Polygalasaponin XXXII from polygala tenuifolia root improves hippocampal-dependent learning and memory

Acta Pharmacologica Sinica

Volumn 30, Issue 9, 2009, Pages 1211-1219

  Xue, Wei ^a   Hu, Jin Feng ^a   Yuan, Yu He ^a   Sun, Jian Dong ^a   Li, Bo Yu ^a   Zhang, Dong Ming ^a   Li, Chuang Jun ^a   Chen, Nai Hong ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Brain derived neurotrophic factor; Learning and memory; MAP kinase signaling system; Polygala tenuifolia Willd; Synaptic transmission; Triterpenoid saponin

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PLANT EXTRACT; POLYGALASAPONIN 32; SAPONIN DERIVATIVE; SCOPOLAMINE; SYNAPSIN I; TRITERPENOID; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; DENTATE GYRUS; DRUG EFFECT; DRUG MECHANISM; ELECTROPHYSIOLOGY; ENZYME ACTIVATION; EVOKED RESPONSE; HIPPOCAMPUS; IMMUNOFLUORESCENCE TEST; LEARNING; LONG TERM POTENTIATION; MALE; MAZE TEST; MOUSE; NONHUMAN; POLYGALA TENUIFOLIA; POLYGALACEAE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SPATIAL MEMORY; SYNAPTIC TRANSMISSION; WESTERN BLOTTING;

ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DENTATE GYRUS; EVOKED POTENTIALS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HIPPOCAMPUS; INJECTIONS, INTRAVENTRICULAR; MALE; MAZE LEARNING; MEMORY; MICE; MICE, INBRED C57BL; NOOTROPIC AGENTS; PHOSPHORYLATION; POLYGALA; RATS; RATS, WISTAR; SAPONINS; SYNAPSINS; SYNAPTIC TRANSMISSION; TRITERPENES;

EID: 70249095933     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2009.112     Document Type: Article

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