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Volumn 71, Issue 1, 2010, Pages 44-55

Targeting the lipid metabolic pathways for the treatment of malaria

Author keywords

Lipid; Malaria; Metabolism; Plasmodium; Therapy

Indexed keywords

3 OXOACYL ACYL CARRIER PROTEIN SYNTHASE; ACYL CARRIER PROTEIN; ANTIMALARIAL AGENT; BORTEZOMIB; CITICOLINE; ETHANOLAMINE; ETHANOLAMINE PHOSPHOTRANSFERASE; MILTEFOSINE; PHOSPHATIDYLCHOLINE; PHOSPHOETHANOLAMINE; PHOSPHOLIPID; PROTOZOAL DNA; S ADENOSYLMETHIONINE; SERINE; THIOLACTOMYCIN; TRICLOSAN;

EID: 76749096268     PISSN: 02724391     EISSN: 10982299     Source Type: Journal    
DOI: 10.1002/ddr.20347     Document Type: Review
Times cited : (92)

References (89)
  • 1
    • 64049114347 scopus 로고    scopus 로고
    • In vitro characterization of the enzyme properties of the phospholipid N-methyltransferase PmtA from Agrobacterium tumefaciens
    • Aktas M, Narberhaus F. 2009. In vitro characterization of the enzyme properties of the phospholipid N-methyltransferase PmtA from Agrobacterium tumefaciens. J Bacteriol 191:2033-2041.
    • (2009) J Bacteriol , vol.191 , pp. 2033-2041
    • Aktas, M.1    Narberhaus, F.2
  • 2
    • 33846965950 scopus 로고    scopus 로고
    • Scavenging of the cofactor lipoate is essential for the survival of the malaria parasite Plasmodium falciparum
    • Allary M, Lu JZ, Zhu L, Prigge ST. 2007. Scavenging of the cofactor lipoate is essential for the survival of the malaria parasite Plasmodium falciparum. Mol Microbiol 63:1331-1344.
    • (2007) Mol Microbiol , vol.63 , pp. 1331-1344
    • Allary, M.1    Lu, J.Z.2    Zhu, L.3    Prigge, S.T.4
  • 3
    • 0022637909 scopus 로고
    • Quaternary ammonium compounds efficiently inhibit Plasmodium falciparum growth in vitro by impairment of choline transport
    • Ancelin ML, Vial HJ. 1986. Quaternary ammonium compounds efficiently inhibit Plasmodium falciparum growth in vitro by impairment of choline transport. Antimicrob Agents Chemother 29:814-820.
    • (1986) Antimicrob Agents Chemother , vol.29 , pp. 814-820
    • Ancelin, M.L.1    Vial, H.J.2
  • 4
    • 0022394011 scopus 로고
    • Inhibitors of choline transport into Plasmodium-infected erythrocytes are effective antiplasmodial compounds in vitro
    • Ancelin ML, Vial HJ, Philippot JR. 1985. Inhibitors of choline transport into Plasmodium-infected erythrocytes are effective antiplasmodial compounds in vitro. Biochem Pharmacol 34: 4068-4071.
    • (1985) Biochem Pharmacol , vol.34 , pp. 4068-4071
    • Ancelin, M.L.1    Vial, H.J.2    Philippot, J.R.3
  • 5
    • 0025966977 scopus 로고
    • Increased permeability to choline in simian erythrocytes after Plasmodium knowlesi infection
    • Ancelin ML, Parant M, Thuet MJ, Philippot JR, Vial HJ. 1991. Increased permeability to choline in simian erythrocytes after Plasmodium knowlesi infection. Biochem J 273:701-709.
    • (1991) Biochem J , vol.273 , pp. 701-709
    • Ancelin, M.L.1    Parant, M.2    Thuet, M.J.3    Philippot, J.R.4    Vial, H.J.5
  • 6
    • 0027282594 scopus 로고
    • Isolation and functional expression in Escherichia coli of a gene encoding phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides
    • Arondel V, Benning C, Somerville CR. 1993. Isolation and functional expression in Escherichia coli of a gene encoding phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. J Biol Chem 268:16002-16008.
    • (1993) J Biol Chem , vol.268 , pp. 16002-16008
    • Arondel, V.1    Benning, C.2    Somerville, C.R.3
  • 7
    • 0034255144 scopus 로고    scopus 로고
    • Modulation of CTP:phosphocholine cytidylyltransferase by membrane curvature elastic stress
    • Attard GS, Templer RH, Smith WS, Hunt AN, Jackowski S. 2000. Modulation of CTP:phosphocholine cytidylyltransferase by membrane curvature elastic stress. Proc Natl Acad Sci USA 97: 9032-9036.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 9032-9036
    • Attard, G.S.1    Templer, R.H.2    Smith, W.S.3    Hunt, A.N.4    Jackowski, S.5
  • 8
    • 0023872348 scopus 로고
    • Correlation of the efficiency of fatty acid derivatives in suppressing Plasmodium falciparum growth in culture with their inhibitory effect on acyl-CoA synthetase activity
    • Beaumelle BD, Vial HJ. 1988. Correlation of the efficiency of fatty acid derivatives in suppressing Plasmodium falciparum growth in culture with their inhibitory effect on acyl-CoA synthetase activity. Mol Biochem Parasitol 28:39-42.
    • (1988) Mol Biochem Parasitol , vol.28 , pp. 39-42
    • Beaumelle, B.D.1    Vial, H.J.2
  • 10
    • 8644252786 scopus 로고    scopus 로고
    • Characterization of the choline carrier of Plasmodium falciparum: A route for the selective delivery of novel antimalarial drugs
    • Biagini GA, Pasini EM, Hughes R, De Koning HP, Vial HJ, O'Neill PM, Ward SA, Bray PG. 2004. Characterization of the choline carrier of Plasmodium falciparum: a route for the selective delivery of novel antimalarial drugs. Blood 104:3372-3377.
    • (2004) Blood , vol.104 , pp. 3372-3377
    • Biagini, G.A.1    Pasini, E.M.2    Hughes, R.3    De Koning, H.P.4    Vial, H.J.5    O'Neill, P.M.6    Ward, S.A.7    Bray, P.G.8
  • 11
    • 0034522758 scopus 로고    scopus 로고
    • The isolation and characterization in yeast of a gene for Arabidopsis S-adenosylmethionine:phosphoethanolamine N-methyltransferase
    • Bolognese CP, McGraw P. 2000. The isolation and characterization in yeast of a gene for Arabidopsis S-adenosylmethionine:phosphoethanolamine N-methyltransferase. Plant Physiol 124:1800-1813.
    • (2000) Plant Physiol , vol.124 , pp. 1800-1813
    • Bolognese, C.P.1    McGraw, P.2
  • 13
    • 0034628578 scopus 로고    scopus 로고
    • Antimalarial activity of compounds interfering with Plasmodium falciparum phospholipid metabolism: Comparison between mono- and bisquaternary ammonium salts
    • Calas M, Ancelin ML, Cordina G, Portefaix P, Piquet G, Vidal-Sailhan V, Vial H. 2000. Antimalarial activity of compounds interfering with Plasmodium falciparum phospholipid metabolism: comparison between mono- and bisquaternary ammonium salts. J Med Chem 43:505-516.
    • (2000) J Med Chem , vol.43 , pp. 505-516
    • Calas, M.1    Ancelin, M.L.2    Cordina, G.3    Portefaix, P.4    Piquet, G.5    Vidal-Sailhan, V.6    Vial, H.7
  • 14
    • 0036000060 scopus 로고    scopus 로고
    • Molecular and biochemical characterization of a coldregulated phosphoethanolamine N-methyltransferase from wheat
    • Charron JB, Breton G, Danyluk J, Muzac I, Ibrahim RK, Sarhan F. 2002. Molecular and biochemical characterization of a coldregulated phosphoethanolamine N-methyltransferase from wheat. Plant Physiol 129:363-373.
    • (2002) Plant Physiol , vol.129 , pp. 363-373
    • Charron, J.B.1    Breton, G.2    Danyluk, J.3    Muzac, I.4    Ibrahim, R.K.5    Sarhan, F.6
  • 15
    • 33750036420 scopus 로고    scopus 로고
    • Novel diphenyl ethers: Design, docking studies, synthesis and inhibition of enoyl ACP reductase of Plasmodium falciparum and Escherichia coli
    • Chhibber M, Kumar G, Parasuraman P, Ramya TN, Surolia N, Surolia A. 2006. Novel diphenyl ethers: design, docking studies, synthesis and inhibition of enoyl ACP reductase of Plasmodium falciparum and Escherichia coli. Bioorg Med Chem 14:8086-8098.
    • (2006) Bioorg Med Chem , vol.14 , pp. 8086-8098
    • Chhibber, M.1    Kumar, G.2    Parasuraman, P.3    Ramya, T.N.4    Surolia, N.5    Surolia, A.6
  • 17
    • 0035807063 scopus 로고    scopus 로고
    • Regulation of CTP: Phosphocholine cytidylyltransferase activity by the physical properties of lipid membranes: an important role for stored curvature strain energy
    • Davies SM, Epand RM, Kraayenhof R, Cornell RB. 2001. Regulation of CTP: phosphocholine cytidylyltransferase activity by the physical properties of lipid membranes: an important role for stored curvature strain energy. Biochemistry 40:10522-10531.
    • (2001) Biochemistry , vol.40 , pp. 10522-10531
    • Davies, S.M.1    Epand, R.M.2    Kraayenhof, R.3    Cornell, R.B.4
  • 18
    • 0021909963 scopus 로고
    • Nutritional requirements of Plasmodium falciparum in culture. I. Exogenously supplied dialyzable components necessary for continuous growth
    • Divo AA, Geary TG, Davis NL, Jensen JB. 1985. Nutritional requirements of Plasmodium falciparum in culture. I. Exogenously supplied dialyzable components necessary for continuous growth. J Protozool 32:59-64.
    • (1985) J Protozool , vol.32 , pp. 59-64
    • Divo, A.A.1    Geary, T.G.2    Davis, N.L.3    Jensen, J.B.4
  • 19
    • 0030908445 scopus 로고    scopus 로고
    • Phospholipid metabolism of serine in Plasmodium-infected erythrocytes involves phosphatidylserine and direct serine decarboxylation
    • Elabbadi N, Ancelin ML, Vial HJ. 1997. Phospholipid metabolism of serine in Plasmodium-infected erythrocytes involves phosphatidylserine and direct serine decarboxylation. Biochem J 324:435-445.
    • (1997) Biochem J , vol.324 , pp. 435-445
    • Elabbadi, N.1    Ancelin, M.L.2    Vial, H.J.3
  • 24
    • 76749155271 scopus 로고    scopus 로고
    • Plasmodium falciparum acyl carrier protein crystal structures in disulfide-linked and reduced states and their prevalence during blood stage growth
    • in press
    • Gallagher JR, Prigge ST. 2009. Plasmodium falciparum acyl carrier protein crystal structures in disulfide-linked and reduced states and their prevalence during blood stage growth. Proteins (in press).
    • (2009) Proteins
    • Gallagher, J.R.1    Prigge, S.T.2
  • 29
    • 0030011405 scopus 로고    scopus 로고
    • Recent advances in the biosynthesis of plant fatty acids
    • Harwood JL. 1996. Recent advances in the biosynthesis of plant fatty acids. Biochim Biophys Acta 1301:7-56.
    • (1996) Biochim Biophys Acta , vol.1301 , pp. 7-56
    • Harwood, J.L.1
  • 30
    • 0017691206 scopus 로고
    • Lipids and the malarial parasite
    • Holz GG. 1977. Lipids and the malarial parasite. Bull World Health Org 55:237-248.
    • (1977) Bull World Health Org , vol.55 , pp. 237-248
    • Holz, G.G.1
  • 32
    • 0031714986 scopus 로고    scopus 로고
    • The Schizosaccharomyces pombe cho1+ gene encodes a phospholipid methyltransferase
    • Kanipes MI, Hill JE, Henry SA. 1998. The Schizosaccharomyces pombe cho1+ gene encodes a phospholipid methyltransferase. Genetics 150:553-562.
    • (1998) Genetics , vol.150 , pp. 553-562
    • Kanipes, M.I.1    Hill, J.E.2    Henry, S.A.3
  • 33
    • 67650129378 scopus 로고    scopus 로고
    • Functional characterization of phospholipid N-methyltransferases from Arabidopsis and soybean
    • Keogh MR, Courtney PD, Kinney AJ, Dewey RE. 2009. Functional characterization of phospholipid N-methyltransferases from Arabidopsis and soybean. J Biol Chem 284:15439-15447.
    • (2009) J Biol Chem , vol.284 , pp. 15439-15447
    • Keogh, M.R.1    Courtney, P.D.2    Kinney, A.J.3    Dewey, R.E.4
  • 34
    • 0025909081 scopus 로고
    • Enhanced choline and Rb1 transport in human erythrocytes infected with the malaria parasite Plasmodium falciparum
    • Kirk K, Wong HY, Elford BC, Newbold CI, Ellory JC. 1991. Enhanced choline and Rb1 transport in human erythrocytes infected with the malaria parasite Plasmodium falciparum. Biochem J 278:521-525.
    • (1991) Biochem J , vol.278 , pp. 521-525
    • Kirk, K.1    Wong, H.Y.2    Elford, B.C.3    Newbold, C.I.4    Ellory, J.C.5
  • 35
    • 0023656673 scopus 로고
    • Yeast phosphatidylethanolamine methylation pathway. Cloning and characterization of two distinct methyltransferase genes
    • Kodaki T, Yamashita S. 1987. Yeast phosphatidylethanolamine methylation pathway. Cloning and characterization of two distinct methyltransferase genes. J Biol Chem 262:15428-15435.
    • (1987) J Biol Chem , vol.262 , pp. 15428-15435
    • Kodaki, T.1    Yamashita, S.2
  • 36
    • 22544476228 scopus 로고    scopus 로고
    • The crystal structure of PfFabZ, the unique beta-hydroxyacyl-ACP dehydratase involved in fatty acid biosynthesis of Plasmodium falciparum
    • Kostrewa D, Winkler FK, Folkers G, Scapozza L, Perozzo R. 2005. The crystal structure of PfFabZ, the unique beta-hydroxyacyl-ACP dehydratase involved in fatty acid biosynthesis of Plasmodium falciparum. Protein Sci 14:1570-1580.
    • (2005) Protein Sci , vol.14 , pp. 1570-1580
    • Kostrewa, D.1    Winkler, F.K.2    Folkers, G.3    Scapozza, L.4    Perozzo, R.5
  • 38
    • 33646933886 scopus 로고    scopus 로고
    • Recombinant expression and biochemical characterization of the unique elongating beta-ketoacyl-acyl carrier protein synthase involved in fatty acid biosynthesis of Plasmodium falciparum using natural and artificial substrates
    • Lack G, Homberger-Zizzari E, Folkers G, Scapozza L, Perozzo R. 2006. Recombinant expression and biochemical characterization of the unique elongating beta-ketoacyl-acyl carrier protein synthase involved in fatty acid biosynthesis of Plasmodium falciparum using natural and artificial substrates. J Biol Chem 281:9538-9546.
    • (2006) J Biol Chem , vol.281 , pp. 9538-9546
    • Lack, G.1    Homberger-Zizzari, E.2    Folkers, G.3    Scapozza, L.4    Perozzo, R.5
  • 40
    • 2942739027 scopus 로고    scopus 로고
    • Choline uptake into the malaria parasite is energized by the membrane potential
    • Lehane AM, Saliba KJ, Allen RJ, Kirk K. 2004. Choline uptake into the malaria parasite is energized by the membrane potential. Biochem Biophys Res Commun 320:311-317.
    • (2004) Biochem Biophys Res Commun , vol.320 , pp. 311-317
    • Lehane, A.M.1    Saliba, K.J.2    Allen, R.J.3    Kirk, K.4
  • 46
    • 0034283869 scopus 로고    scopus 로고
    • Serum factors governing intraerythrocytic development and cell cycle progression of Plasmodium falciparum
    • Mitamura T, Hanada K, Ko-Mitamura EP, Nishijima M, Horii T. 2000. Serum factors governing intraerythrocytic development and cell cycle progression of Plasmodium falciparum. Parasitol Int 49:219-229.
    • (2000) Parasitol Int , vol.49 , pp. 219-229
    • Mitamura, T.1    Hanada, K.2    Ko-Mitamura, E.P.3    Nishijima, M.4    Horii, T.5
  • 50
    • 0034640386 scopus 로고    scopus 로고
    • cDNA cloning of phosphoethanolamine N-methyltransferase from spinach by complementation in Schizosaccharomyces pombe and characterization of the recombinant enzyme
    • Nuccio ML, Ziemak MJ, Henry SA, Weretilnyk EA, Hanson AD. 2000a. cDNA cloning of phosphoethanolamine N-methyltransferase from spinach by complementation in Schizosaccharomyces pombe and characterization of the recombinant enzyme. J Biol Chem 275:14095-14101.
    • (2000) J Biol Chem , vol.275 , pp. 14095-14101
    • Nuccio, M.L.1    Ziemak, M.J.2    Henry, S.A.3    Weretilnyk, E.A.4    Hanson, A.D.5
  • 51
    • 0034640386 scopus 로고    scopus 로고
    • cDNA cloning of phosphoethanolamine N-methyltransferase from spinach by complementation in Schizosaccharomyces pombe and characterization of the recombinant enzyme
    • Nuccio ML, Ziemak MJ, Henry SA, Weretilnyk EA, Hanson AD. 2000b. cDNA cloning of phosphoethanolamine N-methyltransferase from spinach by complementation in Schizosaccharomyces pombe and characterization of the recombinant enzyme. J Biol Chem 275:14095-14101.
    • (2000) J Biol Chem , vol.275 , pp. 14095-14101
    • Nuccio, M.L.1    Ziemak, M.J.2    Henry, S.A.3    Weretilnyk, E.A.4    Hanson, A.D.5
  • 52
    • 0003806169 scopus 로고
    • Oaks SC, Mitchell VS, Pearson GW, Carpenter CCJ, editors, Washington, DC: National Academy Press. 309p
    • Oaks SC, Mitchell VS, Pearson GW, Carpenter CCJ, editors. 1991. Malaria: obstacles and opportunities. Washington, DC: National Academy Press. 309p.
    • (1991) Malaria: Obstacles and opportunities
  • 55
    • 34247893097 scopus 로고    scopus 로고
    • Pathways for phosphatidylcholine biosynthesis: Targets and strategies for antimalarial drugs
    • Pessi G, Ben Mamoun C. 2006. Pathways for phosphatidylcholine biosynthesis: targets and strategies for antimalarial drugs. Future Med, Future Lipidol 1:173-180.
    • (2006) Future Med, Future Lipidol , vol.1 , pp. 173-180
    • Pessi, G.1    Ben Mamoun, C.2
  • 56
    • 1942437433 scopus 로고    scopus 로고
    • A pathway for phosphatidylcholine biosynthesis in Plasmodium falciparum involving phosphoethanolamine methylation
    • Pessi G, Kociubinski G, Mamoun CB. 2004. A pathway for phosphatidylcholine biosynthesis in Plasmodium falciparum involving phosphoethanolamine methylation. Proc Natl Acad Sci USA 101:6206-6211.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 6206-6211
    • Pessi, G.1    Kociubinski, G.2    Mamoun, C.B.3
  • 57
    • 16844367110 scopus 로고    scopus 로고
    • In vivo evidence for the specificity of Plasmodium falciparum phosphoethanolamine methyltransferase and its coupling to the Kennedy pathway
    • Pessi G, Choi JY, Reynolds JM, Voelker DR, Mamoun CB. 2005. In vivo evidence for the specificity of Plasmodium falciparum phosphoethanolamine methyltransferase and its coupling to the Kennedy pathway. J Biol Chem 280:12461-12466.
    • (2005) J Biol Chem , vol.280 , pp. 12461-12466
    • Pessi, G.1    Choi, J.Y.2    Reynolds, J.M.3    Voelker, D.R.4    Mamoun, C.B.5
  • 58
    • 4644355051 scopus 로고    scopus 로고
    • Structural basis for the variation in triclosan affinity to enoyl reductases
    • Pidugu LS, Kapoor M, Surolia N, Surolia A, Suguna K. 2004. Structural basis for the variation in triclosan affinity to enoyl reductases. J Mol Biol 343:147-155.
    • (2004) J Mol Biol , vol.343 , pp. 147-155
    • Pidugu, L.S.1    Kapoor, M.2    Surolia, N.3    Surolia, A.4    Suguna, K.5
  • 60
    • 0037417775 scopus 로고    scopus 로고
    • The initiating steps of a type II fatty acid synthase in Plasmodium falciparum are catalyzed by pfACP, pfMCAT, and pfKASIII
    • Prigge ST, He X, Gerena L, Waters NC, Reynolds KA. 2003. The initiating steps of a type II fatty acid synthase in Plasmodium falciparum are catalyzed by pfACP, pfMCAT, and pfKASIII. Biochemistry 42:1160-1169.
    • (2003) Biochemistry , vol.42 , pp. 1160-1169
    • Prigge, S.T.1    He, X.2    Gerena, L.3    Waters, N.C.4    Reynolds, K.A.5
  • 62
    • 33749517035 scopus 로고    scopus 로고
    • Potent antihematozoan activity of novel bisthiazolium drug T16: Evidence for inhibition of phosphatidylcholine metabolism in erythrocytes infected with Babesia and Plasmodium spp
    • Richier E, Biagini GA, Wein S, Boudou F, Bray PG, Ward SA, Precigout E, Calas M, Dubremetz JF, Vial HJ. 2006. Potent antihematozoan activity of novel bisthiazolium drug T16: evidence for inhibition of phosphatidylcholine metabolism in erythrocytes infected with Babesia and Plasmodium spp. Antimicrob Agents Chemother 50:3381-3388.
    • (2006) Antimicrob Agents Chemother , vol.50 , pp. 3381-3388
    • Richier, E.1    Biagini, G.A.2    Wein, S.3    Boudou, F.4    Bray, P.G.5    Ward, S.A.6    Precigout, E.7    Calas, M.8    Dubremetz, J.F.9    Vial, H.J.10
  • 63
    • 0030581109 scopus 로고    scopus 로고
    • Escherichia coli as a model for the regulation of dissociable (type II) fatty acid biosynthesis
    • Rock CO, Cronan JE. 1996. Escherichia coli as a model for the regulation of dissociable (type II) fatty acid biosynthesis. Biochim Biophys Acta 1302:1-16.
    • (1996) Biochim Biophys Acta , vol.1302 , pp. 1-16
    • Rock, C.O.1    Cronan, J.E.2
  • 64
    • 0001403687 scopus 로고
    • Plasmodial metabolism and related organellar function during various stages of the life-cycle: Proteins, lipids, nucleic acids and vitamins
    • Wernsdorfer W, McGregor I, editors, New York: Churchill Livingstone. p
    • Scheibel LW, Sherman IW. 1988. Plasmodial metabolism and related organellar function during various stages of the life-cycle: proteins, lipids, nucleic acids and vitamins. In: Wernsdorfer W, McGregor I, editors. Principles and practice of malariology. New York: Churchill Livingstone. p 219-252.
    • (1988) Principles and practice of malariology , pp. 219-252
    • Scheibel, L.W.1    Sherman, I.W.2
  • 65
    • 0242580787 scopus 로고    scopus 로고
    • Identification, characterization, and inhibition of Plasmodium falciparum beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ)
    • Sharma SK, Kapoor M, Ramya TN, Kumar S, Kumar G, Modak R, Sharma S, Surolia N, Surolia A. 2003. Identification, characterization, and inhibition of Plasmodium falciparum beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ). J Biol Chem 278:45661-45671.
    • (2003) J Biol Chem , vol.278 , pp. 45661-45671
    • Sharma, S.K.1    Kapoor, M.2    Ramya, T.N.3    Kumar, S.4    Kumar, G.5    Modak, R.6    Sharma, S.7    Surolia, N.8    Surolia, A.9
  • 66
    • 57049111430 scopus 로고    scopus 로고
    • Malaria pulls a FASt one. Cell Host Microbe
    • Spalding MD, Prigge ST. 2008. Malaria pulls a FASt one. Cell Host Microbe 4:509-511.
    • (2008) , vol.4 , pp. 509-511
    • Spalding, M.D.1    Prigge, S.T.2
  • 67
    • 0024256676 scopus 로고
    • Saccharomyces cerevisiae cho2 mutants are deficient in phospholipid methylation and cross-pathway regulation of inositol synthesis
    • Summers EF, Letts VA, McGraw P, Henry SA. 1988. Saccharomyces cerevisiae cho2 mutants are deficient in phospholipid methylation and cross-pathway regulation of inositol synthesis. Genetics 120:909-922.
    • (1988) Genetics , vol.120 , pp. 909-922
    • Summers, E.F.1    Letts, V.A.2    McGraw, P.3    Henry, S.A.4
  • 68
    • 0035126479 scopus 로고    scopus 로고
    • Triclosan offers protection against blood stages of malaria by inhibiting enoyl-ACP reductase of Plasmodium falciparum
    • Surolia N, Surolia A. 2001. Triclosan offers protection against blood stages of malaria by inhibiting enoyl-ACP reductase of Plasmodium falciparum. Nature Med 7:167-173.
    • (2001) Nature Med , vol.7 , pp. 167-173
    • Surolia, N.1    Surolia, A.2
  • 69
    • 33646203969 scopus 로고    scopus 로고
    • Crystal structure of dimeric FabZ of Plasmodium falciparum reveals conformational switching to active hexamers by peptide flips
    • Swarnamukhi PL, Sharma SK, Bajaj P, Surolia N, Surolia A, Suguna K. 2006. Crystal structure of dimeric FabZ of Plasmodium falciparum reveals conformational switching to active hexamers by peptide flips. FEBS Lett 580:2653-2660.
    • (2006) FEBS Lett , vol.580 , pp. 2653-2660
    • Swarnamukhi, P.L.1    Sharma, S.K.2    Bajaj, P.3    Surolia, N.4    Surolia, A.5    Suguna, K.6
  • 71
    • 0017311840 scopus 로고
    • Human malaria parasites in continuous culture
    • Trager W, Jensen JB. 1976. Human malaria parasites in continuous culture. Science 193:673-675.
    • (1976) Science , vol.193 , pp. 673-675
    • Trager, W.1    Jensen, J.B.2
  • 72
    • 36348969601 scopus 로고    scopus 로고
    • Hepatic phosphatidylethanolamine N-methyltransferase, unexpected roles in animal biochemistry and physiology
    • Vance DE, Li Z, Jacobs RL. 2007. Hepatic phosphatidylethanolamine N-methyltransferase, unexpected roles in animal biochemistry and physiology. J Biol Chem 282:33237-33241.
    • (2007) J Biol Chem , vol.282 , pp. 33237-33241
    • Vance, D.E.1    Li, Z.2    Jacobs, R.L.3
  • 75
    • 17444374866 scopus 로고    scopus 로고
    • Plasmodium lipids: Metabolism and Function
    • Sherman IW, editor, Washington, DC: ASM Press. p
    • Vial HJ, Ben Mamoun C. 2005. Plasmodium lipids: metabolism and Function. In: Sherman IW, editor. Molecular approaches to malaria. Washington, DC: ASM Press. p 327-352.
    • (2005) Molecular approaches to malaria , pp. 327-352
    • Vial, H.J.1    Ben Mamoun, C.2
  • 76
    • 0021150752 scopus 로고
    • Phospholipid metabolism as a new target for malaria chemotherapy. Mechanism of action of D-2-amino-1-butanol
    • Vial HJ, Thuet MJ, Ancelin ML, Philippot JR, Chavis C. 1984. Phospholipid metabolism as a new target for malaria chemotherapy. Mechanism of action of D-2-amino-1-butanol. Biochem Pharmacol 33:2761-2770.
    • (1984) Biochem Pharmacol , vol.33 , pp. 2761-2770
    • Vial, H.J.1    Thuet, M.J.2    Ancelin, M.L.3    Philippot, J.R.4    Chavis, C.5
  • 77
    • 0025204534 scopus 로고
    • Biosynthesis and dynamics of lipids in Plasmodium-infected mature mammalian erythrocytes
    • discussion 556-561
    • Vial HJ, Ancelin ML, Philippot JR, Thuet MJ. 1990. Biosynthesis and dynamics of lipids in Plasmodium-infected mature mammalian erythrocytes. Blood Cells 16:531-555; discussion 556-561.
    • (1990) Blood Cells , vol.16 , pp. 531-555
    • Vial, H.J.1    Ancelin, M.L.2    Philippot, J.R.3    Thuet, M.J.4
  • 81
    • 0034678922 scopus 로고    scopus 로고
    • Protein trafficking to the plastid of Plasmodium falciparum is via the secretory pathway
    • Waller RF, Reed MB, Cowman AF, McFadden GI. 2000. Protein trafficking to the plastid of Plasmodium falciparum is via the secretory pathway. Embo J 19:1794-1802.
    • (2000) Embo J , vol.19 , pp. 1794-1802
    • Waller, R.F.1    Reed, M.B.2    Cowman, A.F.3    McFadden, G.I.4
  • 84
    • 30744471157 scopus 로고    scopus 로고
    • Kinetic, inhibition and structural studies on 3-oxoacyl-ACP reductase from Plasmodium falciparum, a key enzyme in fatty acid biosynthesis
    • Wickramasinghe SR, Inglis KA, Urch JE, Muller S, van Aalten DM, Fairlamb AH. 2006. Kinetic, inhibition and structural studies on 3-oxoacyl-ACP reductase from Plasmodium falciparum, a key enzyme in fatty acid biosynthesis. Biochem J 393:447-457.
    • (2006) Biochem J , vol.393 , pp. 447-457
    • Wickramasinghe, S.R.1    Inglis, K.A.2    Urch, J.E.3    Muller, S.4    van Aalten, D.M.5    Fairlamb, A.H.6
  • 85
    • 67650492478 scopus 로고    scopus 로고
    • In vivo profiles in malaria are consistent with a novel physiological state
    • author reply E71-E72
    • Wirth D, Daily J, Winzeler E, Mesirov JP, Regev A. 2009. In vivo profiles in malaria are consistent with a novel physiological state. Proc Natl Acad Sci USA 106:E70; author reply E71-E72.
    • (2009) Proc Natl Acad Sci USA , vol.106
    • Wirth, D.1    Daily, J.2    Winzeler, E.3    Mesirov, J.P.4    Regev, A.5
  • 86
    • 34748897098 scopus 로고    scopus 로고
    • Choline induces transcriptional repression and proteasomal degradation of the malarial phosphoethanolamine methyltransferase
    • Witola WH, Ben Mamoun C. 2007. Choline induces transcriptional repression and proteasomal degradation of the malarial phosphoethanolamine methyltransferase. Eukaryot Cell 6: 1618-1624.
    • (2007) Eukaryot Cell , vol.6 , pp. 1618-1624
    • Witola, W.H.1    Ben Mamoun, C.2
  • 87
    • 33746328378 scopus 로고    scopus 로고
    • Localization of the phosphoethanolamine methyltransferase of the human malaria parasite Plasmodium falciparum to the Golgi apparatus
    • Witola WH, Pessi G, El Bissati K, Reynolds JM, Mamoun CB. 2006. Localization of the phosphoethanolamine methyltransferase of the human malaria parasite Plasmodium falciparum to the Golgi apparatus. J Biol Chem 281:21305-21311.
    • (2006) J Biol Chem , vol.281 , pp. 21305-21311
    • Witola, W.H.1    Pessi, G.2    El Bissati, K.3    Reynolds, J.M.4    Mamoun, C.B.5
  • 88
    • 55549143016 scopus 로고    scopus 로고
    • Disruption of the Plasmodium falciparum PfPMT gene results in a complete loss of phosphatidylcholine biosynthesis via the serine-decarboxylase- phosphoethanolamine-methyltransferase pathway and severe growth and survival defects
    • Witola WH, El Bissati K, Pessi G, Xie C, Roepe PD, Mamoun CB. 2008. Disruption of the Plasmodium falciparum PfPMT gene results in a complete loss of phosphatidylcholine biosynthesis via the serine-decarboxylase- phosphoethanolamine-methyltransferase pathway and severe growth and survival defects. J Biol Chem 283:27636-27643.
    • (2008) J Biol Chem , vol.283 , pp. 27636-27643
    • Witola, W.H.1    El Bissati, K.2    Pessi, G.3    Xie, C.4    Roepe, P.D.5    Mamoun, C.B.6


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