Exploration of potential prodrug approach of the bis-thiazolium salts T3 and T4 for orally delivered antimalarials

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 13, 2010, Pages 3953-3956

  Caldarelli, Sergio A ^a   Boisbrun, Michel ^a   Alarcon, Karine ^a   Hamzé, Abdallah ^a   Ouattara, Mahama ^a   Salom Roig, Xavier ^a   Maynadier, Marjorie ^b   Wein, Sharon ^b   Peyrottes, Suzanne ^a   Pellet, Alain ^c   Calas, Michle ^a   Vial, Henri ^b  

^a UNIVERSITÉ DE MONTPELLIER   (France)

^b UNIVERSITÉ DE MONTPELLIER   (France)

^c SANOFI   (France)

Author keywords

Antimalarials; Choline analogues; Prodrug

Indexed keywords

1,12 BIS[5 (2 HYDROXYETHYL) 4 METHYL 1,3 THIAZOL 3 IUM]DODECANE DIBROMIDE; ANTIMALARIAL AGENT; ANTISPOROZOAL AGENT; CARBONIC ACID DERIVATIVE; PRODRUG; SODIUM CHLORIDE; THIOCARBAMIC ACID; THIOESTER; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANTIMALARIAL ACTIVITY; ARTICLE; CHEMICAL REACTION; CLINICAL TRIAL; CONTROLLED STUDY; DRUG SYNTHESIS; HUMAN; IC 50; IN VITRO STUDY; MALARIA; MOUSE; NONHUMAN; PARASITEMIA; PHYSICAL CHEMISTRY; PLASMODIUM FALCIPARUM; PLASMODIUM VINCKEI INFECTION;

ANIMALS; ANTIMALARIALS; DOSE-RESPONSE RELATIONSHIP, DRUG; MALARIA; MICE; MOLECULAR STRUCTURE; PARASITIC SENSITIVITY TESTS; PLASMODIUM; PRODRUGS; SALTS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

MUS; PLASMODIUM FALCIPARUM; PLASMODIUM VINCKEI;

EID: 77954315436     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.05.001     Document Type: Article

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