Host cells: Mobilizable lipid resources for the intracellular parasite Toxoplasma gondii

Journal of Cell Science

Volumn 115, Issue 15, 2002, Pages 3049-3059

  Charron, Audra J ^a   Sibley, L David ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cholesterol; Endocytosis; Exocytosis; Fatty acid; Organelle association; Parasitophorous vacuole; Phosphatidylcholine; Phospholipid; Vesicular transport

Indexed keywords

CHOLESTEROL; FLUORINE DERIVATIVE; LIPID; LONG CHAIN FATTY ACID; PHOSPHATIDIC ACID; PHOSPHATIDYLCHOLINE; PHOSPHOLIPID; RADIOISOTOPE; FATTY ACID; MEMBRANE LIPID;

ARTICLE; BIOCHEMISTRY; BIOGENESIS; CELL COMPARTMENTALIZATION; CELL ORGANELLE; CELL VACUOLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; HOST CELL; HOST PARASITE INTERACTION; HUMAN; HUMAN CELL; LIPID METABOLISM; LIPID TRANSPORT; LIPOGENESIS; MALE; MORPHOLOGY; NONHUMAN; PRIORITY JOURNAL; THIN LAYER CHROMATOGRAPHY; TOXOPLASMA GONDII; ANIMAL; BIOSYNTHESIS; ELECTRON MICROSCOPY; ENDOCYTOSIS; EXOCYTOSIS; METABOLISM; PARASITOLOGY; PATHOGENICITY; PATHOPHYSIOLOGY; PHYSIOLOGY; TOXOPLASMA; TOXOPLASMOSIS; TRANSPORT VESICLE; ULTRASTRUCTURE;

ANIMALS; CELL COMPARTMENTATION; CHOLESTEROL; ENDOCYTOSIS; EXOCYTOSIS; FATTY ACIDS; HOST-PARASITE RELATIONS; MEMBRANE LIPIDS; MICROSCOPY, ELECTRON; PHOSPHATIDYLCHOLINES; TOXOPLASMA; TOXOPLASMOSIS; TRANSPORT VESICLES; VACUOLES;

EID: 0036674161     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. Transmission and scanning electron microscopy of host cell entry by Toxyplasma gondii
2. Sterol carrier protein-2 expression modulates protein and lipid composition of lipid droplets
3. Lamellar membranes associated with rhoptries in erythrocytic merozoites of Plasmodium knowlesi: A clue to the mechanism of invasion
4. The Toxoplasma gondii rhoptry protein ROP2 is inserted into the parasitophorous vacuole membrane, surrounding the intracellular parasite, and is exposed to the host cell cytoplasm
5. Perilipin is located on the surface layer of intracellular lipid droplets in adipocytes
6. Adipose differentiation-related protein is an ubiquitously expressed lipid storage droplet-associated protein
7. The Toxoplasma micronemal protein MIC4 is an adhesin composed of six conserved apple domains
8. Sequential protein secretion from three distinct organelles of Toxoplasma gondii accompanies invasion of human fibroblasts
9. Toxoplasma gondii exploits host low-density lipoprotein receptor-mediated endocytosis for cholesterol acquisition
10. Toxoplasma invasion of mammalian cells is powered by the actin cytoskeleton of the parasite
11. Participation of myosin in gliding motility and host cell invasion by Toxoplasma gondii
12. Kinetics and pattern of organelle exocytosis during Toxoplasma gondii/host-cell interaction
13. Infection of murine peritoneal macrophages with Toxoplasma gondii exposed to ultraviolet light
14. Disruption of the Saccharomyces cerevisiae homologue to the murine fatty acid transport protein impairs uptake and growth of long-chain fatty acids
15. Characterization of the lipid content of Toxoplasma gondii rhoptries
16. Nile red: A selective fluorescent stain for intracellular lipid droplets
17. Toxoplasma evacuoles: A two-step process of secretion and fusion forms the parasitophorous vacuole
18. Rhoptry lipids and parasitophorous vacuole formation: A slippery issue
19. The interaction between Toxoplasma gondii and mammalian cells. I. Mechanism of entry and intracellular fate of the parasite
20. Triclosan inhibits the growth of Plasmodium falciparum and Toxoplasma gondii by inhibition of Apicomplexan Fab I
21. The amphipathic alpha helices of the Toxoplasma protein GRA2 mediate post-secretory membrane association
22. Toxoplasma gondii resides in a vacuole that avoids fusion with host cell endocytic and exocytic vesicular trafficking pathways
23. Invasion by Toxoplasma gondii establishes a moving junction that selectively excludes host cell plasma membrane proteins on the basis of their membrane anchoring
24. Invasion of Toxoplasma gondii occurs by active penetration of the host cell
25. Mechanisms of lipid-body formation
26. Secretion from the rhoptries of Toxoplasma gondii during host-cell invasion
27. Regulation of phosphatidylcholine metabolism in mammalian cells
28. Molecular trapping of a fluorescent ceramide analogue at the Golgi apparatus of fixed cells: Interaction with endogenous lipids provides a trans-Golgi marker for both light and electron microscopy
29. Interferon-γ blocks the growth of Toxoplasma gondii in human fibroblasts by inducing the host to degraded tryptophan
30. The parasitophorous vacuole membrane surrounding intracellular Toxoplasma gondii functions as a molecular seive
31. Toxoplasma gondii: Purine synthesis and salvage in mutant host cells and parasites
32. Molecular cloning, functional complementation in Saccharomyces cerevisiae and enzymatic properties of phosphatidylinositol synthase from the protozoan parasite Toxoplasma gondii
33. Perilipins are associated with cholesteryl ester droplets in steroidogenic adrenal cortical and Leydig cells
34. Evidence that phosphatidylserine is imported into mitochondria via a mitochondria-associated membrane and that the majority of mitochondrial phosphatidylethanolamine is derived from decarboxylation of phosphatidylserine
35. Phagosome acidification blocked by intracellular Toxoplasma gondii
36. Regulated secretion of multi-lamellar vesicles leads to formation of a tubulo-vesicular network in host cell vacuoles occupied by Toxoplasma gondii
37. The Toxoplasma gondii protein ROP2 mediates host organelle association with the parasitophorous vacuole membrane
38. Association of host cell endoplasmic reticulum and mitochondria with the Toxoplasma gondii parasitophorous vacuole membrane: A high affinity interaction
39. Cholesterol esterification by host and parasite is essential for optimal proliferation of Toxoplasma gondii
40. How proteins move lipids and lipids move proteins
41. Malarial lipids
42. Nuclear-encoded proteins target to the plastid in Toxoplasma gondii and Plasmodium falciparum
43. Protein trafficking to the plastid of Plasmodium falciparum is via the secretory pathway