Symmetrical choline-derived dications display strong anti-kinetoplastid activity

Journal of Antimicrobial Chemotherapy

Volumn 66, Issue 1, 2011, Pages 111-125

  Ibrahim, Hasan M S ^a   Al Salabi, Mohammed I ^a   Sabbagh, Nasser El ^a   Quashie, Neils B ^a   Alkhaldi, Abdulsalam A M ^a   Escale, Roger ^b   Smith, Terry K ^c   Vial, Henri J ^d   de Koning, Harry P ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b UNIVERSITÉ DE MONTPELLIER   (France)

^c UNIVERSITY OF ST ANDREWS   (United Kingdom)

^d UNIVERSITÉ DE MONTPELLIER   (France)

Author keywords

Choline; Leishmaniasis; Lipid metabolism; Protozoan parasite; Trypanosoma brucei

Indexed keywords

CHOLINE DERIVATIVE; CYCLIC AMP;

ANTIPROTOZOAL ACTIVITY; ARTICLE; CALCIUM CELL LEVEL; CELL CYCLE PROGRESSION; CHOLINE UPTAKE; DNA FRAGMENTATION; DRUG EFFICACY; DRUG MECHANISM; IN VITRO STUDY; LEISHMANIA MEXICANA; MEMBRANE PERMEABILITY; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; TRYPANOSOMA BRUCEI;

ANTIPROTOZOAL AGENTS; CATIONS, DIVALENT; CHOLINE; DNA FRAGMENTATION; LEISHMANIA MEXICANA; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; TRYPANOSOMA BRUCEI BRUCEI;

EID: 78650346533     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkq401     Document Type: Article

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