Characterization of leptin intracellular trafficking

European Journal of Histochemistry

Volumn 44, Issue 4, 2000, Pages 325-334

  Wilcke, M ^a   Walum, E ^a  

^a Pharmacia Corporation   (Sweden)

Author keywords

Endocytosis; Intracellular transport; Leptin; OB; Obesity

Indexed keywords

ANTIINFECTIVE AGENT; BAFILOMYCIN A; FLUORESCEIN ISOTHIOCYANATE; FLUORESCENT DYE; IONOPHORE; LEPTIN; MACROLIDE; MONENSIN; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATASE;

ARTICLE; CELL LINE; DRUG ANTAGONISM; ENDOSOME; FLUORESCENT ANTIBODY TECHNIQUE; HUMAN; INTRACELLULAR FLUID; METABOLISM;

ANTI-BACTERIAL AGENTS; CELL LINE; ENDOSOMES; FLUORESCEIN-5-ISOTHIOCYANATE; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; FLUORESCENT DYES; HUMANS; INTRACELLULAR FLUID; IONOPHORES; LEPTIN; MACROLIDES; MONENSIN; PROTON-TRANSLOCATING ATPASES;

EID: 0034510317     PISSN: 1121760X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. The role of neuropeptide Y in the antiobesity action of the obese gene product
2. Evidence that the diabetes gene encodes the leptin receptor: Identification of a mutation in the leptin receptor gene in db/db mice
3. Abnormal splicing of the leptin receptor in diabetic mice
4. Leptin, leptin receptors, and the control of body weight
5. Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells
6. Leptin and OB-R: Body weight regulation by a cytokine receptor
7. Evidence for a central mechanism of obesity in the Zucker rat: Role of neuropeptide Y and leptin
8. Positional cloning of the mouse obese gene and its human homologue
9. Distributions of leptin receptor mRNA isoforms in the rat brain
10. Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues
11. Leptin enters the brain by a saturable system independent of insulin
12. Human blood-brain barrier leptin receptor. Binding and endocytosis in isolated human brain microvessels
13. Monensin and chloroquine inhibit transfer to lysosomes of endocytosed macromolecules in cultured mouse peritoneal macrophages
14. Endocytosis and intracellular processing of tissue-type plasminogen activator by rat liver cells in vivo
15. Receptor-mediated internalization of angiotensin II in bovine adrenal medullary chromaffin cells in primary culture
16. A comparison of catecholamine-induced internalization of beta-adrenergic receptors and receptor-mediated endocytosis of epidermal growth factor in human astrocytoma cells. Inhibition by phenylarsine oxide
17. Hypertonic media inhibit receptor-mediated endocytosis by blocking clathrin-coated pit formation
18. Effect of brefeldin A and lysosomotropic reagents on intracellular trafficking of epidermal growth factor and transferrin in Madin-Darby canine kidney epithelial cells
19. Binding to cellular receptors results in increased iron release from transferrin at mildly acidic pH
20. Absence of Na+,K(+)-ATPase regulation of endosomal acidification in K562 erythroleukemia cells. Analysis via inhibition of transferrin recycling by low temperatures
21. Iterative fractionation of recycling receptors from lysosomally destined ligands in an early sorting endosome
22. Endocytic trafficking of megalin/RAP complexes: Dissociation of the complexes in late endosomes
23. Distribution of newly synthesized lysosomal enzymes in the endocytic pathway of normal rat kidney cells
24. Delivery of ligands from sorting endosomes to late endosomes occurs by maturation of sorting endosomes
25. Characterization of the early endosome and putative endocytic carrier vesicles in vivo and with an assay of vesicle fusion in vitro
26. In vitro studies of endocytic membrane traffic
27. Kinase activity controls the sorting of the epidermal growth factor receptor within the multivesicular body
28. Functional properties of leptin receptor isoforms: Internalization and degradation of leptin and ligand-induced receptor downregulation
29. Subcellular localization and internalization of the four human leptin receptor isoforms
30. Bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase, inhibits acidification and protein degradation in lysosomes of cultured cells
31. Transport from late endosomes to lysosomes, but not sorting of integral membrane proteins in endosomes, depends on the vacuolar proton pump
32. Bafilomycin A1 treatment retards transferrin receptor recycling more than bulk membrane recycling
33. Trafficking of the epidermal growth factor receptor and transferrin in three hepatocytic endosomal fractions
34. Regulation of postendocytic trafficking of the epidermal growth factor receptor through endosomal retention
35. Quantification of low density lipoprotein and transferrin endocytic sorting HEp2 cells using confocal microscopy
36. Endocytosis and lysosomal targeting of epidermal growth factor receptors are mediated by distinct sequences independent of the tyrosine kinase domain