-
1
-
-
4344659685
-
Impaired degradation of mutant α-synuclein by chaperone-mediated autophagy
-
DOI 10.1126/science.1101738
-
AM Cuervo L Stefanis R Fredenburg PT Lansbury D Sulzer 2004 Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy Science 305 1292 1295 15333840 10.1126/science.1101738 1:CAS:528:DC%2BD2cXmvFCit7w%3D (Pubitemid 39129234)
-
(2004)
Science
, vol.305
, Issue.5688
, pp. 1292-1295
-
-
Cuervo, A.M.1
Stafanis, L.2
Fredenburg, R.3
Lansbury, P.T.4
Sulzer, D.5
-
2
-
-
75849156898
-
Structural analogues of schweinfurthin F: Probing the steric, electronic, and hydrophobic properties of the d-ring substructure
-
20116262 10.1016/j.bmc.2009.12.063 1:CAS:528:DC%2BC3cXitVOns7s%3D
-
NC Ulrich JG Kodet NR Mente CH Kuder JA Beutler RJ Hohl DF Wiemer 2010 Structural analogues of schweinfurthin F: probing the steric, electronic, and hydrophobic properties of the d-ring substructure Bioorg Med Chem 18 1676 1683 20116262 10.1016/j.bmc.2009.12.063 1:CAS:528:DC%2BC3cXitVOns7s%3D
-
(2010)
Bioorg Med Chem
, vol.18
, pp. 1676-1683
-
-
Ulrich, N.C.1
Kodet, J.G.2
Mente, N.R.3
Kuder, C.H.4
Beutler, J.A.5
Hohl, R.J.6
Wiemer, D.F.7
-
3
-
-
66449122592
-
Synthesis and biological activity of a fluorescent schweinfurthin analogue
-
19464190 10.1016/j.bmc.2009.04.071 1:CAS:528:DC%2BD1MXnt1Gqsb4%3D
-
CH Kuder JD Neighbors RJ Hohl DF Wiemer 2009 Synthesis and biological activity of a fluorescent schweinfurthin analogue Bioorg Med Chem 17 4718 4723 19464190 10.1016/j.bmc.2009.04.071 1:CAS:528:DC%2BD1MXnt1Gqsb4%3D
-
(2009)
Bioorg Med Chem
, vol.17
, pp. 4718-4723
-
-
Kuder, C.H.1
Neighbors, J.D.2
Hohl, R.J.3
Wiemer, D.F.4
-
4
-
-
33846562891
-
Total synthesis of (R,R,R)- and (S,S,S)-schweinfurthin F: Differences of bioactivity in the enantiomeric series
-
DOI 10.1016/j.bmcl.2006.11.096, PII S0960894X06013576
-
NR Mente AJ Wiemer JD Neighbors JA Beutler RJ Hohl DF Wiemer 2007 Total synthesis of (R,R,R)- and (S,S,S)-schweinfurthin F: differences of bioactivity in the enantiomeric series Bioorg Med Chem Lett 17 911 915 17236766 10.1016/j.bmcl.2006.11.096 1:CAS:528:DC%2BD2sXht12rtbY%3D (Pubitemid 46177630)
-
(2007)
Bioorganic and Medicinal Chemistry Letters
, vol.17
, Issue.4
, pp. 911-915
-
-
Mente, N.R.1
Wiemer, A.J.2
Neighbors, J.D.3
Beutler, J.A.4
Hohl, R.J.5
Wiemer, D.F.6
-
5
-
-
32044436701
-
Synthesis and structure-activity studies of schweinfurthin B analogs: Evidence for the importance of a D-ring hydrogen bond donor in expression of differential cytotoxicity
-
DOI 10.1016/j.bmc.2005.10.025, PII S0968089605010072
-
JD Neighbors MS Salnikova JA Beutler DF Wiemer 2006 Synthesis and structure-activity studies of schweinfurthin B analogs: Evidence for the importance of a d-ring hydrogen bond donor in expression of differential cytotoxicity Bioorg Med Chem 14 1771 1784 16290161 10.1016/j.bmc.2005.10.025 1:CAS:528:DC%2BD28XhtlKmu7s%3D (Pubitemid 43199510)
-
(2006)
Bioorganic and Medicinal Chemistry
, vol.14
, Issue.6
, pp. 1771-1784
-
-
Neighbors, J.D.1
Salnikova, M.S.2
Beutler, J.A.3
Wiemer, D.F.4
-
6
-
-
13244277645
-
Synthesis of nonracemic 3-deoxyschweinfurthin B
-
DOI 10.1021/jo048444r
-
JD Neighbors JA Beutler DF Wiemer 2005 Synthesis of nonracemic 3-deoxyschweinfurthin B J Org Chem 70 925 931 15675850 10.1021/jo048444r 1:CAS:528:DC%2BD2MXjtFCqtg%3D%3D (Pubitemid 40189503)
-
(2005)
Journal of Organic Chemistry
, vol.70
, Issue.3
, pp. 925-931
-
-
Neighbors, J.D.1
Beutler, J.A.2
Wiemer, D.F.3
-
7
-
-
77956341892
-
Fluorescent schweinfurthin B and F analogs with anti-proliferative activity
-
20724169 10.1016/j.bmc.2010.07.056 1:CAS:528:DC%2BC3cXhtFamt77K
-
JJ Topczewski CH Kuder JD Neighbors RJ Hohl DF Wiemer 2010 Fluorescent schweinfurthin B and F analogs with anti-proliferative activity Bioorg Med Chem 18 6734 6741 20724169 10.1016/j.bmc.2010.07.056 1:CAS:528:DC%2BC3cXhtFamt77K
-
(2010)
Bioorg Med Chem
, vol.18
, pp. 6734-6741
-
-
Topczewski, J.J.1
Kuder, C.H.2
Neighbors, J.D.3
Hohl, R.J.4
Wiemer, D.F.5
-
8
-
-
29244482539
-
Erythropoietin receptor signal transduction requires protein geranylgeranylation
-
DOI 10.1124/jpet.105.092510
-
SN Hamadmad MK Henry RJ Hohl 2006 Erythropoietin receptor signal transduction requires protein geranylgeranylation J Pharmacol Exp Ther 316 403 409 16203826 10.1124/jpet.105.092510 1:CAS:528:DC%2BD28XhslCitQ%3D%3D (Pubitemid 41832620)
-
(2006)
Journal of Pharmacology and Experimental Therapeutics
, vol.316
, Issue.1
, pp. 403-409
-
-
Hamadmad, S.N.1
Henry, M.K.2
Hohl, R.J.3
-
9
-
-
3242785011
-
Isoprenoids: Remarkable diversity of form and function
-
DOI 10.1007/s11745-004-1233-3
-
SA Holstein RJ Hohl 2004 Isoprenoids: remarkable diversity of form and function Lipids 39 293 309 15357017 10.1007/s11745-004-1233-3 1:CAS:528:DC%2BD2cXmtFWmtbg%3D (Pubitemid 38971743)
-
(2004)
Lipids
, vol.39
, Issue.4
, pp. 293-309
-
-
Holstein, S.A.1
Hohl, R.J.2
-
10
-
-
0025120211
-
Regulation of the mevalonate pathway
-
DOI 10.1038/343425a0
-
JL Goldstein MS Brown 1990 Regulation of the mevalonate pathway Nature 343 425 430 1967820 10.1038/343425a0 1:CAS:528:DyaK3cXhtlCmtbw%3D (Pubitemid 20065229)
-
(1990)
Nature
, vol.343
, Issue.6257
, pp. 425-430
-
-
Goldstein, J.L.1
Brown, M.S.2
-
11
-
-
0036251153
-
SREBPs: Activators of the complete program of cholesterol and fatty acid synthesis in the liver
-
DOI 10.1172/JCI200215593
-
JD Horton JL Goldstein MS Brown 2002 SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver J Clin Invest 109 1125 1131 11994399 1:CAS:528:DC%2BD38XjsFals7c%3D (Pubitemid 34496588)
-
(2002)
Journal of Clinical Investigation
, vol.109
, Issue.9
, pp. 1125-1131
-
-
Horton, J.D.1
Goldstein, J.L.2
Brown, M.S.3
-
12
-
-
0030941803
-
The SREBP pathway: Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor
-
DOI 10.1016/S0092-8674(00)80213-5
-
MS Brown JL Goldstein 1997 The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor Cell 89 331 340 9150132 10.1016/S0092-8674(00)80213-5 1:CAS:528:DyaK2sXjtFWisb8%3D (Pubitemid 27220877)
-
(1997)
Cell
, vol.89
, Issue.3
, pp. 331-340
-
-
Brown, M.S.1
Goldstein, J.L.2
-
13
-
-
0037162719
-
Crucial step in cholesterol homeostasis: Sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER
-
DOI 10.1016/S0092-8674(02)00872-3
-
T Yang PJ Espenshade ME Wright D Yabe Y Gong R Aebersold JL Goldstein MS Brown 2002 Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER Cell 110 489 500 12202038 10.1016/S0092-8674(02)00872-3 1:CAS:528: DC%2BD38Xmslyjt70%3D (Pubitemid 35232292)
-
(2002)
Cell
, vol.110
, Issue.4
, pp. 489-500
-
-
Yang, T.1
Espenshade, P.J.2
Wright, M.E.3
Yabe, D.4
Gong, Y.5
Aebersold, R.6
Goldstein, J.L.7
Brown, M.S.8
-
14
-
-
0036792050
-
Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins
-
12242332 10.1073/pnas.162488899 1:CAS:528:DC%2BD38XnvFGhsLw%3D
-
D Yabe MS Brown JL Goldstein 2002 Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins Proc Natl Acad Sci USA 99 12753 12758 12242332 10.1073/pnas.162488899 1:CAS:528:DC%2BD38XnvFGhsLw%3D
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 12753-12758
-
-
Yabe, D.1
Brown, M.S.2
Goldstein, J.L.3
-
15
-
-
0034623288
-
Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor
-
10858438 1:CAS:528:DC%2BD3cXmsVKkt7c%3D
-
P Costet Y Luo N Wang AR Tall 2000 Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor J Biol Chem 275 28240 28245 10858438 1:CAS:528:DC%2BD3cXmsVKkt7c%3D
-
(2000)
J Biol Chem
, vol.275
, pp. 28240-28245
-
-
Costet, P.1
Luo, Y.2
Wang, N.3
Tall, A.R.4
-
16
-
-
33748792007
-
Sterol intermediates from cholesterol biosynthetic pathway as liver X receptor ligands
-
DOI 10.1074/jbc.M603781200
-
C Yang JG McDonald A Patel Y Zhang M Umetani F Xu EJ Westover DF Covey DJ Mangelsdorf JC Cohen HH Hobbs 2006 Sterol intermediates from cholesterol biosynthetic pathway as liver X receptor ligands J Biol Chem 281 27816 27826 16857673 10.1074/jbc.M603781200 1:CAS:528:DC%2BD28XpsFOrt7s%3D (Pubitemid 44414494)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.38
, pp. 27816-27826
-
-
Yang, C.1
McDonald, J.G.2
Patel, A.3
Zhang, Y.4
Umetani, M.5
Xu, F.6
Westover, E.J.7
Covey, D.F.8
Mangelsdorf, D.J.9
Cohen, J.C.10
Hobbs, H.H.11
-
17
-
-
77955456415
-
MiR-33 links SREBP-2 induction to repression of sterol transporters
-
20566875 10.1073/pnas.1005191107 1:CAS:528:DC%2BC3cXovFyit7c%3D
-
TJ Marquart RM Allen DS Ory A Baldan 2010 miR-33 links SREBP-2 induction to repression of sterol transporters Proc Natl Acad Sci USA 107 12228 12232 20566875 10.1073/pnas.1005191107 1:CAS:528:DC%2BC3cXovFyit7c%3D
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 12228-12232
-
-
Marquart, T.J.1
Allen, R.M.2
Ory, D.S.3
Baldan, A.4
-
18
-
-
77953787211
-
MiR-33 contributes to the regulation of cholesterol homeostasis
-
20466885 10.1126/science.1189862 1:CAS:528:DC%2BC3cXnsVWntrc%3D
-
KJ Rayner Y Suarez A Davalos S Parathath ML Fitzgerald N Tamehiro EA Fisher KJ Moore C Fernandez-Hernando 2010 MiR-33 contributes to the regulation of cholesterol homeostasis Science 328 1570 1573 20466885 10.1126/science. 1189862 1:CAS:528:DC%2BC3cXnsVWntrc%3D
-
(2010)
Science
, vol.328
, pp. 1570-1573
-
-
Rayner, K.J.1
Suarez, Y.2
Davalos, A.3
Parathath, S.4
Fitzgerald, M.L.5
Tamehiro, N.6
Fisher, E.A.7
Moore, K.J.8
Fernandez-Hernando, C.9
-
19
-
-
0028307290
-
Identification of farnesol as the non-sterol derivative of mevalonic acid required for the accelerated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase
-
8021239 1:CAS:528:DyaK2cXltVarsrc%3D
-
CC Correll L Ng PA Edwards 1994 Identification of farnesol as the non-sterol derivative of mevalonic acid required for the accelerated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase J Biol Chem 269 17390 17393 8021239 1:CAS:528:DyaK2cXltVarsrc%3D
-
(1994)
J Biol Chem
, vol.269
, pp. 17390-17393
-
-
Correll, C.C.1
Ng, L.2
Edwards, P.A.3
-
20
-
-
18544378347
-
Insig-mediated degradation of HMG CoA reductase stimulated by lanosterol, an intermediate in the synthesis of cholesterol
-
DOI 10.1016/j.cmet.2005.01.001, PII S1550413105000288
-
BL Song NB Javitt RA DeBose-Boyd 2005 Insig-mediated degradation of HMG CoA reductase stimulated by lanosterol, an intermediate in the synthesis of cholesterol Cell Metab 1 179 189 16054061 10.1016/j.cmet.2005.01.001 1:CAS:528:DC%2BD2MXivFCqsb4%3D (Pubitemid 43960599)
-
(2005)
Cell Metabolism
, vol.1
, Issue.3
, pp. 179-189
-
-
Song, B.-L.1
Javitt, N.B.2
DeBose-Boyd, R.A.3
-
21
-
-
0035966125
-
Dual mechanisms of ABCA1 regulation by geranylgeranyl pyrophosphate
-
11641412 10.1074/jbc.M109402200 1:CAS:528:DC%2BD38Xktlaqug%3D%3D
-
X Gan R Kaplan JG Menke K MacNaul Y Chen CP Sparrow G Zhou SD Wright TQ Cai 2001 Dual mechanisms of ABCA1 regulation by geranylgeranyl pyrophosphate J Biol Chem 276 48702 48708 11641412 10.1074/jbc.M109402200 1:CAS:528: DC%2BD38Xktlaqug%3D%3D
-
(2001)
J Biol Chem
, vol.276
, pp. 48702-48708
-
-
Gan, X.1
Kaplan, R.2
Menke, J.G.3
MacNaul, K.4
Chen, Y.5
Sparrow, C.P.6
Zhou, G.7
Wright, S.D.8
Cai, T.Q.9
-
22
-
-
34547661859
-
Identification of two herbal compounds with potential cholesterol-lowering activity
-
DOI 10.1016/j.bcp.2007.06.020, PII S0006295207003814
-
Y Zhang H Zhang S Hua L Ma C Chen X Liu L Jiang H Yang P Zhang D Yu Y Guo X Tan J Liu 2007 Identification of two herbal compounds with potential cholesterol-lowering activity Biochem Pharmacol 74 940 947 17673184 10.1016/j.bcp.2007.06.020 1:CAS:528:DC%2BD2sXovFOjtL4%3D (Pubitemid 47212078)
-
(2007)
Biochemical Pharmacology
, vol.74
, Issue.6
, pp. 940-947
-
-
Zhang, Y.1
Zhang, H.2
Hua, S.3
Ma, L.4
Chen, C.5
Liu, X.6
Jiang, L.7
Yang, H.8
Zhang, P.9
Yu, D.10
Guo, Y.11
Tan, X.12
Liu, J.13
-
23
-
-
34347270605
-
The cholesterol-raising factor from coffee beans, cafestol, as an agonist ligand for the farnesoid and pregnane X receptors
-
DOI 10.1210/me.2007-0133
-
ML Ricketts MV Boekschoten AJ Kreeft GJ Hooiveld CJ Moen M Muller RR Frants S Kasanmoentalib SM Post HM Princen JG Porter MB Katan MH Hofker DD Moore 2007 The cholesterol-raising factor from coffee beans, cafestol, as an agonist ligand for the farnesoid and pregnane X receptors Mol Endocrinol 21 1603 1616 17456796 10.1210/me.2007-0133 1:CAS:528:DC%2BD2sXnvValu78%3D (Pubitemid 47001085)
-
(2007)
Molecular Endocrinology
, vol.21
, Issue.7
, pp. 1603-1616
-
-
Ricketts, M.-L.1
Boekschoten, M.V.2
Kreeft, A.J.3
Hooiveld, G.J.E.J.4
Moen, C.J.A.5
Muller, M.6
Frants, R.R.7
Kasanmoentalib, S.8
Post, S.M.9
Princen, H.M.G.10
Porter, J.G.11
Katan, M.B.12
Hofker, M.H.13
Moore, D.D.14
-
24
-
-
0019941618
-
The mechanism of cyclic monoterpene inhibition of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase in vivo in the rat
-
RJ Clegg B Middleton GD Bell DA White 1982 The mechanism of cyclic monoterpene inhibition of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase in vivo in the rat J Biol Chem 257 2294 2299 7061423 1:CAS:528:DyaL38XhsF2ru7Y%3D (Pubitemid 12069783)
-
(1982)
Journal of Biological Chemistry
, vol.257
, Issue.5
, pp. 2294-2299
-
-
Clegg, R.J.1
Middleton, B.2
Duncan Bell, G.3
White, D.A.4
-
25
-
-
0018838247
-
Inhibition of hepatic cholesterol synthesis and S-3-hydroxy-3- methylglutaryl-CoA reductase by mono and bicyclic monoterpenes administered in vivo
-
DOI 10.1016/0006-2952(80)90183-5
-
RJ Clegg B Middleton GD Bell DA White 1980 Inhibition of hepatic cholesterol synthesis and S-3-hydroxy-3-methylglutaryl-CoA reductase by mono and bicyclic monoterpenes administered in vivo Biochem Pharmacol 29 2125 2127 7406925 10.1016/0006-2952(80)90183-5 1:CAS:528:DyaL3cXmtlSktLk%3D (Pubitemid 10086433)
-
(1980)
Biochemical Pharmacology
, vol.29
, Issue.15
, pp. 2125-2127
-
-
Clegg, R.J.1
Middleton, B.2
Bell, G.D.3
White, D.A.4
-
26
-
-
0021118703
-
Quantitative analysis of dose-effect relationships: The combined effects of multiple drugs or enzyme inhibitors
-
6382953 10.1016/0065-2571(84)90007-4 1:CAS:528:DyaL2cXktlaksLk%3D
-
TC Chou P Talalay 1984 Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors Adv Enzyme Regul 22 27 55 6382953 10.1016/0065-2571(84)90007-4 1:CAS:528: DyaL2cXktlaksLk%3D
-
(1984)
Adv Enzyme Regul
, vol.22
, pp. 27-55
-
-
Chou, T.C.1
Talalay, P.2
-
27
-
-
67149120806
-
Actein activates stress- and statin-associated responses and is bioavailable in Sprague-Dawley rats
-
19527300 10.1111/j.1472-8206.2009.00673.x 1:CAS:528:DC%2BD1MXnvVemurY%3D
-
LS Einbond M Soffritti DD Esposti T Park E Cruz T Su HA Wu X Wang YJ Zhang J Ham IJ Goldberg F Kronenberg A Vladimirova 2009 Actein activates stress- and statin-associated responses and is bioavailable in Sprague-Dawley rats Fundam Clin Pharmacol 23 311 321 19527300 10.1111/j.1472-8206.2009.00673.x 1:CAS:528:DC%2BD1MXnvVemurY%3D
-
(2009)
Fundam Clin Pharmacol
, vol.23
, pp. 311-321
-
-
Einbond, L.S.1
Soffritti, M.2
Esposti, D.D.3
Park, T.4
Cruz, E.5
Su, T.6
Wu, H.A.7
Wang, X.8
Zhang, Y.J.9
Ham, J.10
Goldberg, I.J.11
Kronenberg, F.12
Vladimirova, A.13
-
28
-
-
27244453583
-
Steroidal and triterpenoidal fungal metabolites as ligands of liver X receptors
-
JG Ondeyka H Jayasuriya KB Herath Z Guan M Schulman J Collado AW Dombrowski SS Kwon C McCallum N Sharma K MacNaul N Hayes JG Menke SB Singh 2005 Steroidal and triterpenoidal fungal metabolites as ligands of liver X receptors J Antibiot (Tokyo) 58 559 565 1:CAS:528:DC%2BD2MXhtFant73N (Pubitemid 41512929)
-
(2005)
Journal of Antibiotics
, vol.58
, Issue.9
, pp. 559-565
-
-
Ondeyka, J.G.1
Jayasuriya, H.2
Herath, K.B.3
Guan, Z.4
Schulman, M.5
Collado, J.6
Dombrowski, A.W.7
Kwon, S.S.8
McCallum, C.9
Sharma, N.10
MacNaul, K.11
Hayes, N.12
Menke, J.G.13
Singh, S.B.14
-
29
-
-
24744440985
-
Diterpenoid, steroid, and triterpenoid agonists of liver X receptors from diversified terrestrial plants and marine sources
-
DOI 10.1021/np050182g
-
H Jayasuriya KB Herath JG Ondeyka Z Guan RP Borris S Tiwari W de Jong F Chavez J Moss DW Stevenson HT Beck M Slattery N Zamora M Schulman A Ali N Sharma K MacNaul N Hayes JG Menke SB Singh 2005 Diterpenoid, steroid, and triterpenoid agonists of liver X receptors from diversified terrestrial plants and marine sources J Nat Prod 68 1247 1252 16124770 10.1021/np050182g 1:CAS:528: DC%2BD2MXnt1Sit7c%3D (Pubitemid 41291272)
-
(2005)
Journal of Natural Products
, vol.68
, Issue.8
, pp. 1247-1252
-
-
Jayasuriya, H.1
Herath, K.B.2
Ondeyka, J.G.3
Guan, Z.4
Borris, R.P.5
Tiwari, S.6
De Jong, W.7
Chavez, F.8
Moss, J.9
Stevenson, D.W.10
Beck, H.T.11
Slattery, M.12
Zamora, N.13
Schulman, M.14
Ali, A.15
Sharma, N.16
MacNaul, K.17
Hayes, N.18
Menke, J.G.19
Singh, S.B.20
more..
-
30
-
-
0017894322
-
Induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts incubated with compactin (ML-236B), a competitive inhibitor of the reductase
-
MS Brown JR Faust JL Goldstein I Kaneko A Endo 1978 Induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts incubated with compactin (ML-236B), a competitive inhibitor of the reductase J Biol Chem 253 1121 1128 624722 1:CAS:528:DyaE1cXhtlWnsbo%3D (Pubitemid 8288831)
-
(1978)
Journal of Biological Chemistry
, vol.253
, Issue.4
, pp. 1121-1128
-
-
Brown, M.S.1
Faust, J.R.2
Goldstein, J.L.3
-
31
-
-
0346101770
-
Insig-dependent Ubiquitination and Degradation of Mammalian 3-Hydroxy-3-methylglutaryl-CoA Reductase Stimulated by Sterols and Geranylgeraniol
-
DOI 10.1074/jbc.M310053200
-
N Sever BL Song D Yabe JL Goldstein MS Brown RA DeBose-Boyd 2003 Insig-dependent ubiquitination and degradation of mammalian 3-hydroxy-3- methylglutaryl-CoA reductase stimulated by sterols and geranylgeraniol J Biol Chem 278 52479 52490 14563840 10.1074/jbc.M310053200 1:CAS:528: DC%2BD3sXpvFGjs78%3D (Pubitemid 38035841)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.52
, pp. 52479-52490
-
-
Sever, N.1
Song, B.-L.2
Yabe, D.3
Goldstein, J.L.4
Brown, M.S.5
DeBose-Boydb, R.A.6
-
32
-
-
10644229420
-
Statins inhibit synthesis of an oxysterol ligand for the liver X receptor in human macrophages with consequences for cholesterol flux
-
DOI 10.1161/01.ATV.0000148707.93054.7d
-
J Wong CM Quinn AJ Brown 2004 Statins inhibit synthesis of an oxysterol ligand for the liver X receptor in human macrophages with consequences for cholesterol flux Arterioscler Thromb Vasc Biol 24 2365 2371 15514210 10.1161/01.ATV.0000148707.93054.7d 1:CAS:528:DC%2BD2cXhtVaisrjL (Pubitemid 39658043)
-
(2004)
Arteriosclerosis, Thrombosis, and Vascular Biology
, vol.24
, Issue.12
, pp. 2365-2371
-
-
Wong, J.1
Quinn, C.M.2
Brown, A.J.3
-
33
-
-
0037155865
-
Consequences of mevalonate depletion. Differential transcriptional, translational, and post-translational up-regulation of Ras, Rap1a, RhoA, and RhoB
-
DOI 10.1074/jbc.M111369200
-
SA Holstein CL Wohlford-Lenane RJ Hohl 2002 Consequences of mevalonate depletion. Differential transcriptional, translational, and post-translational up-regulation of Ras, Rap1a, RhoA, and RhoB J Biol Chem 277 10678 10682 11788600 10.1074/jbc.M111369200 1:CAS:528:DC%2BD38XisVyksbw%3D (Pubitemid 34968195)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.12
, pp. 10678-10682
-
-
Holstein, S.A.1
Wohlford-Lenane, C.L.2
Hohl, R.J.3
-
34
-
-
0037137175
-
Isoprenoids influence expression of Ras and Ras-related proteins
-
DOI 10.1021/bi026251x
-
SA Holstein CL Wohlford-Lenane RJ Hohl 2002 Isoprenoids influence expression of Ras and Ras-related proteins Biochemistry 41 13698 13704 12427032 10.1021/bi026251x 1:CAS:528:DC%2BD38XotFSqtro%3D (Pubitemid 35332707)
-
(2002)
Biochemistry
, vol.41
, Issue.46
, pp. 13698-13704
-
-
Holstein, S.A.1
Wohlford-Lenane, C.L.2
Hohl, R.J.3
-
35
-
-
0028245959
-
Effect of squalene synthase inhibition on the expression of hepatic cholesterol biosynthetic enzymes, LDL receptor, and cholesterol 7 alpha hydroxylase
-
7911291 10.1006/abbi.1994.1238 1:CAS:528:DyaK2cXksFCntL8%3D
-
GC Ness Z Zhao RK Keller 1994 Effect of squalene synthase inhibition on the expression of hepatic cholesterol biosynthetic enzymes, LDL receptor, and cholesterol 7 alpha hydroxylase Arch Biochem Biophys 311 277 285 7911291 10.1006/abbi.1994.1238 1:CAS:528:DyaK2cXksFCntL8%3D
-
(1994)
Arch Biochem Biophys
, vol.311
, pp. 277-285
-
-
Ness, G.C.1
Zhao, Z.2
Keller, R.K.3
-
36
-
-
33646204998
-
Synthesis and biological activity of isoprenoid bisphosphonates
-
16517172 10.1016/j.bmc.2006.02.010 1:CAS:528:DC%2BD28XksVOisb8%3D
-
LW Shull AJ Wiemer RJ Hohl DF Wiemer 2006 Synthesis and biological activity of isoprenoid bisphosphonates Bioorg Med Chem 14 4130 4136 16517172 10.1016/j.bmc.2006.02.010 1:CAS:528:DC%2BD28XksVOisb8%3D
-
(2006)
Bioorg Med Chem
, vol.14
, pp. 4130-4136
-
-
Shull, L.W.1
Wiemer, A.J.2
Hohl, R.J.3
Wiemer, D.F.4
-
38
-
-
9944233982
-
Simultaneous determination of farnesyl and geranylgeranyl pyrophosphate levels in cultured cells
-
DOI 10.1016/j.ab.2004.09.024, PII S0003269704007602
-
H Tong SA Holstein RJ Hohl 2005 Simultaneous determination of farnesyl and geranylgeranyl pyrophosphate levels in cultured cells Anal Biochem 336 51 59 15582558 10.1016/j.ab.2004.09.024 1:CAS:528:DC%2BD2cXhtVCgtLbK (Pubitemid 39593499)
-
(2005)
Analytical Biochemistry
, vol.336
, Issue.1
, pp. 51-59
-
-
Tong, H.1
Holstein, S.A.2
Hohl, R.J.3
-
39
-
-
0036020892
-
A direct approach to false discovery rates
-
10.1111/1467-9868.00346
-
JD Storey 2002 A direct approach to false discovery rates J Roy Stat Soc B 64 479 498 10.1111/1467-9868.00346
-
(2002)
J Roy Stat Soc B
, vol.64
, pp. 479-498
-
-
Storey, J.D.1
-
41
-
-
3242877218
-
Rab7 is required for the normal progression of the autophagic pathway in mammalian cells
-
DOI 10.1242/jcs.01114
-
MG Gutierrez DB Munafo W Beron MI Colombo 2004 Rab7 is required for the normal progression of the autophagic pathway in mammalian cells J Cell Sci 117 2687 2697 15138286 10.1242/jcs.01114 1:CAS:528:DC%2BD2cXlvFeht74%3D (Pubitemid 38997252)
-
(2004)
Journal of Cell Science
, vol.117
, Issue.13
, pp. 2687-2697
-
-
Gutierrez, M.G.1
Munafo, D.B.2
Beron, W.3
Colombo, M.I.4
-
42
-
-
0030923192
-
K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors
-
DOI 10.1074/jbc.272.22.14459
-
DB Whyte P Kirschmeier TN Hockenberry I Nunez-Oliva L James JJ Catino WR Bishop JK Pai 1997 K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors J Biol Chem 272 14459 14464 9162087 10.1074/jbc.272.22.14459 1:CAS:528:DyaK2sXjsFygs74%3D (Pubitemid 27232866)
-
(1997)
Journal of Biological Chemistry
, vol.272
, Issue.22
, pp. 14459-14464
-
-
Whyte, D.B.1
Kirschmeier, P.2
Hockenberry, T.N.3
Nunez-Oliva, I.4
James, L.5
Catino, J.J.6
Bishop, W.R.7
Pai, J.-K.8
-
43
-
-
77649182629
-
Differential activities of thalidomide and isoprenoid biosynthetic pathway inhibitors in multiple myeloma cells
-
19646757 10.1016/j.leukres.2009.06.035 1:CAS:528:DC%2BC3cXitVKlu74%3D
-
SA Holstein H Tong RJ Hohl 2010 Differential activities of thalidomide and isoprenoid biosynthetic pathway inhibitors in multiple myeloma cells Leuk Res 34 344 351 19646757 10.1016/j.leukres.2009.06.035 1:CAS:528: DC%2BC3cXitVKlu74%3D
-
(2010)
Leuk Res
, vol.34
, pp. 344-351
-
-
Holstein, S.A.1
Tong, H.2
Hohl, R.J.3
-
44
-
-
77954756757
-
Exploiting the mevalonate pathway to distinguish statin-sensitive multiple myeloma
-
20360469 10.1182/blood-2009-07-230508 1:CAS:528:DC%2BC3cXotlahtb0%3D
-
JW Clendening A Pandyra Z Li PC Boutros A Martirosyan R Lehner I Jurisica S Trudel LZ Penn 2010 Exploiting the mevalonate pathway to distinguish statin-sensitive multiple myeloma Blood 115 4787 4797 20360469 10.1182/blood-2009-07-230508 1:CAS:528:DC%2BC3cXotlahtb0%3D
-
(2010)
Blood
, vol.115
, pp. 4787-4797
-
-
Clendening, J.W.1
Pandyra, A.2
Li, Z.3
Boutros, P.C.4
Martirosyan, A.5
Lehner, R.6
Jurisica, I.7
Trudel, S.8
Penn, L.Z.9
-
45
-
-
0029833547
-
Role for sterol regulatory element binding protein in the regulation of farnesyl diphosphate synthase and in the control of cellular levels of cholesterol and triglyceride: Evidence from sterol regulation-defective cells
-
SM Jackson J Ericsson JE Metherall PA Edwards 1996 Role for sterol regulatory element binding protein in the regulation of farnesyl diphosphate synthase and in the control of cellular levels of cholesterol and triglyceride: evidence from sterol regulation-defective cells J Lipid Res 37 1712 1721 8864955 1:CAS:528:DyaK28Xlt1yhtrw%3D (Pubitemid 26275382)
-
(1996)
Journal of Lipid Research
, vol.37
, Issue.8
, pp. 1712-1721
-
-
Jackson, S.M.1
Ericsson, J.2
Metherall, J.E.3
Edwards, P.A.4
-
46
-
-
0029744890
-
Synergistic binding of sterol regulatory element-binding protein and NF- Y to the farnesyl diphosphate synthase promoter is critical for sterol- regulated expression of the gene
-
DOI 10.1074/jbc.271.40.24359
-
J Ericsson SM Jackson PA Edwards 1996 Synergistic binding of sterol regulatory element-binding protein and NF-Y to the farnesyl diphosphate synthase promoter is critical for sterol-regulated expression of the gene J Biol Chem 271 24359 24364 8798690 10.1074/jbc.271.40.24359 1:CAS:528:DyaK28XmtFeitr4%3D (Pubitemid 26333166)
-
(1996)
Journal of Biological Chemistry
, vol.271
, Issue.40
, pp. 24359-24364
-
-
Ericsson, J.1
Jackson, S.M.2
Edwards, P.A.3
-
47
-
-
0042236735
-
Transcriptional regulation of farnesyl pyrophosphate synthase by liver X receptors
-
DOI 10.1016/S0039-128X(03)00100-4
-
J Fukuchi C Song AL Ko S Liao 2003 Transcriptional regulation of farnesyl pyrophosphate synthase by liver X receptors Steroids 68 685 691 12957674 10.1016/S0039-128X(03)00100-4 1:CAS:528:DC%2BD3sXmvVyhtbY%3D (Pubitemid 37075930)
-
(2003)
Steroids
, vol.68
, Issue.7-8
, pp. 685-691
-
-
Fukuchi, J.1
Song, C.2
Ko, A.L.3
Liao, S.4
-
48
-
-
0034809614
-
Sterol regulatory element-binding proteins induce an entire pathway of cholesterol synthesis
-
DOI 10.1006/bbrc.2001.5375
-
Y Sakakura H Shimano H Sone A Takahashi N Inoue H Toyoshima S Suzuki N Yamada 2001 Sterol regulatory element-binding proteins induce an entire pathway of cholesterol synthesis Biochem Biophys Res Commun 286 176 183 11485325 10.1006/bbrc.2001.5375 1:CAS:528:DC%2BD3MXls1egtr4%3D (Pubitemid 32917666)
-
(2001)
Biochemical and Biophysical Research Communications
, vol.286
, Issue.1
, pp. 176-183
-
-
Sakakura, Y.1
Shimano, H.2
Sone, H.3
Takahashi, A.4
Inoue, K.5
Toyoshima, H.6
Suzuki, S.7
Yamada, N.8
-
49
-
-
0031660850
-
Human geranylgeranyl diphosphate synthase: Isolation of the cDNA, chromosomal mapping and tissue expression
-
J Ericsson JM Greene KC Carter BK Shell DR Duan C Florence PA Edwards 1998 Human geranylgeranyl diphosphate synthase: isolation of the cDNA, chromosomal mapping and tissue expression J Lipid Res 39 1731 1739 9741684 1:CAS:528:DyaK1cXlvVyku7s%3D (Pubitemid 28411159)
-
(1998)
Journal of Lipid Research
, vol.39
, Issue.9
, pp. 1731-1739
-
-
Ericsson, J.1
Greene, J.M.2
Carter, K.C.3
Shell, B.K.4
Duan, D.R.5
Florence, C.6
Edwards, P.A.7
-
51
-
-
14444285707
-
Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway
-
DOI 10.1074/jbc.272.6.3137
-
JM Lehmann SA Kliewer LB Moore TA Smith-Oliver BB Oliver JL Su SS Sundseth DA Winegar DE Blanchard TA Spencer TM Willson 1997 Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway J Biol Chem 272 3137 3140 9013544 10.1074/jbc.272.6.3137 1:CAS:528:DyaK2sXhtFenu7o%3D (Pubitemid 27066798)
-
(1997)
Journal of Biological Chemistry
, vol.272
, Issue.6
, pp. 3137-3140
-
-
Lehmann, J.M.1
Kliewer, S.A.2
Moore, L.B.3
Smith-Oliver, T.A.4
Oliver, B.B.5
Su, J.-L.6
Sundseth, S.S.7
Winegar, D.A.8
Blanchard, D.E.9
Spencer, T.A.10
Willson, T.M.11
-
52
-
-
77952151244
-
Schweinfurthin A selectively inhibits proliferation and Rho signaling in glioma and neurofibromatosis type 1 tumor cells in a NF1-GRD-dependent manner
-
20442305 10.1158/1535-7163.MCT-09-0834 1:CAS:528:DC%2BC3cXlsleksbs%3D
-
TJ Turbyville DB Gursel RG Tuskan JC Walrath CA Lipschultz SJ Lockett DF Wiemer JA Beutler KM Reilly 2010 Schweinfurthin A selectively inhibits proliferation and Rho signaling in glioma and neurofibromatosis type 1 tumor cells in a NF1-GRD-dependent manner Mol Cancer Ther 9 1234 1243 20442305 10.1158/1535-7163.MCT-09-0834 1:CAS:528:DC%2BC3cXlsleksbs%3D
-
(2010)
Mol Cancer Ther
, vol.9
, pp. 1234-1243
-
-
Turbyville, T.J.1
Gursel, D.B.2
Tuskan, R.G.3
Walrath, J.C.4
Lipschultz, C.A.5
Lockett, S.J.6
Wiemer, D.F.7
Beutler, J.A.8
Reilly, K.M.9
-
53
-
-
0036472330
-
Oxysterol-binding-protein (OSBP)-related protein 4 binds 25-hydroxycholesterol and interacts with vimentin intermediate filaments
-
DOI 10.1042/0264-6021:3610461
-
C Wang L JeBailey ND Ridgway 2002 Oxysterol-binding-protein (OSBP)-related protein 4 binds 25-hydroxycholesterol and interacts with vimentin intermediate filaments Biochem J 361 461 472 11802775 10.1042/0264-6021:3610461 1:CAS:528:DC%2BD38XhslOqsbo%3D (Pubitemid 34177815)
-
(2002)
Biochemical Journal
, vol.361
, Issue.3
, pp. 461-472
-
-
Wang, C.1
JeBailey, L.2
Ridgway, N.D.3
-
54
-
-
42149161113
-
The R-Ras interaction partner ORP3 regulates cell adhesion
-
DOI 10.1242/jcs.016964
-
M Lehto MI Mayranpaa T Pellinen P Ihalmo S Lehtonen PT Kovanen PH Groop J Ivaska VM Olkkonen 2008 The R-Ras interaction partner ORP3 regulates cell adhesion J Cell Sci 121 695 705 18270267 10.1242/jcs.016964 1:CAS:528: DC%2BD1cXkslOlsLY%3D (Pubitemid 351524168)
-
(2008)
Journal of Cell Science
, vol.121
, Issue.5
, pp. 695-705
-
-
Lehto, M.1
Mayranpaa, M.I.2
Pellinen, T.3
Ihalmo, P.4
Lehtonen, S.5
Kovanen, P.T.6
Groop, P.-H.7
Ivaska, J.8
Olkkonen, V.M.9
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