Synthesis and structure-activity studies of schweinfurthin B analogs: Evidence for the importance of a D-ring hydrogen bond donor in expression of differential cytotoxicity

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 6, 2006, Pages 1771-1784

  Neighbors, Jeffrey D ^a,b   Salnikova, Maya S ^a   Beutler, John A ^c   Wiemer, David F ^a,b  

^a E11 SSH   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

60 Cell assay; Cytotoxic; Schweinfurthin; Stilbene

Indexed keywords

2 (8 HYDROXY 3,7 DIMETHYL OCTA 2,6 DIENYL) 5 [2 (7 HYDROXY 4 METHOXY 8,8,10A TRIMETHYL 5,7,8,8A,9,10A HEXAHYDRO 6H XANTHEN 2 YL) VINYL] BENZENE 1,3 DIOL; 3 DEOXYSCHWEINFURTHIN B; 5 [2 (7 HYDROXY 4 METHOXY 8,8,10A TRIMETHYL 5,7,8,8A,9,10A HEXAHYDRO 6H XANTHENE 2 YL) VINYL] BENZENE 1,3 DIOL; 5 METHOXY 1,1,4A TRIMETHYL 7 STYRYL 2,3,4,4A,9,9A HEXAHYDRO 1H XANTHEN 2 OL; 7 [2 (3 HYDROXYPHENYL) VINYL] 5 METHOXY 1,1,4A TRIMETHYL 2,3,4,4A,9,9A HEXAHYDRO 1H XANTHENE 2 OL; 7 [2 [4 (3,7 DIMETHYL OCTA 2,6 DIENYL) 3,5 DIFLUOROPHENYL] VINYL] 5 METHOXY 1,1 4A TRIMETHYL 2,3,4,4A,9,9A HEXAHYDRO 1H XANTHEN 2 OL; 7 [2 [4 (3,7 DIMETHYL OCTA 6,7 DIENYL) PHENYL] VINYL] 5 METHOXY 1,1,4A TRIMETHYL 2,3,4,4A,9,9A HEXAHYDRO 1H XANTHEN 2 OL; ALDEHYDE; AROMATIC COMPOUND; DIMETHOXY 3 DEOXYSCHWEINFURTHIN B; NATURAL PRODUCT; PHENOL DERIVATIVE; PHOSPHONIC ACID DERIVATIVE; STILBENE DERIVATIVE; UNCLASSIFIED DRUG; XANTHENE DERIVATIVE;

ARTICLE; BIOLOGICAL ACTIVITY; CANCER CELL CULTURE; CANCER SCREENING; CORRELATION COEFFICIENT; CYTOTOXICITY; DRUG ACTIVITY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; HORNER WADSWORTH EMMONS REACTION; HUMAN; HUMAN CELL; HYDROGEN BOND; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

CELL LINE, TUMOR; DRUG EVALUATION, PRECLINICAL; HUMANS; HYDROGEN BONDING; STILBENES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 32044436701     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.10.025     Document Type: Article

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