Traditional used plants against cognitive decline and Alzheimer disease

Frontiers in Pharmacology

Volumn DEC, Issue , 2010, Pages

  Eckert, Gunter Peter ^a  

^a GOETHE UNIVERSITY   (Germany)

Author keywords

Alzheimer's disease; Ayurveda; Kampo; Tcm; Traditional plants

Indexed keywords

EID: 80054861107     PISSN: None     EISSN: 16639812     Source Type: Journal    
DOI: 10.3389/fphar.2010.00138     Document Type: Article

References (117)

1. Abdel-Kader, R., Hauptmann, S., Keil, U., Scherping, I., Leuner, K., Eckert, A., and Müller, W. E. (2007). Stabilization of mitochondrial function by Ginkgo biloba extract (EGb 761). Pharmacol. Res. 56, 493-502.
2. Akhondzadeh, S., and Abbasi, S. H. (2006). Herbal medicine in the treatment of Alzheimer's disease. Am. J. Alzheimers Dis. Other Demen. 21, 113-118.
3. Akhondzadeh, S., Noroozian, M., Mohammadi, M., Ohadinia, S., Jamshidi, A. H., and Khani, M. (2003a). Melissa officinalis extract in the treatment of patients with mild to moderate Alzheimer's disease: a double blind, randomised, placebo controlled trial. J. Neurol. Neurosurg. Psychiatr. 74, 863-866.
4. Akhondzadeh, S., Noroozian, M., Mohammadi, M., Ohadinia, S., Jamshidi, A. H., and Khani, M. (2003b). Salvia officinalis extract in the treatment of patients with mild to moderate Alzheimer's disease: a double blind, randomized and placebocontrolled trial. J. Clin. Pharm. Ther. 28, 53-59.
5. Akhondzadeh, S., Shafiee Sabet, M., Harirchian, M. H., Togha, M., Cheraghmakani, H., Razeghi, S., Hejazi, S. S., Yousefi, M. H., Alimardani, R., Jamshidi, A., Rezazadeh, S. A., Yousefi, A., Zare, F., Moradi, A., and Vossoughi, A. (2010). A 22-week, multicenter, randomized, double-blind controlled trial of Crocus sativus in the treatment of mild-to-moderate Alzheimer's disease. Psychopharmacology (Berl.) 207, 637-643.
6. Andrieu, S., Ousset, P. J., Coley, N., Ouzid, M., Mathiex-Fortunet, H., and Vellas, B. (2008). GuidAge study: a 5-year double blind, randomised trial of EGb 761 for the prevention of Alzheimer's disease in elderly subjects with memory complaints. i. rationale, design and baseline data. Curr. Alzheimer Res. 5, 406-415.
7. Arendt, T. (2009). Synaptic degeneration in Alzheimer's disease. Acta Neuropathol. 118, 167-179.
8. Arulselvan, P., and Subramanian, S. P. (2007). Beneficial effects of Murraya koenigii leaves on antioxidant defense system and ultra structural changes of pancreatic beta-cells in experimental diabetes in rats. Chem. Biol. Interact. 165, 155-164.
9. Barrios-Gonzalez, J., and Miranda, R. U. (2010). Biotechnological production and applications of statins. Appl. Microbiol. Biotechnol. 85, 869-883.
10. Bastianetto, S., Ramassamy, C., Dore, S., Christen, Y., Poirier, J., and Quirion, R. (2000). The Ginkgo biloba extract (EGb 761) protects hippocampal neurons against cell death induced by beta-amyloid. Eur. J. Neurosci. 12, 1882-1890.
11. Baurle, P., Suter, A., and Wormstall, H. (2009). Safety and effectiveness of a traditional ginkgo fresh plant extract - results from a clinical trial. Forsch. Komplementmed. 16, 156-161.
12. Birari, R., Javia, V., and Bhutani, K. K. (2010). Antiobesity and lipid lowering effects of Murraya koenigii (L.) Spreng leaves extracts and mahanimbine on high fat diet induced obese rats. Fitoterapia 81, 1129-1133.
13. Bradwejn, J., Zhou, Y., Koszycki, D., and Shlik, J. (2000). A double-blind, placebo-controlled study on the effects of Gotu Kola (Centella asiatica) on acoustic startle response in healthy subjects. J. Clin. Psychopharmacol. 20, 680-684.
14. Calabrese, C., Gregory, W. L., Leo, M., Kraemer, D., Bone, K., and Oken, B. (2008). Effects of a standardized Bacopa monnieri extract on cognitive performance, anxiety, and depression in the elderly: a randomized, double-blind, placebo-controlled trial. J. Altern. Complement. Med. 14, 707-713.
15. Choi, B. M., Kim, H. J., Oh, G. S., Pae, H. O., Oh, H., Jeong, S., Kwon, T. O., Kim, Y. M., and Chung, H. T. (2002). 1,2,3,4,6-Penta-O-galloyl-beta-dglucose protects rat neuronal cells (Neuro 2A) from hydrogen peroxidemediated cell death via the induction of heme oxygenase-1. Neurosci. Lett. 328, 185-189.
16. Chou, C. H., Gong, C. L., Chao, C. C., Lin, C. H., Kwan, C. Y., Hsieh, C. L., and Leung, Y. M. (2009). Rhynchophylline from Uncaria rhynchophylla functionally turns delayed rectifiers into A-Type K+ channels. J. Nat. Prod. 72, 830-834.
17. Christen, Y. (2004). Ginkgo biloba and neurodegenerative disorders. Front. Biosci. 9, 3091-3104.
18. Citron, M. (2010). Alzheimer's disease: strategies for disease modification. Nat. Rev. Drug Discov. 9, 387-398.
19. Dastmalchi, K., Ollilainen, V., Lackman, P., Boije af Gennas, G., Dorman, H. J., Jarvinen, P. P., Yli-Kauhaluoma, J., and Hiltunen, R. (2009). Acetylcholinesterase inhibitory guided fractionation of Melissa officinalis L. Bioorg. Med. Chem. 17, 867-871.
20. de Caires, S., and Steenkamp, V. (2010). Use of Yokukansan (TJ-54) in the treatment of neurological disorders: a review. Phytother. Res. 24, 1265-1270.
21. Dhanasekaran, M., Holcomb, L. A., Hitt, A. R., Tharakan, B., Porter, J. W., Young, K. A., and Manyam, B. V. (2009). Centella asiatica extract selectively decreases amyloid beta levels in hippocampus of Alzheimer's disease animal model. Phytother. Res. 23, 14-19.
22. Dharmananda, S. (2004). Kampo Medicine - The Practice of Chinese Herbal Medicine in Japan. Portland. OR: Institute for Traditional Medicine.
23. Drever, B. D., Anderson, W. G., Riedel, G., Kim, D. H., Ryu, J. H., Choi, D. Y., and Platt, B. (2008). The seed extract of Cassia obtusifolia offers neuroprotection to mouse hippocampal cultures. J. Pharmacol. Sci. 107, 380-392.
24. Eckert, A., Keil, U., Scherping, I., Hauptmann, S., and Müller, W. E. (2005). Stabilization of mitochondrial membrane potential and improvement of neuronal energy metabolism by Ginkgo Biloba extract EGb 761. Ann. N. Y. Acad. Sci. 1056, 474-485.
25. Egashira, N., Iwasaki, K., Akiyoshi, Y., Takagaki, Y., Hatip-Al-Khatib, I., Mishima, K., Kurauchi, K., Ikeda, T., and Fujiwara, M. (2005). Protective effect of Toki-shakuyaku-san on amyloid beta25-35-induced neuronal damage in cultured rat cortical neurons. Phytother. Res. 19, 450-453.
26. Evans, J. G., Wilcock, G., and Birks, J. (2004). Evidence-based pharmacotherapy of Alzheimer's disease. Int. J. Neuropsychopharmacol. 7, 351-369.
27. Ferri, C. P., Prince, M., Brayne, C., Brodaty, H., Fratiglioni, L., Ganguli, M., Hall, K., Hasegawa, K., Hendrie, H., Huang, Y., Jorm, A., Mathers, C., Menezes, P. R., Rimmer, E., and Scazufca, M. (2005). Global prevalence of dementia: a Delphi consensus study. Lancet 366, 2112-2117.
28. Fujiwara, H., Iwasaki, K., Furukawa, K., Seki, T., He, M., Maruyama, M., Tomita, N., Kudo, Y., Higuchi, M., Saido, T. C., Maeda, S., Takashima, A., Hara, M., Ohizumi, Y., and Arai, H. (2006). Uncaria rhynchophylla, a Chinese medicinal herb, has potent antiaggregation effects on Alzheimer's beta-amyloid proteins. J. Neurosci. Res. 84, 427-433.
29. Fujiwara, H., Tabuchi, M., Yamaguchi, T., Iwasaki, K., Furukawa, K., Sekiguchi, K., Ikarashi, Y., Kudo, Y., Higuchi, M., Saido, T. C., Maeda, S., Takashima, A., Hara, M., Yaegashi, N., Kase, Y., and Arai, H. (2009). A traditional medicinal herb Paeonia suffruticosa and its active constituent 1,2,3,4,6-penta-Ogalloyl-beta-d-glucopyranose have potent anti-aggregation effects on Alzheimer's amyloid beta proteins in vitro and in vivo. J. Neurochem. 109, 1648-1657.
30. Garcia-Alloza, M., Dodwell, S. A., Meyer-Luehmann, M., Hyman, B. T., and Bacskai, B. J. (2006). Plaque-derived oxidative stress mediates distorted neurite trajectories in the Alzheimer mouse model. J. Neuropathol. Exp. Neurol. 65, 1082-1089.
31. Haass, C., and Selkoe, D. J. (2007). Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Nat. Rev. Mol. Cell Biol. 8, 101-112.
32. Hayashi, Y., Ishida, Y., Inoue, T., Udagawa, M., Takeuchi, K., Yoshimuta, H., Kiue, K., Ninomiya, Y., Kawano, J., Sameshima, T., Kawahara, T., Goto, I., Shudo, K., Kurayama, S., Nakamura, J., Okahara, K., and Mitsuyama, Y. (2010). Treatment of behavioral and psychological symptoms of Alzheimer-type dementia with Yokukansan in clinical practice. Prog. Neuropsychopharmacol. Biol. Psychiatry 34, 541-545.
33. Heinrich, M. (2010). Galanthamine from Galanthus and other Amaryllidaceae-chemistry and biology based on traditional use. Alkaloids Chem. Biol. 68, 157-165.
34. Heinrich, M., and Lee Teoh, H. (2004). Galanthamine from snowdrop - the development of a modern drug against Alzheimer's disease from local Caucasian knowledge. J. Ethnopharmacol. 92, 147-162.
35. Ho, Y. S., Yu, M. S., Yang, X. F., So, K. F., Yuen, W. H., and Chang, R. C. (2010). Neuroprotective effects of polysaccharides from wolfberry, the fruits of Lycium barbarum, against homocysteine-induced toxicity in rat cortical neurons. J. Alzheimers Dis. 19, 813-827.
36. Houghton, P. J., and Howes, M. J. (2005). Natural products and derivatives affecting neurotransmission relevant to Alzheimer's and Parkinson's disease. Neurosignals 14, 6-22.
37. Howes, M. J., Perry, N. S., and Houghton, P. J. (2003). Plants with traditional uses and activities, relevant to the management of Alzheimer's disease and other cognitive disorders. Phytother. Res. 17, 1-18.
38. Hsieh, C. L., Cheng, C. Y., Tsai, T. H., Lin, I. H., Liu, C. H., Chiang, S. Y., Lin, J. G., Lao, C. J., and Tang, N. Y. (2006). Paeonol reduced cerebral infarction involving the superoxide anion and microglia activation in ischemia-reperfusion injured rats. J. Ethnopharmacol. 106, 208-215.
39. Hsieh, C. L., Ho, T. Y., Su, S. Y., Lo, W. Y., Liu, C. H., and Tang, N. Y. (2009). Uncaria rhynchophylla and Rhynchophylline inhibit c-Jun N-terminal kinase phosphorylation and nuclear factor-kappaB activity in kainic acid-treated rats. Am. J. Chin. Med. 37, 351-360.
40. Hu, Z. Y., Liu, G., Yuan, H., Yang, S., Zhou, W. X., Zhang, Y. X., and Qiao, S. Y. (2010). Danggui-Shaoyao-San and its active fraction JD-30 improve Abeta-induced spatial recognition deficits in mice. J. Ethnopharmacol. 128, 365-372.
41. Itoh, T., Michijiri, S., Murai, S., Saito, H., Nakamura, K., Itsukaichi, O., Fujiwara, H., and Ookubo, N. (1996). Regulatory effect of Danggui-Shaoyao-San on central cholinergic nervous system dysfunction in mice. Am. J. Chin. Med. 24, 205-217.
42. Iuvone, T., De Filippis, D., Esposito, G., D'Amico, A., and Izzo, A. A. (2006). The spice sage and its active ingredient rosmarinic acid protect PC12 cells from amyloid-beta peptide-induced neurotoxicity. J. Pharmacol. Exp. Ther. 317, 1143-1149.
43. Iwata, N., Tsubuki, S., Takaki, Y., Watanabe, K., Sekiguchi, M., Hosoki, E., Kawashima-Morishima, M., Lee, H. J., Hama, E., Sekine-Aizawa, Y., and Saido, T. C. (2000). Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition. Nat. Med. 6, 143-150.
44. Jia, L., Zhao, Y., and Liang, X. J. (2009). Current evaluation of the millennium phytomedicine - ginseng (II): collected chemical entities, modern pharmacology, and clinical applications emanated from traditional Chinese medicine. Curr. Med. Chem. 16, 2924-2942.
45. Joshi, H., and Parle, M. (2006). Antiamnesic effects of Desmodium gangeticum in mice. Yakugaku Zasshi 126, 795-804.
46. Jung, J. W., Ahn, N. Y., Oh, H. R., Lee, B. K., Lee, K. J., Kim, S. Y., Cheong, J. H., and Ryu, J. H. (2006). Anxiolytic effects of the aqueous extract of Uncaria rhynchophylla. J. Ethnopharmacol. 108, 193-197.
47. Kawasaki, T., Yamanouchi, T., Kashiwabara, A., Inoue, T., Yoshimura, T., Fujimori, S., Tanabe, T., and Aiso, Y. (2000). The influence of traditional Chinese herbal drugs on serum 1, 5-anhydroglucitol levels. Diabetes Res. Clin. Pract. 50, 97-101.
48. Kennedy, D. O., and Scholey, A. B. (2006). The psychopharmacology of European herbs with cognitionenhancing properties. Curr. Pharm. Des. 12, 4613-4623.
49. Kim, D. H., Hyun, S. K., Yoon, B. H., Seo, J. H., Lee, K. T., Cheong, J. H., Jung, S. Y., Jin, C., Choi, J. S., and Ryu, J. H. (2009). Gluco-obtusifolin and its aglycon, obtusifolin, attenuate scopolamine-induced memory impairment. J. Pharmacol. Sci. 111, 110-116.
50. Kimura, T., Hayashida, H., Furukawa, H., and Takamatsu, J. (2010). Pilot study of pharmacological treatment for frontotemporal dementia: effect of Yokukansan on behavioral symptoms. Psychiatry Clin. Neurosci. 64, 207-210.
51. Komatsu, M., Ueda, Y., and Hiramatsu, M. (1999). Different changes in concentrations of monoamines and their metabolites and amino acids in various brain regions by the herbal medicine/Toki- Shakuyaku-San between female and male senescence-accelerated mice (SAMP8) [In Process Citation]. Neurochem. Res. 24, 825-831.
52. Kou, J., Zhu, D., and Yan, Y. (2005). Neuroprotective effects of the aqueous extract of the Chinese medicine Danggui-Shaoyao-san on aged mice. J. Ethnopharmacol. 97, 313-318.
53. Kumar, V. (2006). Potential medicinal plants for CNS disorders: an overview. Phytother. Res. 20, 1023-1035.
54. Lai, C. S., Yu, M. S., Yuen, W. H., So, K. F., Zee, S. Y., and Chang, R. C. (2008). Antagonizing beta-amyloid peptide neurotoxicity of the anti-aging fungus Ganoderma lucidum. Brain Res. 1190, 215-224.
55. Le Bars, P. L. (2003). Magnitude of effect and special approach to Ginkgo biloba extract EGb 761 in cognitive disorders. Pharmacopsychiatry 36(Suppl. 1), S44-S49.
56. Lee, C. L., Kuo, T. F., Wang, J. J., and Pan, T. M. (2007). Red mold rice ameliorates impairment of memory and learning ability in intracerebroventricular amyloid beta-infused rat by repressing amyloid beta accumulation. J. Neurosci. Res. 85, 3171-3182.
57. Lee, C. L., Kuo, T. F., Wu, C. L., Wang, J. J., and Pan, T. M. (2010). Red mold rice promotes neuroprotective sAPPalpha secretion instead of Alzheimer's risk factors and amyloid beta expression in hyperlipidemic Abeta40-infused rats. J. Agric. Food Chem. 58, 2230-2238.
58. Lee, C. L., Tsai, T. Y., Wang, J. J., and Pan, T. M. (2006). In vivo hypolipidemic effects and safety of low dosage Monascus powder in a hamster model of hyperlipidemia. Appl. Microbiol. Biotechnol. 70, 533-540.
59. Lee, J., Son, D., Lee, P., Kim, D. K., Shin, M. C., Jang, M. H., Kim, C. J., Kim, Y. S., Kim, S. Y., and Kim, H. (2003). Protective effect of methanol extract of Uncaria rhynchophylla against excitotoxicity induced by N-methyld-aspartate in rat hippocampus. J. Pharmacol. Sci. 92, 70-73.
60. Lee, J. S., Yoo, H., Suh, Y. G., Jung, J. K., and Kim, J. (2008). Structure-activity relationship of pentacylic triterpene esters from Uncaria rhynchophylla as inhibitors of phospholipase Cgamma1. Planta Med. 74, 1481-1487.
61. Li, C., Yang, J., Yu, S., Chen, N., Xue, W., Hu, J., and Zhang, D. (2008a). Triterpenoid saponins with neuroprotective effects from the roots of Polygala tenuifolia. Planta Med. 74, 133-141.
62. Li, M. H., Chen, J. M., Peng, Y., Wu, Q., and Xiao, P. G. (2008b). Investigation of Danshen and related medicinal plants in China. J. Ethnopharmacol. 120, 419-426.
63. Lin, H. Q., Ho, M. T., Lau, L. S., Wong, K. K., Shaw, P. C., and Wan, D. C. (2008). Anti-acetylcholinesterase activities of traditional Chinese medicine for treating Alzheimer's disease. Chem. Biol. Interact. 175, 352-354.
64. Liu, P., Hu, Y., Guo, D. H., Lu, B. R., Rahman, K., Mu, L. H., and Wang, D. X. (2010a). Antioxidant activity of oligosaccharide ester extracted from Polygala tenuifolia roots in senescenceaccelerated mice. Pharm. Biol. 48, 828-833.
65. Liu, T., Jin, H., Sun, Q. R., Xu, J. H., and Hu, H. T. (2010b). The neuroprotective effects of Tanshinone IIA on beta-amyloid-induced toxicity in rat cortical neurons. Neuropharmacology 59, 594-604.
66. Luo, C., Wu, Q., Huang, X. N., Sun, A. S., and Shi, J. S. (2003). Ginkgo biloba leaf extract enhances levels of caspase-3 and amyloid precursor protein in normal rat hippocampus. Acta Pharmacol. Sin. 24, 152-156.
67. Lv, J., Jia, H., Jiang, Y., Ruan, Y., Liu, Z., Yue, W., Beyreuther, K., Tu, P., and Zhang, D. (2009). Tenuifolin, an extract derived from tenuigenin, inhibits amyloid-beta secretion in vitro. Acta Physiol. (Oxf.) 196, 419-425.
68. Ma, J., Li, Y., Ye, Q., Li, J., Hua, Y., Ju, D., Zhang, D., Cooper, R., and Chang, M. (2000). Constituents of red yeast rice, a traditional Chinese food and medicine. J. Agric. Food Chem. 48, 5220-5225.
69. Maruyama, M., Tomita, N., Iwasaki, K., Ootsuki, M., Matsui, T., Nemoto, M., Okamura, N., Higuchi, M., Tsutsui, M., Suzuki, T., Seki, T., Kaneta, T., Furukawa, K., and Arai, H. (2006). Benefits of combining donepezil plus traditional Japanese herbal medicine on cognition and brain perfusion in Alzheimer's disease: a 12-week observer-blind, donepezil monotherapy controlled trial. J. Am. Geriatr. Soc. 54, 869-871.
70. Mashkovsky, M. D., and Kruglikova-Lvov, R. P. (1951). On the pharmacology of the new alklaloid galantamine. Farmakol. Toxicol. (Moscow) 14, 27-30.
71. Mattson, M. P. (2004). Pathways towards and away from Alzheimer's disease. Nature 430, 631-639.
72. Mazza, M., Capuano, A., Bria, P., and Mazza, S. (2006). Ginkgo biloba and donepezil: a comparison in the treatment of Alzheimer's dementia in a randomized placebo-controlled double-blind study. Eur. J. Neurol. 13, 981-985.
73. Müller, W. E., Eckert, A., Kurz, C., Eckert, G. P., and Leuner, K. (2010). Mitochondrial dysfunction: common final pathway in brain aging and Alzheimer's disease - therapeutic aspects. Mol. Neurobiol. 41, 159-171.
74. Naito, R., and Tohda, C. (2006). Characterization of anti-neurodegenerative effects of Polygala tenuifolia in Abeta(25-35)-treated cortical neurons. Biol. Pharm. Bull. 29, 1892-1896.
75. Ng, T. B. (2006). Pharmacological activity of sanchi ginseng (Panax notoginseng). J. Pharm. Pharmacol. 58, 1007-1019.
76. Nishizawa, K., Inoue, O., Saito, Y., and Suzuki, A. (1994). Protective effects of kamikihi-to, a traditional Chinese medicine, against cerebral ischemia, hypoxia and anoxia in mice and gerbils. Jpn. J. Pharmacol. 64, 171-177.
77. Oh, M. H., Houghton, P. J., Whang, W. K., and Cho, J. H. (2004). Screening of Korean herbal medicines used to improve cognitive function for anticholinesterase activity. Phytomedicine 11, 544-548.
78. Pendry, B., Busia, K., and Bell, C. M. (2005). Phytochemical evaluation of selected antioxidant-containing medicinal plants for use in the preparation of a herbal formula - a preliminary study. Chem. Biodivers. 2, 917-922.
79. Qian, Y. F., Wang, H., Yao, W. B., and Gao, X. D. (2008). Aqueous extract of the Chinese medicine, Danggui-Shaoyao-San, inhibits apoptosis in hydrogen peroxide-induced PC12 cells by preventing cytochrome c release and inactivating of caspase cascade. Cell Biol. Int. 32, 304-311.
80. Qiu, C., De Ronchi, D., and Fratiglioni, L. (2007). The epidemiology of the dementias: an update. Curr. Opin. Psychiatry 20, 380-385.
81. Qiu, C., Kivipelto, M., and von Strauss, E. (2009). Epidemiology of Alzheimer'sdisease: occurrence, determinants, and strategies toward intervention. Dialogues Clin. Neurosci. 11, 111-128.
82. Ren, Y., Houghton, P., and Hider, R. C. (2006). Relevant activities of extracts and constituents of animals used in traditional Chinese medicine for central nervous system effects associated with Alzheimer's disease. J. Pharm. Pharmacol. 58, 989-996.
83. Ren, Y., Houghton, P. J., Hider, R. C., and Howes, M. J. (2004). Novel diterpenoid acetylcholinesterase inhibitors from Salvia miltiorhiza. Planta Med. 70, 201-204.
84. Schindowski, K., Leutner, S., Kressmann, S., Eckert, A., and Müller, W. E. (2001). Age-related increase of oxidative stressinduced apoptosis in mice prevention by Ginkgo biloba extract (EGb761). J. Neural Transm. 108, 969-978.
85. Sekiguchi, K., Yamaguchi, T., Tabuchi, M., Ikarashi, Y., and Kase, Y. (2009). Effects of yokukansan, a traditional Japanese medicine, on aggressiveness induced by intracerebroventricular injection of amyloid beta protein into mice. Phytother. Res. 23, 1175-1181.
86. Shi, J. S., Yu, J. X., Chen, X. P., and Xu, R. X. (2003). Pharmacological actions of Uncaria alkaloids, Rhynchophylline and Isorhynchophylline. Acta Pharmacol. Sin. 24, 97-101.
87. Stackman, R. W., Eckenstein, F., Frei, B., Kulhanek, D., Nowlin, J., and Quinn, J. F. (2003). Prevention of age-related spatial memory deficits in a transgenic mouse model of Alzheimer's disease by chronic Ginkgo biloba treatment. Exp. Neurol. 184, 510-520.
88. Stoll, S., Scheuer, K., Pohl, O., and Müller, W. E. (1996). Ginkgo biloba extract (EGb 761) independently improves changes in passive avoidance learning and brain membrane fluidity in the aging mouse. Pharmacopsychiatry 29, 144-149.
89. Sun, Y., Xie, T. T., Wang, D. X., and Liu, P. (2009). Effect of Polygala tenuifolia Willd YZ-50 on the mRNA expression of brain-derived neurotrophic factor and its receptor TrkB in rats with chronic stress depression. Nan Fang Yi Ke Da Xue Xue Bao 29, 1199-1203.
90. Tabuchi, M., Yamaguchi, T., Iizuka, S., Imamura, S., Ikarashi, Y., and Kase, Y. (2009). Ameliorative effects of yokukansan, a traditional Japanese medicine, on learning and noncognitive disturbances in the Tg2576 mouse model of Alzheimer's disease. J. Ethnopharmacol. 122, 157-162.
91. Tamura, T., Tohda, C., and Kamatsu, K. (2002). Therapeutic effects of Zokumei-to on spatial learning impairment and synaptic loss in a mouse model of Alzheimer's disease. Bull. Jpn. Soc. Neurochem. 41, 352.
92. Tang, W. K., Ungvari, G. S., and Leung, H. C. M. (2002). Effect of piracetam on ECT-induced cognitive disturbances: a randomized, placebo-controlled, double-blind study. J. ECT 18, 130-137.
93. Tohda, C., Naito, R., and Joyashiki, E. (2008). Kihi-to, a herbal traditional medicine, improves Abeta(25-35)-induced memory impairment and losses of neurites and synapses. BMC Complement. Altern. Med. 8, 49. doi: 10.1186/1472-6882-8-49.
94. Tohda, C., Tamura, T., and Komatsu, K. (2003). Repair of amyloid beta(25- 35)-induced memory impairment and synaptic loss by a Kampo formula, Zokumei-to. Brain Res. 990, 141-147.
95. Tsolaki, M., Pantazi, T., and Kazis, A. (2001). Efficacy of acetylcholinesterase inhibitors versus nootropics in Alzheimer's disease: a retrospective, longitudinal study. J. Int. Med. Res. 29, 28-36.
96. Tsuyoshi, M., and Jun, H. (2009). Clinical potential of Yi-Gan San (Yokukansan) for the treatment of psychiatric disorders. Curr. Psychiatry Rev. 5, 271-275.
97. Uabundit, N., Wattanathorn, J., Mucimapura, S., and Ingkaninan, K. (2010). Cognitive enhancement and neuroprotective effects of Bacopa monnieri in Alzheimer's disease model. J. Ethnopharmacol. 127, 26-31.
98. Umeyama, A., Yahisa, Y., Okada, M., Okayama, E., Uda, A., Shoji, N., Lee, J. J., Takei, M., and Hashimoto, T. (2010). Triterpene esters from Uncaria rhynchophylla drive potent IL-12-dependent Th1 polarization. J. Nat. Med. 64, 506-509.
99. Vasudevan, M., and Parle, M. (2009). Antiamnesic potential of Murraya koenigii leaves. Phytother. Res. 23, 308-316.
100. Veerendra Kumar, M. H., and Gupta, Y. K. (2003). Effect of Centella asiatica on cognition and oxidative stress in an intracerebroventricular streptozotocin model of Alzheimer's disease in rats. Clin. Exp. Pharmacol. Physiol. 30, 336-342.
101. Wang, T. H., and Lin, T. F. (2007). Monascus rice products. Adv. Food Nutr. Res. 53, 123-159.
102. Wang, Y. H., and Du, G. H. (2009). Ginsenoside Rg1 inhibits beta-secretase activity in vitro and protects against Abeta-induced cytotoxicity in PC12 cells. J. Asian. Nat. Prod. Res. 11, 604-612.
103. Watanabe, C. M., Wolffram, S., Ader, P., Rimbach, G., Packer, L., Maguire, J. J., Schultz, P. G., and Gohil, K. (2001). The in vivo neuromodulatory effects of the herbal medicine Ginkgo biloba. Proc. Natl. Acad. Sci. U.S.A. 98, 6577-6580.
104. Wimo, A., Winblad, B., Aguero-Torres, H., and von Strauss, E. (2003). The magnitude of dementia occurrence in the world. Alzheimer Dis. Assoc. Disord. 17, 63-67.
105. Xie, J. T., Chang, W. T., Wang, C. Z., Mehendale, S. R., Li, J., Ambihaipahar, R., Ambihaipahar, U., Fong, H. H., and Yuan, C. S. (2006). Curry leaf (Murraya koenigii Spreng.) reduces blood cholesterol and glucose levels in ob/ob mice. Am. J. Chin. Med. 34, 279-284.
106. Xu, Y., Cao, Z., Khan, I., and Luo, Y. (2008). Gotu Kola (Centella Asiatica) extract enhances phosphorylation of cyclic AMP response element binding protein in neuroblastoma cells expressing amyloid beta peptide. J. Alzheimers Dis. 13, 341-349.
107. Xue, W., Hu, J. F., Yuan, Y. H., Sun, J. D., Li, B. Y., Zhang, D. M., Li, C. J., and Chen, N. H. (2009). Polygalasaponin XXXII from Polygala tenuifolia root improves hippocampal-dependent learning and memory. Acta Pharmacol. Sin. 30, 1211-1219.
108. Yabe, T., Tuchida, H., Kiyohara, H., Takeda, T., and Yamada, H. (2003). Induction of NGF synthesis in astrocytes by onjisaponins of Polygala tenuifolia, constituents of kampo (Japanese herbal) medicine, Ninjin-yoei-to. Phytomedicine 10, 106-114.
109. Yamaguchi, K., Kido, H., Kawakatsu, T., Fukuroi, T., Suzuki, M., Yanabu, M., Nomura, S., Kokawa, T., and Yasunaga, K. (1993). Effects of kami-kihi-to (jiawei-gui-pi-tang) on autoantibodies in patients with chronic immune thrombocytopenic purpura. Am. J. Chin. Med. 21, 251-255.
110. Yan, H., Li, L., and Tang, X. C. (2007). Treating senile dementia with traditional Chinese medicine. Clin Interv Aging 2, 201-208.
111. Yang, L., Hao, J., Zhang, J., Xia, W., Dong, X., Hu, X., Kong, F., and Cui, X. (2009). Ginsenoside Rg3 promotes beta-amyloid peptide degradation by enhancing gene expression of neprilysin. J. Pharm. Pharmacol. 61, 375-380.
112. Yao, Z. X., Drieu, K., and Papadopoulos, V. (2001). The Ginkgo biloba extract EGb 761 rescues the PC12 neuronal cells from beta-amyloid-induced cell death by inhibiting the formation of beta-amyloid-derived diffusible neurotoxic ligands. Brain Res. 889, 181-190.
113. Yin, Y., Huang, L., Liu, Y., Huang, S., Zhuang, J., Chen, X., Zhang, L., Wu, H., Shao, F., and Zhao, Z. (2008). Effect of tanshinone on the levels of nitric oxide synthase and acetylcholinesterase in the brain of Alzheimer's disease rat model. Clin. Invest. Med. 31, E248-E257.
114. Yu, M. S., Leung, S. K., Lai, S. W., Che, C. M., Zee, S. Y., So, K. F., Yuen, W. H., and Chang, R. C. (2005). Neuroprotective effects of anti-aging oriental medicine Lycium barbarum against betaamyloid peptide neurotoxicity. Exp. Gerontol. 40, 716-727.
115. Yuen, M. F., Tam, S., Fung, J., Wong, D. K., Wong, B. C., and Lai, C. L. (2006). Traditional Chinese medicine causing hepatotoxicity in patients with chronic hepatitis B infection: a 1-year prospective study. Aliment. Pharmacol. Ther. 24, 1179-1186.
116. Zhou, Y. Q., Yang, Z. L., Xu, L., Li, P., and Hu, Y. Z. (2009). Akebia saponin D, a saponin component from Dipsacus asper Wall, protects PC 12 cells against amyloid-beta induced cytotoxicity. Cell Biol. Int. 33, 1102-1110.
117. Ziegler-Graham, K., Brookmeyer, R., Johnson, E., and Arrighi, H. M. (2008). Worldwide variation in the doubling time of Alzheimer's disease incidence rates. Alzheimers Dement, 4, 316-323.