Triterpene esters from Uncaria rhynchophylla drive potent IL-12-dependent Th1 polarization

Journal of Natural Medicines

Volumn 64, Issue 4, 2010, Pages 506-509

  Umeyama, Akemi ^a   Yahisa, Yoshinori ^a   Okada, Minori ^a   Okayama, Eriko ^a   Uda, Ayaka ^a   Shoji, Noboru ^a   Lee, Je Jung ^b   Takei, Masao ^b   Hashimoto, Toshihiro ^a  

^a TOKUSHIMA BUNRI UNIVERSITY   (Japan)

^b Chonnam National University Research Institute of Medical Sciences   (South Korea)

Author keywords

Dendritic cells; Rubiaceae; Th1 polarization; Triterpene derivatives; Uncaria rhynchophylla

Indexed keywords

B7 ANTIGEN; CD14 ANTIGEN; CD83 ANTIGEN; CD86 ANTIGEN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HLA DR ANTIGEN; INTERLEUKIN 12; INTERLEUKIN 4; PLANT EXTRACT; T6 ANTIGEN; TRITERPENE ESTER; UNCARIA RHYNCHOPHYLLA EXTRACT; UNCARINIC ACID C; UNCARINIC ACID D; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN HL 60; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; DRUG ACTIVITY; DRUG EFFICACY; DRUG POTENCY; DRUG STRUCTURE; HUMAN; HUMAN CELL; IC 50; IMMUNOMODULATION; IN VITRO STUDY; NONHUMAN; PHENOTYPE; POLARIZATION; RUBIACEAE; SPECTROSCOPY; TH1 CELL; UNCARIA RHYNCHOPHYLLA;

CELL POLARITY; ESTERS; HL-60 CELLS; HUMANS; INTERLEUKIN-12; PLANT EXTRACTS; PLANT STRUCTURES; TH1 CELLS; TRITERPENES; UNCARIA;

EID: 77956707952     PISSN: 13403443     EISSN: 18610293     Source Type: Journal    
DOI: 10.1007/s11418-010-0438-1     Document Type: Article

References (11)

1. H2 hypothesis of T cell-mediated tissue damage Nat Med 13 139 145
2. M Takei A Umeyama N Shoji T Hashimoto 2008 Diterpene, 16-phyllocladanol enhances Th1 polarization induced by LPS-primed DC, but not TNF-alpha-primed DC Biochem Biophy Res Commun 370 6 10
3. M Takei A Umeyama S Arihara 2006 T-cadinol and calamenene induce dendritic cells from human monocytes and drive Th1 polarization Eur J Pharmacol 537 190 199
4. K Endo Y Osima H Kikuchi Y Koshihara H Hikino 1983 Hypotensive principles of Uncaria hooks Planta Med 49 188 190
5. + channels Naunyn Schmiedebergs Arch Pharmacol 369 232 238
6. TH Kang Y Murakami H Takayama M Kitajima N Aimi H Watanabe K Matsumoto 2004 Protective effect of rhynchophylline and isorhynchophylline on in vitro ischemia-induced neuronal damage in the hippocampus: putative neurotransmitter receptors involved in their action Life Sci 76 331 343
7. D Yuan B Ma C Wu J Yang L Zhang S Liu L Wu Y Kano 2008 Alkaloids from the leaves of Uncaria rhynchophylla and their inhibitory activity on no production in lipopolysaccharide-activated microglia J Nat Prod 71 7 1271 1274
8. SS Hong XH Han SY Park WH Choi MK Lee JD Hur BY Hwang JS Ro 2005 Monoamine oxidase inhibitor from Uncaria rhynchophylla Nat Prod Sci 11 3 145 149
9. JS Lee H Yoo YG Suh JK Jung J Kim 2008 Structure-activity relationship of pentacyclic triterpene esters from Uncaria rhynchophylla as inhibitors of phospholipase Cgamma1 Planta Med 74 12 1481 1487
10. JS Lee J Kim BY Kim HS Lee JS Ahn YS Chang 2000 Inhibition of phospholipase Cγ1 and cancer cell proliferation by triterpene esters from Uncaria rhynchophylla J Nat Prod 63 753 756
11. M Takei E Tachikawa H Hasegawa J-J Lee 2004 Dendritic cell maturation promoted by M1 and M4, end products of steroidal ginseng saponins metabolized in digestive tracts, drive a potent Th1 polarization Biochem Pharmacol 68 441 452