메뉴 건너뛰기




Volumn 27, Issue 11, 2011, Pages 496-504

Membrane lipidomics for the discovery of new antiparasitic drug targets

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOTERICIN B; ANTIPARASITIC AGENT; CARDIOLIPIN; EDELFOSINE; FATTY ACID SYNTHASE; LIPID; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLGLYCEROL; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLSERINE; SITAMAQUINE; THIOLACTOMYCIN; TRICLOSAN;

EID: 80054789441     PISSN: 14714922     EISSN: 14715007     Source Type: Journal    
DOI: 10.1016/j.pt.2011.07.002     Document Type: Review
Times cited : (18)

References (75)
  • 1
    • 77951848594 scopus 로고    scopus 로고
    • Evaluation of blood agar microtiter plates for culturing Leishmania parasites to titrate parasite burden in spleen and peripheral blood of patients with visceral leishmaniasis
    • Maurya R., et al. Evaluation of blood agar microtiter plates for culturing Leishmania parasites to titrate parasite burden in spleen and peripheral blood of patients with visceral leishmaniasis. J. Clin. Microbiol. 2010, 48:1932-1934.
    • (2010) J. Clin. Microbiol. , vol.48 , pp. 1932-1934
    • Maurya, R.1
  • 2
    • 33748568158 scopus 로고    scopus 로고
    • Mathematical model of the first wave of Plasmodium falciparum asexual parasitemia in non-immune and vaccinated individuals
    • Dietz K., et al. Mathematical model of the first wave of Plasmodium falciparum asexual parasitemia in non-immune and vaccinated individuals. Am. J. Trop. Med. Hyg. 2006, 75:46-55.
    • (2006) Am. J. Trop. Med. Hyg. , vol.75 , pp. 46-55
    • Dietz, K.1
  • 3
    • 34547586443 scopus 로고    scopus 로고
    • Overwhelming parasitemia with Plasmodium falciparum infection in a patient receiving infliximab therapy for rheumatoid arthritis
    • Geraghty E.M., et al. Overwhelming parasitemia with Plasmodium falciparum infection in a patient receiving infliximab therapy for rheumatoid arthritis. Clin. Infect. Dis. 2007, 44:e82-e84.
    • (2007) Clin. Infect. Dis. , vol.44
    • Geraghty, E.M.1
  • 4
    • 0025993193 scopus 로고
    • Schistosome female reproductive development
    • Loverde P.T., Chen L. Schistosome female reproductive development. Parasitol. Today 1991, 7:303-308.
    • (1991) Parasitol. Today , vol.7 , pp. 303-308
    • Loverde, P.T.1    Chen, L.2
  • 5
    • 33646180655 scopus 로고    scopus 로고
    • Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm
    • Bethony J., et al. Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm. Lancet 2006, 367:1521-1532.
    • (2006) Lancet , vol.367 , pp. 1521-1532
    • Bethony, J.1
  • 6
    • 64549142415 scopus 로고    scopus 로고
    • Potential and limits of in silico target discovery - case study of the search for new antimalarial chemotherapeutic targets
    • Saidani N., et al. Potential and limits of in silico target discovery - case study of the search for new antimalarial chemotherapeutic targets. Infect. Genet. Evol. 2009, 9:359-367.
    • (2009) Infect. Genet. Evol. , vol.9 , pp. 359-367
    • Saidani, N.1
  • 7
    • 76749096268 scopus 로고    scopus 로고
    • Targeting the lipid metabolic pathways for the treatment of malaria
    • Ben Mamoun C., et al. Targeting the lipid metabolic pathways for the treatment of malaria. Drug Dev. Res. 2010, 71:44-55.
    • (2010) Drug Dev. Res. , vol.71 , pp. 44-55
    • Ben Mamoun, C.1
  • 8
    • 77954956306 scopus 로고    scopus 로고
    • Lipidomics: coming to grips with lipid diversity
    • Shevchenko A., Simons K. Lipidomics: coming to grips with lipid diversity. Nat. Rev. Mol. Cell Biol. 2010, 11:593-598.
    • (2010) Nat. Rev. Mol. Cell Biol. , vol.11 , pp. 593-598
    • Shevchenko, A.1    Simons, K.2
  • 9
    • 60549109072 scopus 로고    scopus 로고
    • Lipidomics joins the omics evolution
    • Dennis E.A. Lipidomics joins the omics evolution. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:2089-2090.
    • (2009) Proc. Natl. Acad. Sci. U.S.A. , vol.106 , pp. 2089-2090
    • Dennis, E.A.1
  • 10
    • 84873090174 scopus 로고    scopus 로고
    • Lipidomics approaches for a comprehensive analysis of fatty acids and metabolites by LC/ESI-MS
    • Kita Y., et al. Lipidomics approaches for a comprehensive analysis of fatty acids and metabolites by LC/ESI-MS. Prostaglandins Other Lipid Mediat. 2006, 79:150-151.
    • (2006) Prostaglandins Other Lipid Mediat. , vol.79 , pp. 150-151
    • Kita, Y.1
  • 11
    • 22144478635 scopus 로고    scopus 로고
    • The emerging field of lipidomics
    • Wenk M.R. The emerging field of lipidomics. Nat. Rev. Drug Discov. 2005, 4:594-610.
    • (2005) Nat. Rev. Drug Discov. , vol.4 , pp. 594-610
    • Wenk, M.R.1
  • 12
    • 0037546957 scopus 로고    scopus 로고
    • Lipidomics
    • McKee D.L. Lipidomics. Scientist 2003, 17:20.
    • (2003) Scientist , vol.17 , pp. 20
    • McKee, D.L.1
  • 13
    • 0344413852 scopus 로고    scopus 로고
    • Lipidomics is emerging
    • Lagarde M., et al. Lipidomics is emerging. Biochim. Biophys. Acta 2003, 1634:61.
    • (2003) Biochim. Biophys. Acta , vol.1634 , pp. 61
    • Lagarde, M.1
  • 14
    • 84873085552 scopus 로고    scopus 로고
    • Lipidomics: probing lipid-protein interactions using immobilized lipids
    • Feng L., et al. Lipidomics: probing lipid-protein interactions using immobilized lipids. FASEB J. 2003, 17:A993-A994.
    • (2003) FASEB J. , vol.17
    • Feng, L.1
  • 15
    • 0026035172 scopus 로고
    • Modification of host cell membrane lipid composition by the intra-erythrocytic human malaria parasite Plasmodium falciparum
    • Hsiao L.L., et al. Modification of host cell membrane lipid composition by the intra-erythrocytic human malaria parasite Plasmodium falciparum. Biochem. J. 1991, 274:121-132.
    • (1991) Biochem. J. , vol.274 , pp. 121-132
    • Hsiao, L.L.1
  • 16
    • 36849024386 scopus 로고    scopus 로고
    • Lipidomic analysis of Toxoplasma gondii reveals unusual polar lipids
    • Welti R., et al. Lipidomic analysis of Toxoplasma gondii reveals unusual polar lipids. Biochemistry 2007, 46:13882-13890.
    • (2007) Biochemistry , vol.46 , pp. 13882-13890
    • Welti, R.1
  • 17
    • 44949192200 scopus 로고    scopus 로고
    • Subcellular localization and dynamics of a digalactolipid-like epitope in Toxoplasma gondii
    • Botte C., et al. Subcellular localization and dynamics of a digalactolipid-like epitope in Toxoplasma gondii. J. Lipid Res. 2008, 49:746-762.
    • (2008) J. Lipid Res. , vol.49 , pp. 746-762
    • Botte, C.1
  • 18
    • 60349121591 scopus 로고    scopus 로고
    • Export of a Toxoplasma gondii rhoptry neck protein complex at the host cell membrane to form the moving junction during invasion
    • Besteiro S., et al. Export of a Toxoplasma gondii rhoptry neck protein complex at the host cell membrane to form the moving junction during invasion. PLoS Pathog. 2009, 5:e1000309.
    • (2009) PLoS Pathog. , vol.5
    • Besteiro, S.1
  • 19
    • 33748646357 scopus 로고    scopus 로고
    • Toxoplasma gondii grown in human cells uses GalNAc-containing glycosylphosphatidylinositol precursors to anchor surface antigens while the immunogenic Glc-GalNAc-containing precursors remain free at the parasite cell surface
    • Azzouz N., et al. Toxoplasma gondii grown in human cells uses GalNAc-containing glycosylphosphatidylinositol precursors to anchor surface antigens while the immunogenic Glc-GalNAc-containing precursors remain free at the parasite cell surface. Int. J. Biochem. Cell Biol. 2006, 38:1914-1925.
    • (2006) Int. J. Biochem. Cell Biol. , vol.38 , pp. 1914-1925
    • Azzouz, N.1
  • 20
    • 22144485970 scopus 로고    scopus 로고
    • Removal of phospholipid contaminants through precipitation of glycosylphosphatidylinositols
    • Azzouz N., et al. Removal of phospholipid contaminants through precipitation of glycosylphosphatidylinositols. Anal. Biochem. 2005, 343:152-158.
    • (2005) Anal. Biochem. , vol.343 , pp. 152-158
    • Azzouz, N.1
  • 21
    • 20944445676 scopus 로고    scopus 로고
    • Immunolocalisation of an ABC transporter, P-glycoprotein, in the eggshells and cuticles of free-living and parasitic stages of Haemonchus contortus
    • Riou M., et al. Immunolocalisation of an ABC transporter, P-glycoprotein, in the eggshells and cuticles of free-living and parasitic stages of Haemonchus contortus. Parasitol. Res. 2005, 96:142-148.
    • (2005) Parasitol. Res. , vol.96 , pp. 142-148
    • Riou, M.1
  • 22
    • 0041527072 scopus 로고    scopus 로고
    • Modulation of the multidrug resistance (MDR) system in the nematode Haemonchus contortus by changing cholesterol content: effects on resistance to anthelmintics
    • Riou M., et al. Modulation of the multidrug resistance (MDR) system in the nematode Haemonchus contortus by changing cholesterol content: effects on resistance to anthelmintics. J. Antimicrob. Chemother. 2003, 52:180-187.
    • (2003) J. Antimicrob. Chemother. , vol.52 , pp. 180-187
    • Riou, M.1
  • 23
    • 63049136500 scopus 로고    scopus 로고
    • From lipids analysis towards lipidomics, a new challenge for the analytical chemistry of the 21st century. Part II: analytical lipidomics
    • Navas-Iglesias N., et al. From lipids analysis towards lipidomics, a new challenge for the analytical chemistry of the 21st century. Part II: analytical lipidomics. Trends Anal. Chem. 2009, 28:393-403.
    • (2009) Trends Anal. Chem. , vol.28 , pp. 393-403
    • Navas-Iglesias, N.1
  • 24
    • 34250209872 scopus 로고    scopus 로고
    • Top-down lipidomic screens by multivariate analysis of high-resolution survey mass spectra
    • Schwudke D., et al. Top-down lipidomic screens by multivariate analysis of high-resolution survey mass spectra. Anal. Chem. 2007, 79:4083-4093.
    • (2007) Anal. Chem. , vol.79 , pp. 4083-4093
    • Schwudke, D.1
  • 25
    • 77954486157 scopus 로고    scopus 로고
    • Profiling of lipids in Leishmania donovani using hydrophilic interaction chromatography in combination with Fourier transform mass spectrometry
    • Zheng L., et al. Profiling of lipids in Leishmania donovani using hydrophilic interaction chromatography in combination with Fourier transform mass spectrometry. Rapid Commun. Mass Spectrom. 2010, 24:2074-2082.
    • (2010) Rapid Commun. Mass Spectrom. , vol.24 , pp. 2074-2082
    • Zheng, L.1
  • 26
    • 68949157005 scopus 로고    scopus 로고
    • Mass spectrometry: from proteomics to metabolomics and lipidomics
    • Griffiths W.J., Wang Y. Mass spectrometry: from proteomics to metabolomics and lipidomics. Chem. Soc. Rev. 2009, 38:1882-1896.
    • (2009) Chem. Soc. Rev. , vol.38 , pp. 1882-1896
    • Griffiths, W.J.1    Wang, Y.2
  • 27
    • 63449085648 scopus 로고    scopus 로고
    • Hyphenated tools for phospholipidomics
    • Willmann J., et al. Hyphenated tools for phospholipidomics. J. Biomol. Tech. 2008, 19:211-216.
    • (2008) J. Biomol. Tech. , vol.19 , pp. 211-216
    • Willmann, J.1
  • 28
    • 67849111947 scopus 로고    scopus 로고
    • Sphingolipidomics: methods for the comprehensive analysis of sphingolipids
    • Haynes C.A., et al. Sphingolipidomics: methods for the comprehensive analysis of sphingolipids. J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. 2009, 877:2696-2708.
    • (2009) J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. , vol.877 , pp. 2696-2708
    • Haynes, C.A.1
  • 29
    • 48749109742 scopus 로고    scopus 로고
    • A matter of fat: an introduction to lipidomic profiling methods
    • Roberts L.D., et al. A matter of fat: an introduction to lipidomic profiling methods. J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. 2008, 871:174-181.
    • (2008) J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. , vol.871 , pp. 174-181
    • Roberts, L.D.1
  • 30
    • 79952902364 scopus 로고    scopus 로고
    • Determination of endocannabinoids in nematodes and human brain tissue by liquid chromatography electrospray ionization tandem mass spectrometry
    • Lehtonen M., et al. Determination of endocannabinoids in nematodes and human brain tissue by liquid chromatography electrospray ionization tandem mass spectrometry. J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. 2011, 879:677-694.
    • (2011) J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. , vol.879 , pp. 677-694
    • Lehtonen, M.1
  • 31
    • 34648812303 scopus 로고    scopus 로고
    • MALDI-TOF MS in lipidomics
    • Schiller J., et al. MALDI-TOF MS in lipidomics. Front. Biosci. 2007, 12:2568-2579.
    • (2007) Front. Biosci. , vol.12 , pp. 2568-2579
    • Schiller, J.1
  • 32
    • 18344393519 scopus 로고    scopus 로고
    • Shotgun lipidomics: electrospray ionization mass spectrometric analysis and quantitation of cellular lipidomes directly from crude extracts of biological samples
    • Han X., Gross R.W. Shotgun lipidomics: electrospray ionization mass spectrometric analysis and quantitation of cellular lipidomes directly from crude extracts of biological samples. Mass Spectrom. Rev. 2005, 24:367-412.
    • (2005) Mass Spectrom. Rev. , vol.24 , pp. 367-412
    • Han, X.1    Gross, R.W.2
  • 33
    • 33947396093 scopus 로고    scopus 로고
    • Comparison of atmospheric pressure photoionization and atmospheric pressure chemical ionization for normal-phase LC/MS chiral analysis of pharmaceuticals
    • Cai S.S., et al. Comparison of atmospheric pressure photoionization and atmospheric pressure chemical ionization for normal-phase LC/MS chiral analysis of pharmaceuticals. Anal. Chem. 2007, 79:2491-2498.
    • (2007) Anal. Chem. , vol.79 , pp. 2491-2498
    • Cai, S.S.1
  • 34
    • 77953363034 scopus 로고    scopus 로고
    • Comprehensive blood plasma lipidomics by liquid chromatography/quadrupole time-of-flight mass spectrometry
    • Sandra K., et al. Comprehensive blood plasma lipidomics by liquid chromatography/quadrupole time-of-flight mass spectrometry. J. Chromatogr. A 2010, 1217:4087-4099.
    • (2010) J. Chromatogr. A , vol.1217 , pp. 4087-4099
    • Sandra, K.1
  • 35
    • 33847659164 scopus 로고    scopus 로고
    • Relationships between sterol/phospholipid composition and xenobiotic transport in nematodes
    • Riou M., et al. Relationships between sterol/phospholipid composition and xenobiotic transport in nematodes. Parasitol. Res. 2007, 100:1125-1134.
    • (2007) Parasitol. Res. , vol.100 , pp. 1125-1134
    • Riou, M.1
  • 36
    • 79954629646 scopus 로고    scopus 로고
    • Lipid analysis by thin-layer chromatography - a review of the current state
    • Fuchs B., et al. Lipid analysis by thin-layer chromatography - a review of the current state. J. Chromatogr. A 2010, 1218:2754-2774.
    • (2010) J. Chromatogr. A , vol.1218 , pp. 2754-2774
    • Fuchs, B.1
  • 37
    • 84934439878 scopus 로고    scopus 로고
    • Metabolic labeling and structural analysis of glycosylphosphatidylinositols from parasitic protozoa
    • Azzouz N., et al. Metabolic labeling and structural analysis of glycosylphosphatidylinositols from parasitic protozoa. Methods Mol. Biol. 2008, 446:183-198.
    • (2008) Methods Mol. Biol. , vol.446 , pp. 183-198
    • Azzouz, N.1
  • 38
    • 0036690618 scopus 로고    scopus 로고
    • Synthesis of chloroplast galactolipids in apicomplexan parasites
    • Marechal E., et al. Synthesis of chloroplast galactolipids in apicomplexan parasites. Eukaryot. Cell 2002, 1:653-656.
    • (2002) Eukaryot. Cell , vol.1 , pp. 653-656
    • Marechal, E.1
  • 39
    • 32944461857 scopus 로고    scopus 로고
    • Toxoplasma gondii acyl-lipid metabolism: de novo synthesis from apicoplast-generated fatty acids versus scavenging of host cell precursors
    • Bisanz C., et al. Toxoplasma gondii acyl-lipid metabolism: de novo synthesis from apicoplast-generated fatty acids versus scavenging of host cell precursors. Biochem. J. 2006, 394:197-205.
    • (2006) Biochem. J. , vol.394 , pp. 197-205
    • Bisanz, C.1
  • 40
    • 0035126479 scopus 로고    scopus 로고
    • Triclosan offers protection against blood stages of malaria by inhibiting enoyl-ACP reductase of Plasmodium falciparum
    • Surolia N., Surolia A. Triclosan offers protection against blood stages of malaria by inhibiting enoyl-ACP reductase of Plasmodium falciparum. Nat. Med. 2001, 7:167-173.
    • (2001) Nat. Med. , vol.7 , pp. 167-173
    • Surolia, N.1    Surolia, A.2
  • 41
    • 0036674161 scopus 로고    scopus 로고
    • Host cells: mobilizable lipid resources for the intracellular parasite Toxoplasma gondii
    • Charron A.J., Sibley L.D. Host cells: mobilizable lipid resources for the intracellular parasite Toxoplasma gondii. J. Cell Sci. 2002, 115:3049-3059.
    • (2002) J. Cell Sci. , vol.115 , pp. 3049-3059
    • Charron, A.J.1    Sibley, L.D.2
  • 42
    • 33748353213 scopus 로고    scopus 로고
    • Apicoplast fatty acid synthesis is essential for organelle biogenesis and parasite survival in Toxoplasma gondii
    • Mazumdar J., et al. Apicoplast fatty acid synthesis is essential for organelle biogenesis and parasite survival in Toxoplasma gondii. Proc. Natl. Acad. Sci. U.S.A. 2006, 103:13192-13197.
    • (2006) Proc. Natl. Acad. Sci. U.S.A. , vol.103 , pp. 13192-13197
    • Mazumdar, J.1
  • 43
    • 0038281249 scopus 로고    scopus 로고
    • Phosphoinositide recognition domains
    • Lemmon M.A. Phosphoinositide recognition domains. Traffic 2003, 4:201-213.
    • (2003) Traffic , vol.4 , pp. 201-213
    • Lemmon, M.A.1
  • 44
    • 77954927316 scopus 로고    scopus 로고
    • New methods for capturing the mystery lipid, PtdIns5P
    • Backer J.M. New methods for capturing the mystery lipid, PtdIns5P. Biochem. J. 2010, 428:e1-e2.
    • (2010) Biochem. J. , vol.428
    • Backer, J.M.1
  • 45
    • 79952239104 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-monophosphate is involved in toxoplasma apicoplast biogenesis
    • Tawk L., et al. Phosphatidylinositol 3-monophosphate is involved in toxoplasma apicoplast biogenesis. PLoS Pathog. 2010, 7:e1001286.
    • (2010) PLoS Pathog. , vol.7
    • Tawk, L.1
  • 46
    • 77952733646 scopus 로고    scopus 로고
    • Drug resistance is affected by colocalization of P-glycoproteins in raft-like structures unexpected in eggshells of the nematode Haemonchus contortus
    • Riou M., et al. Drug resistance is affected by colocalization of P-glycoproteins in raft-like structures unexpected in eggshells of the nematode Haemonchus contortus. Biochem. Cell Biol. 2010, 88:459-467.
    • (2010) Biochem. Cell Biol. , vol.88 , pp. 459-467
    • Riou, M.1
  • 47
    • 0027934426 scopus 로고
    • Glycosyl-phosphatidylinositol molecules of the parasite and the host
    • Ferguson M.A., et al. Glycosyl-phosphatidylinositol molecules of the parasite and the host. Parasitology 1994, 108(Suppl.):S45-S54.
    • (1994) Parasitology , vol.108 , Issue.SUPPL.
    • Ferguson, M.A.1
  • 48
    • 77958515323 scopus 로고    scopus 로고
    • Binding of Toxoplasma gondii glycosylphosphatidylinositols to galectin-3 is required for their recognition by macrophages
    • Debierre-Grockiego F., et al. Binding of Toxoplasma gondii glycosylphosphatidylinositols to galectin-3 is required for their recognition by macrophages. J. Biol. Chem. 2010, 285:32744-32750.
    • (2010) J. Biol. Chem. , vol.285 , pp. 32744-32750
    • Debierre-Grockiego, F.1
  • 49
    • 29544443397 scopus 로고    scopus 로고
    • Lipid biology of Apicomplexa: perspectives for new drug targets, particularly for Toxoplasma gondii
    • Sonda S., Hehl A.B. Lipid biology of Apicomplexa: perspectives for new drug targets, particularly for Toxoplasma gondii. Trends Parasitol. 2006, 22:41-47.
    • (2006) Trends Parasitol. , vol.22 , pp. 41-47
    • Sonda, S.1    Hehl, A.B.2
  • 50
    • 34249984441 scopus 로고    scopus 로고
    • Plasmodium falciparum biosynthesizes sulfoglycosphingolipids
    • Landoni M., et al. Plasmodium falciparum biosynthesizes sulfoglycosphingolipids. Mol. Biochem. Parasitol. 2007, 154:22-29.
    • (2007) Mol. Biochem. Parasitol. , vol.154 , pp. 22-29
    • Landoni, M.1
  • 51
    • 0036718457 scopus 로고    scopus 로고
    • Antibodies to Plasmodium falciparum glycosylphosphatidylinositols: inverse association with tolerance of parasitemia in Papua New Guinean children and adults
    • Boutlis C.S., et al. Antibodies to Plasmodium falciparum glycosylphosphatidylinositols: inverse association with tolerance of parasitemia in Papua New Guinean children and adults. Infect. Immun. 2002, 70:5052-5057.
    • (2002) Infect. Immun. , vol.70 , pp. 5052-5057
    • Boutlis, C.S.1
  • 52
    • 33751425006 scopus 로고    scopus 로고
    • Integration and mining of malaria molecular, functional and pharmacological data: how far are we from a chemogenomic knowledge space?
    • Birkholtz L.M., et al. Integration and mining of malaria molecular, functional and pharmacological data: how far are we from a chemogenomic knowledge space?. Malar. J. 2006, 5:110.
    • (2006) Malar. J. , vol.5 , pp. 110
    • Birkholtz, L.M.1
  • 53
    • 75549090213 scopus 로고    scopus 로고
    • KEGG for representation and analysis of molecular networks involving diseases and drugs
    • Kanehisa M., et al. KEGG for representation and analysis of molecular networks involving diseases and drugs. Nucleic Acids Res. 2010, 38:D355-D360.
    • (2010) Nucleic Acids Res. , vol.38
    • Kanehisa, M.1
  • 54
    • 75549090505 scopus 로고    scopus 로고
    • The MetaCyc database of metabolic pathways and enzymes and the BioCyc collection of pathway/genome databases
    • Caspi R., et al. The MetaCyc database of metabolic pathways and enzymes and the BioCyc collection of pathway/genome databases. Nucleic Acids Res. 2010, 38:D473-D479.
    • (2010) Nucleic Acids Res. , vol.38
    • Caspi, R.1
  • 55
    • 79959358804 scopus 로고    scopus 로고
    • Plasmodium falciparum metabolic pathways (MPMP) project upgraded with a database of subcellular locations of gene products
    • Ginsburg H., Tilley L. Plasmodium falciparum metabolic pathways (MPMP) project upgraded with a database of subcellular locations of gene products. Trends Parasitol. 2011, 27:285-286.
    • (2011) Trends Parasitol. , vol.27 , pp. 285-286
    • Ginsburg, H.1    Tilley, L.2
  • 56
    • 0037228888 scopus 로고    scopus 로고
    • A type II pathway for fatty acid biosynthesis presents drug targets in Plasmodium falciparum
    • Waller R.F., et al. A type II pathway for fatty acid biosynthesis presents drug targets in Plasmodium falciparum. Antimicrob. Agents Chemother. 2003, 47:297-301.
    • (2003) Antimicrob. Agents Chemother. , vol.47 , pp. 297-301
    • Waller, R.F.1
  • 57
    • 0037417775 scopus 로고    scopus 로고
    • The initiating steps of a type II fatty acid synthase in Plasmodium falciparum are catalyzed by pfACP, pfMCAT, and pfKASIII
    • Prigge S.T., et al. The initiating steps of a type II fatty acid synthase in Plasmodium falciparum are catalyzed by pfACP, pfMCAT, and pfKASIII. Biochemistry 2003, 42:1160-1169.
    • (2003) Biochemistry , vol.42 , pp. 1160-1169
    • Prigge, S.T.1
  • 58
    • 0035119443 scopus 로고    scopus 로고
    • Triclosan inhibits the growth of Plasmodium falciparum and Toxoplasma gondii by inhibition of apicomplexan Fab I
    • McLeod R., et al. Triclosan inhibits the growth of Plasmodium falciparum and Toxoplasma gondii by inhibition of apicomplexan Fab I. Int. J. Parasitol. 2001, 31:109-113.
    • (2001) Int. J. Parasitol. , vol.31 , pp. 109-113
    • McLeod, R.1
  • 59
    • 57049187017 scopus 로고    scopus 로고
    • The fatty acid biosynthesis enzyme FabI plays a key role in the development of liver-stage malarial parasites
    • Yu M., et al. The fatty acid biosynthesis enzyme FabI plays a key role in the development of liver-stage malarial parasites. Cell Host Microbe 2008, 4:567-578.
    • (2008) Cell Host Microbe , vol.4 , pp. 567-578
    • Yu, M.1
  • 60
    • 78651247956 scopus 로고    scopus 로고
    • Triclosan is minimally effective in rodent malaria models
    • 34-35 author reply
    • Baschong W., et al. Triclosan is minimally effective in rodent malaria models. Nat. Med. 2011, 17:33-34. 34-35 author reply.
    • (2011) Nat. Med. , vol.17 , pp. 33-34
    • Baschong, W.1
  • 61
    • 78651252319 scopus 로고    scopus 로고
    • Triclosan is minimally effective in rodent malaria models - reply
    • Surolia A., Surolia N. Triclosan is minimally effective in rodent malaria models - reply. Nat. Med. 2011, 17:34-35.
    • (2011) Nat. Med. , vol.17 , pp. 34-35
    • Surolia, A.1    Surolia, N.2
  • 62
    • 77957323256 scopus 로고    scopus 로고
    • Exploring metabolomic approaches to analyse phospholipid biosynthetic pathways in Plasmodium
    • Besteiro S., et al. Exploring metabolomic approaches to analyse phospholipid biosynthetic pathways in Plasmodium. Parasitology 2010, 137:1343-1356.
    • (2010) Parasitology , vol.137 , pp. 1343-1356
    • Besteiro, S.1
  • 63
    • 73149087664 scopus 로고    scopus 로고
    • Rodent and nonrodent malaria parasites differ in their phospholipid metabolic pathways
    • Dechamps S., et al. Rodent and nonrodent malaria parasites differ in their phospholipid metabolic pathways. J. Lipid Res. 2010, 51:81-96.
    • (2010) J. Lipid Res. , vol.51 , pp. 81-96
    • Dechamps, S.1
  • 64
    • 77954315436 scopus 로고    scopus 로고
    • Exploration of potential prodrug approach of the bis-thiazolium salts T3 and T4 for orally delivered antimalarials
    • Caldarelli S.A., et al. Exploration of potential prodrug approach of the bis-thiazolium salts T3 and T4 for orally delivered antimalarials. Bioorg. Med. Chem. Lett. 2010, 20:3953-3956.
    • (2010) Bioorg. Med. Chem. Lett. , vol.20 , pp. 3953-3956
    • Caldarelli, S.A.1
  • 65
    • 78650346533 scopus 로고    scopus 로고
    • Symmetrical choline-derived dications display strong anti-kinetoplastid activity
    • Ibrahim H.M., et al. Symmetrical choline-derived dications display strong anti-kinetoplastid activity. J. Antimicrob. Chemother. 2010, 66:111-125.
    • (2010) J. Antimicrob. Chemother. , vol.66 , pp. 111-125
    • Ibrahim, H.M.1
  • 66
    • 0022523008 scopus 로고
    • Concentration- and time-dependence of amphotericin-B induced permeability changes across ergosterol-containing liposomes
    • Cohen B.E. Concentration- and time-dependence of amphotericin-B induced permeability changes across ergosterol-containing liposomes. Biochim. Biophys. Acta 1986, 857:117-122.
    • (1986) Biochim. Biophys. Acta , vol.857 , pp. 117-122
    • Cohen, B.E.1
  • 67
    • 21444457549 scopus 로고    scopus 로고
    • Alteration of fatty acid and sterol metabolism in miltefosine-resistant Leishmania donovani promastigotes and consequences for drug-membrane interactions
    • Rakotomanga M., et al. Alteration of fatty acid and sterol metabolism in miltefosine-resistant Leishmania donovani promastigotes and consequences for drug-membrane interactions. Antimicrob. Agents Chemother. 2005, 49:2677-2686.
    • (2005) Antimicrob. Agents Chemother. , vol.49 , pp. 2677-2686
    • Rakotomanga, M.1
  • 68
    • 0344291484 scopus 로고    scopus 로고
    • Comparative molecular dynamics simulations of amphotericin B-cholesterol/ergosterol membrane channels
    • Baginski M., et al. Comparative molecular dynamics simulations of amphotericin B-cholesterol/ergosterol membrane channels. Biochim. Biophys. Acta 2002, 1567:63-78.
    • (2002) Biochim. Biophys. Acta , vol.1567 , pp. 63-78
    • Baginski, M.1
  • 69
    • 0036655702 scopus 로고    scopus 로고
    • Ion passage pathways and thermodynamics of the amphotericin B membrane channel
    • Resat H., Baginski M. Ion passage pathways and thermodynamics of the amphotericin B membrane channel. Eur. Biophys. J. 2002, 31:294-305.
    • (2002) Eur. Biophys. J. , vol.31 , pp. 294-305
    • Resat, H.1    Baginski, M.2
  • 70
    • 73949091654 scopus 로고    scopus 로고
    • Membrane sterol depletion impairs miltefosine action in wild-type and miltefosine-resistant Leishmania donovani promastigotes
    • Saint-Pierre-Chazalet M., et al. Membrane sterol depletion impairs miltefosine action in wild-type and miltefosine-resistant Leishmania donovani promastigotes. J. Antimicrob. Chemother. 2009, 64:993-1001.
    • (2009) J. Antimicrob. Chemother. , vol.64 , pp. 993-1001
    • Saint-Pierre-Chazalet, M.1
  • 71
    • 70350431479 scopus 로고    scopus 로고
    • Langmuir monolayer study toward combined antileishmanian therapy involving amphotericin B and edelfosine
    • Hac-Wydro K., et al. Langmuir monolayer study toward combined antileishmanian therapy involving amphotericin B and edelfosine. J. Phys. Chem. B 2009, 113:14239-14246.
    • (2009) J. Phys. Chem. B , vol.113 , pp. 14239-14246
    • Hac-Wydro, K.1
  • 72
    • 55849137267 scopus 로고    scopus 로고
    • Sitamaquine sensitivity in Leishmania species is not mediated by drug accumulation in acidocalcisomes
    • Lopez-Martin C., et al. Sitamaquine sensitivity in Leishmania species is not mediated by drug accumulation in acidocalcisomes. Antimicrob. Agents Chemother. 2008, 52:4030-4036.
    • (2008) Antimicrob. Agents Chemother. , vol.52 , pp. 4030-4036
    • Lopez-Martin, C.1
  • 73
    • 33846410660 scopus 로고    scopus 로고
    • Interaction of sitamaquine with membrane lipids of Leishmania donovani promastigotes
    • Duenas-Romero A.M., et al. Interaction of sitamaquine with membrane lipids of Leishmania donovani promastigotes. Biochim. Biophys. Acta 2007, 1768:246-252.
    • (2007) Biochim. Biophys. Acta , vol.1768 , pp. 246-252
    • Duenas-Romero, A.M.1
  • 74
    • 77954756315 scopus 로고    scopus 로고
    • Membrane drug transport in helminths
    • Kerboeuf D., et al. Membrane drug transport in helminths. Anti-Infective Agents Med. Chem. 2010, 9:113-129.
    • (2010) Anti-Infective Agents Med. Chem. , vol.9 , pp. 113-129
    • Kerboeuf, D.1
  • 75
    • 65549098612 scopus 로고    scopus 로고
    • Cellular transport and lipid interactions of miltefosine
    • Barratt G., et al. Cellular transport and lipid interactions of miltefosine. Curr. Drug Metab. 2009, 10:247-255.
    • (2009) Curr. Drug Metab. , vol.10 , pp. 247-255
    • Barratt, G.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.