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Volumn 167, Issue 2-3, 2011, Pages 192-200

Leptin differentially regulates NPY secretion in hypothalamic cell lines through distinct intracellular signal transduction pathways

Author keywords

AMPK; Leptin; MAPK; Neuropeptide Y; PI3K; Secretion; Signal transduction

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; JANUS KINASE 2; LEPTIN; LEPTIN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; NEUROPEPTIDE Y; PHOSPHATIDYLINOSITOL 3 KINASE; STAT3 PROTEIN; STRESS ACTIVATED PROTEIN KINASE;

EID: 79953232634     PISSN: 01670115     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.regpep.2011.01.005     Document Type: Article
Times cited : (32)

References (59)
  • 2
    • 0029739826 scopus 로고    scopus 로고
    • Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice
    • Vaisse C., Halaas J.L., Horvath C.M., Darnell J.E., Stoffel M., Friedman J.M. Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice. Nat Genet 1996, 14:95-97.
    • (1996) Nat Genet , vol.14 , pp. 95-97
    • Vaisse, C.1    Halaas, J.L.2    Horvath, C.M.3    Darnell, J.E.4    Stoffel, M.5    Friedman, J.M.6
  • 3
    • 0032177037 scopus 로고    scopus 로고
    • Unraveling the central nervous system pathways underlying responses to leptin
    • Elmquist J.K., Maratos-Flier E., Saper C.B., Flier J.S. Unraveling the central nervous system pathways underlying responses to leptin. Nat Neurosci 1998, 1:445-450.
    • (1998) Nat Neurosci , vol.1 , pp. 445-450
    • Elmquist, J.K.1    Maratos-Flier, E.2    Saper, C.B.3    Flier, J.S.4
  • 4
    • 0030878110 scopus 로고    scopus 로고
    • Congenital leptin deficiency is associated with severe early onset obesity in humans
    • Montague C.T., FI, Whitehead J.P., Soos M.S., Rau H., et al. Congenital leptin deficiency is associated with severe early onset obesity in humans. Nature 1997, 903-908.
    • (1997) Nature , pp. 903-908
    • Montague, C.T.1    FI2    Whitehead, J.P.3    Soos, M.S.4    Rau, H.5
  • 6
    • 0029048408 scopus 로고
    • Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks
    • Campfield L.A., Smith F.J., Guisez Y., Devos R., Burn P. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 1995, 269:546-549.
    • (1995) Science , vol.269 , pp. 546-549
    • Campfield, L.A.1    Smith, F.J.2    Guisez, Y.3    Devos, R.4    Burn, P.5
  • 10
    • 0030010388 scopus 로고    scopus 로고
    • Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin
    • Chehab F.F., Lim M.E., Lu R. Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nat Genet 1996, 12:318-320.
    • (1996) Nat Genet , vol.12 , pp. 318-320
    • Chehab, F.F.1    Lim, M.E.2    Lu, R.3
  • 11
    • 0031051499 scopus 로고    scopus 로고
    • Leptin treatment rescues the sterility of genetically obese ob/ob males
    • Mounzih K., Lu R., Chehab F.F. Leptin treatment rescues the sterility of genetically obese ob/ob males. Endocrinology 1997, 138:1190-1193.
    • (1997) Endocrinology , vol.138 , pp. 1190-1193
    • Mounzih, K.1    Lu, R.2    Chehab, F.F.3
  • 12
    • 0031014413 scopus 로고    scopus 로고
    • Early onset of reproductive function in normal female mice treated with leptin
    • Chehab F.F., Mounzih K., Lu R., Lim M.E. Early onset of reproductive function in normal female mice treated with leptin. Science 1997, 275:88-90.
    • (1997) Science , vol.275 , pp. 88-90
    • Chehab, F.F.1    Mounzih, K.2    Lu, R.3    Lim, M.E.4
  • 14
    • 0031813699 scopus 로고    scopus 로고
    • Evidence for GnRH regulation by leptin: leptin administration prevents reduced pulsatile LH secretion during fasting
    • Nagatani S., Guthikonda P., Thompson R.C., Tsukamura H., Maeda K.I., Foster D.L. Evidence for GnRH regulation by leptin: leptin administration prevents reduced pulsatile LH secretion during fasting. Neuroendocrinology 1998, 67:370-376.
    • (1998) Neuroendocrinology , vol.67 , pp. 370-376
    • Nagatani, S.1    Guthikonda, P.2    Thompson, R.C.3    Tsukamura, H.4    Maeda, K.I.5    Foster, D.L.6
  • 16
    • 0022873040 scopus 로고
    • Neuropeptide Y chronically injected into the hypothalamus: a powerful neurochemical inducer of hyperphagia and obesity
    • Stanley B.G., Kyrkouli S., Lampert S., Leibowitz S. Neuropeptide Y chronically injected into the hypothalamus: a powerful neurochemical inducer of hyperphagia and obesity. Peptides 1986, 7:1189-1192.
    • (1986) Peptides , vol.7 , pp. 1189-1192
    • Stanley, B.G.1    Kyrkouli, S.2    Lampert, S.3    Leibowitz, S.4
  • 17
    • 0027965835 scopus 로고
    • Neuropeptide Y stimulates luteinizing hormone-releasing hormone release from supefused hypothalamic GT1-7 cells
    • Besecke L.M., Wolfe A.M., Pierce M.E., Takahashi J.S., Levine J.E. Neuropeptide Y stimulates luteinizing hormone-releasing hormone release from supefused hypothalamic GT1-7 cells. Endocrinology 1994, 135:1621-1627.
    • (1994) Endocrinology , vol.135 , pp. 1621-1627
    • Besecke, L.M.1    Wolfe, A.M.2    Pierce, M.E.3    Takahashi, J.S.4    Levine, J.E.5
  • 18
    • 0028827244 scopus 로고
    • Central administration of antisense oligodeoxynucleotides to neuropeptide Y (NPY) mRNA reveals the critical role of newly synthesized NPY in regulation of LHRH release
    • Kalra P.S., Bonavera J.J., Kalra S.P. Central administration of antisense oligodeoxynucleotides to neuropeptide Y (NPY) mRNA reveals the critical role of newly synthesized NPY in regulation of LHRH release. Regul Pept 1995, 59:215-220.
    • (1995) Regul Pept , vol.59 , pp. 215-220
    • Kalra, P.S.1    Bonavera, J.J.2    Kalra, S.P.3
  • 19
    • 0029047920 scopus 로고
    • Evidence that hypothalamic neuropeptide Y gene expression increases before the onset of the preovulatory LH surge
    • Sahu A., Crowley W.R., Kalra S.P. Evidence that hypothalamic neuropeptide Y gene expression increases before the onset of the preovulatory LH surge. J Neuroendocrinol 1995, 7:291-296.
    • (1995) J Neuroendocrinol , vol.7 , pp. 291-296
    • Sahu, A.1    Crowley, W.R.2    Kalra, S.P.3
  • 20
    • 0034528940 scopus 로고    scopus 로고
    • Attenuation of luteinizing hormone surges in neuropeptide Y knockout mice
    • Xu M., Hill J.W., Levine J.E. Attenuation of luteinizing hormone surges in neuropeptide Y knockout mice. Neuroendocrinology 2000, 72:263-271.
    • (2000) Neuroendocrinology , vol.72 , pp. 263-271
    • Xu, M.1    Hill, J.W.2    Levine, J.E.3
  • 21
    • 0026559230 scopus 로고
    • Neuropeptide Y is a neuromodulator of pulsatile luteinizing hormone-releasing hormone release in the gonadectomized rhesus monkey
    • Woller M.J., McDonald J.K., Reboussin D.M., Terasawa E. Neuropeptide Y is a neuromodulator of pulsatile luteinizing hormone-releasing hormone release in the gonadectomized rhesus monkey. Endocrinology 1992, 130:2333-2342.
    • (1992) Endocrinology , vol.130 , pp. 2333-2342
    • Woller, M.J.1    McDonald, J.K.2    Reboussin, D.M.3    Terasawa, E.4
  • 22
    • 0033303823 scopus 로고    scopus 로고
    • Morphological evidence for direct interaction between arcuate nucleus neuropeptide Y (NPY) neurons and gonadotropin-releasing hormone neurons and the possible involvement of NPY Y1 receptors
    • Li C., Chen P., Smith M.S. Morphological evidence for direct interaction between arcuate nucleus neuropeptide Y (NPY) neurons and gonadotropin-releasing hormone neurons and the possible involvement of NPY Y1 receptors. Endocrinology 1999, 140:5382-5390.
    • (1999) Endocrinology , vol.140 , pp. 5382-5390
    • Li, C.1    Chen, P.2    Smith, M.S.3
  • 23
    • 0026474999 scopus 로고
    • Neuropeptide Y potentiates luteinizing hormone (LH)-releasing hormone-induced LH secretion only under conditions leading to preovulatory LH surges
    • Bauer-Dantoin A.C., McDonald J.K., Levine J.E. Neuropeptide Y potentiates luteinizing hormone (LH)-releasing hormone-induced LH secretion only under conditions leading to preovulatory LH surges. Endocrinology 1992, 131:2946-2952.
    • (1992) Endocrinology , vol.131 , pp. 2946-2952
    • Bauer-Dantoin, A.C.1    McDonald, J.K.2    Levine, J.E.3
  • 24
    • 0027475201 scopus 로고
    • Neuropeptide Y administered chronically into the lateral ventricle profoundly inhibits both the gonadotropic and the somatotropic axis in intact adult female rats
    • Catzeflis C., Pierroz D.D., Rohner-Jeanrenaud F., Rivier J.E., Sizonenko P.C., Aubert M.L. Neuropeptide Y administered chronically into the lateral ventricle profoundly inhibits both the gonadotropic and the somatotropic axis in intact adult female rats. Endocrinology 1993, 132:224-234.
    • (1993) Endocrinology , vol.132 , pp. 224-234
    • Catzeflis, C.1    Pierroz, D.D.2    Rohner-Jeanrenaud, F.3    Rivier, J.E.4    Sizonenko, P.C.5    Aubert, M.L.6
  • 25
    • 1342332152 scopus 로고    scopus 로고
    • The neuropeptide Y Y1 receptor mediates NPY-induced inhibition of the gonadotrope axis under poor metabolic conditions
    • Gonzales C., Voirol M.J., Giacomini M., Gaillard R.C., Pedrazzini T., Pralong F.P. The neuropeptide Y Y1 receptor mediates NPY-induced inhibition of the gonadotrope axis under poor metabolic conditions. FASEB J 2004, 18:137-139.
    • (2004) FASEB J , vol.18 , pp. 137-139
    • Gonzales, C.1    Voirol, M.J.2    Giacomini, M.3    Gaillard, R.C.4    Pedrazzini, T.5    Pralong, F.P.6
  • 26
    • 0024994253 scopus 로고
    • Third-ventricular infusion of neuropeptide Y suppresses luteinizing hormone secretion in ovariectomized rhesus macaques
    • Kaynard A.H., Pau K.Y., Hess D.L., Spies H.G. Third-ventricular infusion of neuropeptide Y suppresses luteinizing hormone secretion in ovariectomized rhesus macaques. Endocrinology 1990, 127:2437-2444.
    • (1990) Endocrinology , vol.127 , pp. 2437-2444
    • Kaynard, A.H.1    Pau, K.Y.2    Hess, D.L.3    Spies, H.G.4
  • 27
    • 0024413592 scopus 로고
    • Neuropeptide-Y suppresses pulsatile secretion of luteinizing hormone in ovariectomized rats: possible site of action
    • McDonald J.K., Lumpkin M.D., DePaolo L.V. Neuropeptide-Y suppresses pulsatile secretion of luteinizing hormone in ovariectomized rats: possible site of action. Endocrinology 1989, 125:186-191.
    • (1989) Endocrinology , vol.125 , pp. 186-191
    • McDonald, J.K.1    Lumpkin, M.D.2    DePaolo, L.V.3
  • 28
    • 0343187546 scopus 로고
    • Neuropeptide Y affects secretion of luteinizing hormone and growth hormone in ovariectomized rats
    • McDonald J.K., Lumpkin M.D., Samson W.K., McCann S.M. Neuropeptide Y affects secretion of luteinizing hormone and growth hormone in ovariectomized rats. Proc Natl Acad Sci USA 1985, 82:561-564.
    • (1985) Proc Natl Acad Sci USA , vol.82 , pp. 561-564
    • McDonald, J.K.1    Lumpkin, M.D.2    Samson, W.K.3    McCann, S.M.4
  • 33
    • 0347717868 scopus 로고    scopus 로고
    • Generation of a phenotypic array of hypothalamic neuronal cell models to study complex neuroendocrine disorders
    • Belsham D.D., Cai F., Cui H., Smukler S.R., Salapatek A.M., Shkreta L. Generation of a phenotypic array of hypothalamic neuronal cell models to study complex neuroendocrine disorders. Endocrinology 2004, 145:393-400.
    • (2004) Endocrinology , vol.145 , pp. 393-400
    • Belsham, D.D.1    Cai, F.2    Cui, H.3    Smukler, S.R.4    Salapatek, A.M.5    Shkreta, L.6
  • 34
    • 33747813597 scopus 로고    scopus 로고
    • Coordinate regulation of neuropeptide Y and agouti-related peptide gene expression by estrogen depends on the ratio of estrogen receptor (ER) alpha to ERbeta in clonal hypothalamic neurons
    • Titolo D., Cai F., Belsham D.D. Coordinate regulation of neuropeptide Y and agouti-related peptide gene expression by estrogen depends on the ratio of estrogen receptor (ER) alpha to ERbeta in clonal hypothalamic neurons. Mol Endocrinol 2006, 20:2080-2092.
    • (2006) Mol Endocrinol , vol.20 , pp. 2080-2092
    • Titolo, D.1    Cai, F.2    Belsham, D.D.3
  • 35
    • 67651235884 scopus 로고    scopus 로고
    • Hypothalamic cell lines to investigate neuroendocrine control mechanisms
    • Mayer C.M., Fick L.J., Gingerich S., Belsham D.D. Hypothalamic cell lines to investigate neuroendocrine control mechanisms. Front Neuroendocrinol 2009, 30:405-423.
    • (2009) Front Neuroendocrinol , vol.30 , pp. 405-423
    • Mayer, C.M.1    Fick, L.J.2    Gingerich, S.3    Belsham, D.D.4
  • 38
    • 2142758640 scopus 로고    scopus 로고
    • Orexigen-sensitive NPY/AgRP pacemaker neurons in the hypothalamic arcuate nucleus
    • van den Top M., Lee K., Whyment A.D., Blanks A.M., Spanswick D. Orexigen-sensitive NPY/AgRP pacemaker neurons in the hypothalamic arcuate nucleus. Nat Neurosci 2004, 7:493-494.
    • (2004) Nat Neurosci , vol.7 , pp. 493-494
    • van den Top, M.1    Lee, K.2    Whyment, A.D.3    Blanks, A.M.4    Spanswick, D.5
  • 39
    • 33845945261 scopus 로고    scopus 로고
    • Inhibition by glucose or leptin of hypothalamic neurons expressing neuropeptide Y requires changes in AMP-activated protein kinase activity
    • Mountjoy P.D., Bailey S.J., Rutter G.A. Inhibition by glucose or leptin of hypothalamic neurons expressing neuropeptide Y requires changes in AMP-activated protein kinase activity. Diabetologia 2007, 50:168-177.
    • (2007) Diabetologia , vol.50 , pp. 168-177
    • Mountjoy, P.D.1    Bailey, S.J.2    Rutter, G.A.3
  • 41
    • 0026651708 scopus 로고
    • Heterogeneity in pancreatic beta-cell population
    • Pipeleers D.G. Heterogeneity in pancreatic beta-cell population. Diabetes 1992, 41:777-781.
    • (1992) Diabetes , vol.41 , pp. 777-781
    • Pipeleers, D.G.1
  • 43
    • 0032558725 scopus 로고    scopus 로고
    • Leptin and the regulation of body weight in mammals
    • Friedman J.M., Halaas J.L. Leptin and the regulation of body weight in mammals. Nature 1998, 395:763-770.
    • (1998) Nature , vol.395 , pp. 763-770
    • Friedman, J.M.1    Halaas, J.L.2
  • 44
    • 0032919990 scopus 로고    scopus 로고
    • Leptin's actions on the reproductive axis: perspectives and mechanisms
    • Cunningham M.J., Clifton D.K., Steiner R.A. Leptin's actions on the reproductive axis: perspectives and mechanisms. Biol Reprod 1999, 60:216-222.
    • (1999) Biol Reprod , vol.60 , pp. 216-222
    • Cunningham, M.J.1    Clifton, D.K.2    Steiner, R.A.3
  • 45
    • 0031010408 scopus 로고    scopus 로고
    • Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues
    • Fei H., Okano H.J., Li C., Lee G.H., Zhao C., Darnell R., Friedman J.M. Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues. Proc Natl Acad Sci USA 1997, 94:7001-7005.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 7001-7005
    • Fei, H.1    Okano, H.J.2    Li, C.3    Lee, G.H.4    Zhao, C.5    Darnell, R.6    Friedman, J.M.7
  • 46
    • 0029895233 scopus 로고    scopus 로고
    • Localization of leptin receptor mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization
    • Mercer J.G., Hoggard N., Williams L.M., Lawrence C.B., Hannah L.T., Trayhurn P. Localization of leptin receptor mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization. FEBS Lett 1996, 387:113-116.
    • (1996) FEBS Lett , vol.387 , pp. 113-116
    • Mercer, J.G.1    Hoggard, N.2    Williams, L.M.3    Lawrence, C.B.4    Hannah, L.T.5    Trayhurn, P.6
  • 47
    • 0033038418 scopus 로고    scopus 로고
    • Interacting appetite-regulating pathways in the hypothalamic regulation of body weight
    • Kalra S.P., Dube M.G., Pu S., Xu B., Horvath T.L., Kalra P.S. Interacting appetite-regulating pathways in the hypothalamic regulation of body weight. Endocr Rev 1999, 20:68-100.
    • (1999) Endocr Rev , vol.20 , pp. 68-100
    • Kalra, S.P.1    Dube, M.G.2    Pu, S.3    Xu, B.4    Horvath, T.L.5    Kalra, P.S.6
  • 48
    • 0035313069 scopus 로고    scopus 로고
    • Leptin-induced nuclear translocation of STAT3 immunoreactivity in hypothalamic nuclei involved in body weight regulation
    • Hubschle T., Thom E., Watson A., Roth J., Klaus S., Meyerhof W. Leptin-induced nuclear translocation of STAT3 immunoreactivity in hypothalamic nuclei involved in body weight regulation. J Neurosci 2001, 21:2413-2424.
    • (2001) J Neurosci , vol.21 , pp. 2413-2424
    • Hubschle, T.1    Thom, E.2    Watson, A.3    Roth, J.4    Klaus, S.5    Meyerhof, W.6
  • 50
    • 0036321620 scopus 로고    scopus 로고
    • A phosphatidylinositol 3-kinase phosphodiesterase 3B-cyclic AMP pathway in hypothalamic action of leptin on feeding
    • Zhao A.Z., Huan J.N., Gupta S., Pal R., Sahu A. A phosphatidylinositol 3-kinase phosphodiesterase 3B-cyclic AMP pathway in hypothalamic action of leptin on feeding. Nat Neurosci 2002, 5:727-728.
    • (2002) Nat Neurosci , vol.5 , pp. 727-728
    • Zhao, A.Z.1    Huan, J.N.2    Gupta, S.3    Pal, R.4    Sahu, A.5
  • 51
    • 0034640508 scopus 로고    scopus 로고
    • Activation of downstream signals by the long form of the leptin receptor
    • Banks A.S., Davis S.M., Bates S.H., Myers M.G. Activation of downstream signals by the long form of the leptin receptor. J Biol Chem 2000, 275:14563-14572.
    • (2000) J Biol Chem , vol.275 , pp. 14563-14572
    • Banks, A.S.1    Davis, S.M.2    Bates, S.H.3    Myers, M.G.4
  • 54
    • 62749109421 scopus 로고    scopus 로고
    • Hypothalamic ERK mediates the anorectic and thermogenic sympathetic effects of leptin
    • Rahmouni K., Sigmund C.D., Haynes W.G., Mark A.L. Hypothalamic ERK mediates the anorectic and thermogenic sympathetic effects of leptin. Diabetes 2009, 58:536-542.
    • (2009) Diabetes , vol.58 , pp. 536-542
    • Rahmouni, K.1    Sigmund, C.D.2    Haynes, W.G.3    Mark, A.L.4
  • 57
    • 0023771365 scopus 로고
    • Ultrastructural localization of neuropeptide Y and galanin immunoreactivity in the paraventricular nucleus of the hypothalamus in the rat
    • Sawchenko P.E., Pfeiffer S.W. Ultrastructural localization of neuropeptide Y and galanin immunoreactivity in the paraventricular nucleus of the hypothalamus in the rat. Brain Res 1988, 474:231-245.
    • (1988) Brain Res , vol.474 , pp. 231-245
    • Sawchenko, P.E.1    Pfeiffer, S.W.2
  • 58
    • 77950547451 scopus 로고    scopus 로고
    • POMC-expressing progenitors give rise to antagonistic neuronal populations in hypothalamic feeding circuits
    • Padilla S.L., Carmody J.S., Zeltser L.M. POMC-expressing progenitors give rise to antagonistic neuronal populations in hypothalamic feeding circuits. Nat Med 2010, 16:403-405.
    • (2010) Nat Med , vol.16 , pp. 403-405
    • Padilla, S.L.1    Carmody, J.S.2    Zeltser, L.M.3
  • 59
    • 0029826746 scopus 로고    scopus 로고
    • Joint migration of gonadotropin-releasing hormone (GnRH) and neuropeptide Y (NPY) neurons from olfactory placode to central nervous system
    • Hilal E.M., Chen J.H., Silverman A.J. Joint migration of gonadotropin-releasing hormone (GnRH) and neuropeptide Y (NPY) neurons from olfactory placode to central nervous system. J Neurobiol 1996, 31:487-502.
    • (1996) J Neurobiol , vol.31 , pp. 487-502
    • Hilal, E.M.1    Chen, J.H.2    Silverman, A.J.3


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