Global chimeric exchanges within the intracellular face of the bradykinin B2 receptor with corresponding angiotensin II type 1a receptor regions: Generation of fully functional hybrids showing characteristic signaling of the AT1a receptor

Journal of Cellular Biochemistry

Volumn 85, Issue 4, 2002, Pages 809-819

  Yu, Jun ^a   Prado, Gregory N ^a   Taylor, Linda ^a   Piserchio, Andrea ^b   Gupta, Abhas ^b   Mierke, Dale F ^b   Polgar, Peter ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BROWN UNIVERSITY   (United States)

Author keywords

Angiotensin; Angiotensin II; Angiotensin type 1a receptor; AT1a; Bradykinin; Bradykinin B2 receptor; C terminus; Chimera; Connective tissue growth factor; CTGF; Hybrid receptors; Intracellular loops; Mutant receptors; Mutations; Signal transduction

Indexed keywords

ANGIOTENSIN RECEPTOR; ARACHIDONIC ACID; BRADYKININ B2 RECEPTOR; CONNECTIVE TISSUE GROWTH FACTOR; G PROTEIN COUPLED RECEPTOR; MESSENGER RNA; PHOSPHATIDYLINOSITOL;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CHIMERA; CONTROLLED STUDY; GENE EXPRESSION; INTERNALIZATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; RAT; RECEPTOR BINDING; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; BASE SEQUENCE; BINDING SITES; BRADYKININ; CELL LINE; DNA, COMPLEMENTARY; DNA-BINDING PROTEINS; GENE EXPRESSION; GROWTH SUBSTANCES; IMMEDIATE-EARLY PROTEINS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PLANT PROTEINS; RATS; RECEPTOR, ANGIOTENSIN, TYPE 1; RECEPTOR, BRADYKININ B2; RECEPTORS, ANGIOTENSIN; RECEPTORS, BRADYKININ; RECOMBINANT FUSION PROTEINS; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANSFECTION;

ARA;

EID: 0036242166     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcb.10171     Document Type: Article

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