A traditional medicinal herb Paeonia suffruticosa and its active constituent 1,2,3,4,6-penta-O-galloyl-β-d-glucopyranose have potent anti-aggregation effects on Alzheimer's amyloid β proteins in vitro and in vivo

Journal of Neurochemistry

Volumn 109, Issue 6, 2009, Pages 1648-1657

  Fujiwara, Hironori ^b   Tabuchi, Masahiro ^c   Yamaguchi, Takuji ^c   Iwasaki, Koh ^b   Furukawa, Katsutoshi ^a   Sekiguchi, Kyoji ^c   Ikarashi, Yasushi ^c   Kudo, Yukitsuka ^a   Higuchi, Makoto ^d,e   Saido, Takaomi C ^e   Maeda, Sumihiro ^e   Takashima, Akihiko ^e   Hara, Masahiko ^f   Yaegashi, Nobuo ^b   Kase, Yoshio ^c   Arai, Hiroyuki ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c TSUMURA AND CO   (Japan)

^d NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^e RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

^f Japan Science and Technology Agency   (Japan)

Author keywords

1,2,3,4,6 penta O galloyl d glucopyranose; Alzheimer's disease; Amyloid protein; Medicinal herb; Paeonia suffruticosa; Tg2576 transgenic mice

Indexed keywords

1,2,3,4,6 PENTA O GALLOYL BETA DEXTRO GLUCOPYRANOSE; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; PAEONIA SUFFRUTICOSA EXTRACT; SERENIC AGENT; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; DRUG MECHANISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MEMORY; MEMORY DISORDER; MOUSE; NEUROPROTECTION; NONHUMAN; PAEONIA SUFFRUTICOSA; PASSIVE AVOIDANCE; PRIORITY JOURNAL; TASK PERFORMANCE;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; AVOIDANCE LEARNING; BEHAVIOR, ANIMAL; CELL LINE, TRANSFORMED; CELL SURVIVAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; HYDROLYZABLE TANNINS; MEMORY; MICE; MICE, TRANSGENIC; MODELS, MOLECULAR; PAEONIA; PEPTIDE FRAGMENTS; PHYTOTHERAPY; PLANT EXTRACTS; TIME FACTORS;

MUS MUSCULUS; PAEONIA SUFFRUTICOSA;

EID: 65949101254     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2009.06069.x     Document Type: Article

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