gene expression in novel NT-expressing cell models. J Neurosci 25:9497-9506 (Pubitemid 41464764)
    • (2005) Journal of Neuroscience , vol.25 , Issue.41 , pp. 9497-9506
    • Cui, H.1    Cai, F.2    Belsham, D.D.3
  • 36
    • 79953232634 scopus 로고    scopus 로고
    • Leptin differentially regulates NPY secretion in hypothalamic cell lines through distinct intracellular signal transduction pathways
    • Dhillon SS, Belsham DD 2011 Leptin differentially regulates NPY secretion in hypothalamic cell lines through distinct intracellular signal transduction pathways. Regul Pept 167:192-200
    • (2011) Regul Pept , vol.167 , pp. 192-200
    • Dhillon, S.S.1    Belsham, D.D.2
  • 37
  • 41
    • 0033744128 scopus 로고    scopus 로고
    • Leptin rapidly inhibits hypothalamic neuropeptide Y secretion and stimulates corticotropin- Releasing hormone secretion in adrenalectomized mice
    • Jang M, Mistry A, Swick AG, Romsos DR 2000 Leptin rapidly inhibits hypothalamic neuropeptide Y secretion and stimulates corticotropin- releasing hormone secretion in adrenalectomized mice. J Nutr 130:2813-2820
    • (2000) J Nutr , vol.130 , pp. 2813-2820
    • Jang, M.1    Mistry, A.2    Swick, A.G.3    Romsos, D.R.4
  • 43
    • 0842308719 scopus 로고    scopus 로고
    • The role of leptin>STAT3 signaling in neuroendocrine function: An integrative perspective
    • DOI 10.1007/s00109-003-0494-z
    • Bates SH, Myers MG 2004 The role of leptin->STAT3 signaling in neuroendocrine function: an integrative perspective. J Mol Med 82: 12-20 (Pubitemid 38168098)
    • (2004) Journal of Molecular Medicine , vol.82 , Issue.1 , pp. 12-20
    • Bates, S.H.1    Myers, M.G.2
  • 44
    • 0345168238 scopus 로고    scopus 로고
    • The role of leptin receptor signaling in feeding and neuroendocrine function
    • DOI 10.1016/j.tem.2003.10.003
    • Bates SH, Myers Jr MG 2003 The role of leptin receptor signaling in feeding and neuroendocrine function. Trends Endocrinol Metab 14:447-452 (Pubitemid 37517345)
    • (2003) Trends in Endocrinology and Metabolism , vol.14 , Issue.10 , pp. 447-452
    • Bates, S.H.1    Myers Jr., M.G.2
  • 45
    • 40849083773 scopus 로고    scopus 로고
    • Hypothalamic phosphatidylinositol 3-kinase pathway of leptin signaling is impaired during the development of diet-induced obesity in FVB/N mice
    • DOI 10.1210/en.2007-1307
    • Metlakunta AS, Sahu M, Sahu A 2008 Hypothalamic phosphatidylinositol 3-kinase pathway of leptin signaling is impaired during the development of diet-induced obesity in FVB/N mice. Endocrinology 149:1121-1128 (Pubitemid 351397951)
    • (2008) Endocrinology , vol.149 , Issue.3 , pp. 1121-1128
    • Metlakunta, A.S.1    Sahu, M.2    Sahu, A.3
  • 48
    • 33745747676 scopus 로고    scopus 로고
    • A novel leptin signalling pathway via PTEN inhibition in hypothalamic cell lines and pancreatic β-cells
    • DOI 10.1038/sj.emboj.7601118, PII 7601118
    • Ning K, Miller LC, Laidlaw HA, Burgess LA, Perera NM, Downes CP, Leslie NR, Ashford ML 2006 A novel leptin signalling pathway via PTEN inhibition in hypothalamic cell lines and pancreatic β-cells. EMBO J 25:2377-2387 (Pubitemid 44012221)
    • (2006) EMBO Journal , vol.25 , Issue.11 , pp. 2377-2387
    • Ning, K.1    Miller, L.C.2    Laidlaw, H.A.3    Burgess, L.A.4    Perera, N.M.5    Downes, C.P.6    Leslie, N.R.7    Ashford, M.L.J.8
  • 49
    • 0347318052 scopus 로고    scopus 로고
    • The AMP-activated protein kinase cascade - A unifying system for energy control
    • DOI 10.1016/j.tibs.2003.11.005
    • Carling D 2004 The AMP-activated protein kinase cascade-a unifying system for energy control. Trends Biochem Sci 29:18-24 (Pubitemid 38068476)
    • (2004) Trends in Biochemical Sciences , vol.29 , Issue.1 , pp. 18-24
    • Carling, D.1
  • 50
    • 0030901556 scopus 로고    scopus 로고
    • Electrical stimulation inactivates muscle acetyl-CoA carboxylase and increases AMP-activated protein kinase
    • Hutber CA, Hardie DG, Winder WW 1997 Electrical stimulation inactivates muscle acetyl-CoA carboxylase and increases AMP-activated protein kinase. Am J Physiol 272:E262-E266
    • (1997) Am J Physiol , vol.272
    • Hutber, C.A.1    Hardie, D.G.2    Winder, W.W.3
  • 53
    • 0033008075 scopus 로고    scopus 로고
    • Functional properties of leptin receptor isoforms: Internalization and degradation of leptin and ligand-induced receptor downregulation
    • DOI 10.2337/diabetes.48.2.279
    • Uotani S, Bjørbaek C, Tornøe J, Flier JS 1999 Functional properties of leptin receptor isoforms: internalization and degradation of leptin and ligand-induced receptor downregulation. Diabetes 48:279-286 (Pubitemid 29061099)
    • (1999) Diabetes , vol.48 , Issue.2 , pp. 279-286
    • Uotani, S.1    Bjorbaek, C.2    Tornoe, J.3    Flier, J.S.4
  • 54
    • 0034510317 scopus 로고    scopus 로고
    • Characterization of leptin intracellular trafficking
    • Wilcke M, Walum E 2000 Characterization of leptin intracellular trafficking. Eur J Histochem 44:325-334 (Pubitemid 32119690)
    • (2000) European Journal of Histochemistry , vol.44 , Issue.4 , pp. 325-334
    • Wilcke, M.1    Walum, E.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.