Ginkgo biloba leaf extract enhances levels of caspase-3 and amyloid precursor protein in normal rat hippocampus

Acta Pharmacologica Sinica

Volumn 24, Issue 2, 2003, Pages 152-156

  Luo, Can ^a   Wu, Qin ^a   Huang, Xie Nan ^a   Sun, An Sheng ^a   Shi, Jing Shan ^a  

^a ZUNYI MEDICAL UNIVERSITY   (China)

Author keywords

Amyloid beta protein precursor; Caspases; Ginkgo biloba; Immunohistochemisty

Indexed keywords

AMYLOID PRECURSOR PROTEIN; CASPASE 3; GINKGO BILOBA EXTRACT;

AGE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; GINKGO BILOBA; HIPPOCAMPUS; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; PLANT LEAF; PROTEIN EXPRESSION; RAT; STAINING;

AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; CASPASE 3; CASPASES; DRUGS, CHINESE HERBAL; ENZYME PRECURSORS; GINKGO BILOBA; HIPPOCAMPUS; MALE; PLANT LEAVES; PLANTS, MEDICINAL; RATS; RATS, WISTAR;

EID: 0037309645     PISSN: 16714083     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Hardy JA, Higgins GA. Alzheimer's disease: The amyloid cascade hypothesis. Science 1992; 256: 184-5.
2. Elkoe DJ. Translating cell biology into therapeutic advances in Alzheimer's disease. Nature 1999; 399: A23-31.
3. Games D, Adams D, Alessandrini R, Barbour R, Berthelette P, Blackwell C, et al. Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein. Nature 1995; 373: 523-7.
4. Hsiao K, Chapman P, Nilsen S, Eckman C, Harigaya Y, Younkin S, et al. Correlative memory deficits, Aβ elevation, and amyloid plaques in transgenic mice. Science 1996; 274: 99-102.
5. Gervais FG, Xu D, Robertson GS, Vaillancourt JP, Zhu Y, Huang J, et al. Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation. Cell 1999; 97: 395-406.
6. Soriano S, Lu DC, Chandra S, Pietrzik CU, Koo EH. The amyloidogenic pathway of amyloid precursor protein (APP) is independent of its cleavage by caspases. J Biol Chem 2001; 276: 29045-50.
7. Kanowski S, Herrmann WM, Stephan K, Wierich W, Horr R. Proof of efficacy of the Ginkgo biloba special extract (GbE 761) in outpatients suffering from mild to moderate primary degenerative dementia of the Alzheimer type or multi-infarct dementia. Pharmacopsychiatry 1996; 29: 47-56.
8. Le Bars PL, Katz MM, Berman N, Itil TM, Freedman AM, Schatzberg AF, et al. A placebo-controlled, double-blind, randomized trial of an extract of Ginkgo biloba for dementis. North American EGb study group. JAMA 1997; 278: 1327-32.
9. Hofferberth B. The efficacy of GbE 761 in patients with senile dementia of Alzheimer type, A double-blind, placebo-controlled study on different levels of investigation. Human Psychopharmacol 1994; 9: 215-22.
10. Wirth S, Stemmelin J, Will B, Christen YVES, Di Scala G. Facilitative effects of EGb 761 on olfactory recognition in young and aged rats. Pharmacol Biochem Behav 2000; 65: 321-6.
11. Winter JC. The effects of an extract of Ginkgo biloba, EGb 761, on cognitive behavior and longevity in the rat. Physiol Behav 1998; 63: 425-33.
12. Yang SF, Yang ZQ, Wu Q, Sun AS, Huang XN, Shi JS. Protective effect and mechanism of Ginkgo biloba leaf extracts for Parkinson disease induced by 1-methyl-4-phenyl-l,2,3, 6-tetrahydropyridine. Acta Pharmacol Sin 2001; 22: 1089-93.
13. Kiegstein J. Neuroprotective properties of Ginkgo biloba constituents demonstrated in vivo and vitro. J Rev Bras Neurol Agosto 1994; 30 (Suppl 1): 7.
14. Zhang Y, Ming L, Li JP, Li WP, Fang M. Protective effects of Egb on apoptosis of neurons. Chin J Pharmacol Ther 2001; 6: 25-7.
15. Pietri S, Maurelli E, Drieu K, Culcasi M. Cardioprotective and anti-oxidant effects of the terpenoid constituents of Ginkgo biloba extract (EGb 761). J Mol Cell Cardiol 1997; 29: 733-42.
16. Janssens D, Michiels C, Delaive E, Eliaers F, Drieu K, et al. Protection of hypoxia-induced ATP decrease in endothelial cells by Ginkgo biloba extract and bilobalide. Biochem Pharmacol 1995; 50: 991-9.
17. Turcan M, Cozmei C, Carasevici E, Haulica I. Effect of the EGb 761 (Ginkgo bilboa extract) on primary immune response in experimental chronic stress. Rev Med Chir Soc Med Nat Iasi 1995; 99: 154-9.
18. Kim YS, Pyo MK, Park KM, Park PH, Hahn BS, Wu SJ, et al. Antiplatelet and antithrombotic effects of a combination of ticlopidine and Ginkgo biloba ext (EGb 761). Thromb Res 1998; 91: 33-8.
19. Sastre J, Millan A, Garcia de la Asuncion J, Pla R, Juan G, Pallardo, et al. A Ginkgo biloba extract (EGb 761) prevents mitochondrial aging by protecting against oxidative stress. Free Radic Biol Med 1998; 24: 298-304.
20. Wettstein A. Cholinesterase inhibitor and ginkgo extracts in therapy of dementia. A comparison of effectiveness based on controlled studies. Fortschr Med 1999; 117: 48-9.
21. Winter JC. The effects of an extract of Ginkgo biloba, EGb 761, on cognitive behavior and longevity in the rat. Physiol Behav 1998; 63: 425-33.
22. Selkoe DJ. Physiological production of the ss-amyloid protein and the mechanism of Alzheimer's disease. Trends Neurol Sci 1993; 16: 403-9.
23. Selkoe DJ. Alzheimer's disease: genotypes, phenotype, and treatments. Science 1997; 275: 630-1.
24. Lu DC, Rabizadeh S, Chandra S, Shayya RF, Ellerby LM, Ye X, et al. A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor. Nat Med 2000; 6: 397-404.
25. Perez RG, Soriano S, Hayes JD, Ostaszewski, B, Xia W, Selkoe DJ, et al. Mutagenesis identifies new signals for β-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Aβ42. J Biol Chem 1999; 274: 18851-6.