Sitamaquine sensitivity in Leishmania species is not mediated by drug accumulation in acidocalcisomes

Antimicrobial Agents and Chemotherapy

Volumn 52, Issue 11, 2008, Pages 4030-4036

  López Martín, Carmen ^a   Pérez Victoria, José María ^a   Carvalho, Luis ^a   Castanys, Santiago ^a   Gamarro, Francisco ^a  

^a INSTITUTO DE PARASITOLOGÍA Y BIOMEDICINA LÓPEZ NEYRA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

POLYPHOSPHATE; SITAMAQUINE;

ACIDITY; ANTIBIOTIC SENSITIVITY; ANTIPROTOZOAL ACTIVITY; ARTICLE; CELL COMPARTMENTALIZATION; CONTROLLED STUDY; DRUG ACCUMULATION; LEISHMANIA; LEISHMANIA BRAZILIENSIS; LEISHMANIA DONOVANI; LEISHMANIA INFANTUM; LEISHMANIA MAJOR; LEISHMANIA MEXICANA; LEISHMANIA TROPICA; LIPOPHILICITY; NONHUMAN; PRIORITY JOURNAL;

AMINOQUINOLINES; ANIMALS; ANTIPROTOZOAL AGENTS; CYTOPLASMIC VESICLES; DRUG RESISTANCE; HUMANS; HYDROGEN-ION CONCENTRATION; LEISHMANIA; LEISHMANIASIS; MUTATION; POLYPHOSPHATES; SPECIES SPECIFICITY;

EID: 55849137267     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00964-08     Document Type: Article

References (28)

1. Alvar, J., S. Croft, and P. Olliaro. 2006. Chemotherapy in the treatment and control of leishmaniasis. Adv. Parasitol. 61:223-274.
2. Araujo-Santos, J. M., F. Gamarro, S. Castanys, A. Herrmann, and T. Pomorski. 2003. Rapid transport of phospholipids across the plasma membrane of Leishmania infantum. Biochem. Biophys. Res. Commun. 306:250-255.
3. Aschar-Sobbi, R., A. Y. Abramov, C. Diao, M. E. Kargacin, G. J. Kargacin, R. J. French, and E. Pavlov. 2008. High sensitivity, quantitative measurements of polyphosphate using a new DAPI-based approach. J. Fluoresc. 18:859-866.
4. Besteiro, S., D. Tonn, L. Tetley, G. H. Coombs, and J. C. Mottram. 2008. The AP3 adaptor is involved in the transport of membrane proteins to acidocal-cisomes of Leishmania. J. Cell Sci. 121:561-570.
5. Diwu, Z., C. S. Chen, C. Zhang, D. H. Klaubert, and R. P. Haugland. 1999. A novel acidotropic pH indicator and its potential application in labeling acidic organelles of live cells. Chem. Biol. 6:411-418.
6. Docampo, R., W. de Souza, K. Miranda, P. Rohloff, and S. N. Moreno. 2005. Acidocalcisomes: conserved from bacteria to man. Nat. Rev. Microbiol. 3:251-261.
7. Docampo, R., and S. N. Moreno. 1999. Acidocalcisome: a novel Ca2+ storage compartment in trypanosomatids and apicomplexan parasites. Parasitol. Today 15:443-448.
8. Docampo, R., and S. N. Moreno. 2001. Bisphosphonates as chemotherapeutic agents against trypanosomatid and apicomplexan parasites. Curr. Drug Targets Infect. Disord. 1:51-61.
9. Duenas-Romero, A. M., P. M. Loiseau, and M. Saint-Pierre-Chazalet. 2007. Interaction of sitamaquine with membrane lipids of Leishmania donovani promastigotes. Biochim. Biophys. Acta 1768:246-252.
10. Emerson, L. R., M. E. Nau, R. K. Martin, D. E. Kyle, M. Vahey, and D. F. Wirth. 2002. Relationship between chloroquine toxicity and iron acquisition in Saccharomyces cerevisiae. Antimicrob. Agents Chemother. 46:787-796.
11. Ferella, M., Z. H. Li, B. Andersson, and R. Docampo. 2008. Farnesyl diphosphate synthase localizes to the cytoplasm of Trypanosoma cruzi and T. brucei. Exp. Parasitol. 119:308-312.
12. Garnier, T., M. B. Brown, M. J. Lawrence, and S. L. Croft. 2006. In-vitro and in-vivo studies on a topical formulation of sitamaquine dihydrochloride for cutaneous leishmaniasis. J. Pharm. Pharmacol. 58:1043-1054.
13. Gligorijevic, B., T. Bennett, R. McAllister, J. S. Urbach, and P. D. Roepe. 2006. Spinning disk confocal microscopy of live, intraerythrocytic malarial parasites. 2. Altered vacuolar volume regulation in drug resistant malaria. Biochemistry 45:12411-12423.
14. Hawley, S. R., P. G. Bray, B. K. Park, and S. A. Ward. 1996. Amodiaquine accumulation in Plasmodium falciparum as a possible explanation for its superior antimalarial activity over chloroquine. Mol. Biochem. Parasitol. 80:15-25.
15. Holopainen, J. M., J. Saarikoski, P. K. Kinnunen, and I. Jarvela. 2001. Elevated lysosomal pH in neuronal ceroid lipofuscinoses (NCLs). Eur. J. Biochem. 268:5851-5856.
16. Kinnamon, K. E., E. A. Steck, P. S. Loizeaux, W. L. Hanson, W. L. Chapman, Jr., and V. B. Waits. 1978. The antileishmanial activity of lepidines. Am. J. Trop. Med. Hyg. 27:751-757.
17. Lanteri, C. A., R. R. Tidwell, and S. R. Meshnick. 2008. The mitochondrion is a site of trypanocidal action of the aromatic diamidine DB75 in bloodstream forms of Trypanosoma brucei. Antimicrob. Agents Chemother. 52: 875-882.
18. Marchesini, N., and R. Docampo. 2002. A plasma membrane P-type H(+)-ATPase regulates intracellular pH in Leishmania mexicana amazonensis. Mol. Biochem. Parasitol. 119:225-236.
19. Mathis, A. M., A. S. Bridges, M. A. Ismail, A. Kumar, I. Francesconi, M. Anbazhagan, Q. Hu, F. A. Tanious, T. Wenzler, J. Saulter, W. D. Wilson, R. Brun, D. W. Boykin, R. R. Tidwell, and J. E. Hall. 2007. Diphenyl furans and aza analogs: effects of structural modification on in vitro activity, DNA binding, and accumulation and distribution in trypanosomes. Antimicrob. Agents Chemother. 51:2801-2810.
20. Mikus, J., and D. Steverding. 2000. A simple colorimetric method to screen drug cytotoxicity against Leishmania using the dye Alamar Blue. Parasitol. Int. 48:265-269.
21. Mullin, K. A., B. J. Foth, S. C. Ilgoutz, J. M. Callaghan, J. L. Zawadzki, G. I. McFadden, and M. J. McConville. 2001. Regulated degradation of an endoplasmic reticulum membrane protein in a tubular lysosome in Leishmania mexicana. Mol. Biol. Cell 12:2364-2377.
22. Perez-Victoria, F. J., S. Castanys, and F. Gamarro. 2003. Leishmania donovani resistance to miltefosine involves a defective inward translocation of the drug. Antimicrob. Agents Chemother. 47:2397-2403.
23. Sanchez, C. P., W. D. Stein, and M. Lanzer. 2007. Is PfCRT a channel or a carrier? Two competing models explaining chloroquine resistance in Plasmodium falciparum. Trends Parasitol. 23:332-339.
24. Seifert, K., S. Matu, F. J. Perez-Victoria, S. Castanys, F. Gamarro, and S. L. Croft. 2003. Characterisation of Leishmania donovani promastigotes resistant to hexadecylphosphocholine (miltefosine). Int. J. Antimicrob. Agents 22:380-387.
25. Seifert, K., F. J. Pérez-Victoria, M. Stettler, M. P. Sánchez-Cañete, S. Castanys, F. Gamarro, and S. L. Croft. 2007. Inactivation of the miltefosine transporter, LdMT, causes miltefosine resistance that is conferred to the amastigote stage of Leishmania donovani and persists in vivo. Int. J. Antimicrob. Agents 30:229-235.
26. Reference deleted.
27. Vercesi, A. E., C. O. Rodrigues, R. Catisti, and R. Docampo. 2000. Presence of a Na(+)/H(+) exchanger in acidocalcisomes of Leishmania donovani and their alkalization by antileishmanial drugs. FEBS Lett. 473:203-206.
28. Yeates, C. 2002. Sitamaquine (GlaxoSmithKline/Walter Reed Army Institute). Curr. Opin. Investig. Drugs 3:1446-1452.